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1.	Fullman, Nancy, et al. (author) Measuring performance on the Healthcare Access and Quality Index for 195 countries and territories and selected subnational locations: A systematic analysis from the Global Burden of Disease Study 2016 2018 In: The Lancet. - : Lancet Publishing Group. - 1474-547X .- 0140-6736. ; 391:10136, s. 2236-2271 Journal article (peer-reviewed)
2.	Lopez-Garcia, SC, et al. (author) Treatment and long-term outcome in primary distal renal tubular acidosis 2019 In: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. - : Oxford University Press (OUP). - 1460-2385. ; 34:6, s. 981-991 Journal article (peer-reviewed)
3.	Manav, Melek Cemre, et al. (author) Structural basis for (p)ppGpp synthesis by the Staphylococcus aureus small alarmone synthetase RelP 2018 In: Journal of Biological Chemistry. - : The American Society for Biochemistry and Molecular Biology. - 0021-9258 .- 1083-351X. ; 293:9, s. 3254-3264 Journal article (peer-reviewed)abstract The stringent response is a global reprogramming of bacterial physiology that renders cells more tolerant to antibiotics and induces virulence gene expression in pathogens in response to stress. This process is driven by accumulation of the intracellular alarmone guanosine-5'-di(tri)phosphate-3'-diphosphate ((p)ppGpp), which is produced by enzymes of the RelA SpoT homologue (RSH) family. The Gram-positive Firmicute pathogen, Staphylococcus aureus, encodes three RSH enzymes: a multidomain RSH (Rel) that senses amino acid starvation on the ribosome and two small alarmone synthetase (SAS) enzymes, RelQ (SAS1) and RelP (SAS2). In Bacillus subtilis, RelQ (SAS1) was shown to form a tetramer that is activated by pppGpp and inhibited by single-stranded RNA, but the structural and functional regulation of RelP (SAS2) is unexplored. Here, we present crystal structures of S. aureus RelP in two major functional states, pre-catalytic (bound to GTP and the non-hydrolyzable ATP analogue, adenosine 5'-(alpha,beta-methylene) triphosphate (AMP-CPP)), and post-catalytic (bound to pppGpp). We observed that RelP also forms a tetramer, but unlike RelQ (SAS1), it is strongly inhibited by both pppGpp and ppGpp and is insensitive to inhibition by RNA. We also identified putative metal ion-binding sites at the subunit interfaces that were consistent with the observed activation of the enzyme by Zn2+ ions. The structures reported here reveal the details of the catalytic mechanism of SAS enzymes and provide a molecular basis for understanding differential regulation of SAS enzymes in Firmicute bacteria.

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Conti, G. (1); Larsson, Anders (1); Prakash, V (1); Sahebkar, Amirhossei ... (1); van Boven, Job F. M. (1); Bassat, Quique (1); show more...; Mitchell, Philip B (1); McKee, Martin (1); Madotto, Fabiana (1); März, Winfried (1); Koyanagi, Ai (1); Zaidi, Zoubida (1); Aboyans, Victor (1); Koul, Parvaiz A. (1); Edvardsson, David (1); Nolte, Ellen (1); Brenner, Hermann (1); Dhimal, Meghnath (1); Sheikh, Aziz (1); Adhikari, Tara Balla ... (1); Gething, Peter W. (1); Hay, Simon I. (1); Tripathy, Srikanth P ... (1); Schutte, Aletta E. (1); Sinha, R. (1); Afshin, Ashkan (1); Cornaby, Leslie (1); Abbafati, Cristiana (1); Abebe, Zegeye (1); Afarideh, Mohsen (1); Agrawal, Sutapa (1); Alahdab, Fares (1); Badali, Hamid (1); Badawi, Alaa (1); Bensenor, Isabela M. (1); Bernabe, Eduardo (1); Dandona, Lalit (1); Dandona, Rakhi (1); Esteghamati, Alireza (1); Farzadfar, Farshad (1); Feigin, Valery L. (1); Fernandes, Joao C. (1); Flor, Luisa Sorio (1); Ganji, Morsaleh (1); Geleijnse, Johanna M ... (1); Grosso, Giuseppe (1); Hamidi, Samer (1); Harikrishnan, Sivada ... (1); Hassen, Hamid Yimam (1); Islami, Farhad (1); show less...

University: Umeå University (2); Karolinska Institutet (2); Uppsala University (1); Lund University (1); Chalmers University of Technology (1); Högskolan Dalarna (1)

Language: English (3)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

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