| 1. |
- Bravo, L, et al.
(author)
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- 2021
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swepub:Mat__t
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| 2. |
- Tabiri, S, et al.
(author)
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- 2021
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swepub:Mat__t
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| 3. |
- Khatri, C, et al.
(author)
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Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
- 2021
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In: BMJ open. - : BMJ. - 2044-6055. ; 11:11, s. e050830-
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Journal article (peer-reviewed)abstract
- Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
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| 4. |
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| 5. |
- Beral, V, et al.
(author)
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Alcohol, tobacco and breast cancer - collaborative reanalysis of individual data from 53 epidemiological studies, including 58515 women with breast cancer and 95067 women without the disease
- 2002
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In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 87, s. 1234-45
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Journal article (peer-reviewed)abstract
- Alcohol and tobacco consumption are closely correlated and published results on their association with breast cancer have not always allowed adequately for confounding between these exposures. Over 80% of the relevant information worldwide on alcohol and tobacco consumption and breast cancer were collated, checked and analysed centrally. Analyses included 58515 women with invasive breast cancer and 95067 controls from 53 studies. Relative risks of breast cancer were estimated, after stratifying by study, age, parity and, where appropriate, women's age when their first child was born and consumption of alcohol and tobacco. The average consumption of alcohol reported by controls from developed countries was 6.0 g per day, i.e. about half a unit/drink of alcohol per day, and was greater in ever-smokers than never-smokers, (8.4 g per day and 5.0 g per day, respectively). Compared with women who reported drinking no alcohol, the relative risk of breast cancer was 1.32 (1.19 - 1.45, P < 0.00001) for an intake of 35 - 44 g per day alcohol, and 1.46 (1.33 - 1.61, P < 0.00001) for greater than or equal to 45 g per day alcohol. The relative risk of breast cancer increased by 7.1% (95% CI 5.5-8.7%; P<0.00001) for each additional 10 g per day intake of alcohol, i.e. for each extra unit or drink of alcohol consumed on a daily basis. This increase was the same in ever-smokers and never-smokers (7.1 % per 10 g per day, P < 0.00001, in each group). By contrast, the relationship between smoking and breast cancer was substantially confounded by the effect of alcohol. When analyses were restricted to 22 255 women with breast cancer and 40 832 controls who reported drinking no alcohol, smoking was not associated with breast cancer (compared to never-smokers, relative risk for ever-smokers= 1.03, 95% CI 0.98 - 1.07, and for current smokers=0.99, 0.92 - 1.05). The results for alcohol and for tobacco did not vary substantially across studies, study designs, or according to 15 personal characteristics of the women; nor were the findings materially confounded by any of these factors. If the observed relationship for alcohol is causal, these results suggest that about 4% of the breast cancers in developed countries are attributable to alcohol. In developing countries, where alcohol consumption among controls averaged only 0.4 g per day, alcohol would have a negligible effect on the incidence of breast cancer. In conclusion, smoking has little or no independent effect on the risk of developing breast cancer; the effect of alcohol on breast cancer needs to be interpreted in the context of its beneficial effects, in moderation, on cardiovascular disease and its harmful effects on cirrhosis and cancers of the mouth, larynx, oesophagus and liver. (C) 2002 Cancer Research UK.
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| 6. |
- Grossmann, Igor, et al.
(author)
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Insights into the accuracy of social scientists' forecasts of societal change
- 2023
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In: Nature Human Behaviour. - : Springer Nature. - 2397-3374. ; 7, s. 484-501
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Journal article (peer-reviewed)abstract
- How well can social scientists predict societal change, and what processes underlie their predictions? To answer these questions, we ran two forecasting tournaments testing the accuracy of predictions of societal change in domains commonly studied in the social sciences: ideological preferences, political polarization, life satisfaction, sentiment on social media, and gender-career and racial bias. After we provided them with historical trend data on the relevant domain, social scientists submitted pre-registered monthly forecasts for a year (Tournament 1; N = 86 teams and 359 forecasts), with an opportunity to update forecasts on the basis of new data six months later (Tournament 2; N = 120 teams and 546 forecasts). Benchmarking forecasting accuracy revealed that social scientists' forecasts were on average no more accurate than those of simple statistical models (historical means, random walks or linear regressions) or the aggregate forecasts of a sample from the general public (N = 802). However, scientists were more accurate if they had scientific expertise in a prediction domain, were interdisciplinary, used simpler models and based predictions on prior data. How accurate are social scientists in predicting societal change, and what processes underlie their predictions? Grossmann et al. report the findings of two forecasting tournaments. Social scientists' forecasts were on average no more accurate than those of simple statistical models.
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| 7. |
- Klonoff, D. C., et al.
(author)
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A Glycemia Risk Index (GRI) of Hypoglycemia and Hyperglycemia for Continuous Glucose Monitoring Validated by Clinician Ratings
- 2022
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In: Journal of Diabetes Science and Technology. - : SAGE Publications. - 1932-2968.
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Journal article (peer-reviewed)abstract
- Background: A composite metric for the quality of glycemia from continuous glucose monitor (CGM) tracings could be useful for assisting with basic clinical interpretation of CGM data. Methods: We assembled a data set of 14-day CGM tracings from 225 insulin-treated adults with diabetes. Using a balanced incomplete block design, 330 clinicians who were highly experienced with CGM analysis and interpretation ranked the CGM tracings from best to worst quality of glycemia. We used principal component analysis and multiple regressions to develop a model to predict the clinician ranking based on seven standard metrics in an Ambulatory Glucose Profile: very low–glucose and low-glucose hypoglycemia; very high–glucose and high-glucose hyperglycemia; time in range; mean glucose; and coefficient of variation. Results: The analysis showed that clinician rankings depend on two components, one related to hypoglycemia that gives more weight to very low-glucose than to low-glucose and the other related to hyperglycemia that likewise gives greater weight to very high-glucose than to high-glucose. These two components should be calculated and displayed separately, but they can also be combined into a single Glycemia Risk Index (GRI) that corresponds closely to the clinician rankings of the overall quality of glycemia (r = 0.95). The GRI can be displayed graphically on a GRI Grid with the hypoglycemia component on the horizontal axis and the hyperglycemia component on the vertical axis. Diagonal lines divide the graph into five zones (quintiles) corresponding to the best (0th to 20th percentile) to worst (81st to 100th percentile) overall quality of glycemia. The GRI Grid enables users to track sequential changes within an individual over time and compare groups of individuals. Conclusion: The GRI is a single-number summary of the quality of glycemia. Its hypoglycemia and hyperglycemia components provide actionable scores and a graphical display (the GRI Grid) that can be used by clinicians and researchers to determine the glycemic effects of prescribed and investigational treatments.
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| 8. |
- Anney, Richard, et al.
(author)
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A genome-wide scan for common alleles affecting risk for autism.
- 2010
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In: Human Molecular Genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 19:20, s. 4072-4082
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Journal article (peer-reviewed)abstract
- Although autism spectrum disorders (ASDs) have a substantial genetic basis, most of the known genetic risk has been traced to rare variants, principally copy number variants (CNVs). To identify common risk variation, the Autism Genome Project (AGP) Consortium genotyped 1558 rigorously defined ASD families for 1 million single-nucleotide polymorphisms (SNPs) and analyzed these SNP genotypes for association with ASD. In one of four primary association analyses, the association signal for marker rs4141463, located within MACROD2, crossed the genome-wide association significance threshold of P < 5 × 10(-8). When a smaller replication sample was analyzed, the risk allele at rs4141463 was again over-transmitted; yet, consistent with the winner's curse, its effect size in the replication sample was much smaller; and, for the combined samples, the association signal barely fell below the P < 5 × 10(-8) threshold. Exploratory analyses of phenotypic subtypes yielded no significant associations after correction for multiple testing. They did, however, yield strong signals within several genes, KIAA0564, PLD5, POU6F2, ST8SIA2 and TAF1C.
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| 9. |
- Bayley, PJ, et al.
(author)
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2013 SYR Accepted Poster Abstracts
- 2013
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In: International journal of yoga therapy. - 1531-2054. ; 23:1, s. 32-53
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Journal article (peer-reviewed)
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| 10. |
- Pinto, Dalila, et al.
(author)
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Functional impact of global rare copy number variation in autism spectrum disorders.
- 2010
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 466:7304, s. 368-372
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Journal article (peer-reviewed)abstract
- The autism spectrum disorders (ASDs) are a group of conditions characterized by impairments in reciprocal social interaction and communication, and the presence of restricted and repetitive behaviours. Individuals with an ASD vary greatly in cognitive development, which can range from above average to intellectual disability. Although ASDs are known to be highly heritable ( approximately 90%), the underlying genetic determinants are still largely unknown. Here we analysed the genome-wide characteristics of rare (<1% frequency) copy number variation in ASD using dense genotyping arrays. When comparing 996 ASD individuals of European ancestry to 1,287 matched controls, cases were found to carry a higher global burden of rare, genic copy number variants (CNVs) (1.19 fold, P = 0.012), especially so for loci previously implicated in either ASD and/or intellectual disability (1.69 fold, P = 3.4 x 10(-4)). Among the CNVs there were numerous de novo and inherited events, sometimes in combination in a given family, implicating many novel ASD genes such as SHANK2, SYNGAP1, DLGAP2 and the X-linked DDX53-PTCHD1 locus. We also discovered an enrichment of CNVs disrupting functional gene sets involved in cellular proliferation, projection and motility, and GTPase/Ras signalling. Our results reveal many new genetic and functional targets in ASD that may lead to final connected pathways.
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| 11. |
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| 12. |
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| 13. |
- Reilly, C., et al.
(author)
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Global development and adaptive behaviour in children with early-onset epilepsy: a population-based case-control study
- 2019
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In: Developmental Medicine and Child Neurology. - : Wiley. - 0012-1622. ; 61:2
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Journal article (peer-reviewed)abstract
- Aim There are limited population-based data on global development and adaptive behaviour in children with early-onset epilepsy. The aims of this study were: (1) to identify the prevalence of deficits in global development and adaptive behaviour experienced by children with early-onset epilepsy; (2) to identify factors associated with such deficits; and (3) to compare the relationship between measures of neurodevelopment in the group with epilepsy to a group without epilepsy who had other neurological or neurodevelopmental difficulties. Method The Sussex Early Epilepsy and Neurobehaviour study is a prospective, community-based study involving children (1-7y) with epilepsy. We undertook comprehensive psychological assessment with participants, including measures of global development and adaptive behaviour. We compared the children with epilepsy with a sex, age, and developmentally-matched group of children without epilepsy who had neurodevelopmental or neurological difficulties using correlation matrices. Results Forty-eight children (91% of the eligible population) with epilepsy underwent assessment. Seventy-one per cent of children displayed delayed global development (SD) and 56% showed significant deficits (SD) in adaptive behaviour. Our analysis revealed that non-white ethnicity and use of polytherapy were independently associated with decreased scores on measures of global development and adaptive behaviour. The correlations between measures of developmental functioning were higher in children with epilepsy than in those without. Interpretation Children with early-onset epilepsy frequently have difficulties with global development and adaptive behaviour. The higher correlations between neurodevelopmental measures in children with epilepsy suggest that the profile in children with epilepsy is different. This may have significant implications for both neuropathology and interventions. What this paper adds Children with early-onset epilepsy are at significant risk of intellectual disability. Developmental impairment is associated with use of polytherapy but not with any seizure parameters. Developmental profiles in young children with epilepsy differ from other conditions.
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| 14. |
- Welsh, Joshua A., et al.
(author)
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Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
- 2024
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In: Journal of Extracellular Vesicles. - : John Wiley and Sons Inc. - 2001-3078. ; 13:2
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Journal article (peer-reviewed)abstract
- Extracellular vesicles (EVs), through their complex cargo, can reflect the state of their cell of origin and change the functions and phenotypes of other cells. These features indicate strong biomarker and therapeutic potential and have generated broad interest, as evidenced by the steady year-on-year increase in the numbers of scientific publications about EVs. Important advances have been made in EV metrology and in understanding and applying EV biology. However, hurdles remain to realising the potential of EVs in domains ranging from basic biology to clinical applications due to challenges in EV nomenclature, separation from non-vesicular extracellular particles, characterisation and functional studies. To address the challenges and opportunities in this rapidly evolving field, the International Society for Extracellular Vesicles (ISEV) updates its ‘Minimal Information for Studies of Extracellular Vesicles’, which was first published in 2014 and then in 2018 as MISEV2014 and MISEV2018, respectively. The goal of the current document, MISEV2023, is to provide researchers with an updated snapshot of available approaches and their advantages and limitations for production, separation and characterisation of EVs from multiple sources, including cell culture, body fluids and solid tissues. In addition to presenting the latest state of the art in basic principles of EV research, this document also covers advanced techniques and approaches that are currently expanding the boundaries of the field. MISEV2023 also includes new sections on EV release and uptake and a brief discussion of in vivo approaches to study EVs. Compiling feedback from ISEV expert task forces and more than 1000 researchers, this document conveys the current state of EV research to facilitate robust scientific discoveries and move the field forward even more rapidly.
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| 15. |
- Böhm, Johann, et al.
(author)
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Mutation spectrum in the large GTPase dynamin 2, and genotype-phenotype correlation in autosomal dominant centronuclear myopathy.
- 2012
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In: Human mutation. - : Hindawi Limited. - 1098-1004 .- 1059-7794. ; 33:6, s. 949-59
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Journal article (peer-reviewed)abstract
- Centronuclear myopathy (CNM) is a genetically heterogeneous disorder associated with general skeletal muscle weakness, type I fiber predominance and atrophy, and abnormally centralized nuclei. Autosomal dominant CNM is due to mutations in the large GTPase dynamin 2 (DNM2), a mechanochemical enzyme regulating cytoskeleton and membrane trafficking in cells. To date, 40 families with CNM-related DNM2 mutations have been described, and here we report 60 additional families encompassing a broad genotypic and phenotypic spectrum. In total, 18 different mutations are reported in 100 families and our cohort harbors nine known and four new mutations, including the first splice-site mutation. Genotype-phenotype correlation hypotheses are drawn from the published and new data, and allow an efficient screening strategy for molecular diagnosis. In addition to CNM, dissimilar DNM2 mutations are associated with Charcot-Marie-Tooth (CMT) peripheral neuropathy (CMTD1B and CMT2M), suggesting a tissue-specific impact of the mutations. In this study, we discuss the possible clinical overlap of CNM and CMT, and the biological significance of the respective mutations based on the known functions of dynamin 2 and its protein structure. Defects in membrane trafficking due to DNM2 mutations potentially represent a common pathological mechanism in CNM and CMT.
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| 16. |
- Dammann, Dyre Oliver, 1985, et al.
(author)
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Applications of radar interferometry for measuring ice motion
- 2021
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In: Proceedings of the International Conference on Port and Ocean Engineering under Arctic Conditions, POAC. - 0376-6756 .- 2077-7841. - 9781713841005 ; 2021-June
-
Conference paper (peer-reviewed)abstract
- Ongoing sea ice decline has major implications for human activities near sea ice due to shorter seasons for on-ice operations and thinner ice with reduced load-bearing capacity and stability in many regions. This may in turn lead to increased sea ice mobility and impacts of ice movement on structures. We investigate space-borne radar interferometry (InSAR) as a technique to measure mm-scale sea ice motion of stationary ice over weeks to months. We find that InSAR enables mapping of bottomfast and stabilized landfast ice as regions with near-zero or reduced deformation. We further use this data to derive landfast ice strain and stress enabling estimation of the fracturing potential along the Northstar Island ice road in the Beaufort Sea, Alaska. We further examine ground-based radar interferometry (GRI) as a tool to collect continuous near real-time measurements on the km-scale not possible with InSAR. Based on GRI measurements conducted in Utqiaġvik, Alaska, we demonstrate the ability to evaluate ice strain in stationary ice and track vertical ice displacement due to tides. We also collected GRI measurements at 500 Hz during a drifting ice camp in the Beaufort Sea. The high sampling rate enabled tracking of continuous strain and detection of subtle variations in behavior between ice regimes. Through this work, interferometry shows promise as a tool to observe ice motion at the relevant scales needed for assessing sea ice stability, identify precursors to failure events, and better understand the relationship between different ice properties and loads on structures.
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| 17. |
- Dammann, Dyre Oliver, 1985, et al.
(author)
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Assessing sea ice trafficability in a changing arctic
- 2018
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In: Arctic. - : The Arctic Institute of North America. - 1923-1245 .- 0004-0843. ; 71:1, s. 59-75
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Journal article (peer-reviewed)abstract
- Arctic sea ice has undergone rapid changes during the last few decades, with negative implications for over-ice travel and on-ice operations, which benefit from services provided by the sea ice. A Parameter-based Trafficability Hierarchy (PATH) is presented here as a framework for developing quantitative assessment strategies that can guide planning and execution of operations on or near sea ice and quantify the impacts of recent changes on ice use. A PATH assessment has been completed for three case studies in Arctic Alaska. These cases, which correspond to a range of different icescapes and ice uses, identify and quantify different parameters linked to trafficability and safe operations. For ice road applications, PATH was used to determine an ice thickness compensation factor, a factor increasing the minimal thickness threshold for operations, to help translate sporadic auger ice thickness measurements along the Kotzebue-Kiana community ice road into an envelope for safe operations. A compensation factor as high as 1.5 was found to be necessary to ensure safety because of the high local thickness variability that is currently a concern for ice road operators. A PATH assessment of ice roughness for ice trail routing at Utqiaġvik draws on satellite remote sensing and is relevant for over-ice travel in general, including escape, evacuation, and rescue. We compared the routing of local snowmobile trails with Synthetic Aperture Radar (SAR) data products to identify specific ranges of ice conditions, roughness, and topography favored for ice trail construction. The same combination of data sources was used to identify potentially beneficial trail routes. Finally, an ice stability and safety assessment was completed for ice road construction and maintenance by industry near the Northstar Island oil production facility. We evaluated small-scale ice displacement data obtained from SAR interferometry to infer internal ice strain and stress and used these data in assessing the potential for fractures to reduce load-bearing capacity.
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| 18. |
- Dammann, Dyre Oliver, 1985, et al.
(author)
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Evaluating landfast sea ice stress and fracture in support of operations on sea ice using SAR interferometry
- 2018
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In: Cold Regions Science and Technology. - : Elsevier BV. - 0165-232X. ; 149, s. 51-64
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Journal article (peer-reviewed)abstract
- Recent Arctic warming has led to reduced sea-ice thickness and a more dynamic landfast ice cover with potential widespread consequences for ice users. Here, we develop an approach to assess the small-scale deformation of landfast ice critical to on-ice operations using synthetic aperture radar interferometry (InSAR). InSAR has previously proven successful in determining long-term qualitative climatology of ice deformation around on-ice operations, but is now used to explore its potential for providing quantitative guidance for ice road planning, construction, and maintenance. A validation effort using X-band SAR and high-precision GPS data over Elson Lagoon, Alaska, confirms the ability of InSAR to accurately estimate 3-dimensional sea ice strain values accumulated between SAR image acquisitions, using an inverse model. The inverse model was further applied to L-band InSAR data over the Northstar Island ice road near Prudhoe Bay, Alaska. Assuming an elasto-brittle rheology, the derived strain values yielded a spatial distribution of internal stress consistent with preexisting ice defects and morphology. In several localized regions of the study area, stress values exceeded expected yield stress. Resulting relative fracture intensity potential was shown to conform with local knowledge based on road inspections by engineers, and may be used to guide ice road planning, construction and maintenance efforts. The results presented here demonstrate that InSAR is an accurate tool for estimating landfast ice deformation and stability in support of ice use. The findings may also provide substantial new insights into the mechanics of landfast ice.
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| 19. |
- Dammann, Dyre Oliver, 1985, et al.
(author)
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Iceberg topography and volume classification using TanDEM-X interferometry
- 2019
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In: Cryosphere. - : Copernicus GmbH. - 1994-0424 .- 1994-0416. ; 13:7, s. 1861-1875
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Journal article (peer-reviewed)abstract
- Icebergs in polar regions affect water salinity, alter marine habitats, and impose serious hazards on maritime operations and navigation. These impacts mainly depend on the iceberg volume, which remains an elusive parameter to measure. We investigate the capability of TanDEM-X bistatic single-pass synthetic aperture radar interferometry (InSAR) to derive iceberg subaerial morphology and infer total volume. We cross-verify InSAR results with Operation IceBridge (OIB) data acquired near Wordie Bay, Antarctica, as part of the OIB/TanDEM-X Antarctic Science Campaign (OTASC). While icebergs are typically classified according to size based on length or maximum height, we develop a new volumetric classification approach for applications where iceberg volume is relevant. For icebergs with heights exceeding 5 m, we find iceberg volumes derived from TanDEM-X and OIB data match within 7 %. We also derive a range of possible iceberg keel depths relevant to grounding and potential impacts on subsea installations. These results suggest that TanDEM-X could pave the way for future single-pass interferometric systems for scientific and operational iceberg mapping and classification based on iceberg volume and keel depth.
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| 20. |
- Dammann, Dyre Oliver, 1985, et al.
(author)
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Instantaneous sea ice drift speed from TanDEM-X interferometry
- 2019
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In: Cryosphere. - : Copernicus GmbH. - 1994-0424 .- 1994-0416. ; 13:4, s. 1395-1408
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Journal article (peer-reviewed)abstract
- The drift of sea ice is an important geophysical process with widespread implications for the ocean energy budget and ecosystems. Drifting sea ice can also threaten marine operations and present a hazard for ocean vessels and installations. Here, we evaluate single-pass along-track synthetic aperture radar (SAR) interferometry (S-ATI) as a tool to assess ice drift while discussing possible applications and inherent limitations. Initial validation shows that TanDEM-X phase-derived drift speed corresponds well with drift products from a ground-based radar at Utqiagvik, Alaska. Joint analysis of TanDEM-X and Sentinel-1 data covering the Fram Strait demonstrates that S-ATI can help quantify the opening/closing rate of leads with possible applications for navigation. S-ATI enables an instantaneous assessment of ice drift and dynamic processes that are otherwise difficult to observe. For instance, by evaluating sea ice drift through the Vilkitsky Strait, Russia, we identified short-lived transient convergence patterns. We conclude that S-ATI enables the identification and analysis of potentially important dynamic processes (e.g., drift, rafting, and ridging). However, current limitations of S-ATI are significant (e.g., data availability and they presently only provide the cross-track vector component of the ice drift field) but may be significantly reduced with future SAR systems.
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| 21. |
- Dammann, Dyre Oliver, 1985, et al.
(author)
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Mapping Arctic Bottomfast Sea Ice Using SAR Interferometry
- 2018
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In: Remote Sensing. - : MDPI AG. - 2072-4292. ; 10:5
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Journal article (peer-reviewed)abstract
- Bottomfast sea ice is an integral part of many near-coastal Arctic ecosystems with implications for subsea permafrost, coastal stability and morphology. Bottomfast sea ice is also of great relevance to over-ice travel by coastal communities, industrial ice roads, and marine habitats. There are currently large uncertainties around where and how much bottomfast ice is present in the Arctic due to the lack of effective approaches for detecting bottomfast sea ice on large spatial scales. Here, we suggest a robust method capable of detecting bottomfast sea ice using spaceborne synthetic aperture radar interferometry. This approach is used to discriminate between slowly deforming floating ice and completely stationary bottomfast ice based on the interferometric phase. We validate the approach over freshwater ice in the Mackenzie Delta, Canada, and over sea ice in the Colville Delta and Elson Lagoon, Alaska. For these areas, bottomfast ice, as interpreted from the interferometric phase, shows high correlation with local bathymetry and in-situ ice auger and ground penetrating radar measurements. The technique is further used to track the seasonal evolution of bottomfast ice in the Kasegaluk Lagoon, Alaska, by identifying freeze-up progression and areas of liquid water throughout winter.
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| 22. |
- Dammann, Dyre Oliver, 1985, et al.
(author)
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Mapping pan-Arctic landfast sea ice stability using Sentinel-1 interferometry
- 2019
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In: Cryosphere. - : Copernicus GmbH. - 1994-0424 .- 1994-0416. ; 13:2, s. 557-577
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Journal article (peer-reviewed)abstract
- Arctic landfast sea ice has undergone substantial changes in recent decades, affecting ice stability and including potential impacts on ice travel by coastal populations and on industry ice roads. We present a novel approach for evaluating landfast sea ice stability on a pan-Arctic scale using Synthetic Aperture Radar Interferometry (InSAR). Using Sentinel-1 images from spring 2017, we discriminate between bottomfast, stabilized, and nonstabilized landfast ice over the main marginal seas of the Arctic Ocean (Beaufort, Chukchi, East Siberian, Laptev, and Kara seas). This approach draws on the evaluation of relative changes in interferometric fringe patterns. This first comprehensive assessment of Arctic bottomfast sea ice extent has revealed that most of the bottomfast sea ice is situated around river mouths and coastal shallows. The Laptev and East Siberian seas dominate the aerial extent, covering roughly 4100 and 5100 km(2), respectively. These seas also contain the largest extent of stabilized and nonstabilized landfast ice, but are subject to the largest uncertainties surrounding the mapping scheme. Even so, we demonstrate the potential for using InSAR for assessing the stability of landfast ice in several key regions around the Arctic, providing a new understanding of how stability may vary between regions. InSAR-derived stability may serve for strategic planning and tactical decision support for different uses of coastal ice. In a case study of the Nares Strait, we demonstrate that interferograms may reveal early-warning signals for the breakup of stationary sea ice.
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| 23. |
- Dammann, Dyre Oliver, 1985, et al.
(author)
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New possibilities using TSX and TDX in support of sea ice use
- 2018
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In: Proceedings of the European Conference on Synthetic Aperture Radar, EUSAR. - 2197-4403. ; 2018-June, s. 159-164
-
Conference paper (peer-reviewed)abstract
- Sea ice travel and on-ice operations are important for Arctic coastal communities and industrial operations. Recent rapid changes in Arctic sea ice impacting ice users emphasize the need for assessment strategies capable of guiding decision makers and documenting change in key ice-use related parameters. In this paper, we demonstrate the potential for the use of TSX and TDX interferometry to assess deformation, drift, and roughness of coastal sea ice. Through on-ice validation using Structure-from-Motion and high-precision GPS, we demonstrate a high level of detail and accuracy potentially enabling the use of these products in decision making.
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| 24. |
- Dammann, Dyre Oliver, 1985, et al.
(author)
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Traversing Sea Ice-Linking Surface Roughness and Ice Trafficability Through SAR Polarimetry and Interferometry
- 2018
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In: IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing. - 2151-1535 .- 1939-1404. ; 11:2, s. 416-433
-
Journal article (peer-reviewed)abstract
- Arctic landfast sea ice is widely utilized for transportation by local communities and industry, with trafficability largely governed by ice roughness. Here, we introduce an approach to evaluate ice roughness that can aid in routing of ice roads and assessment of spatial variability and long-term changes in trafficability. Drawing on synthetic aperture radar (SAR) polarimetry, SAR interferometry (InSAR), and other remote sensing techniques, we integrated approaches into the trafficability assessment that had rarely been applied over sea ice in the past. Analysis of aerial photogrammetry obtained through structure-from-motion helped verify cm-scale accuracy of X-band InSAR-derived ridge height and link L-band polarimetric classification to specific roughness regimes. Jointly, these approaches enable a km-scale evaluation of ridge topography and cm-to m-scale roughness-both critical for the assessment of trafficability. A trafficability index was derived from such SAR data in conjunction with analysis of ice trail routing and ice use near Utqiaġvik, Alaska. The index identifies areas of reduced trafficability, associated with pressure ridges or rubble ice, and served to delineate favorable trail routes for different modes of transportation, with potential uses ranging from ice road routing to emergency evacuation. Community outreach is needed to explore how this approach could assist different ice users in reducing risk, minimizing trail or ice construction efforts, and improving safety.
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| 25. |
- Leggat, DJ, et al.
(author)
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Vaccination induces HIV broadly neutralizing antibody precursors in humans
- 2022
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In: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 378:6623, s. 964-
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Journal article (peer-reviewed)abstract
- Broadly neutralizing antibodies (bnAbs) can protect against HIV infection but have not been induced by human vaccination. A key barrier to bnAb induction is vaccine priming of rare bnAb-precursor B cells. In a randomized, double-blind, placebo-controlled phase 1 clinical trial, the HIV vaccine–priming candidate eOD-GT8 60mer adjuvanted with AS01Bhad a favorable safety profile and induced VRC01-class bnAb precursors in 97% of vaccine recipients with median frequencies reaching 0.1% among immunoglobulin G B cells in blood. bnAb precursors shared properties with bnAbs and gained somatic hypermutation and affinity with the boost. The results establish clinical proof of concept for germline-targeting vaccine priming, support development of boosting regimens to induce bnAbs, and encourage application of the germline-targeting strategy to other targets in HIV and other pathogens.
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| 26. |
- Mahoney, Craig, et al.
(author)
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Slope Estimation from ICESat/GLAS
- 2014
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In: Remote Sensing. - : MDPI AG. - 2072-4292. ; 6:10, s. 10051-10069
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Journal article (peer-reviewed)abstract
- We present a novel technique to infer ground slope angle from waveform LiDAR, known as the independent slope method (ISM). The technique is applied to large footprint waveforms (similar to 60 m mean diameter) from the Ice, Cloud and Land Elevation Satellite (ICESat) Geoscience Laser Altimeter System (GLAS) to produce a slope dataset of near-global coverage at 0.5 degrees x 0.5 degrees resolution. ISM slope estimates are compared against high resolution airborne LiDAR slope measurements for nine sites across three continents. ISM slope estimates compare better with the aircraft data (R-2 = 0.87 and RMSE = 5.16 degrees) than the Shuttle Radar Topography Mission Digital Elevation Model (SRTM DEM) inferred slopes (R-2 = 0.71 and RMSE = 8.69 degrees). ISM slope estimates are concurrent with GLAS waveforms and can be used to correct biophysical parameters, such as tree height and biomass. They can also be fused with other DEMs, such as SRTM, to improve slope estimates.
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| 27. |
- McFarlane, G., et al.
(author)
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Enamel daily secretion rates of deciduous molars from a global sample of children
- 2021
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In: Archives of Oral Biology. - : Elsevier BV. - 0003-9969. ; 132
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Journal article (peer-reviewed)abstract
- Objective: To investigate and describe the variation in enamel daily secretion rates (DSRs) of naturally exfoliated deciduous molars (n = 345) from five modern-day populations (Aotearoa New Zealand, Britain, Canada, France, and Sweden). Design: Each tooth was thin sectioned and examined using a high-powered Olympus BX51 microscope and DP25 digital microscope camera. Mean DSRs were recorded for the inner, mid, and outer regions of cuspal and lateral enamel, excluding enamel nearest the enamel-dentin junction and at the outermost crown surface. Results: Mean DSRs did not vary significantly between populations, or by sex. Cuspal enamel grew slightly faster than lateral enamel (mean difference 0.16 mu m per day; p < 0.001). The trajectory of DSRs remained relatively constant from inner to outer cuspal enamel and increased slightly in lateral enamel (p = 0.003). Conclusions: The DSRs of deciduous molars from modern-day children are remarkably consistent when compared among populations. While growth rates are faster in cuspal than lateral enamel, the trajectory of enamel formation changes only slightly from inner to outer regions. The trajectory of DSRs for deciduous molars differs to that of permanent molar enamel, which typically display a steep increase in matrix deposition from inner to outer enamel.
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| 28. |
- Noetel, Michael, et al.
(author)
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Prediction Versus Explanation in Educational Psychology : a Cross-Theoretical Approach to Using Teacher Behaviour to Predict Student Engagement in Physical Education
- 2023
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In: Educational psychology review. - New York, NY : Springer. - 1040-726X .- 1573-336X. ; 35:3
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Research review (peer-reviewed)abstract
- Educational psychology usually focuses on explaining phenomena. As a result, researchers seldom explore how well their models predict the outcomes they care about using best-practice approaches to predictive statistics. In this paper, we focus less on explanation and more on prediction, showing how both are important for advancing the field. We apply predictive models to the role of teachers on student engagement, i.e. the thoughts, attitudes, and behaviours, that translate motivation into progress. We integrate the suggestions from four prominent motivational theories (self-determination theory, achievement goal theory, growth mindset theory, and transformational leadership theory), and aim to identify those most critical behaviours for predicting changes in students’ engagement in physical education. Students (N = 1324 all from year 7, 52% girls) from 17 low socio-economic status schools rated their teacher’s demonstration of 71 behaviours in the middle of the school year. We also assessed students’ engagement at the beginning and end of the year. We trained elastic-net regression models on 70% of the data and then assessed their predictive validity on the held-out data (30%). The models showed that teacher behaviours predicted 4.39% of the variance in students’ change in engagement. Some behaviours that were most consistently associated with a positive change in engagement were being good role models (β = 0.046), taking interest in students’ lives outside of class (β = 0.033), and allowing students to make choices (β = 0.029). The influential behaviours did not neatly fit within any single motivational theory. These findings support arguments for integrating different theoretical approaches, and suggest practitioners may want to consider multiple theories when designing interventions. More generally, we argue that researchers in educational psychology should more frequently test how well their models not just explain, but predict the outcomes they care about. © 2023, Crown.
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| 29. |
- Seto, Mabel, et al.
(author)
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Exploring common genetic contributors to neuroprotection from amyloid pathology.
- 2022
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In: Brain communications. - : Oxford University Press (OUP). - 2632-1297. ; 4:2
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Journal article (peer-reviewed)abstract
- Preclinical Alzheimer's disease describes some individuals who harbour Alzheimer's pathologies but are asymptomatic. For this study, we hypothesized that genetic variation may help protect some individuals from Alzheimer's-related neurodegeneration. We therefore conducted a genome-wide association study using 5891064 common variants to assess whether genetic variation modifies the association between baseline beta-amyloid, as measured by both cerebrospinal fluid and positron emission tomography, and neurodegeneration defined using MRI measures of hippocampal volume. We combined and jointly analysed genotype, biomarker and neuroimaging data from non-Hispanic white individuals who were enrolled in four longitudinal ageing studies (n=1065). Using regression models, we examined the interaction between common genetic variants (Minor Allele Frequency >0.01), including APOE-ɛ4 and APOE-ɛ2, and baseline cerebrospinal levels of amyloid (CSF Aβ42) on baseline hippocampal volume and the longitudinal rate of hippocampal atrophy. For targeted replication of top findings, we analysed an independent dataset (n=808) where amyloid burden was assessed by Pittsburgh Compound B ([11C]-PiB) positron emission tomography. In this study, we found that APOE-ɛ4 modified the association between baseline CSF Aβ42 and hippocampal volume such that APOE-ɛ4 carriers showed more rapid atrophy, particularly in the presence of enhanced amyloidosis. We also identified a novel locus on chromosome 3 that interacted with baseline CSF Aβ42. Minor allele carriers of rs62263260, an expression quantitative trait locus for the SEMA5B gene (P=1.46×10-8; 3:122675327) had more rapid neurodegeneration when amyloid burden was high and slower neurodegeneration when amyloid was low. The rs62263260×amyloid interaction on longitudinal change in hippocampal volume was replicated in an independent dataset (P=0.0112) where amyloid burden was assessed by positron emission tomography. In addition to supporting the established interaction between APOE and amyloid on neurodegeneration, our study identifies a novel locus that modifies the association between beta-amyloid and hippocampal atrophy. Annotation results may implicate SEMA5B, a gene involved in synaptic pruning and axonal guidance, as a high-quality candidate for functional confirmation and future mechanistic analysis.
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| 30. |
- Wray, Selina, et al.
(author)
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Creation of an Open-Access, Mutation-Defined Fibroblast Resource for Neurological Disease Research
- 2012
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In: PLoS ONE. - : Public Library of Science (PLoS). - 1932-6203. ; 7:8
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Journal article (peer-reviewed)abstract
- Our understanding of the molecular mechanisms of many neurological disorders has been greatly enhanced by the discovery of mutations in genes linked to familial forms of these diseases. These have facilitated the generation of cell and animal models that can be used to understand the underlying molecular pathology. Recently, there has been a surge of interest in the use of patient-derived cells, due to the development of induced pluripotent stem cells and their subsequent differentiation into neurons and glia. Access to patient cell lines carrying the relevant mutations is a limiting factor for many centres wishing to pursue this research. We have therefore generated an open-access collection of fibroblast lines from patients carrying mutations linked to neurological disease. These cell lines have been deposited in the National Institute for Neurological Disorders and Stroke (NINDS) Repository at the Coriell Institute for Medical Research and can be requested by any research group for use in in vitro disease modelling. There are currently 71 mutation-defined cell lines available for request from a wide range of neurological disorders and this collection will be continually expanded. This represents a significant resource that will advance the use of patient cells as disease models by the scientific community.
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