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| 2. |
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| 5. |
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| 6. |
- Bravo, L, et al.
(author)
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- 2021
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swepub:Mat__t
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| 7. |
- Tabiri, S, et al.
(author)
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- 2021
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swepub:Mat__t
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| 8. |
- Craddock, Nick, et al.
(author)
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Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
- 2010
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7289, s. 713-720
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Journal article (peer-reviewed)abstract
- Copy number variants (CNVs) account for a major proportion of human genetic polymorphism and have been predicted to have an important role in genetic susceptibility to common disease. To address this we undertook a large, direct genome-wide study of association between CNVs and eight common human diseases. Using a purpose-designed array we typed,19,000 individuals into distinct copy-number classes at 3,432 polymorphic CNVs, including an estimated similar to 50% of all common CNVs larger than 500 base pairs. We identified several biological artefacts that lead to false-positive associations, including systematic CNV differences between DNAs derived from blood and cell lines. Association testing and follow-up replication analyses confirmed three loci where CNVs were associated with disease-IRGM for Crohn's disease, HLA for Crohn's disease, rheumatoid arthritis and type 1 diabetes, and TSPAN8 for type 2 diabetes-although in each case the locus had previously been identified in single nucleotide polymorphism (SNP)-based studies, reflecting our observation that most common CNVs that are well-typed on our array are well tagged by SNPs and so have been indirectly explored through SNP studies. We conclude that common CNVs that can be typed on existing platforms are unlikely to contribute greatly to the genetic basis of common human diseases.
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| 9. |
- Drake, Thomas M., et al.
(author)
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Outcomes following small bowel obstruction due to malignancy in the national audit of small bowel obstruction
- 2019
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In: European Journal of Surgical Oncology. - : Elsevier BV. - 0748-7983 .- 1532-2157. ; 45:12, s. 2319-2324
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Journal article (peer-reviewed)abstract
- © 2019 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology Introduction: Patients with cancer who develop small bowel obstruction are at high risk of malnutrition and morbidity following compromise of gastrointestinal tract continuity. This study aimed to characterise current management and outcomes following malignant small bowel obstruction. Methods: A prospective, multicentre cohort study of patients with small bowel obstruction who presented to UK hospitals between 16th January and 13th March 2017. Patients who presented with small bowel obstruction due to primary tumours of the intestine (excluding left-sided colonic tumours) or disseminated intra-abdominal malignancy were included. Outcomes included 30-day mortality and in-hospital complications. Cox-proportional hazards models were used to generate adjusted effects estimates, which are presented as hazard ratios (HR) alongside the corresponding 95% confidence interval (95% CI). The threshold for statistical significance was set at the level of P ≤ 0.05 a-priori. Results: 205 patients with malignant small bowel obstruction presented to emergency surgery services during the study period. Of these patients, 50 had obstruction due to right sided colon cancer, 143 due to disseminated intraabdominal malignancy, 10 had primary tumours of the small bowel and 2 patients had gastrointestinal stromal tumours. In total 100 out of 205 patients underwent a surgical intervention for obstruction. 30-day in-hospital mortality rate was 11.3% for those with primary tumours and 19.6% for those with disseminated malignancy. Severe risk of malnutrition was an independent predictor for poor mortality in this cohort (adjusted HR 16.18, 95% CI 1.86 to 140.84, p = 0.012). Patients with right-sided colon cancer had high rates of morbidity. Conclusions: Mortality rates were high in patients with disseminated malignancy and in those with right sided colon cancer. Further research should identify optimal management strategy to reduce morbidity for these patient groups.
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| 10. |
- Aflaki, Inga Narbutaite, et al.
(author)
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Entrepreneurship in the polis : Understanding political entrepreneurship
- 2015. - 1
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Book (other academic/artistic)abstract
- Dynamics of entrepreneurship have attracted growing attention from scholars of political science, policy studies, public administration and planning, as well as more recently, from the realms of international relations and foreign policy analysis. Under the banner of political entrepreneurship, this volume considers and maps out conceptual approaches to the study of entrepreneurship drawn from these fields, discusses synergies, envisages new analytical tools and offers contemporary empirical case studies, illustrating the diverse political contexts in which entrepreneurship takes place in the polis. Drawing upon an international cast of senior academics and cutting edge young researchers, the volume takes a closer look at key aspects of political entrepreneurship, such as, defining political entrepreneurs, how it relates to change, decision-making and strategies, organizational arrangements, institutional rules, varying contexts and future research agendas. By highlighting the political aspects of entrepreneurship, the volume presents new exciting opportunities for understanding entrepreneurial activities at regional, national and international levels. The volume will be of particular relevance to scholars and students of political science, policy studies, public administration, planning, international relations and business studies as well as practitioners interested in the nexus and utility of entrepreneurship in the modern-day political world.
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| 11. |
- Agarwal, Girish, et al.
(author)
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Light, the universe and everything-12 Herculean tasks for quantum cowboys and black diamond skiers
- 2018
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In: Journal of Modern Optics. - : Informa UK Limited. - 0950-0340 .- 1362-3044. ; 65:11, s. 1261-1308
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Journal article (peer-reviewed)abstract
- The Winter Colloquium on the Physics of Quantum Electronics (PQE) has been a seminal force in quantum optics and related areas since 1971. It is rather mind-boggling to recognize how the concepts presented at these conferences have transformed scientific understanding and human society. In January 2017, the participants of PQE were asked to consider the equally important prospects for the future, and to formulate a set of questions representing some of the greatest aspirations in this broad field. The result is this multi-authored paper, in which many of the world's leading experts address the following fundamental questions: (1) What is the future of gravitational wave astronomy? (2) Are there new quantum phases of matter away from equilibrium that can be found and exploited - such as the time crystal? (3) Quantum theory in uncharted territory: What can we learn? (4) What are the ultimate limits for laser photon energies? (5) What are the ultimate limits to temporal, spatial and optical resolution? (6) What novel roles will atoms play in technology? (7) What applications lie ahead for nitrogen-vacancy centres in diamond? (8) What is the future of quantum coherence, squeezing and entanglement for enhanced super-resolution and sensing? (9) How can we solve (some of) humanity's biggest problems through new quantum technologies? (10) What new understanding of materials and biological molecules will result from their dynamical characterization with free-electron lasers? (11) What new technologies and fundamental discoveries might quantum optics achieve by the end of this century? (12) What novel topological structures can be created and employed in quantum optics?
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| 12. |
- Cleynen, Isabelle, et al.
(author)
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Inherited determinants of Crohn's disease and ulcerative colitis phenotypes : a genetic association study
- 2016
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In: The Lancet. - New York, USA : Elsevier. - 0140-6736 .- 1474-547X. ; 387:10014, s. 156-167
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Journal article (peer-reviewed)abstract
- Background: Crohn's disease and ulcerative colitis are the two major forms of inflammatory bowel disease; treatment strategies have historically been determined by this binary categorisation. Genetic studies have identified 163 susceptibility loci for inflammatory bowel disease, mostly shared between Crohn's disease and ulcerative colitis. We undertook the largest genotype association study, to date, in widely used clinical subphenotypes of inflammatory bowel disease with the goal of further understanding the biological relations between diseases.Methods This study included patients from 49 centres in 16 countries in Europe, North America, and Australasia. We applied the Montreal classification system of inflammatory bowel disease subphenotypes to 34,819 patients (19,713 with Crohn's disease, 14,683 with ulcerative colitis) genotyped on the Immunochip array. We tested for genotype-phenotype associations across 156,154 genetic variants. We generated genetic risk scores by combining information from all known inflammatory bowel disease associations to summarise the total load of genetic risk for a particular phenotype. We used these risk scores to test the hypothesis that colonic Crohn's disease, ileal Crohn's disease, and ulcerative colitis are all genetically distinct from each other, and to attempt to identify patients with a mismatch between clinical diagnosis and genetic risk profile.Findings: After quality control, the primary analysis included 29,838 patients (16,902 with Crohn's disease, 12,597 with ulcerative colitis). Three loci (NOD2, MHC, and MST1 3p21) were associated with subphenotypes of inflammatory bowel disease, mainly disease location (essentially fixed over time; median follow-up of 10·5 years). Little or no genetic association with disease behaviour (which changed dramatically over time) remained after conditioning on disease location and age at onset. The genetic risk score representing all known risk alleles for inflammatory bowel disease showed strong association with disease subphenotype (p=1·65 × 10(-78)), even after exclusion of NOD2, MHC, and 3p21 (p=9·23 × 10(-18)). Predictive models based on the genetic risk score strongly distinguished colonic from ileal Crohn's disease. Our genetic risk score could also identify a small number of patients with discrepant genetic risk profiles who were significantly more likely to have a revised diagnosis after follow-up (p=6·8 × 10(-4)).Interpretation: Our data support a continuum of disorders within inflammatory bowel disease, much better explained by three groups (ileal Crohn's disease, colonic Crohn's disease, and ulcerative colitis) than by Crohn's disease and ulcerative colitis as currently defined. Disease location is an intrinsic aspect of a patient's disease, in part genetically determined, and the major driver to changes in disease behaviour over time.Funding: International Inflammatory Bowel Disease Genetics Consortium members funding sources (see Acknowledgments for full list).
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| 13. |
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Denmark and the European Union
- 2013. - 1
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Editorial collection (other academic/artistic)abstract
- This book offers an accessible, coherent and comprehensive analysis of the recent, contemporary and future challenges and possibilities facing Denmark in the European integration process. The book traces the formal as well as the informal ways of influence and adaptation in Denmark’s relations with the European Union. In doing so, it also offers a contribution to our understanding of Europe as a differentiated political arena. Topics covered include: ◦ Identifying the challenges and opportunities of Danish EU membership, via the policies pursued by Denmark in Europe. ◦ The ways in which Denmark adapts to the European integration process. ◦ Consequences of EU integration for citizen rights, democracy, policy coordination and implementation efficiency. Denmark and the European Union will be of interest to students and scholars of European Union and integration politics.
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| 14. |
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| 15. |
- Dimitrakopoulos, Dimitris, et al.
(author)
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Better Regulation of Utilities in Europe
- 1998
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Reports (other academic/artistic)abstract
- This working report commissioned by a leading think tank in Brussels examined the common challenges for policy-makers in four states in monitoring the Utilities sector in Europe
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| 16. |
- Ellinghaus, David, et al.
(author)
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Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies
- 2013
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In: Gastroenterology. - : Elsevier BV. - 0016-5085 .- 1528-0012. ; 145:2, s. 339-347
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Journal article (peer-reviewed)abstract
- BACKGROUND & AIMS: Genome-wide association studies (GWAS) have identified 140 Crohn's disease (CD) susceptibility loci. For most loci, the variants that cause disease are not known and the genes affected by these variants have not been identified. We aimed to identify variants that cause CD through detailed sequencing, genetic association, expression, and functional studies.METHODS: We sequenced whole exomes of 42 unrelated subjects with CD and 5 healthy subjects (controls) and then filtered single nucleotide variants by incorporating association results from meta-analyses of CD GWAS and in silico mutation effect prediction algorithms. We then genotyped 9348 subjects with CD, 2868 subjects with ulcerative colitis, and 14,567 control subjects and associated variants analyzed in functional studies using materials from subjects and controls and in vitro model systems.RESULTS: We identified rare missense mutations in PR domain-containing 1 (PRDM1) and associated these with CD. These mutations increased proliferation of T cells and secretion of cytokines on activation and increased expression of the adhesion molecule L-selectin. A common CD risk allele, identified in GWAS, correlated with reduced expression of PRDM1 in ileal biopsy specimens and peripheral blood mononuclear cells (combined P = 1.6 x 10(-8)). We identified an association between CD and a common missense variant, Val248Ala, in nuclear domain 10 protein 52 (NDP52) (P = 4.83 x 10(-9)). We found that this variant impairs the regulatory functions of NDP52 to inhibit nuclear factor kappa B activation of genes that regulate inflammation and affect the stability of proteins in Toll-like receptor pathways.CONCLUSIONS: We have extended the results of GWAS and provide evidence that variants in PRDM1 and NDP52 determine susceptibility to CD. PRDM1 maps adjacent to a CD interval identified in GWAS and encodes a transcription factor expressed by T and B cells. NDP52 is an adaptor protein that functions in selective autophagy of intracellular bacteria and signaling molecules, supporting the role of autophagy in the pathogenesis of CD.
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| 17. |
- Franke, Andre, et al.
(author)
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Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
- 2010
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:12, s. 1118-1125
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Journal article (peer-reviewed)abstract
- We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the top association signals in 15,694 cases, 14,026 controls and 414 parent-offspring trios. We identified 30 new susceptibility loci meeting genome-wide significance (P < 5 × 10⁻⁸). A series of in silico analyses highlighted particular genes within these loci and, together with manual curation, implicated functionally interesting candidate genes including SMAD3, ERAP2, IL10, IL2RA, TYK2, FUT2, DNMT3A, DENND1B, BACH2 and TAGAP. Combined with previously confirmed loci, these results identify 71 distinct loci with genome-wide significant evidence for association with Crohn's disease.
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| 18. |
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| 19. |
- Green, Richard E., et al.
(author)
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Three crocodilian genomes reveal ancestral patterns of evolution among archosaurs
- 2014
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 346:6215, s. 1335-
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Journal article (peer-reviewed)abstract
- To provide context for the diversification of archosaurs-the group that includes crocodilians, dinosaurs, and birds-we generated draft genomes of three crocodilians: Alligator mississippiensis (the American alligator), Crocodylus porosus (the saltwater crocodile), and Gavialis gangeticus (the Indian gharial). We observed an exceptionally slow rate of genome evolution within crocodilians at all levels, including nucleotide substitutions, indels, transposable element content and movement, gene family evolution, and chromosomal synteny. When placed within the context of related taxa including birds and turtles, this suggests that the common ancestor of all of these taxa also exhibited slow genome evolution and that the comparatively rapid evolution is derived in birds. The data also provided the opportunity to analyze heterozygosity in crocodilians, which indicates a likely reduction in population size for all three taxa through the Pleistocene. Finally, these data combined with newly published bird genomes allowed us to reconstruct the partial genome of the common ancestor of archosaurs, thereby providing a tool to investigate the genetic starting material of crocodilians, birds, and dinosaurs.
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| 20. |
- Griffiths, Bridget, et al.
(author)
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The BILAG multi-centre open randomized controlled trial comparing ciclosporin vs azathioprine in patients with severe SLE.
- 2010
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In: Rheumatology (Oxford, England). - : Oxford University Press (OUP). - 1462-0332 .- 1462-0324. ; 49, s. 723-732
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Journal article (peer-reviewed)abstract
- Objective. To determine whether low-dose ciclosporin was a more effective corticosteroid-sparing agent than AZA in patients with SLE. Methods. Patients with SLE requiring a change or initiation of a corticosteroid-sparing agent and who were taking >/=15 mg of prednisolone/day were randomized to receive either ciclosporin or AZA during this 12-month open-label multi-centre trial. There were strict guidelines for the reduction of prednisolone. The primary outcome was the absolute mean change in prednisolone. Results. Eighty-nine patients were randomized. Using an intention-to-treat analysis, the absolute mean change in prednisolone dose between baseline and 12 months, adjusted for baseline prednisolone dose, was 9.0 mg for ciclosporin (95% CI 7.2, 10.8) and 10.7 mg for AZA (95% CI 8.8, 12.7). The difference in the change between treatment groups was -1.7 mg (95% CI -4.4, 0.9; P = 0.2). No significant differences were detected for the secondary outcomes: change in disease activity [classic British Isles Lupus Assessment Group (BILAG) index], number of flares, development of new damage or change in quality of life. A similar number of patients in each arm stopped the study drugs due to adverse events and ineffectiveness. No patient developed severe hypertension or a persistent rise in creatinine. One patient in the ciclosporin arm developed a significant increase in proteinuria due to disease activity. Conclusions. Both drugs were effective corticosteroid-sparing agents. Ciclosporin was not a more effective corticosteroid-sparing agent. Ciclosporin may be considered in patients who are unable to tolerate AZA. Patients on ciclosporin require close monitoring of blood pressure and creatinine. Trial registration. Current Controlled Trials, http://www.controlled-trials.com/, ISRCTN35919612.
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| 21. |
- Grove, Eric, et al.
(author)
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When Actions Speak Louder than Words: The Changing Security Architecture and the Future of NATO
- 1999
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Reports (other academic/artistic)abstract
- This commissioned report for NATO, completed as part of a NATO Fellowship award, examined the crisis management policy options available to NATO. The report argues that rather than devising 'top down' approaches to crisis management, logistical challenges of undertakinjg crisis management operations in Europe required a 'bottom up' perspective
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| 22. |
- Heap, Graham A., et al.
(author)
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HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants
- 2014
-
In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 46:10, s. 1131-1134
-
Journal article (peer-reviewed)abstract
- Pancreatitis occurs in approximately 4% of patients treated with the thiopurines azathioprine or mercaptopurine. Its development is unpredictable and almost always leads to drug withdrawal. We identified patients with inflammatory bowel disease (IBD) who had developed pancreatitis within 3 months of starting these drugs from 168 sites around the world. After detailed case adjudication, we performed a genome-wide association study on 172 cases and 2,035 controls with IBD. We identified strong evidence of association within the class II HLA region, with the most significant association identified at rs2647087 (odds ratio 2.59, 95% confidence interval 2.07-3.26, P = 2 x 10(-16)). We replicated these findings in an independent set of 78 cases and 472 controls with IBD matched for drug exposure. Fine mapping of the H LA region identified association with the HLA-DQA1*02:01-HLA-DRB1*07:01 haplotype. Patients heterozygous at rs2647087 have a 9% risk of developing pancreatitis after administration of a thiopurine, whereas homozygotes have a 17% risk.
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| 23. |
- Hoshino, Ayuko, et al.
(author)
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Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers
- 2020
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In: Cell. - : CELL PRESS. - 0092-8674 .- 1097-4172. ; 182:4, s. 1044-
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Journal article (peer-reviewed)abstract
- There is an unmet clinical need for improved tissue and liquid biopsy tools for cancer detection. We investigated the proteomic profile of extracellular vesicles and particles (EVPs) in 426 human samples from tissue explants (TEs), plasma, and other bodily fluids. Among traditional exosome markers, CD9, HSPA8, ALIX, and HSP90AB1 represent pan-EVP markers, while ACTB, MSN, and RAP1B are novel pan-EVP markers. To confirm that EVPs are ideal diagnostic tools, we analyzed proteomes of TE- (n =151) and plasma-derived (n =120) EVPs. Comparison of TE EVPs identified proteins (e.g., VCAN, TNC, and THBS2) that distinguish tumors from normal tissues with 90% sensitivity/94% specificity. Machine-learning classification of plasma-derived EVP cargo, including immunoglobulins, revealed 95% sensitivity/90% specificity in detecting cancer Finally, we defined a panel of tumor-type-specific EVP proteins in TEs and plasma, which can classify tumors of unknown primary origin. Thus, EVP proteins can serve as reliable biomarkers for cancer detection and determining cancer type.
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| 24. |
- Huaraca Huasco, Walter, et al.
(author)
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Fine root dynamics across pantropical rainforest ecosystems
- 2021
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In: Global Change Biology. - : John Wiley & Sons. - 1354-1013 .- 1365-2486. ; 27:15, s. 3657-3680
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Journal article (peer-reviewed)abstract
- Fine roots constitute a significant component of the net primary productivity (NPP) of forest ecosystems but are much less studied than aboveground NPP. Comparisons across sites and regions are also hampered by inconsistent methodologies, especially in tropical areas. Here, we present a novel dataset of fine root biomass, productivity, residence time, and allocation in tropical old-growth rainforest sites worldwide, measured using consistent methods, and examine how these variables are related to consistently determined soil and climatic characteristics. Our pantropical dataset spans intensive monitoring plots in lowland (wet, semi-deciduous, and deciduous) and montane tropical forests in South America, Africa, and Southeast Asia (n = 47). Large spatial variation in fine root dynamics was observed across montane and lowland forest types. In lowland forests, we found a strong positive linear relationship between fine root productivity and sand content, this relationship was even stronger when we considered the fractional allocation of total NPP to fine roots, demonstrating that understanding allocation adds explanatory power to understanding fine root productivity and total NPP. Fine root residence time was a function of multiple factors: soil sand content, soil pH, and maximum water deficit, with longest residence times in acidic, sandy, and water-stressed soils. In tropical montane forests, on the other hand, a different set of relationships prevailed, highlighting the very different nature of montane and lowland forest biomes. Root productivity was a strong positive linear function of mean annual temperature, root residence time was a strong positive function of soil nitrogen content in montane forests, and lastly decreasing soil P content increased allocation of productivity to fine roots. In contrast to the lowlands, environmental conditions were a better predictor for fine root productivity than for fractional allocation of total NPP to fine roots, suggesting that root productivity is a particularly strong driver of NPP allocation in tropical mountain regions.
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| 25. |
- Johnson, Debra, et al.
(author)
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Eastern Europe: Challenges and Business Opportunities
- 1995
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Book (peer-reviewed)abstract
- This short book evaluates the contemporary changes affecting Eastern Europe since 1989 and the role of the European Union in harnassing future political, economic and business opportunities
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| 26. |
- Lindh, Magnus, et al.
(author)
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Becoming Electronic Parliamentarians? ICT Usage in the Swedish Riksdag
- 2008
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In: The Internet and European Parliamentary Democracy: A Comparative Study of the Ethics of Political Communication in the Digital Age. - : Routledge. - 9780415459488
-
Book chapter (peer-reviewed)abstract
- The chapter presents the findings from a quantitative survey of over 80 parliamentarians, as well as website surveys combined with qualitative interviews. The authors explore the degree of usage of Information and Communication Technologies (ICTs) by Swedish parliamentarians. They suggest that, by 2005, Swedish MPs were becoming 'electonic parliamentarians' and that this, combined with the growing usage of political blogs, places increasing demands upon party organisations and the Riksdag to consider the broader management and accountability issues of greater ICT usage by individual MPs. The authors argue that there is a pressing requirement for further research on these organisational and institutional dimensions by scholars of legislative studies, particularly, given the developments in ICT-advanced political systems, like Sweden. The chapter was also published in the Journal of Legislative Studies in 2007
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| 27. |
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| 28. |
- Lindh, Magnus, 1960-, et al.
(author)
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Becoming Electronic Parliamentarians? ICT Usage in the Swedish Riksdag
- 2007
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In: Journal of Legislative Studies. - London : Routledge. - 1357-2334 .- 1743-9337. ; 13 (3), s. 422-440
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Journal article (peer-reviewed)abstract
- Drawing upon a quantiative survey of over 80 parliamentarians, as well as website surveys combined with qualitative interviews, the authors explore the degree of usage of Information and Communication Technologies (ICTs) by Swedish parliamentarians. They suggest that, by 2005, Swedish MPs were becoming 'electronic parliamentarians' and that this, combined with the growing usage of political blogs, places increasing demands upon party organisations and the Riksdag to consider the broader managment and accountability issues of greater ICT usage by individual MPs. The authors argue that there is a pressing requirement for further research on these organisational and institutional dimensions by scholars of legislative studies, particularly, given the developments in ICT-advanced political systems, like Sweden
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| 29. |
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| 30. |
- Lindh, Magnus, et al.
(author)
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Fusing Regions? Sustainable Nordic Regional Governance in the Context of European Integration
- 2007
-
Conference paper (peer-reviewed)abstract
- This breifing paper outlined the research questions and design associated with the study of Regional Action and European integration using fusion techniques. The paper draws upon some of the initial ideas developed for the successful Fusing Regions? project being funded by the Nordic Council of Ministers' research programme in 2007-2008
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| 31. |
- Lindh, Magnus, 1960-, et al.
(author)
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Fusing Regions? Sustainable Regional Action and European Integration, Nordic Regional Action in a Fused Europe?
- 2011
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In: <em>The Road to Europe: </em>. - Brugge : Vanden Broele Publishers. - 978 90 4960 411 0
-
Book chapter (peer-reviewed)abstract
- The chapter, published in a volume by a leading publisher in Belgium and based on proceedings of a major international conference held at Ghent University in 2010, presents the concepts of regional action and fusion as fruitful approaches to understanding how regional actors in Finland and Sweden 'get the best out of the EU'.
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| 32. |
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| 33. |
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| 34. |
- Lindh, Magnus, 1960-
(author)
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Regionen och EU? : Uppfattningar och attityder till EU-relaterade frågor i Västsverige
- 2016
-
Doctoral thesis (other academic/artistic)abstract
- This thesis explores perceptions and preferences on regional action in EU-related frameworks among regional actors in Western Sweden. Building upon the literature on Europeanisation and the Fusion approach, three dimensions of Europeanisation are clarified and explored– download, upload and crossload – and together with a set of five variables that constitute the Micro Fusion Framework; a comprehensive analytical tool is developed. The thesis analyses the intense debate among the members of West Sweden that took place from 2011 to 2013 that focused on how to functionally organise the regional office in Brussels in order to meet future challenges. Surprisingly, the members eventually decided to terminate their cooperation and close the jointly owned office in Brussels in spite of the fact that it has been widely regarded as successful and effective. Diverging perceptions and preferences is understood in terms of three positions on regional action; a download-, upload- and a coherent oriented position. Finally, the thesis presents the empirical findings and discusses in relation to three fusion scenarios, infusion, defusion and clustered fusion.In terms of Micro Fusion Framework, the dynamics shaping why West Sweden was finally regarded as a dysfunctional arena for regional action are explained by a shift of attention and action among regional actors in Western Sweden that led to pressure for further institutional adaptation in order to meet the demand of how ‘to get the best out of the EU’. Further, this redefinition of how to handle EU-affairs within the upload-oriented position was accompanied by positive attitudes towards the potential to bypass the state and thereby pursue regional priorities directly in Brussels given the compound nature of the EU. In contrast, those regional actors that are found to be more download-oriented often question the benefits of uploading activities in practice and advocate close relations to the state. A coherent oriented position recognises the importance of activities related to both of the vertical dimensions of Europeanisation.
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| 35. |
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| 36. |
- Lindh, Magnus, 1960-, et al.
(author)
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Understanding Regional Action and the European Union : A Fusion Approach
- 2007
-
Reports (other academic/artistic)abstract
- What do European regions do in order to influence the European Union? How can regions get the best out of the EU? This working paper represents the final stage in the first phase of an ongoing research project aiming at answering these questions by comparing regional actors’ activities towards the European Union.The project focuses on: (i) exploring and categorising existing regional action among Nordic regional policy-makers, with an emphasis on assessing the attention given to, and the action undertaken by, these policy-makers on EU questions; (ii) evaluating the conceptions and attitudes of regional actors toward existing and future participation in EU-related frameworks in order to, (iii), facilitate the development of an empirically and theoretically informed model for comparing Nordic regional relations with the EU.In this working paper the conceptual elements that will be used to describe and understand regional action are presented.The research project is funded by Nordic Council of Ministers as part of the Internationalisation of Regional Development Policies – Needs and Demands in the Nordic Countries research programme and the Centre for Research on Regional Development (Cerut) at Karlstad University.
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| 37. |
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| 38. |
- Lödén, Hans, et al.
(author)
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Fusing Regions? : Investigating Sustainable Regional Action in Nordic Regions
- 2009
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Conference paper (peer-reviewed)abstract
- The paper introduces the concept of regional action and then investigates the propensity for such regional action undertaken by policy-makers in three specific regions in Finland, Sweden and Norway. The paper focuses on the changing roles of regional networks and the implications for them as boundaries become blurred, the paper contends that the activities of regional policy-makers need to be understood through an appreciation that European integration is contributing to the transformation of regions and the blurring (or fusing) of regional competencies. There is therefore, in our view, an urgent need to focus research specifically upon how Nordic regional policy-makers act towards the European Union, and in what degrees and forms, regional action is sustainable at the functional level.The research project is funded by the Nordic Council of Ministers as part of the Internationalisation of Regional Development Policies Needs and Demands in the Nordic countries research programme, and are a comparative study that focuses upon: (i) the behaviour, strategies and levels of action and interaction of regional actors in EU structures and (ii) the attitudes of regional actors towards interacting with the EU. The study concentrates on regional actors behaviour and attitudes in a variety of policy fields that is affected by EU.This paper represents a part in the final phase of this project, which has a deadline for the final report in May, 2009, and are founded on an earlier paper, Regional Action and the European Union: A Fusion Approach, presented by the authors at the NISA conference in Odense (May 2007) and at the Performing Regions/Regional Performance: Regions and Regionalism in and Beyond Europe conference at Lancaster University (September 2007).Methodological issues are not discussed in this paper; instead it focuses on the design of the study and the relation between the core concepts. Finally, we initiate a discussion on how to make policy recommendations as a result of a theoretically informed empirical study.
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| 39. |
- Lödén, Hans, et al.
(author)
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The Swedish Left and European Integration
- 2008
-
Conference paper (peer-reviewed)abstract
- The paper applies a three dimensional (normative, institutional, and policy) evaluation to the policy orientations of the three primary parties of the Swedish Left - the Social Democratic Party, the Left Party and the Green Party - towards the debates on the 2004 Constitutional Treaty and the 2007 Lisbon Reform Treaty. The authors argue that the development of a common pro-EU membership position among all three parties of the Swedish Left is still some way off. The paper forms the basis of a chapter to be published by Manchester University Press in a volume in 2009/10
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| 40. |
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| 41. |
- Lödén, Hans, et al.
(author)
-
The Swedish Left and European Integration: Linking Laval and Lisbon
- 2008
-
Conference paper (pop. science, debate, etc.)abstract
- This paper (co-authored with Hans Loden) evaluates the policy positions of the three primary parties of the Swedish Left - the Social Democratic Party, the Left Party and the Greens - towards the 2004 Constitutional Treaty and 2007 Lisbon Treaty. The paper argues that the policy discourses and policy positions of the Swedish Left reflect an attempt to link discussions emanating from the Laval case with the ratification of the Lisbon Treaty in Sweden during 2008. The paper was given at an international workshop funded by the London office of the Friedrich Ebert Stiftung Foundation, that brought together leading experts to present evaluations covering 12 different European countries. The paper is based on a chapter to be published in an edited volume by Manchester University Press in 2009/10
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| 42. |
- Miles, Lee
(author)
-
A Fusing Europe in a Confusing World?
- 2006
-
Conference paper (pop. science, debate, etc.)abstract
- Lee Miles gave the opening Keynote Lecture in a dedicated and specially commissioned public lecture series held at Vaxjo University during 2006. The Keynote Lecture went on to form the basis of a book chapter published in 2007
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| 43. |
- Miles, Lee
(author)
-
A Fusing Europe? Insights for EU Governance
- 2009
-
In: 50 Years pf the European Treaties: looking back and thinking forward (essays in european law). - Oxford, Portland : Hart Publishing. - 1841138320 ; , s. 19-42
-
Book chapter (peer-reviewed)abstract
- The chapter reflects upon past achievements of the European Union as well as ponders about the future evolution of the European Union as a 'fusing Europe'. The author arges that, at least in terms of policy analysis, EU external relations policy represents an area where the interface between past achievements and propensitites for further EU development are highly discernible. The chapter proposes that fusion approaches and the concept of a fusing Europe provide a useful starting point for theoretizing about the EU's current development, especially in relation to the 2007 Treaty of Lisbon
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| 44. |
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| 45. |
- Miles, Lee
(author)
-
Active Clusters and Clustered Activity: Key to Innovation Partnerships?
- 2010
-
Conference paper (peer-reviewed)abstract
- This presentation, given at a Research Workshop as part a EU Framework 7 funded Capacities Project on 'Sharing Innovative Practices in University Modernization', directed by the European University Association (EUA) in Brussels, examines the complex relationship between University's involvement in innovation and regional growth and the development of innovation clusters that bring together business interests. The presentation, that gives evidence to a final FP7 funded report to be delivered to the European Commission's DG for Research, examines the case of Sweden and particularly the interaction between regional clusters and actors in Värmland and Karlstad University, which is regarded as a leading innovator in the Swedish higher education setting on questions of innovative practices
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| 46. |
- Miles, Lee, et al.
(author)
-
After the Referendum : A Swedish Euro Paradox?
- 2004
-
In: Cooperation and Conflict. - London : Sage. - 0010-8367 .- 1460-3691. ; 39:2, s. 201-206
-
Journal article (peer-reviewed)abstract
- The article reviews the studies of international reactions to the Swedish euro referendum of 14 September 2003. The authors argue that the country may consequently face a 'Swedish euro Paradox' that will make any attempts by the Swedish political elite to push forward adoption of the euro in the future rather problematic
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| 47. |
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| 48. |
- Miles, Lee
(author)
-
Are the Swedes 'Unofficial Fusionists'?
- 2002
-
In: Current Politics and Economics of Europe. - New York : Nova Science. - 1057-2309. ; 11:2, s. 131-146
-
Journal article (peer-reviewed)abstract
- The article argues that Swedish policy-makers dealing with EU questions operate as 'unofficial fusionists'
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| 49. |
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| 50. |
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