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- Stolk, Jan, et al.
(author)
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Randomised controlled trial for emphysema with a selective agonist of the gamma-type retinoic acid receptor
- 2012
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In: European Respiratory Journal. - : European Respiratory Society (ERS). - 1399-3003 .- 0903-1936. ; 40:2, s. 306-312
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Journal article (peer-reviewed)abstract
- Palovarotene is an oral gamma-selective retinoid agonist. In animal emphysema models, palovarotene reduced inflammation, promoted structural repair and functional improvement. REPAIR (Retinoid treatment of Emphysema in Patients on the alpha(1)-antitrypsin International Registry), was an investigator-initiated, double-blind, placebo-controlled randomised study to assess the safety and efficacy of 5 mg.day(-1) palovarotene given for 1 year to 262 patients with severe alpha(1)-antitrypsin deficiency and emphysema confirmed by computed tomography. Change in volume-adjusted 15th percentile point lung density from baseline in 1 year was the primary endpoint; functional end-points were also regularly assessed. We randomly assigned 133 and 129 patients to placebo or palovarotene, respectively. Both groups were well matched for all baseline characteristics, including respiratory medications. 88% and 85% of patients completed 1 year of treatment with placebo and palovarotene, respectively. Palovarotene was generally well tolerated. In the study completers population, the placebo-corrected difference of lung density was -0.45 HU at week 28 (p=0.64) and -0.25 HU at week 52 (p=0.94). A nonsignificant treatment difference in most functional parameters of the lung in favour of the drug was observed over time suggesting potential pharmacological effects of palovarotene. Palovarotene 5 mg.day(-1) over 1 yr failed to show a significant benefit on lung density in moderate-to-severe emphysema secondary to severe alpha(1)-antitrypsin deficiency.
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| 4. |
- Martell, J., et al.
(author)
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Combined Neutron and X-Ray Tomography-A Versatile and Non-Destructive Tool in Planetary Geosciences
- 2024
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In: Journal of Geophysical Research - Planets. - : American Geophysical Union (AGU). - 2169-9097 .- 2169-9100. ; 129:2
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Research review (peer-reviewed)abstract
- With several upcoming sample return missions, such as the Mars Sample Return Campaign, non-destructive methods will be key to maximizing their scientific output. In this study, we demonstrate that the combination of neutron and X-ray tomography provides an important tool for the characterization of such valuable samples. These methods allow quantitative analyses of internal sample features and also provide a guide for further destructive analyses with little to no sample treatment, which maintains sample integrity, including minimizing the risk of potential contamination. Here, we present and review the results from four case studies of terrestrial impactites and meteorites along with their analytical setup. Using combined X-ray and neutron tomography, a Ni-Fe silicide spherule, that is, projectile material, was located within a Libyan Desert Glass sample and the distribution of hydrous phases was pinpointed in selected impactite samples from the Chicxulub IODP-ICDP Expedition 364 drill core and the Luizi impact structure, as well as in the Miller Range 03346 Martian meteorite. Neutron and X-ray tomography give complementary three-dimensional information about the distribution of different phases within a geologic sample. We demonstrate that these two methods can be successfully used to locate meteoritic material (i.e., from the impacting object) and hydrous components in terrestrial impactites and meteorites. This can help shed light on aqueous processes in the Solar System as well as the impact cratering process. Non-destructive methods like these will be important for up-coming sample return missions to characterize the returned samples and guide further destructive analyses. Combined neutron and X-ray imaging was used to locate projectile material and hydrous phases in meteorites and terrestrial impactites Locating and identifying projectile material can shed light on the impact cratering process Combined neutron/X-ray tomography can serve as a fundamental method for the characterization of material from (future) sample return missions
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