| 1. |
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| 2. |
- Bergman, Annika, et al.
(author)
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No germline mutations in supposed tumour suppressor genes SAFB1 and SAFB2 in familial breast cancer with linkage to 19p.
- 2008
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In: BMC Medical Genetics. - : BioMed Central. - 1471-2350. ; 9
-
Journal article (peer-reviewed)abstract
- BACKGROUND: The scaffold attachment factor B1 and B2 genes, SAFB1/SAFB2 (both located on chromosome 19p13.3) have recently been suggested as tumour suppressor genes involved in breast cancer development. The assumption was based on functional properties of the two genes and loss of heterozygosity of intragenic markers in breast tumours further strengthened the postulated hypothesis. In addition, linkage studies in Swedish breast cancer families also indicate the presence of a susceptibility gene for breast cancer at the 19p locus. Somatic mutations in SAFB1/SAFB2 have been detected in breast tumours, but to our knowledge no studies on germline mutations have been reported. In this study we investigated the possible involvement of SAFB1/SAFB2 on familiar breast cancer by inherited mutations in either of the two genes.RESULTS: Mutation analysis in families showing linkage to the SAFB1/2 locus was performed by DNA sequencing. The complete coding sequence of the two genes SAFB1 and SAFB2 was analyzed in germline DNA from 31 affected women. No missense or frameshift mutations were detected. One polymorphism was found in SAFB1 and eight polymorphisms were detected in SAFB2. MLPA-anlysis showed that both alleles of the two genes were preserved which excludes gene inactivation by large deletions.CONCLUSION: SAFB1 and SAFB2 are not likely to be causative of the hereditary breast cancer syndrome in west Swedish breast cancer families.
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| 3. |
- Bridel, Claire, et al.
(author)
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Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology : A Systematic Review and Meta-analysis
- 2019
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In: JAMA Neurology. - : American Medical Association (AMA). - 2168-6149 .- 2168-6157. ; 76:9, s. 1035-1048
-
Research review (peer-reviewed)abstract
- Importance Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a number of neurological conditions compared with healthy controls (HC) and is a candidate biomarker for neuroaxonal damage. The influence of age and sex is largely unknown, and levels across neurological disorders have not been compared systematically to date.Objectives To assess the associations of age, sex, and diagnosis with NfL in CSF (cNfL) and to evaluate its potential in discriminating clinically similar conditions.Data Sources PubMed was searched for studies published between January 1, 2006, and January 1, 2016, reporting cNfL levels (using the search terms neurofilament light and cerebrospinal fluid) in neurological or psychiatric conditions and/or in HC.Study Selection Studies reporting NfL levels measured in lumbar CSF using a commercially available immunoassay, as well as age and sex.Data Extraction and Synthesis Individual-level data were requested from study authors. Generalized linear mixed-effects models were used to estimate the fixed effects of age, sex, and diagnosis on log-transformed NfL levels, with cohort of origin modeled as a random intercept.Main Outcome and Measure The cNfL levels adjusted for age and sex across diagnoses.Results Data were collected for 10 059 individuals (mean [SD] age, 59.7 [18.8] years; 54.1% female). Thirty-five diagnoses were identified, including inflammatory diseases of the central nervous system (n = 2795), dementias and predementia stages (n = 4284), parkinsonian disorders (n = 984), and HC (n = 1332). The cNfL was elevated compared with HC in a majority of neurological conditions studied. Highest levels were observed in cognitively impaired HIV-positive individuals (iHIV), amyotrophic lateral sclerosis, frontotemporal dementia (FTD), and Huntington disease. In 33.3% of diagnoses, including HC, multiple sclerosis, Alzheimer disease (AD), and Parkinson disease (PD), cNfL was higher in men than women. The cNfL increased with age in HC and a majority of neurological conditions, although the association was strongest in HC. The cNfL overlapped in most clinically similar diagnoses except for FTD and iHIV, which segregated from other dementias, and PD, which segregated from atypical parkinsonian syndromes.Conclusions and Relevance These data support the use of cNfL as a biomarker of neuroaxonal damage and indicate that age-specific and sex-specific (and in some cases disease-specific) reference values may be needed. The cNfL has potential to assist the differentiation of FTD from AD and PD from atypical parkinsonian syndromes.
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| 4. |
- Divakar, Pradeep K., et al.
(author)
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Evolution of complex symbiotic relationships in a morphologically derived family of lichen-forming fungi
- 2015
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In: New Phytologist. - : Wiley. - 0028-646X .- 1469-8137. ; 208:4, s. 1217-1226
-
Journal article (peer-reviewed)abstract
- We studied the evolutionary history of the Parmeliaceae (Lecanoromycetes, Ascomycota), one of the largest families of lichen-forming fungi with complex and variable morphologies, also including several lichenicolous fungi. We assembled a six-locus data set including nuclear, mitochondrial and low-copy protein-coding genes from 293 operational taxonomic units (OTUs). The lichenicolous lifestyle originated independently three times in lichenized ancestors within Parmeliaceae, and a new generic name is introduced for one of these fungi. In all cases, the independent origins occurred c. 24 million yr ago. Further, we show that the Paleocene, Eocene and Oligocene were key periods when diversification of major lineages within Parmeliaceae occurred, with subsequent radiations occurring primarily during the Oligocene and Miocene. Our phylogenetic hypothesis supports the independent origin of lichenicolous fungi associated with climatic shifts at the Oligocene-Miocene boundary. Moreover, diversification bursts at different times may be crucial factors driving the diversification of Parmeliaceae. Additionally, our study provides novel insight into evolutionary relationships in this large and diverse family of lichen-forming ascomycetes.
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| 5. |
- Eldh, Maria, 1980, et al.
(author)
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MicroRNA in exosomes isolated directly from the liver circulation in patients with metastatic uveal melanoma
- 2014
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In: BMC Cancer. - London : Springer Science and Business Media LLC. - 1471-2407. ; 14
-
Journal article (peer-reviewed)abstract
- Uveal melanoma is a tumour arising from melanocytes of the eye, and 30 per cent of these patients develop liver metastases. Exosomes are small RNA containing nano-vesicles released by most cells, including malignant melanoma cells. This clinical translational study included patients undergoing isolated hepatic perfusion (IHP) for metastatic uveal melanoma, from whom exosomes were isolated directly from liver perfusates. The objective was to determine whether exosomes are present in the liver circulation, and to ascertain whether these may originate from melanoma cells.
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| 6. |
- Grinberg, Marianna, et al.
(author)
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Reaching the limits of prognostication in non-small cell lung cancer : an optimized biomarker panel fails to outperform clinical parameters.
- 2017
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In: Modern Pathology. - : Elsevier BV. - 0893-3952 .- 1530-0285. ; 30:7, s. 964-977
-
Journal article (peer-reviewed)abstract
- Numerous protein biomarkers have been analyzed to improve prognostication in non-small cell lung cancer, but have not yet demonstrated sufficient value to be introduced into clinical practice. Here, we aimed to develop and validate a prognostic model for surgically resected non-small cell lung cancer. A biomarker panel was selected based on (1) prognostic association in published literature, (2) prognostic association in gene expression data sets, (3) availability of reliable antibodies, and (4) representation of diverse biological processes. The five selected proteins (MKI67, EZH2, SLC2A1, CADM1, and NKX2-1 alias TTF1) were analyzed by immunohistochemistry on tissue microarrays including tissue from 326 non-small cell lung cancer patients. One score was obtained for each tumor and each protein. The scores were combined, with or without the inclusion of clinical parameters, and the best prognostic model was defined according to the corresponding concordance index (C-index). The best-performing model was subsequently validated in an independent cohort consisting of tissue from 345 non-small cell lung cancer patients. The model based only on protein expression did not perform better compared to clinicopathological parameters, whereas combining protein expression with clinicopathological data resulted in a slightly better prognostic performance (C-index: all non-small cell lung cancer 0.63 vs 0.64; adenocarcinoma: 0.66 vs 0.70, squamous cell carcinoma: 0.57 vs 0.56). However, this modest effect did not translate into a significantly improved accuracy of survival prediction. The combination of a prognostic biomarker panel with clinicopathological parameters did not improve survival prediction in non-small cell lung cancer, questioning the potential of immunohistochemistry-based assessment of protein biomarkers for prognostication in clinical practice.Modern Pathology advance online publication, 10 March 2017; doi:10.1038/modpathol.2017.14.
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| 7. |
- Hammar, Linus, 1979, et al.
(author)
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Cumulative impact assessment for ecosystem-based marine spatial planning
- 2020
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In: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 734
-
Journal article (peer-reviewed)abstract
- Claims for ocean space are growing while marine ecosystems suffer from centuries of insufficient care. Human pressures from runoff, atmospheric emissions, marine pollution, fishing, shipping, military operations and other activities wear on habitats and populations. Ecosystem-based marine spatial planning (MSP) has emerged worldwide as a strategic instrument for handling conflicting spatial claims among competing sectors and the environment. The twofold objective of both boosting the blue economy and protecting the environment is challenging in practice and marine planners need decision support. Cumulative Impact Assessment (CIA) was originally developed to provide an overview of the human imprint on the world's ocean ecosystems. We have now added a scenario component to the CIA model and used it within Swedish ecosystem-based MSP. This has allowed us to project environmental impacts for different planning alternatives throughout the planning process, strengthening the integration of environmental considerations into strategic decision-making. Every MSP decision may entail a local shift of environmental impact, causing positive or negative consequences for ecosystem components. The results from Swedish MSP in the North Sea and Baltic Sea illustrate that MSP certainly has the potential to lower net cumulative environmental impact, both locally and across sea basins, as long as environmental values are rated high and prevailing pressures derive from activities that are part of MSP. By synthesizing innumerous data into comprehensible decision support that informs marine planners of the likely environmental consequences of different options, CIA enables ecosystem-based MSP in practice.
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| 8. |
- Jansen, Willemijn J, et al.
(author)
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Prevalence of cerebral amyloid pathology in persons without dementia: a meta-analysis.
- 2015
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In: JAMA. - : American Medical Association (AMA). - 1538-3598 .- 0098-7484. ; 313:19, s. 1924-38
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Journal article (peer-reviewed)abstract
- Cerebral amyloid-β aggregation is an early pathological event in Alzheimer disease (AD), starting decades before dementia onset. Estimates of the prevalence of amyloid pathology in persons without dementia are needed to understand the development of AD and to design prevention studies.
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| 9. |
- Liss, Jan-Erik, et al.
(author)
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Knubbved istället för vanlig ved? : slutrapport från projekt Styckeved för småskalig eldning
- 2010
-
Reports (other academic/artistic)abstract
- Chunkwood is a wood fuel with a fuel particle length between 50 and 150 mm, i.e. with a size between wood chips and conventional firewood. Chunkwood can be produced and handled as rational as wood chips and can dry during storage like conventional firewood. This is known since long. In project Smallwood for small scale heating we have investigated if chunkwood can be used in a small scale as a fuel for heating detached houses in conventional firewood boilers as well as automatically fed to a boiler in a similar way as wood chips. We have also compared complete systems for small scale production, distribution and heating with chunkwood, wood chips and conventional firewood. Storage of chunkwood produced for testing small scale boilers confirmed that chunkwood can dry during storage at least as good as conventional firewood. Tests in different boilers for detached homes showed that chunkwood can be used in conventional firewood boilers as well as in automatically fed wood chips boilers. Chunkwood can be delivered to the customer to the same or lower cost as wood chips and firewood, but need much less handling by the customer than conventional firewood. However, if chunkwood is used in a conventional firewood boiler, it needs some handling by shovel and wheelbarrow. Technical development of handling from the storage to the boiler is needed. In a somewhat larger scale, e.g. a boiler for apartment blocks or a small district heating system, chunkwood should be very interesting as a replacement of fuel pellets or fuel briquettes. It would be interesting with some projects, which in this scale demonstrates the whole system from the forest to heat.
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| 10. |
- Mattsson, Niklas, 1979, et al.
(author)
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Cerebrospinal Fluid Microglial Markers in Alzheimer's Disease: Elevated Chitotriosidase Activity but Lack of Diagnostic Utility
- 2011
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In: NeuroMolecular Medicine. - : Springer Science and Business Media LLC. - 1535-1084 .- 1559-1174. ; 13:2, s. 151-159
-
Journal article (peer-reviewed)abstract
- Activated microglial cells, which are the resident macrophages of the central nervous system, surround amyloid beta-plaques in Alzheimer's disease (AD) brains. Inflammation including microglial activation may contribute in AD pathogenesis, and biomarkers for this process may thus be of value to study AD pathogenesis and might facilitate development of therapies targeting these cells. We therefore examined cerebrospinal fluid (CSF) biomarkers in patients with AD, other dementias, mild cognitive impairment and in healthy controls. Samples were analyzed for markers with known association to macrophage activity, including chitotriosidase, YKL-40 (CHI3L1, HC gp-39) and chemokine CC motif ligand 2 (CCL2, MCP1). Patients with AD had higher chitotriosidase activity than controls and patients with stable mild cognitive impairment, consistent with the presence of activated microglial cells in AD brains, but with large overlaps between groups. CCL2 and YKL-40 concentrations did not differ among groups. Microglial markers are unlikely to be useful for AD diagnosis, but might be useful for identification of distinct subgroups of patients, and for the development and implementation of drugs targeting microglial pathology.
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| 11. |
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| 12. |
- Prade, Thomas, et al.
(author)
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Vall som biogassubstrat : utvärdering av skördesystemets och odlingsintensitetens påverkan på biogasutbytet
- 2014
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Reports (other academic/artistic)abstract
- I ett fältförsök på marginalmark odlades och skördades olika vallblandningar som biogassubstrat. Syftet med studien var att (a) undersöka biomassa- och metanavkastningen för de olika vallblandningarna och (b) analysera spridningen av metanpotentialbestämningarnas resultat för att undersöka möjligheter till minskning av analyskostnaderna genom annan provtagnings- och provberedningsstrategi. En gödslad kommersiell vall gav med 8,1 ton ts/ha den högsta biomassaavkastningen vid två skördar per år. Vid bara en skörd per år var det den gödslade kommersiella vallen och den befintliga vegetationen som gav högst biomassaavkastning. Metanpotentialsskillnaderna mellan vallblandningarna var ganska små vid samma skördetidpunkt. Däremot ökar den specifika metanpotentialen (liter metan per kg VS) med två skördar per år. Beräkningarna visade att antalet analyser för metanpotentialbestämningen kan reduceras betydligt när samlingsprover används i analyserna. På detta sätt minskar man variationen inom leden, vilket bidrar till att skillnader mellan olika behandlingar enklare kan upptäckas.
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| 13. |
- Sandblom, Gabriel, et al.
(author)
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Prostate Cancer Registration in Four Swedish Regions 1996 : Differences in Incidence, Age Structure and Management
- 1999
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In: Scandinavian Journal of Urology and Nephrology. - : Informa UK Limited. - 0036-5599 .- 1651-2065. ; 33:5, s. 306-311
-
Journal article (peer-reviewed)abstract
- Introduction: In 1996 registration of prostate cancer in four of the six Swedish regions was started to facilitate evaluation of geographical variations in incidence and treatment.Material and methods: For all cases of prostate cancer, personal identification number, tumour stage, tumour grade and primary treatment were registered.Results: In the four regions covered by the register, 3541 cases of prostate cancer were registered. Altogether there were 5795 cases of prostate cancer diagnosed in Sweden the same year. The age-standardized incidence varied from 89/100 000 to 169/100 000 among counties. The proportion of localized tumours correlated positively to the incidence (p < 0.05) and negatively to mean age at diagnosis (p < 0.01). There was also a significant positive correlation between the proportion of localized tumours and the percentage of patients given curative treatment. All registered variables showed large geographical variations, especially concerning percentage of T1c tumours, treatment of localized tumours and choice of palliative treatment.Conclusion: Diagnostic activity varied considerably among counties, resulting in large variation in age-standardized incidence. High incidence is associated with a larger proportion of localized tumours, which, in turn, is associated with early age at diagnosis. In counties where a policy of detecting tumours early is practised, curative treatment is also given more often. Treatment of localized tumours and preference for palliative treatment seem to depend on local traditions. The lack of cytological and histopathological standards makes geographical comparisons based on tumour grade impossible.
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| 14. |
- Sutton, Mark A., et al.
(author)
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Dynamics of ammonia exchange with cut grassland : Synthesis of results and conclusions of the GRAMINAE Integrated Experiment
- 2009
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In: Biogeosciences. - Goettingen : Nicolaus Copernicus University Press. - 1726-4170 .- 1726-4189. ; 6:12, s. 2907-2934
-
Journal article (peer-reviewed)abstract
- Improved data on biosphere-atmosphere exchange are fundamental to understanding the production and fate of ammonia (NH3) in the atmosphere. The GRAMINAE Integrated Experiment combined novel measurement and modelling approaches to provide the most comprehensive analysis of the interactions to date. Major intercomparisons of micrometeorological parameters and NH3 flux measurements using the aerodynamic gradient method and relaxed eddy accumulation (REA) were conducted. These showed close agreement, though the REA systems proved insufficiently precise to investigate vertical flux divergence. Grassland management had a large effect on fluxes: emissions increased after grass cutting (−50 to 700 ng m-2 s-1 NH3) and after N-fertilization (0 to 3800 ng m-2 s -1) compared with before the cut (−60 to 40 ng m-2 s -1). © Author(s) 2009.
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| 15. |
- Abreu-Vieira, Gustavo, et al.
(author)
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Cidea improves the metabolic profile through expansion of adipose tissue
- 2015
-
In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 6
-
Journal article (peer-reviewed)abstract
- In humans, Cidea (cell death-inducing DNA fragmentation factor alpha-like effector A) is highly but variably expressed in white fat, and expression correlates with metabolic health. Here we generate transgenic mice expressing human Cidea in adipose tissues (aP2-hCidea mice) and show that Cidea is mechanistically associated with a robust increase in adipose tissue expandability. Under humanized conditions (thermoneutrality, mature age and prolonged exposure to high-fat diet), aP2-hCidea mice develop a much more pronounced obesity than their wild-type littermates. Remarkably, the malfunctioning of visceral fat normally caused by massive obesity is fully overcome-perilipin 1 and Akt expression are preserved, tissue degradation is prevented, macrophage accumulation is decreased and adiponectin expression remains high. Importantly, the aP2-hCidea mice display enhanced insulin sensitivity. Our data establish a functional role for Cidea and suggest that, in humans, the association between Cidea levels in white fat and metabolic health is not only correlative but also causative.
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| 16. |
- Akander, Jan, et al.
(author)
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Development of an AI model utilizing buildings’ thermal mass to optimize heating energy and indoor temperature in a historical building cocated in a cold climate
- 2024
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In: Buildings. - : MDPI. - 2075-5309. ; 14:7
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Journal article (peer-reviewed)abstract
- Historical buildings account for a significant portion of the energy use of today’s building stock, and there are usually limited energy saving measures that can be applied due to antiquarian and esthetic restrictions. The purpose of this case study is to evaluate the use of the building structure of a historical stone building as a heating battery, i.e., to periodically store thermal energy in the building’s structures without physically changing them. The stored heat is later utilized at times of, e.g., high heat demand, to reduce peaking as well as overall heat supply. With the help of Artificial Intelligence and Convolutional Neural Network Deep Learning Modelling, heat supply to the building is controlled by weather forecasting and a binary calendarization of occupancy for the optimization of energy use and power demand under sustained comfortable indoor temperatures. The study performed indicates substantial savings in total (by approximately 30%) and in peaking energy (by approximately 20% based on daily peak powers) in the studied building and suggests that the method can be applied to other, similar cases.
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| 17. |
- Amato, M, et al.
(author)
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Literature review on STEM education
- 2019
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In: Do Well Science. - Breslavia : Società Dante Alighieri. - 9788394521301 ; , s. 15-27
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Book chapter (other academic/artistic)
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| 18. |
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| 19. |
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| 20. |
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| 21. |
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| 22. |
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| 23. |
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| 24. |
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| 25. |
- Andersson, Linda, 1973, et al.
(author)
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Deficiency in perilipin 5 reduces mitochondrial function and membrane depolarization in mouse hearts.
- 2017
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In: The international journal of biochemistry & cell biology. - : Elsevier BV. - 1878-5875 .- 1357-2725. ; 91:Pt A, s. 9-13
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Journal article (peer-reviewed)abstract
- Myocardial triglycerides stored in lipid droplets are important in regulating the intracellular delivery of fatty acids for energy generation in mitochondria, for membrane biosynthesis, and as agonists for intracellular signaling. Previously, we showed that deficiency in the lipid droplet protein perilipin 5 (Plin5) markedly reduces triglyceride storage in cardiomyocytes and increases the flux of fatty acids into phospholipids. Here, we investigated whether Plin5 deficiency in cardiomyocytes alters mitochondrial function. We found that Plin5 deficiency reduced mitochondrial oxidative capacity. Furthermore, in mitochondria from Plin5((-/)(-)) hearts, the fatty acyl composition of phospholipids in mitochondrial membranes was altered and mitochondrial membrane depolarization was markedly compromised. These findings suggest that mitochondria isolated from hearts deficient in Plin5, have specific functional defects.
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| 26. |
- Andersson, Per, et al.
(author)
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Cooperation and Competition during Evolution of Technology Based Service Innovation : The Case of Development of NFC Enabled Mobile Services in Nice
- 2013
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In: 12th International Conference on Mobile Business, ICMB 2013. - : Association for Information Systems.
-
Conference paper (peer-reviewed)abstract
- Concurrent cooperation and competition is an important characteristic of innovation processes. We illustrate this with reference to a case on new mobile, NFC (Near Field Communications) based services: a systemic service innovation project in Nice, named Cityzi. Cityzi is a local sub-process in the globally dispersed efforts to develop and implement mobile services enabled by the NFC technique that can be used for mobile communication. The project requires cooperation, also between competing actors, to determine technical interfaces as well as development and implementation of business models for production and use of the services in practice. Due to the heterogeneity of resources that need to be combined, actors from different industrial as well as public policy sectors participate in the project. We apply a network perspective for our analysis of cooperation and competition during service innovation processes, specifically focusing on network overlapping processes. A dynamic conceptual model is suggested to capture the complexities of implementing largescale ICT infrastructure projects, when going from trial to commercialization.
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| 27. |
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| 28. |
- Andersson, Per, et al.
(author)
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Global policy networks’ involvement in service innovation. Turning the mobile phone into a wallet by applying NFC technology
- 2011
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In: The IMP Journal. - 2059-1403 .- 0809-7259. ; 5:3, s. 193-211
-
Journal article (peer-reviewed)abstract
- The mobile phone attracts an increasing number of service applications enabled by technical developments. On-going efforts aim to widen the scope of mobile payments and “turning the mobile phone into a wallet” with the help of Near Field Technology (NFC). A number of industries are involved in this development. To enable large scale commercial application of the new technology for mobile payments, several global industry associations, what we label Global Policy Networks (GPNs), are involved in standard setting, certification, visions and promotion of business applications, etc. The purpose of the paper is to analyze the role of GPNs in establishing global policies to enable business actors to develop and implement local policies applying the new technology for business purposes. The paper focuses on how some yet to be settled global policy issues affect local policies.
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| 29. |
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| 30. |
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| 31. |
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| 32. |
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| 33. |
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| 34. |
- Andersson, Per, et al.
(author)
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Technical development and the formation of new business ventures, The case of new mobile payment and ticketing services
- 2011
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In: The IMP Journal. - : Emerald. - 2059-1403 .- 0809-7259. ; 5:1, s. 23-41
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Journal article (peer-reviewed)abstract
- How do new business ventures emerge, and how is their emergence linked to technical development? What are the challenges of forming new business ventures when the business involves the connection of previously unconnected or loosely connected networks? This paper analyses the connections between technical development and the formation of new business ventures. A set of case studies is presented that show how existing market structures, business development and associated wireless, technologies and systems are affected by the emergence of new mobile payment and ticketing services. This paper presents result from an on-going research project on near field communication based services in Sweden. In late 2008 the project “Foundation For NFC/Sensor Network B2B2C Services” (FORCE) was initiated by TeliaSonera Mobile Network, KTH Center for Wireless System, and Center for Information and Communication Research at the Stockholm School of Economics.
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| 35. |
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| 36. |
- Andersson, Per, et al.
(author)
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The formation of new business ventures in networks : creating new intermediary roles and extracting value from the exploitation of technology
- 2010
-
Conference paper (peer-reviewed)abstract
- This paper analyzes new business formation connected to the use of established mobile technologies and associated services. The purpose of the paper is to describe how a set of alternative business network situations can emerge when established wireless application technologies are exploited and new value is created and new business ventures are formed. A set of short cases describe how new business can be created based on established SMS applications and services. The paper discusses central aspects of the formation of new business ventures in networks. Here, focus is on opportunities to create value based on the exploitation of existing technology. The technology is used in a new way and is perceived by existing actors as an opportunity to exploit by creating a new intermediary performing a new role. In business practice, technology development is related to formation of new business ventures, they cannot be separated from each other.
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| 37. |
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| 38. |
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| 39. |
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| 40. |
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| 41. |
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| 42. |
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| 43. |
- Articus, Kristina, et al.
(author)
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Phylogenetic studies in Usnea.
- 2000
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In: The Fourth IAL Symposium Progress and Problems in Lichenology at the Turn of the Millenium, Abstracts: 100. Barcelona..
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Conference paper (other academic/artistic)
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| 44. |
- Articus, Kristina, 1971-
(author)
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Phylogenetic Studies in Usnea (Parmeliaceae) and Allied Genera
- 2004
-
Doctoral thesis (other academic/artistic)abstract
- This thesis deals with the phylogeny of the lichen genus Usnea (Parmeliaceae, Ascomycetes). The relationships and the morphological variation among Usnea species has been studied, as well as the relationship of Usnea to allied genera. Two species, U. florida and U. subfloridana, which earlier were regarded to form two separate species have been synonymized. In an analysis based on sequence data these two taxa formed a monophyletic group of intermixed specimens. Usnea florida and U. subfloridana have earlier been regarded to form a species pair, but the species pairs concept cannot be applied in this case. The morphological characters traditionally used for species recognition of a number of European Usnea species have been analyzed regarding their reliability. The evolution and distribution of the morphological characters was studied in relation to a phylogeny based on sequence data. Most characters proved to be homoplastic in relation to the phylogeny. Few characters were consistent in a clade, and the same character could be inconsistent in another clade. Therefore a combination of several characters is recommended for species recognition. The relationship of Neuropogon to Usnea was investigated based on sequence data. Neuropogon showed to be closely related to Usnea subg. Usnea. The subgenera Eumitria and Dolichousnea formed the sister group to the clade comprising subg. Usnea and Neuropogon. Usnea is paraphyletic in this investigation. Eumitria is treated as a genus and the subgenus Dolichousnea is elevated to generic rank. The position of Usnea, Neuropogon, Eumitria, and Dolichousnea in the family Parmeliaceae was investigated based on a phylogeny obtained by sequence data. Protousnea probably forms the sister group to the clade of Usnea, Neuropogon, Eumitria, and Dolichousnea. Several monophyletic groups in the family Parmeliaceae were identified.
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| 45. |
- Articus, Kristina, et al.
(author)
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Ribosomal DNA and beta-tubulin data do not support the separation of the lichens Usnea florida and U-subfloridana as distinct species
- 2002
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In: Mycological Research. - 0953-7562 .- 1469-8102. ; 106, s. 412-418
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Journal article (peer-reviewed)abstract
- The lichens Usnea florida and U. subfloridana have since long been recognised as distinct species. They show many similarities in morphology, but have different reproductive strategies. Usnea florida is always provided with many apothecia and produces no specialised asexual propagules. Usnea subfloridana has soralia, isidiomorphs and occasionally apothecia. Phylogenetic analyses based on continuous sequences of the ITS and LSU regions of the nuclear ribosomal DNA and the gene coding for beta-tubulin, show that specimens of the two species form one monophyletic group of intermixed specimens, and not two groups corresponding to morphology, which Would have been expected if two species were at hand. The 'species pair' concept in lichenology is discussed. Other Usnea species included in the study are: U. articulata, U. barbata, U. ceratina, U. filipendula. U. hirta, U. rigida and U. wasmuthii.
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| 46. |
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| 47. |
- Arup, Ulf, et al.
(author)
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High performance thin layer chromatography (HPTLC), an improved technique for screening lichen substances.
- 1993
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In: The Lichenologist. - : Cambridge University Press (CUP). - 0024-2829 .- 1096-1135. ; 25, s. 61-71
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Journal article (peer-reviewed)abstract
- High performance thin layer chromatography (HPTLC) is a method that can be used for screening lichen substances. It is as simple to use as standard TLC, but has many advantages: It is more sensitive, it is possible to run more samples in a shorter period of time, and the amount of solvent used is much smaller. The material needed and the methods used are described in detail. Horizontal chromatogram development was used. Since two of the solvents used in system B have been substituted, and since the properties of the HPTLC plates are slightly different, our results are not entirely in accordance with the standardized TLC method. A revised table for the identification of 69 lichen substances (obtained from 62 taxa) is accordingly presented.
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| 48. |
- Arup, Ulf, et al.
(author)
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Professor Ingvar Kärnfelt - a birthday tribute
- 2009
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In: The Lichenologist. - Cambridge : Cambridge University Press. - 0024-2829 .- 1096-1135. ; 41:5, s. 453-456
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Journal article (other academic/artistic)abstract
- On 19 July 2009 Ingvar Kärnefelt celebrated his 65th birthday. This could have meant that we, his former students, would be celebrating him in his retirement from his position as head of the Biological Museums at Lund University. We are grateful that this is not the case, as Ingvar will carry on, probably for at least one or two more years. Instead, we celebrate Ingvar because he is the main reason for all of us having studied lichenology in Lund. This special issue of The Lichenologist is dedicated to him as a birthday tribute in honour of his long and fruitful lichenological career. The main authors of all the papers in this issue are former students of Ingvar. For several of us he has not only acted as supervisor but later also as the director of the Botanical Museum where we meet him in our daily work.
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| 49. |
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| 50. |
- Arup, Ulf, et al.
(author)
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The sister group relation of Parmeliaceae (Lecanorales, Ascomycota)
- 2007
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In: Mycologia. - : Informa UK Limited. - 0027-5514 .- 1557-2536. ; 99:1, s. 42-49
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Journal article (peer-reviewed)abstract
- The family Parmeliaceae (Lecanorales, Ascomycota) is possibly the largest, best known and most thoroughly studied lichen family within its order. Despite this fact the relationship between Parmeliaceae and other groups in Lecanorales is still poorly known. The aim of the present study is to contribute to finding the sister group of Parmeliaceae as an aid in future studies on the phylogeny and character evolution of the group. We do this by sampling all potential relatives to the Parmeliaceae that we have identified, i.e. Cypsoplaca, Japewia, Mycoblastus, Protoparmelia, and Tephromela, a good representation of the major groups within the Parmeliaceae s. lat. and a good representation of other taxa in the core Lecanorales. We use molecular data from two genes, the large subunit of the nuclear ribosomal RNA gene (nrLSU) and the small subunit of the mitochondrial ribosomal RNA gene (mrSSU), and a Bayesian analysis of the combined data. The results show that the closest relatives to Parmeliaceae are the two genera Protoparmelia and Gypsoplaca, which are crustose lichens. Parmeliaceae in our sense is a well supported group, including also the family segregates Alectoriaceae, Hypogymniaceae, Usneaceae and Anziaceae.
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