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| 2. |
- Ferreira, Mjv, et al.
(author)
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Poster Session 3 : Tuesday 5 May 2015, 08
- 2015
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In: European Heart Journal Cardiovascular Imaging. - : Oxford University Press (OUP). - 2047-2404 .- 2047-2412. ; 16 Suppl 1
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Journal article (peer-reviewed)
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- Durno, C., et al.
(author)
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Survival Benefit for Individuals With Constitutional Mismatch Repair Deficiency Undergoing Surveillance
- 2021
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In: Journal of Clinical Oncology. - : American Society of Clinical Oncology (ASCO). - 0732-183X .- 1527-7755. ; 39:25
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Journal article (peer-reviewed)abstract
- PURPOSE Constitutional mismatch repair deficiency syndrome (CMMRD) is a lethal cancer predisposition syndrome characterized by early-onset synchronous and metachronous multiorgan tumors. We designed a surveillance protocol for early tumor detection in these individuals. PATIENTS AND METHODS Data were collected from patients with confirmed CMMRD who were registered in the International Replication Repair Deficiency Consortium. Tumor spectrum, efficacy of the surveillance protocol, and malignant transformation of low-grade lesions were examined for the entire cohort. Survival outcomes were analyzed for patients followed prospectively from the time of surveillance implementation. RESULTS A total of 193 malignant tumors in 110 patients were identified. Median age of first cancer diagnosis was 9.2 years (range: 1.7-39.5 years). For patients undergoing surveillance, all GI and other solid tumors, and 75% of brain cancers were detected asymptomatically. By contrast, only 16% of hematologic malignancies were detected asymptomatically (P < .001). Eighty-nine patients were followed prospectively and used for survival analysis. Five-year overall survival (OS) was 90% (95% CI, 78.6 to 100) and 50% (95% CI, 39.2 to 63.7) when cancer was detected asymptomatically and symptomatically, respectively (P = .001). Patient outcome measured by adherence to the surveillance protocol revealed 4-year OS of 79% (95% CI, 54.8 to 90.9) for patients undergoing full surveillance, 55% (95% CI, 28.5 to 74.5) for partial surveillance, and 15% (95% CI, 5.2 to 28.8) for those not under surveillance (P < .0001). Of the 64 low-grade tumors detected, the cumulative likelihood of transformation from low-to high-grade was 81% for GI cancers within 8 years and 100% for gliomas in 6 years. CONCLUSION Surveillance and early cancer detection are associated with improved OS for individuals with CMMRD.
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| 11. |
- Ercan, Ayse Bahar, et al.
(author)
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Clinical and biological landscape of constitutional mismatch-repair deficiency syndrome: an International Replication Repair Deficiency Consortium cohort study.
- 2024
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In: The Lancet Oncology. - : ELSEVIER SCIENCE INC. - 1470-2045 .- 1474-5488. ; 25:5, s. 668-682
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Journal article (peer-reviewed)abstract
- Constitutional mismatch repair deficiency (CMMRD) syndrome is a rare and aggressive cancer predisposition syndrome. Because a scarcity of data on this condition contributes to management challenges and poor outcomes, we aimed to describe the clinical spectrum, cancer biology, and impact of genetics on patient survival in CMMRD.In this cohort study, we collected cross-sectional and longitudinal data on all patients with CMMRD, with no age limits, registered with the International Replication Repair Deficiency Consortium (IRRDC) across more than 50 countries. Clinical data were extracted from the IRRDC database, medical records, and physician-completed case record forms. The primary objective was to describe the clinical features, cancer spectrum, and biology of the condition. Secondary objectives included estimations of cancer incidence and of the impact of the specific mismatch-repair gene and genotype on cancer onset and survival, including after cancer surveillance and immunotherapy interventions.We analysed data from 201 patients (103 males, 98 females) enrolled between June 5, 2007 and Sept 9, 2022. Median age at diagnosis of CMMRD or a related cancer was 8·9 years (IQR 5·9-12·6), and median follow-up from diagnosis was 7·2 years (3·6-14·8). Endogamy among minorities and closed communities contributed to high homozygosity within countries with low consanguinity. Frequent dermatological manifestations (117 [93%] of 126 patients with complete data) led to a clinical overlap with neurofibromatosis type 1 (35 [28%] of 126). 339 cancers were reported in 194 (97%) of 201 patients. The cumulative cancer incidence by age 18 years was 90% (95% CI 80-99). Median time between cancer diagnoses for patients with more than one cancer was 1·9 years (IQR 0·8-3·9). Neoplasms developed in 15 organs and included early-onset adult cancers. CNS tumours were the most frequent (173 [51%] cancers), followed by gastrointestinal (75 [22%]), haematological (61 [18%]), and other cancer types (30 [9%]). Patients with CNS tumours had the poorest overall survival rates (39% [95% CI 30-52] at 10 years from diagnosis; log-rank p<0·0001 across four cancer types), followed by those with haematological cancers (67% [55-82]), gastrointestinal cancers (89% [81-97]), and other solid tumours (96% [88-100]). All cancers showed high mutation and microsatellite indel burdens, and pathognomonic mutational signatures. MLH1 or MSH2 variants caused earlier cancer onset than PMS2 or MSH6 variants, and inferior survival (overall survival at age 15 years 63% [95% CI 55-73] for PMS2, 49% [35-68] for MSH6, 19% [6-66] for MLH1, and 0% for MSH2; p<0·0001). Frameshift or truncating variants within the same gene caused earlier cancers and inferior outcomes compared with missense variants (p<0·0001). The greater deleterious effects of MLH1 and MSH2 variants as compared with PMS2 and MSH6 variants persisted despite overall improvements in survival after surveillance or immune checkpoint inhibitor interventions.The very high cancer burden and unique genomic landscape of CMMRD highlight the benefit of comprehensive assays in timely diagnosis and precision approaches toward surveillance and immunotherapy. These data will guide the clinical management of children and patients who survive into adulthood with CMMRD.The Canadian Institutes for Health Research, Stand Up to Cancer, Children's Oncology Group National Cancer Institute Community Oncology Research Program, Canadian Cancer Society, Brain Canada, The V Foundation for Cancer Research, BioCanRx, Harry and Agnieszka Hall, Meagan's Walk, BRAINchild Canada, The LivWise Foundation, St Baldrick Foundation, Hold'em for Life, and Garron Family Cancer Center.
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| 13. |
- Mushtaq, I, et al.
(author)
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A unique amphiphilic triblock copolymer, nontoxic to human blood and potential supramolecular drug delivery system for dexamethasone
- 2021
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In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1, s. 21507-
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Journal article (peer-reviewed)abstract
- The drug delivery system (DDS) often causes toxicity, triggering undesired cellular injuries. Thus, developing supramolecules used as DDS with tunable self-assembly and nontoxic behavior is highly desired. To address this, we aimed to develop a tunable amphiphilic ABA-type triblock copolymer that is nontoxic to human blood cells but also capable of self-assembling, binding and releasing the clinically used drug dexamethasone. We synthesized an ABA-type amphiphilic triblock copolymer (P2L) by incorporating tetra(aniline) TANI as a hydrophobic and redox active segment along with monomethoxy end-capped polyethylene glycol (mPEG2k; Mw = 2000 g mol−1) as biocompatible, flexible and hydrophilic part. Cell cytotoxicity was measured in whole human blood in vitro and lung cancer cells. Polymer-drug interactions were investigated by UV–Vis spectroscopy and computational analysis. Our synthesized copolymer P2L exhibited tuned self-assembly behavior with and without external stimuli and showed no toxicity in human blood samples. Computational analysis showed that P2L can encapsulate the clinically used drug dexamethasone and that drug uptake or release can also be triggered under oxidation or low pH conditions. In conclusion, copolymer P2L is nontoxic to human blood cells with the potential to carry and release anticancer/anti-inflammatory drug dexamethasone. These findings may open up further investigations into implantable drug delivery systems/devices with precise drug administration and controlled release at specific locations.
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| 14. |
- Mushtaq, N., et al.
(author)
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Perovskite SrFe1-xTixO3-δ (x < = 0.1) cathode for low temperature solid oxide fuel cell
- 2018
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In: Ceramics International. - : Elsevier. - 0272-8842 .- 1873-3956. ; 44:9, s. 10266-10272
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Journal article (peer-reviewed)abstract
- Stable and compatible cathode materials are a key factor for realizing the low-temperature (LT, ≤600 °C) operation and practical implementations of solid oxide fuel cells (SOFCs). In this study, perovskite oxides SrFe1-xTixO3-δ (x < = 0.1), with various ratios of Ti doping, are prepared by a sol-gel method for cathode material for LT-SOFCs. The structure, morphology and thermo-gravimetric characteristics of the resultant SFT powders are investigated. It is found that the Ti is successfully doped into SrFeO3-δ to form a single phase cubic perovskite structure and crystal structure of SFT shows better stability than SrFeO3-δ. The dc electrical conductivity and electrochemical properties of SFT are measured and analysed by four-probe and electrochemical impedance spectra (EIS) measurements, respectively. The obtained SFT exhibits a very low polarization resistance (Rp),.01 Ωcm2 at 600◦C. The SFT powders using as cathode in fuel cell devices, exhibit maximum power density of 551 mW cm−2 with open circuit voltage (OCV) of 1.15 V at 600◦C. The good performance of the SFT cathode indicates a high rate of oxygen diffusion through the material at cathode. By enabling operation at low temperatures, SFT cathodes may result in a practical implementation of SOFCs.
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| 15. |
- Nobre, Liana, et al.
(author)
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Outcomes of BRAF V600E pediatric gliomas treated with targeted BRAF inhibition
- 2020
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In: JCO Precision Oncology. - 2473-4284. ; 3, s. 561-571
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Journal article (peer-reviewed)abstract
- © 2020 by American Society of Clinical Oncology PURPOSE Children with pediatric gliomas harboring a BRAF V600E mutation have poor outcomes with current chemoradiotherapy strategies. Our aim was to study the role of targeted BRAF inhibition in these tumors. PATIENTS AND METHODS We collected clinical, imaging, molecular, and outcome information from patients with BRAF V600E–mutated glioma treated with BRAF inhibition across 29 centers from multiple countries. RESULTS Sixty-seven patients were treated with BRAF inhibition (pediatric low-grade gliomas [PLGGs], n = 56; pediatric high-grade gliomas [PHGGs], n = 11) for up to 5.6 years. Objective responses were observed in 80% of PLGGs, compared with 28% observed with conventional chemotherapy (P, .001). These responses were rapid (median, 4 months) and sustained in 86% of tumors up to 5 years while receiving therapy. After discontinuation of BRAF inhibition, 76.5% (13 of 17) of patients with PLGG experienced rapid progression (median, 2.3 months). However, upon rechallenge with BRAF inhibition, 90% achieved an objective response. Poor prognostic factors in conventional therapies, such as concomitant homozygous deletion of CDKN2A, were not associated with lack of response to BRAF inhibition. In contrast, only 36% of those with PHGG responded to BRAF inhibition, with all but one tumor progressing within 18 months. In PLGG, responses translated to 3-year progression-free survival of 49.6% (95% CI, 35.3% to 69.5%) versus 29.8% (95% CI, 20% to 44.4%) for BRAF inhibition versus chemotherapy, respectively (P = .02). CONCLUSION Use of BRAF inhibition results in robust and durable responses in BRAF V600E–mutated PLGG. Prospective studies are required to determine long-term survival and functional outcomes with BRAF inhibitor therapy in childhood gliomas.
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| 18. |
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| 19. |
- Czeszumski, Artur, et al.
(author)
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#EEGManyLabs: Investigating the Replicability of Influential EEG Experiments
- 2024
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Other publication (other academic/artistic)abstract
- There is growing awareness across the neuroscience community that the replicability of findings on the relationship between brain activity and cognitive phenomena can be improved by conducting studies with high statistical power that adhere to well-defined and standardized analysis pipelines. Inspired by efforts from the psychological sciences, and with the desire to examine some of the foundational findings using electroencephalography (EEG), we have launched #EEGManyLabs, a large-scale international collaborative replication effort. Since its discovery in the early 20th century, EEG has had a profound influence on our understanding of human cognition, but there is limited evidence on the replicability of some of the most highly cited discoveries. After a systematic search and selection process, we have identified 27 of the most influential and continually cited studies in the field. We plan to directly test the replicability of key findings from 20 of these studies in teams of at least three independent laboratories. The design and protocol of each replication effort will be submitted as a Registered Report and peer-reviewed prior to data collection. Prediction markets, open to all EEG researchers, will be used as a forecasting tool to examine which findings the community expects to replicate. This project will update our confidence in some of the most influential EEG findings and generate a large open access database that can be used to inform future research practices. Finally, through this international effort, we hope to create a cultural shift towards inclusive, high-powered multi-laboratory collaborations.
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| 20. |
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| 21. |
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| 22. |
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| 23. |
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| 24. |
- Mushtaq, M., et al.
(author)
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Cell stemness is maintained upon concurrent expression of RB and the mitochondrial ribosomal protein S18-2
- 2020
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 117:27, s. 15673-15683
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Journal article (peer-reviewed)abstract
- Stemness encompasses the capability of a cell for self-renewal and differentiation. The stern cell maintains a balance between proliferation, quiescence, and regeneration via interactions with the microenvironment. Previously, we showed that ectopic expression of the mitochondrial ribosomal protein S18-2 (MRPS18-2) led to immortalization of primary fibroblasts, accompanied by induction of an embryonic stern cell (ESC) phenotype. Moreover, we demonstrated interaction between S18-2 and the retinoblastoma-associated protein (RB) and hypothesized that the simultaneous expression of RB and S18-2 is essential for maintaining cell sternness. Here, we experimentally investigated the role of S18-2 in cell sternness and differentiation. Concurrent expression of RB and S18-2 resulted in immortalization of Rb1(-/-) primary mouse embryonic fibroblasts and in aggressive tumor growth in severe combined immunodeficiency mice. These cells, which express both RB and S18-2 at high levels, exhibited the potential to differentiate into various lineages in vitro, including osteogenic, chondrogenic, and adipogenic lineages. Mechanistically, S18-2 formed a multimeric protein complex with prohibitin and the ring finger protein 2 (RNF2). This molecular complex increased the monoubiquitination of histone H2A(Lys119), a characteristic trait of ESC5, by enhanced E3-ligase activity of RNF2. Furthermore, we found enrichment of KLF4 at the S18-2 promoter region and that the S18-2 expression is positively correlated with KLF4 levels. Importantly, knockdown of S18-2 in zebrafish larvae led to embryonic lethality. Collectively, our findings suggest an important role for S18-2 in cell sternness and differentiation and potentially also in cancerogenesis.
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| 25. |
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| 26. |
- Mushtaq, M, et al.
(author)
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DNA Tumor Viruses and Cell Metabolism
- 2016
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In: Oxidative medicine and cellular longevity. - : Hindawi Limited. - 1942-0994 .- 1942-0900. ; 2016, s. 6468342-
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Journal article (peer-reviewed)abstract
- Viruses play an important role in cancerogenesis. It is estimated that approximately 20% of all cancers are linked to infectious agents. The viral genes modulate the physiological machinery of infected cells that lead to cell transformation and development of cancer. One of the important adoptive responses by the cancer cells is their metabolic change to cope up with continuous requirement of cell survival and proliferation. In this review we will focus on how DNA viruses alter the glucose metabolism of transformed cells. Tumor DNA viruses enhance “aerobic” glycolysis upon virus-induced cell transformation, supporting rapid cell proliferation and showing the Warburg effect. Moreover, viral proteins enhance glucose uptake and controls tumor microenvironment, promoting metastasizing of the tumor cells.
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| 27. |
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| 28. |
- Mushtaq, S., et al.
(author)
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An innovative systematic approach to internalize external costs of salinization in major irrigated systems
- 2016
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In: Groundwater for Sustainable Development. - : Elsevier. - 2352-801X. ; 2-3, s. 16-26
-
Journal article (peer-reviewed)abstract
- Agricultural production has external costs embedded in different forms. These externalities have not yet been internalized in the market's prices. The study applied a basin-wide systematic approach to manage river salinity, which is one of the most vexatious of these externalities, and needs urgent remediation. The application of the approach is exemplarily demonstrated for the Murray Darling Basin (MDB) in Australia. An in-depth economic analysis indicates that in the upper areas, plant-based options are suitable and economically viable, while in middle and downstream parts of the MDB, more options are suitable such as irrigation management, subsurface drainage and effluent reuse, and salt interception systems and Sequential Biological Concentration (SBC). The SBC differs from most other options since it provides direct economic benefits to the operators and is profitable. We adopt Pigouvian recommendations as polluters pay principle to internalize externality. Charging salinity credits in terms of polluters pay principle (e.g. in this case of about A$53 t-1) would result in attractive economic returns even at higher level of salinity, thus offering sufficient incentives to invest in relevant salinity management strategy. We recommended that potential salinity mitigation technique should consider regional characteristics and that it should be focused on high impact salinity zones to increase the effectiveness of the effort.
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| 29. |
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| 30. |
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| 31. |
- Mushtaq, S., et al.
(author)
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Integrated assessment of water-energy-GHG emissions tradeoffs in an irrigated lucerne production system in eastern Australia
- 2015
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In: Journal of Cleaner Production. - : Elsevier BV. - 0959-6526 .- 1879-1786. ; 103, s. 491-498
-
Journal article (peer-reviewed)abstract
- Robust understanding of possible trade-offs and synergies between climate change, energy and water sector policies is critical to achieving economically viable and environmentally sound agricultural production systems in a low-carbon water-constrained economy, in which greenhouse gas (GHG) emissions are penalized and water savings rewarded. Accurate assessment of the potential costs/benefits of investment decisions can help to optimize the economic efficiency of agricultural production while minimizing environmental impacts. This paper presents a novel integrated framework, based on carbon and water accounting, which enables analysis of potential trade-offs between water savings, energy consumption, GHG emissions and economic costs/benefits associated with the adoption of new water efficient irrigation technologies. The framework was applied to an irrigated lucerne cropping system in eastern Australia and compares the costs/benefits of old roll-line sprinkler irrigation systems against new pressurized systems. Positive synergies were found with the adoption of the new technology, which saved both water and energy use, reduced total GHG emissions and resulted in net economic returns across a range of carbon prices. The results of this study provide support for an integrated evidence-based approach to policy development and strategic decision-making and for the prioritization of investments on both economic and environmental grounds.
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| 32. |
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| 33. |
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| 34. |
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| 35. |
- Snyder, Joel S., et al.
(author)
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#EEGManyLabs: Investigating the replicability of influential EEG experiments
- 2021
-
In: Cortex. - : Elsevier. - 1973-8102 .- 0010-9452. ; 144, s. 213-229
-
Journal article (peer-reviewed)abstract
- There is growing awareness across the neuroscience community that the replicability of findings about the relationship between brain activity and cognitive phenomena can be improved by conducting studies with high statistical power that adhere to well-defined and standardised analysis pipelines. Inspired by recent efforts from the psychological sciences, and with the desire to examine some of the foundational findings using electroencephalog-raphy (EEG), we have launched #EEGManyLabs, a large-scale international collaborative replication effort. Since its discovery in the early 20th century, EEG has had a profound in-fluence on our understanding of human cognition, but there is limited evidence on the replicability of some of the most highly cited discoveries. After a systematic search and se-lection process, we have identified 27 of the most influential and continually cited studies in the field. We plan to directly test the replicability of key findings from 20 of these studies in teams of at least three independent laboratories. The design and protocol of each replication effort will be submitted as a Registered Report and peer-reviewed prior to data collection. Prediction markets, open to all EEG researchers, will be used as a forecasting tool to examine which findings the community expects to replicate. This project will update our confidence in some of the most influential EEG findings and generate a large open access database that can be used to inform future research practices. Finally, through this international effort, we hope to create a cultural shift towards inclusive, high-powered multi-laboratory collaborations. (c) 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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| 36. |
- Wu, Y., et al.
(author)
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Electrolyte-free fuel cell : Principles and crosslink research
- 2020
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In: Solid Oxide Fuel Cells. - : Wiley. ; , s. 347-378
-
Book chapter (peer-reviewed)abstract
- Semiconductors and the associated methodologies applied to electrochemistry have recently grown as an emerging field in energy materials and technologies. Fuel cells have been developed in line with traditional electrochemistry employing three basic functional components: anode, electrolyte and cathode. The electrolyte is a key component to the device performance by providing an ionic charge flow pathway between the anode and cathode but preventing electron conduction. By contrast, semiconductors and the derived heterostructures with electronic (hole) conducting materials have been strongly developed with much better ionic conductors instead of a conventional ionic electrolyte for novel fuel cells. Energy band structures and alignments, band-bending and built-in-field are all important parameters in this context to accomplish the necessary fuel cell functionalities. This chapter extends widely the semiconductor-based electrochemical energy conversion and storage technologies, describing their fundamentals and working principles, with an intention to advance the understanding of the semiconductors and energy bands role in electrochemical devices of energy conversion and storage, as well as applications for emerging demands, widely involving in energy applications, such as photo catalysis/water splitting; battery and solar cell etc. It provides new ideas and new solutions to the problems beyond the conventional electrochemistry and presents new inter-disciplinary approaches to develop clean energy conversion and storage technologies.
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| 37. |
- Yousaf, M., et al.
(author)
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Evaluation of rare earth (Yb, La) doped (Sm3Fe5O12) garnet ferrite membrane for LT-SOFC
- 2020
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In: International journal of hydrogen energy. - : Elsevier Ltd. - 0360-3199 .- 1879-3487.
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Journal article (peer-reviewed)abstract
- Rare earth element doping is a popular methodology for improving the electrical and electrochemical properties of materials. Inspired by this ideology, garnet ferrite material Sm3Fe5O12 (SFO) doped by rare earth (Yb, La) metal ions to form Sm3-0.5Yb0.5Fe5O12 (SYFO) and Sm3-0.5La0·5Fe5O12 (SLFO). The samples are synthesized by sol gel auto combustion and have been applied as electrolyte membrane for the first time in low temperature solid oxide fuel cell (LT-SOFC). The results indicate that the as-prepared materials have triple charge transport (H+/O−2/e−) carrier which promotes the hydrogen oxidation reaction (HOR) and oxygen reduction reactions (ORR) in SOFC at triple phase boundary region (TPB). Electrochemical impedance spectroscopy (EIS) reveals that the polarization resistance of SLFO membrane significantly reduces from 0.92 Ω-cm2 to 0.45 Ω-cm2 and the power output improve from 310 mW/cm2 to 650 mW/cm2 at 550 °C temperature in comparison with that of SYFO and SFO electrolyte supported cells. UV-vis diffused spectroscopy explains the semiconducting nature of the prepared materials due to the existence of optical bandgap in the semiconductor region. The further investigation also verifies the protonic conduction of SLFO membrane by constructing oxygen ion blocking fuel cell with configuration of Ni-NCAL/BZCY/SLFO/BZCY/Ni-NCAL having 427.94 mW/Cm2 fuel cell performance with 1.03 OCV at 550 °C temperature.
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| 38. |
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| 39. |
- Zahid, Nida, et al.
(author)
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Predictors of neurocognition outcomes in children and young people with primary brain tumor presenting to tertiary care hospitals of Karachi, Pakistan : a prospective cohort study
- 2024
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In: Child's Nervous System. - : Springer. - 0256-7040 .- 1433-0350.
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Journal article (peer-reviewed)abstract
- IntroductionPrimary brain tumors are a common cause of morbidity and mortality in children and young people (CYP) globally. Impaired neurocognitive function is a potential severe consequence in primary brain tumor (PBT) survivors. There are no in-depth studies from low- and middle-income countries (LMICs) to inform management and follow-up. The research questions of this study were as follows: Are the sociodemographic factors (lower age of CYP, female gender, low socioeconomic status, low parental education), disease-related factors (high grade of tumor, presence of seizures, presence of hydrocephalous), and treatment-related factors (adjuvant therapy, no surgical intervention, post-treatment seizures, placement of shunts) associated with decline in neurcognition outcomes 12 months post-treatment in CYP with PBTs?MethodsA prospective cohort study was conducted from November 2020 to July 2023 at the Aga Khan University Hospital and Jinnah Postgraduate Medical Centre, tertiary care hospitals in Karachi, Pakistan. All CYP aged 5 to 21 years with a newly diagnosed PBTs were eligible. The neurocognition assessment was undertaken by a psychologist at two points, i.e., pre-treatment and at 12 months post-treatment using validated tools. The verbal intelligence was assessed by Slosson Intelligence tool, revised 3rd edition (SIT-R3), perceptual reasoning by Raven’s Progressive Matrices (RPM), and the Processing Speed Index by Wechsler Intelligence Scale (WISC V) and Wechsler Adult Intelligence Scale (WAIS-IV). The data were analyzed by STATA version 12 software. Generalized estimating equation (GEE) was used to determine the factors associated with the mean change in 12 months post-treatment verbal and non-verbal neurocognition scores. Unadjusted and adjusted beta coefficients with their 95% confidence intervals were reported.ResultsA total of 48 CYPs with PBTs were enrolled, 23 (48%) of them were lost to follow-up and 10 (21%) died. The remaining 25 (52%) were reassessed 12 months after treatment. On multivariable analysis, a significant decline in verbal intelligence scores at 12 months was predicted by post-treatment seizures beta = − 20.8 (95% CI, − 38.2, − 3.4), mothers having no formal educational status and lower household monthly income. Similarly, a significant decline in perceptual reasoning scores was also predicted by post-treatment seizures beta = − 10.7 (95% CI, − 20.6, − 0.8), mothers having no formal education and having lower household monthly income. Worsening of processing speed scores at 12 months post-treatment were predicted by tumor histology, post-treatment seizures beta = − 33.9 (95% CI, − 47.7, − 20.0), lower educational status of the mother, and having lower household monthly. However, an improvement was seen in processing speed scores after surgical tumor resection.ConclusionIn this novel study, the post-treatment mean change in verbal and non-verbal neurocognition scores was associated with sociodemographic, tumor, and treatment factors. These findings may have potential implications for targeted early psychological screening of higher risk CYP with PBTs. Identification of these predictors may serve as a foundation for developing more cost-effective treatment thereby alleviating the burden of neurocognitive morbidity. However to establish generalizability, future research should prioritize larger-scale, multicountry studies. (Trial registration: ClinicalTrials.gov Identifier: NCT05709522)
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