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1.	Glasbey, JC, et al. (author) 2021 swepub:Mat__t
2.	Adamina, M, et al. (author) The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study 2022 In: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. - : Wiley. - 1463-1318. ; 24:6, s. 708-726 Journal article (peer-reviewed)
3.	Fadeel, B, et al. (author) Safety Assessment of Graphene-Based Materials: Focus on Human Health and the Environment 2018 In: ACS nano. - : American Chemical Society (ACS). - 1936-086X .- 1936-0851. ; 12:11, s. 10582-10620 Journal article (peer-reviewed)
4.	Geng, KY, et al. (author) Intrinsic deletion at 10q23.31, including the PTEN gene locus, is aggravated upon CRISPR-Cas9-mediated genome engineering in HAP1 cells mimicking cancer profiles 2024 In: Life science alliance. - 2575-1077. ; 7:2 Journal article (peer-reviewed)
5.	Geng, K, et al. (author) Target-enriched nanopore sequencing and de novo assembly reveals co-occurrences of complex on-target genomic rearrangements induced by CRISPR-Cas9 in human cells 2022 In: Genome research. - 1549-5469. ; 32:10, s. 1876-1891 Journal article (peer-reviewed)
6.	Geng, KY, et al. (author) Target-enriched nanopore sequencing and de novo assembly reveals co-occurrences of complex on-target genomic rearrangements induced by CRISPR-Cas9 in human cells 2022 In: Genome research. - : Cold Spring Harbor Laboratory. - 1549-5469 .- 1088-9051. ; 32:10, s. 1876-1891 Journal article (peer-reviewed)abstract The CRISPR-Cas9 system is widely used to permanently delete genomic regions via dual guide RNAs. Genomic rearrangements induced by CRISPR-Cas9 can occur, but continuous technical developments make it possible to characterize complex on-target effects. We combined an innovative droplet-based target enrichment approach with long-read sequencing and coupled it to a customized de novo sequence assembly. This approach enabled us to dissect the sequence content at kilobase scale within an on-target genomic locus. We here describe extensive genomic disruptions by Cas9, involving the allelic co-occurrence of a genomic duplication and inversion of the target region, as well as integrations of exogenous DNA and clustered interchromosomal DNA fragment rearrangements. Furthermore, we found that these genomic alterations led to functional aberrant DNA fragments and can alter cell proliferation. Our findings broaden the consequential spectrum of the Cas9 deletion system, reinforce the necessity of meticulous genomic validations, and introduce a data-driven workflow enabling detailed dissection of the on-target sequence content with superior resolution.
7.	Revechon, G, et al. (author) Somatic mutations in vascular wall function and age-associated disease 2023 In: European heart journal. - 1522-9645. ; 44:40, s. 4208-4210 Journal article (peer-reviewed)
8.	Soeteman-Hernandez, LG, et al. (author) Safe innovation approach: Towards an agile system for dealing with innovations 2019 In: MATERIALS TODAY COMMUNICATIONS. - : Elsevier BV. - 2352-4928. ; 20 Journal article (other academic/artistic)

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Result 1-8 of 8

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Type of publication: journal article (7)

Type of content: peer-reviewed (6); other academic/artistic (1)

Author/Editor: Chen, S. (2); Lopes, L. (2); Losada, M. (2); Moss, J. (2); Nordberg, M. (2); Qureshi, A. (2); show more...; Romano, M. (2); Zhang, H. (2); Davies, E. (2); Gupta, A. (2); Martin, J. (2); Aytac, E (2); Cosimelli, M (2); Davies, RJ (2); Golda, T (2); Hompes, R (2); Kanemitsu, Y (2); Lakkis, Z (2); Poggioli, G (2); Rottoli, M (2); Shaikh, (2); Tsarkov, P (2); Wilson, M (2); Baker, A. (2); Persiani, R. (2); Silva, M. (2); Kumar, A. (2); Moore, R. (2); Osman, N. (2); Russ, J. (2); Williams, G. (2); Giraudo, G. (2); Sharma, N. (2); Singh, R. (2); Meneghini, S. (2); Nowak, K. (2); Costa, M. (2); Thompson, D. (2); O'Brien, S. (2); Barker, D. (2); Mukherjee, S. (2); Patel, P. (2); Khan, A. (2); Hunt, L (2); Abate, E. (2); Lee, M (2); Li, Z (2); Agrawal, A (2); Ali, M (2); Ali, S (2); show less...

University: Karolinska Institutet (8)

Language: English (8)

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