| 1. |
- Biella, Riccardo, et al.
(author)
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The 2022 Drought Needs to be a Turning Point for European Drought Risk Management
- 2024
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In: Natural hazards and earth system sciences. - 1561-8633 .- 1684-9981.
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Journal article (other academic/artistic)abstract
- The 2022 European drought has underscored critical deficiencies in European water management. This paper explores these shortcomings and suggests a way forward for European drought risk management. Data for this study was gathered through a continent-wide survey of water managers involved in this event. The survey collected 481 responses from 30 European countries and is comprised of 19 questions concerning sectorial impact in the regions of the responders and drought risk management practices of their organizations. Information from the survey is enriched with climate-related information to offer a comprehensive overview of drought risk management in Europe. Our research focuses on four key aspects: the increasing risk of drought, its spatial and temporal impacts, current drought risk management approaches, and the evolution of drought risk management across the continent. Our findings reveal a consensus on the growing risk of drought, which is confounded by the rising frequency and intensity of droughts. While the 2022 event affected most of the continent, our findings show significant regional disparities in drought risk management capacity among the various countries. Our analysis indicates that current drought risk management measures often rely on short-term operational concerns, particularly in agriculture-dominated economies, leading to potentially maladaptive practices. An overall positive trend in drought risk management, with organizations showing increased awareness and preparedness, indicates how this crisis can be the ideal moment to mainstream European-wide drought risk management. Consequently, we advocate for a European Drought Directive, to harmonize and enforce drought risk management policies across the continent. This directive should promote a systemic, integrated, and long-term risk management perspective. The directive should also set clear guidelines for drought risk management at the national level and for cross-boundary drought collaboration.
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| 2. |
- Biella, Riccardo, et al.
(author)
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The 2022 Drought Shows the Importance of Preparedness in European Drought Risk Management
- 2024
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In: Natural hazards and earth system sciences. - 1561-8633 .- 1684-9981.
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Journal article (other academic/artistic)abstract
- Droughts in Europe are becoming increasingly frequent and severe, with the 2022 drought surpassing previous records and causing widespread socio-economic impacts. This study employs a Europe-wide survey that integrates data from 481 respondents from 30 European countries, involved in the management of the 2022 European drought, together with hydroclimatic data (i.e., Standardized Precipitation Evapotranspiration Index; SPEI), to provide a holistic assessment of the effect of drought preparedness on response effectiveness and timeliness during the 2022 drought through statistical methods. It specifically assesses the role of forecasting systems and Drought Management Plans (DMPs) in improving preparedness and in facilitating more effective and timely responses. Additionally, the study investigates how drought management practices and awareness have evolved as a consequence of the 2018 European drought and how recent experiences shape water managers’ perceptions. The findings emphasize the urgent need for a standardized, continent-wide drought risk management coordination to address the multifaceted nature of drought risk by integrating climatic and societal factors, and advocates for a Drought Directive as a means to achieve it. This research aims to inform policy development towards sustainable and holistic drought risk management, highlighting the crucial roles of preparedness, awareness, and adaptive strategies in mitigating future drought impacts.
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| 3. |
- Johansson, Ellen, et al.
(author)
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Asynchrony of Apical Polarization, Luminogenesis, and Functional Differentiation in the Developing Thyroid Gland
- 2021
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In: Frontiers in Endocrinology. - : Frontiers Media SA. - 1664-2392. ; 12
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Journal article (peer-reviewed)abstract
- Follicular thyroid tissue originates from progenitors derived from a midline endodermal primordium. Current understanding infers that folliculogenesis in the embryonic thyroid designates the latest morphogenetic event taking place after the final anatomical shape and position of the gland is established. However, this concept does not consider the fact that the thyroid isthmus develops chronologically before the lobes and also contains all progenitors required for lobulation. To elucidate whether cells committed to a thyroid fate might be triggered to differentiate asynchronously related to maturation and developmental stage, mouse embryonic thyroid tissues from E12.5-17.5 were subjected to immunofluorescent labeling of biomarkers (progenitors: NKX2-1; differentiation: thyroglobulin/TG); folliculogenesis: E-cadherin/CDH1; luminogenesis: mucin 1/MUC1; apical polarity: pericentrin/PCNT; basement membrane: laminin; growth: Ki67), quantitative RT-PCR analysis (Nkx2.1, Tg, Muc1) and transmission electron microscopy. Tg expression was detectable as early as E12.5 and gradually increased >1000-fold until E17.5. Muc1 and Nkx2.1 transcript levels increased in the same time interval. Prior to lobulation (E12.5-13.5), MUC1 and TG distinguished pre-follicular from progenitor cells in the developing isthmus characterized by intense cell proliferation. Luminogenesis comprised redistribution of MUC1+ vesicles or vacuoles, transiently associated with PCNT, to the apical cytoplasm and the subsequent formation of MUC1+ nascent lumens. Apical polarization of pre-follicular cells and lumen initiation involved submembraneous vesicular traffic, reorganization of adherens junctions and ciliogenesis. MUC1 did not co-localize with TG until a lumen with a MUC1+ apical membrane was established. MUC1 delineated the lumen of all newly formed follicles encountered in the developing lobes at E15.5-17.5. Folliculogenesis started before establishment of a complete follicular basal lamina. These observations indicate that embryonic thyroid differentiation is an asynchronous process consistent with the idea that progenitors attaining a stationary position in the connecting isthmus portion undergo apical polarization and generate follicles already at a primordial stage of thyroid development, i.e. foregoing growth of the lobes. Although the thyroid isthmus eventually comprises minute amounts of the total thyroid volume and contributes little to the overall hormone production, it is of principal interest that local cues related to the residence status of cells – independently of a prevailing high multiplication rate – govern the thyroid differentiation program. Copyright © 2021 Johansson, Liang, Moccia, Carlsson, Andersson, Fagman and Nilsson.
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| 4. |
- Schoultz, Elin, et al.
(author)
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Tissue architecture delineates field cancerization in brafv600e-induced tumor development
- 2022
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In: DMM Disease Models and Mechanisms. - 1754-8403 .- 1754-8411. ; 15:2
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Journal article (peer-reviewed)abstract
- Cancer cells hijack developmental growth mechanisms but whether tissue morphogenesis and architecture modify tumorigenesis is unknown. Here, we characterized a new mouse model of sporadic thyroid carcinogenesis based on inducible expression of BRAF carrying a Val600 Glu (V600E) point mutation (BRAFV600E) from the thyroglobulin promoter (TgCreERT2). Spontaneous activation of this Braf-mutant allele due to leaky activity of the Cre recombinase revealed that intrinsic properties of thyroid follicles determined BRAF-mutant cell fate. Papillary thyroid carcinomas developed multicentrically within a normal microenvironment. Each tumor originated from a single follicle that provided a confined space for growth of a distinct tumor phenotype. Lineage tracing revealed oligoclonal tumor development in infancy and early selection of BRAFV600E kinase inhibitor-resistant clones. Somatic mutations were few, non-recurrent and limited to advanced tumors. Female mice developed larger tumors than males, reproducing the gender difference of human thyroid cancer. These data indicate that BRAFV600E-induced tumorigenesis is spatiotemporally regulated depending on the maturity and heterogeneity of follicles. Moreover, thyroid tissue organization seems to determine whether a BRAFmutant lineage becomes a cancerized lineage. The TgCreERT2; BrafCA/+ sporadic thyroid cancer mouse model provides a new tool to evaluate drug therapy at different stages of tumor evolution.
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