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- De Boer, Agatha M., et al.
(author)
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Control of the glacial carbon budget by topographically induced mixing
- 2014
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In: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 41:12, s. 4277-4284
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Journal article (peer-reviewed)abstract
- Evidence for the oceanic uptake of atmospheric CO2 during glaciations suggests that there was less production of southern origin deep water but, paradoxically, a larger volume of southern origin water than today. Here we demonstrate, using a theoretical box model, that the inverse relationship between volume and production rate of this water mass can be explained by invoking mixing rates in the deep ocean that are proportional to topographic outcropping area scaled with ocean floor slope. Furthermore, we show that the resulting profile, of a near-linear decrease in mixing intensity away from the bottom, generates a positive feedback on CO2 uptake that can initiate a glacial cycle. The results point to the importance of using topography-dependent mixing when studying the large-scale ocean circulation, especially in the paleo-intercomparison models that have failed to produce the weaker and more voluminous bottom water of the Last Glacial Maximum.
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| 5. |
- Jüling, André, et al.
(author)
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Multidecadal variability in the climate system : phenomena and mechanisms
- 2020
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In: The European Physical Journal Plus. - : Springer Science and Business Media LLC. - 2190-5444. ; 135:6
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Research review (peer-reviewed)abstract
- An open and fundamental issue in climate dynamics is the origin of multidecadal variability in the climate system. Resolving this issue is essential for adequate attribution of human-induced climate change. The purpose of this paper is to provide a perspective on multidecadal variability from the analysis of observations and results from model simulations. Data from the instrumental record indicate the existence of large-scale coherent patterns of multidecadal variability in sea surface temperature. Combined with long time series of proxy data, these results provide ample evidence for the existence of multidecadal sea surface temperature variations. Results of a hierarchy of climate models have provided several mechanisms of this variability, ranging from pure atmospheric forcing, via internal ocean processes to coupled ocean-atmosphere interactions. An important problem is that current state-of-the-art climate models underestimate multidecadal variability. We argue that these models miss important processes in their representation of ocean eddies and focus on a robust mechanism of multidecadal variability which is found in multi-century simulations with climate models having a strongly eddying ocean component.
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| 6. |
- Ladds, MJGW, et al.
(author)
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Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
- 2018
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1, s. 2071-
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Journal article (peer-reviewed)abstract
- The original PDF version of this Article listed the authors as “Marcus J.G.W. Ladds,” where it should have read “Marcus J. G. W. Ladds, Ingeborg M. M. van Leeuwen, Catherine J. Drummond et al.#”.Also in the PDF version, it was incorrectly stated that “Correspondence and requests for materials should be addressed to S. Lín.”, instead of the correct “Correspondence and requests for materials should be addressed to S. Laín.”This has been corrected in the PDF version of the Article. The HTML version was correct from the time of publication.
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| 10. |
- Orton, G, et al.
(author)
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Earth-based observations of the Galileo probe entry site
- 1996
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In: SCIENCE. - : AMER ASSOC ADVANCEMENT SCIENCE. - 0036-8075. ; 272:5263, s. 839-840
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Journal article (peer-reviewed)abstract
- Earth-based observations of Jupiter indicate that the Galileo probe probably entered Jupiter's atmosphere just inside a region that has less cloud cover and drier conditions than more than 99 percent of the rest of the planet. The visual appearance of the
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| 11. |
- Sachweh, MCC, et al.
(author)
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Incompatible effects of p53 and HDAC inhibition on p21 expression and cell cycle progression
- 2013
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In: Cell death & disease. - : Springer Science and Business Media LLC. - 2041-4889. ; 4, s. e533-
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Journal article (peer-reviewed)abstract
- Nutlin-3 selectively activates p53 by inhibiting the interaction of this tumor suppressor with its negative regulator murine double minute 2 (mdm2), while trichostatin A (TSA) is one of the most potent histone deacetylase (HDAC) inhibitors currently available. As both Nutlin-3 and TSA increase the levels of the cell cycle inhibitor p21(cip1/waf1) in cells, we investigated whether a combination of these compounds would further augment p21 levels. Contrary to expectations, we found that short-term exposure to Nutlin-3 and TSA in combination did not have an additive effect on p21 expression. Instead, we observed that activation of p53 prevented the ability of TSA to increase p21 levels. Furthermore, TSA inhibited Nutlin-3-induced expression of p53-dependent mRNAs including P21. This negative effect of TSA on Nutlin-3 was significantly less pronounced in the case of hdm2, another p53 downstream target. Aside from suggesting a model to explain these incompatible effects of Nutlin-3 and TSA, we discuss the implications of our findings in cancer therapy and cell reprogramming.
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| 13. |
- Siefert, Andrew, et al.
(author)
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A global meta-analysis of the relative extent of intraspecific trait variation in plant communities
- 2015
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In: Ecology Letters. - : Wiley. - 1461-023X .- 1461-0248. ; 18:12, s. 1406-1419
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Research review (peer-reviewed)abstract
- Recent studies have shown that accounting for intraspecific trait variation (ITV) may better address major questions in community ecology. However, a general picture of the relative extent of ITV compared to interspecific trait variation in plant communities is still missing. Here, we conducted a meta-analysis of the relative extent of ITV within and among plant communities worldwide, using a data set encompassing 629 communities (plots) and 36 functional traits. Overall, ITV accounted for 25% of the total trait variation within communities and 32% of the total trait variation among communities on average. The relative extent of ITV tended to be greater for whole-plant (e.g. plant height) vs. organ-level traits and for leaf chemical (e.g. leaf N and P concentration) vs. leaf morphological (e.g. leaf area and thickness) traits. The relative amount of ITV decreased with increasing species richness and spatial extent, but did not vary with plant growth form or climate. These results highlight global patterns in the relative importance of ITV in plant communities, providing practical guidelines for when researchers should include ITV in trait-based community and ecosystem studies.
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| 14. |
- Silvano, Alessandro, et al.
(author)
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Observing Antarctic Bottom Water in the Southern Ocean
- 2023
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In: Frontiers in Marine Science. - 2296-7745. ; 10
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Research review (peer-reviewed)abstract
- Dense, cold waters formed on Antarctic continental shelves descend along the Antarctic continental margin, where they mix with other Southern Ocean waters to form Antarctic Bottom Water (AABW). AABW then spreads into the deepest parts of all major ocean basins, isolating heat and carbon from the atmosphere for centuries. Despite AABW's key role in regulating Earth's climate on long time scales and in recording Southern Ocean conditions, AABW remains poorly observed. This lack of observational data is mostly due to two factors. First, AABW originates on the Antarctic continental shelf and slope where in situ measurements are limited and ocean observations by satellites are hampered by persistent sea ice cover and long periods of darkness in winter. Second, north of the Antarctic continental slope, AABW is found below approximately 2 km depth, where in situ observations are also scarce and satellites cannot provide direct measurements. Here, we review progress made during the past decades in observing AABW. We describe 1) long-term monitoring obtained by moorings, by ship-based surveys, and beneath ice shelves through bore holes; 2) the recent development of autonomous observing tools in coastal Antarctic and deep ocean systems; and 3) alternative approaches including data assimilation models and satellite-derived proxies. The variety of approaches is beginning to transform our understanding of AABW, including its formation processes, temporal variability, and contribution to the lower limb of the global ocean meridional overturning circulation. In particular, these observations highlight the key role played by winds, sea ice, and the Antarctic Ice Sheet in AABW-related processes. We conclude by discussing future avenues for observing and understanding AABW, impressing the need for a sustained and coordinated observing system.
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| 15. |
- Stewart, K. D., et al.
(author)
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On Cabbeling and Thermobaricity in the Surface Mixed Layer
- 2017
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In: Journal of Physical Oceanography. - 0022-3670 .- 1520-0485. ; 47:7, s. 1775-1787
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Journal article (peer-reviewed)abstract
- The surface mixed layer (ML) governs atmosphere-ocean fluxes, and thereby affects Earth's climate. Accurate representation of ML processes in ocean models remains a challenge, however. The O(100) m deep ML exhibits substantial horizontal thermohaline gradients, despite being near-homogenous vertically, making it an ideal location for processes that result from the nonlinearity of the equation of state, such as cabbeling and thermobaricity. Traditional approaches to investigate these processes focus on their roles in interior water-mass transformation and are ill suited to examine their influence on the ML. However, given the climatic significance of the ML, quantifying the extent to which cabbeling and thermobaricity influence the ML density field offers insight into improving ML representations in ocean models. A recent simplified equation of state of seawater allows the local effects of cabbeling and thermobaric processes in the ML to be expressed analytically as functions of the local temperature gradient and ML depth. These simplified expressions are used to estimate the extent to which cabbeling and thermobaricity contribute to local ML density differences. These estimates compare well with values calculated directly using the complete nonlinear equation of state. Cabbeling and thermobaricity predominantly influence the ML density field poleward of 30 degrees. Mixed layer thermobaricity is basin-scale and winter intensified, while ML cabbeling is perennial and localized to intense, zonally coherent regions associated with strong temperature fronts, such as the Antarctic Circumpolar Current and the Kuroshio and Gulf Stream Extensions. For latitudes between 40 degrees and 50 degrees in both hemispheres, the zonally averaged effects of ML cabbeling and ML thermobaricity can contribute on the order of 10% of the local ML density difference.
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