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3. |
- Aad, G., et al.
(author)
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- 2015
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Journal article (peer-reviewed)
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4. |
- Aad, G., et al.
(author)
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- 2014
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Journal article (peer-reviewed)
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5. |
- Aad, G., et al.
(author)
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- 2013
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In: New Journal of Physics. - : IOP Publishing. - 1367-2630. ; 15
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Journal article (peer-reviewed)
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6. |
- Aad, G., et al.
(author)
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- 2013
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Journal article (peer-reviewed)
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7. |
- Aad, G., et al.
(author)
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- 2014
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Journal article (peer-reviewed)
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8. |
- Aad, G., et al.
(author)
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- 2014
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In: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 112:4
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Journal article (peer-reviewed)
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9. |
- Aad, G., et al.
(author)
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- 2013
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In: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 111:23
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Journal article (peer-reviewed)
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10. |
- Aad, G., et al.
(author)
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- 2014
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In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :5
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Journal article (peer-reviewed)
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11. |
- Aad, G., et al.
(author)
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- 2014
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In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :4
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Journal article (peer-reviewed)
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12. |
- Aad, G., et al.
(author)
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- 2013
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Journal article (peer-reviewed)
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13. |
- Aad, G., et al.
(author)
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- 2013
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In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :10
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Journal article (peer-reviewed)
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14. |
- Aad, G., et al.
(author)
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- 2014
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Journal article (peer-reviewed)
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15. |
- Aad, G., et al.
(author)
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- 2013
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Journal article (peer-reviewed)
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16. |
- Aad, G., et al.
(author)
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- 2013
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In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :4
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Journal article (peer-reviewed)
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17. |
- Aad, G., et al.
(author)
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- 2013
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Journal article (peer-reviewed)
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18. |
- Aad, G., et al.
(author)
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- 2014
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In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :2
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Journal article (peer-reviewed)
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19. |
- Aad, G., et al.
(author)
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- 2013
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In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :10
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Journal article (peer-reviewed)
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20. |
- Aad, G., et al.
(author)
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- 2014
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Journal article (peer-reviewed)
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21. |
- Aad, G., et al.
(author)
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- 2013
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Journal article (peer-reviewed)
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22. |
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24. |
- Blokland, G. A. M., et al.
(author)
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Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders
- 2022
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In: Biological Psychiatry. - : Elsevier BV. - 0006-3223 .- 1873-2402. ; 91:1, s. 102-117
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Journal article (peer-reviewed)abstract
- Background: Sex differences in incidence and/or presentation of schizophrenia (SCZ), major depressive disorder (MDD), and bipolar disorder (BIP) are pervasive. Previous evidence for shared genetic risk and sex differences in brain abnormalities across disorders suggest possible shared sex-dependent genetic risk. Methods: We conducted the largest to date genome-wide genotype-by-sex (G×S) interaction of risk for these disorders using 85,735 cases (33,403 SCZ, 19,924 BIP, and 32,408 MDD) and 109,946 controls from the PGC (Psychiatric Genomics Consortium) and iPSYCH. Results: Across disorders, genome-wide significant single nucleotide polymorphism–by-sex interaction was detected for a locus encompassing NKAIN2 (rs117780815, p = 3.2 × 10−8), which interacts with sodium/potassium-transporting ATPase (adenosine triphosphatase) enzymes, implicating neuronal excitability. Three additional loci showed evidence (p < 1 × 10−6) for cross-disorder G×S interaction (rs7302529, p = 1.6 × 10−7; rs73033497, p = 8.8 × 10−7; rs7914279, p = 6.4 × 10−7), implicating various functions. Gene-based analyses identified G×S interaction across disorders (p = 8.97 × 10−7) with transcriptional inhibitor SLTM. Most significant in SCZ was a MOCOS gene locus (rs11665282, p = 1.5 × 10−7), implicating vascular endothelial cells. Secondary analysis of the PGC-SCZ dataset detected an interaction (rs13265509, p = 1.1 × 10−7) in a locus containing IDO2, a kynurenine pathway enzyme with immunoregulatory functions implicated in SCZ, BIP, and MDD. Pathway enrichment analysis detected significant G×S interaction of genes regulating vascular endothelial growth factor receptor signaling in MDD (false discovery rate-corrected p < .05). Conclusions: In the largest genome-wide G×S analysis of mood and psychotic disorders to date, there was substantial genetic overlap between the sexes. However, significant sex-dependent effects were enriched for genes related to neuronal development and immune and vascular functions across and within SCZ, BIP, and MDD at the variant, gene, and pathway levels. © 2021 Society of Biological Psychiatry
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25. |
- Aad, G., et al.
(author)
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- 2014
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In: The European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6052. ; 74:6
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Journal article (peer-reviewed)
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26. |
- Aad, G., et al.
(author)
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- 2014
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In: Physical Review C (Nuclear Physics). - 0556-2813 .- 1089-490X. ; 90:2
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Journal article (peer-reviewed)
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27. |
- Aad, G., et al.
(author)
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- 2014
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Journal article (peer-reviewed)
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28. |
- Aad, G., et al.
(author)
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- 2014
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Journal article (peer-reviewed)
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29. |
- Aad, G., et al.
(author)
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- 2014
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Journal article (peer-reviewed)
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30. |
- Aad, G., et al.
(author)
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- 2014
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In: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 112:9
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Journal article (peer-reviewed)
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31. |
- Aad, G., et al.
(author)
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- 2014
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Journal article (peer-reviewed)
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32. |
- Aad, G., et al.
(author)
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- 2014
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In: Physical Review D. Particles and fields. - 0556-2821 .- 1089-4918. ; 89:9
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Journal article (peer-reviewed)
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33. |
- Aad, G., et al.
(author)
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- 2014
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In: Physical Review Letters. - 1079-7114 .- 0031-9007. ; 112:20
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Journal article (peer-reviewed)
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34. |
- Aad, G., et al.
(author)
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- 2014
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In: Journal of High Energy Physics. - : Springer. - 1029-8479 .- 1126-6708. ; :6
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Journal article (peer-reviewed)
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35. |
- Aad, G., et al.
(author)
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- 2014
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In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :6
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Journal article (peer-reviewed)
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36. |
- Aad, G., et al.
(author)
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- 2014
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In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :6
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Journal article (peer-reviewed)
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37. |
- Aad, G., et al.
(author)
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- 2014
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In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :5
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Journal article (peer-reviewed)
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38. |
- Aad, G., et al.
(author)
-
- 2014
-
Journal article (peer-reviewed)
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39. |
- Aad, G., et al.
(author)
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- 2014
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In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :6
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Journal article (peer-reviewed)
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40. |
- Aad, G., et al.
(author)
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- 2014
-
In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :4
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Journal article (peer-reviewed)
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41. |
- Aad, G., et al.
(author)
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- 2014
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In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :4
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Journal article (peer-reviewed)
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42. |
- Aad, G., et al.
(author)
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- 2014
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In: Journal of High Energy Physics. - 1029-8479 .- 1126-6708. ; :5, s. 1-52
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Journal article (peer-reviewed)
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43. |
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44. |
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48. |
- Aad, G, et al.
(author)
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Determination of spin and parity of the Higgs boson in the [Formula: see text] decay channel with the ATLAS detector.
- 2015
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In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 75:5
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Journal article (peer-reviewed)abstract
- Studies of the spin and parity quantum numbers of the Higgs boson in the [Formula: see text] final state are presented, based on proton-proton collision data collected by the ATLAS detector at the Large Hadron Collider, corresponding to an integrated luminosity of 20.3 fb[Formula: see text] at a centre-of-mass energy of [Formula: see text] TeV. The Standard Model spin-parity [Formula: see text] hypothesis is compared with alternative hypotheses for both spin and CP. The case where the observed resonance is a mixture of the Standard-Model-like Higgs boson and CP-even ([Formula: see text]) or CP-odd ([Formula: see text]) Higgs boson in scenarios beyond the Standard Model is also studied. The data are found to be consistent with the Standard Model prediction and limits are placed on alternative spin and CP hypotheses, including CP mixing in different scenarios.
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