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- Bouyoucef, S E, et al.
(author)
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Poster Session 2 : Monday 4 May 2015, 08
- 2015
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In: European Heart Journal Cardiovascular Imaging. - : Oxford University Press (OUP). - 2047-2404 .- 2047-2412. ; 16 Suppl 1
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Journal article (peer-reviewed)
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- Ferreira, Mjv, et al.
(author)
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Poster Session 3 : Tuesday 5 May 2015, 08
- 2015
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In: European Heart Journal Cardiovascular Imaging. - : Oxford University Press (OUP). - 2047-2404 .- 2047-2412. ; 16 Suppl 1
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Journal article (peer-reviewed)
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- 2019
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Journal article (peer-reviewed)
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- Luis, Tiago C., et al.
(author)
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Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors
- 2016
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In: Nature Immunology. - : Springer Science and Business Media LLC. - 1529-2908 .- 1529-2916. ; 17:12, s. 1424-1435
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Journal article (peer-reviewed)abstract
- The final stages of restriction to the T cell lineage occur in the thymus after the entry of thymus-seeding progenitors (TSPs). The identity and lineage potential of TSPs remains unclear. Because the first embryonic TSPs enter a non-vascularized thymic rudiment, we were able to directly image and establish the functional and molecular properties of embryonic thymopoiesis-initiating progenitors (T-IPs) before their entry into the thymus and activation of Notch signaling. T-IPs did not include multipotent stem cells or molecular evidence of T cell-restricted progenitors. Instead, single-cell molecular and functional analysis demonstrated that most fetal T-IPs expressed genes of and had the potential to develop into lymphoid as well as myeloid components of the immune system. Moreover, studies of embryos deficient in the transcriptional regulator RBPJ demonstrated that canonical Notch signaling was not involved in pre-thymic restriction to the T cell lineage or the migration of T-IPs.
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15. |
- Mizuno, Hiroyasu, et al.
(author)
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Nanorheology and nanotribology of two-component liquid crystal
- 2009
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In: SAE International Journal of Fuels and Lubricants. - : SAE International. - 1946-3952 .- 1946-3960. ; 1:1, s. 1517-1523
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Journal article (peer-reviewed)abstract
- Rheological and tribological properties of a model lubricant consisting of a two-component liquid crystal, mixtures of Sudan Black B (dye) and 4-cyano-4'-hexylbiphenyl (6CB, liquid crystal), nano-films confined between mica surfaces were studied as functions of the surface separation distance (D) and the normal load (N). The compositions of Sudan Black B/6CB binary system were determined by FECO spectroscopy. The rheological properties which reflects the structuring and packing of binary system were examined employing the resonance shear measurement with varying the separation distance at the nanometer resolution. FECO spectroscopy revealed that apparent extinction coefficient of Sudan Black B/6CB increased monotonically with decreasing D, especially below ca. 6 nm, at all initial dye concentrations studied, 0.06-1.03 wt%. This indicated the increase in the Sudan Black B concentration in the gap between mica surfaces with the decreasing D, due to the interaction of a large planar structure dye, Sudan Black B, with mica surface. The resonance shear measurement revealed the sudden drop of the amplitude during the shear, which was not observed for one component 6CB. This drop corresponded to the stick-slip transition, which reflected the structural change in the confined dye/liquid crystal from the solid-like to liquid-like state. The combination of FECO spectroscopy and resonance shear measurement can give insights into the properties of multi-component mixtures depending on their composition.
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