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| 2. |
- Bravo, L, et al.
(author)
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- 2021
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swepub:Mat__t
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- Tabiri, S, et al.
(author)
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- 2021
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swepub:Mat__t
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- Akhtar, Ahmad Saleem, et al.
(author)
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Fully automated centrifugal microfluidic platform for COVID-19 detection using computer vision-based readout
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Other publication (other academic/artistic)abstract
- COVID-19 pandemic made it evident that the world is unprepared for effectively tackling a pandemic resulting from an infectious disease. The conventional diagnostic methods for detection of infectious diseases were limited to centralized laboratories. As the burden of testing increased with the spread of the disease, the centralized testing facilities were strained for resources and personnel. These problems were further exacerbated in low- and middle-income countries where the health and transport infrastructure are not very well developed. To overcome this reliance on centralized testing and to facilitate decentralized testing, focus was shifted towards development of novel point-of-care diagnostic methods. We report the development of a fully automated centrifugal microfluidic platform that uses loop mediated isothermal amplification (LAMP) combined with computer vision-based readout for COVID-19 detection. The integrated platform allows sample to answer analysis at the push of a single button and can process 26 samples in 40 minutes. The platform performs a completely automated assay protocol involving heating, rotation and detection without the need for user intervention. A limit of detection of approximately 100 RNA copies in 10 µL reaction was achieved using RNA fragments spiked in water and similar results were obtained for artificial saliva samples.
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| 9. |
- Bissell, Malenka M., et al.
(author)
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4D Flow cardiovascular magnetic resonance consensus statement : 2023 update
- 2023
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In: Journal of Cardiovascular Magnetic Resonance. - : BMC. - 1097-6647 .- 1532-429X. ; 25:1
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Research review (peer-reviewed)abstract
- Hemodynamic assessment is an integral part of the diagnosis and management of cardiovascular disease. Four-dimensional cardiovascular magnetic resonance flow imaging (4D Flow CMR) allows comprehensive and accurate assessment of flow in a single acquisition. This consensus paper is an update from the 2015 ‘4D Flow CMR Consensus Statement’. We elaborate on 4D Flow CMR sequence options and imaging considerations. The document aims to assist centers starting out with 4D Flow CMR of the heart and great vessels with advice on acquisition parameters, post-processing workflows and integration into clinical practice. Furthermore, we define minimum quality assurance and validation standards for clinical centers. We also address the challenges faced in quality assurance and validation in the research setting. We also include a checklist for recommended publication standards, specifically for 4D Flow CMR. Finally, we discuss the current limitations and the future of 4D Flow CMR. This updated consensus paper will further facilitate widespread adoption of 4D Flow CMR in the clinical workflow across the globe and aid consistently high-quality publication standards.
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| 10. |
- Borges, J., et al.
(author)
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Microstructural evolution of Au/TiO2 nanocomposite films : The influence of Au concentration and thermal annealing
- 2015
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In: Thin Solid Films. - : Elsevier BV. - 0040-6090 .- 1879-2731. ; 580, s. 77-88
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Journal article (peer-reviewed)abstract
- Nanocomposite thin films consisting of a dielectric matrix, such as titanium oxide (TiO2), with embedded gold (Au) nanoparticles were prepared and will be analysed and discussed in detail in the present work. The evolution of morphological and structural features was studied for a wide range of Au concentrations and for annealing treatments in air, for temperatures ranging from 200 to 800 degrees C. Major findings revealed that for low Au atomic concentrations (at.%), there are only traces of clustering, and just for relatively high annealing temperatures, T >= 500 degrees C. Furthermore, the number of Au nanoparticles is extremely low, even for the highest annealing temperature, T = 800 degrees C. It is noteworthy that the TiO2 matrix also crystallizes in the anatase phase for annealing temperatures above 300 degrees C. For intermediate Au contents (5 at.% <= C-Au <= 15 at.%), the formation of gold nanoclusters was much more evident, beginning at lower annealing temperatures (T >= 200 degrees C) with sizes ranging from 2 to 25 nm as the temperature increased. A change in the matrix crystallization from anatase to rutile was also observed in this intermediate range of compositions. For the highest Au concentrations (>20 at.%), the films tended to form relatively larger clusters, with sizes above 20 nm (for T >= 400 degrees C). It is demonstrated that the structural and morphological characteristics of the films are strongly affected by the annealing temperature, as well as by the particular amounts, size and distribution of the Au nanoparticles dispersed in the TiO2 matrix.
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| 11. |
- Borges, J., et al.
(author)
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Thin films composed of Ag nanoclusters dispersed in TiO2 : Influence of composition and thermal annealing on the microstructure and physical responses
- 2015
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In: Applied Surface Science. - : Elsevier BV. - 0169-4332 .- 1873-5584. ; 358, s. 595-604
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Journal article (peer-reviewed)abstract
- Noble metal powders containing gold and silver have been used for many centuries, providing different colours in the windows of the medieval cathedrals and in ancient Roman glasses. Nowadays, the interest in nanocomposite materials containing noble nanoparticles embedded in dielectric matrices is related with their potential use for a wide range of advanced technological applications. They have been proposed for environmental and biological sensing, tailoring colour of functional coatings, or for surface enhanced Raman spectroscopy. Most of these applications rely on the so-called localised surface plasmon resonance absorption, which is governed by the type of the noble metal nanoparticles, their distribution, size and shape and as well as of the dielectric characteristics of the host matrix. The aim of this work is to study the influence of the composition and thermal annealing on the morphological and structural changes of thin films composed of Ag metal clusters embedded in a dielectric TiO2 matrix. Since changes in size, shape and distribution of the clusters are fundamental parameters for tailoring the properties of plasmonic materials, a set of films with different Ag concentrations was prepared. The optical properties and the thermal behaviour of the films were correlated with the structural and morphological changes promoted by annealing. The films were deposited by DC magnetron sputtering and in order to promote the clustering of the Ag nanoparticles the as-deposited samples were subjected to an in-air annealing protocol. It was demonstrated that the clustering of metallic Ag affects the optical response spectrum and the thermal behaviour of the films.
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| 12. |
- Jörger, Katharina, et al.
(author)
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MEIOZORES 2019 - EXPLORING THE MARINE MEIOFAUNA OF THE AZORES
- 2021
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In: AÇOREANA. ; , s. 17-41
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Journal article (peer-reviewed)abstract
- In July 2019 an international team of 39 senior and junior researchers from ninecountries met at the University of the Azores in Ponta Delgada, São Miguel for a 10-daysworkshop/ summer school to explore the meiofaunal biodiversity in marine sediments of the Azores. In total, we sampled intertidal and subtidal sediments from 54 localities on 14 major sites around São Miguel and additionally explored eight freshwater and terrestrial sites for rotifers. We sorted and investigated more than 2000 living specimens in the field, yielding approximately 180 species of soft-bodied meiofauna, representing most major clades of meiofauna with a focus on nematodes, polychaete annelids, proseriate andrhabdocoel flatworms, gastrotrichs, acoelomorphs, nemerteans, molluscs and cnidarians. Most of the encountered diversity shows similarities to the North-East Atlantic continental meiofauna, but in-depth morphological and molecular analyses are still pending. About 60 of the 180 species could not be assigned a species-level identification in the field, and nearly 15% of the total diversity is expected to be new to science and is awaiting formal description. Herein, we present an overview of the results of the workshop, providing detailed information on the sampling sites, methodology and encountered diversity, and we offer a preliminary discussion on aspects of faunal elements shared with other biogeographic regions. We highlight the most common members of the marine meiofauna of the Azores, provide preliminary diversity estimates and suggest a roadmap for future research towards a better understanding of the meiofauna in this remote archipelago.
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| 14. |
- Wouk de Menezes, Luana Cristina, et al.
(author)
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Nonradiative Energy Transfer between Porphyrin and Copolymer in Films Processed by Organic Solvent and Water-Dispersible Nanoparticles with Photovoltaic Applications
- 2018
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In: The Journal of Physical Chemistry C. - : American Chemical Society (ACS). - 1932-7447 .- 1932-7455. ; 122:10, s. 5796-5804
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Journal article (peer-reviewed)abstract
- In organic photovoltaic (OPV) devices, one way to increase light harvesting is to combine materials with complementary absorptions. However, the physical properties behind this process, such as Forster resonance energy transfer (FRET), remain elusive. A mixture of the metalloporphyrin Zn(SBrTTP) and the donor acceptor copolymer PSiF-DBT in films processed by organic solvent and water-soluble nanoparticles was investigated, and the energy transfer rate was correlated to the bilayer of an OPV device with a fullerene derivative (C-70). Using steady-state and time-resolved emission studies, the FRET from the porphyrin to the copolymer was observed and found to be highest in the film processed by organic solvent treatment at 100 degrees C. The devices processed by organic solvents showed superior performance to blended materials when treated at 100 degrees C, increasing the current without reducing open-circuit voltage. In nanoparticle systems, we observed that, with a smaller distance between the materials, higher FRET is performed. The device's performance showed higher current as the materials were closer together. To go beyond materials with complementary absorption, the optimization of energy transfer between them might be a promising way to increase charge generation in photovoltaic devices with different morphologies.
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