| 1. |
- Kanai, M, et al.
(author)
-
- 2023
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swepub:Mat__t
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| 2. |
- Niemi, MEK, et al.
(author)
-
- 2021
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swepub:Mat__t
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| 3. |
- Sliz, E., et al.
(author)
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Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata
- 2023
-
In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 14:1
-
Journal article (peer-reviewed)abstract
- Uterine leiomyomata (UL) are the most common tumours of the female genital tract and the primary cause of surgical removal of the uterus. Genetic factors contribute to UL susceptibility. To add understanding to the heritable genetic risk factors, we conduct a genome-wide association study (GWAS) of UL in up to 426,558 European women from FinnGen and a previous UL meta-GWAS. In addition to the 50 known UL loci, we identify 22 loci that have not been associated with UL in prior studies. UL-associated loci harbour genes enriched for development, growth, and cellular senescence. Of particular interest are the smooth muscle cell differentiation and proliferation-regulating genes functioning on the myocardin-cyclin dependent kinase inhibitor 1A pathway. Our results further suggest that genetic predisposition to increased fat-free mass may be causally related to higher UL risk, underscoring the involvement of altered muscle tissue biology in UL pathophysiology. Overall, our findings add to the understanding of the genetic pathways underlying UL, which may aid in developing novel therapeutics.
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| 4. |
- Armesto, N., et al.
(author)
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Heavy-ion collisions at the LHC-Last call for predictions
- 2008
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In: Journal of Physics G. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 35:5, s. 054001-
-
Research review (peer-reviewed)abstract
- This writeup is a compilation of the predictions for the forthcoming Heavy Ion Program at the Large Hadron Collider, as presented at the CERN Theory Institute 'Heavy Ion Collisions at the LHC - Last Call for Predictions', held from 14th May to 10th June 2007.
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| 5. |
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| 6. |
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| 7. |
- Kurki, MI, et al.
(author)
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FinnGen provides genetic insights from a well-phenotyped isolated population
- 2023
-
In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 613:7944, s. 508-
-
Journal article (peer-reviewed)abstract
- Population isolates such as those in Finland benefit genetic research because deleterious alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor allele frequency < 5%). These variants survived the founding bottleneck rather than being distributed over a large number of ultrarare variants. Although this effect is well established in Mendelian genetics, its value in common disease genetics is less explored1,2. FinnGen aims to study the genome and national health register data of 500,000 Finnish individuals. Given the relatively high median age of participants (63 years) and the substantial fraction of hospital-based recruitment, FinnGen is enriched for disease end points. Here we analyse data from 224,737 participants from FinnGen and study 15 diseases that have previously been investigated in large genome-wide association studies (GWASs). We also include meta-analyses of biobank data from Estonia and the United Kingdom. We identified 30 new associations, primarily low-frequency variants, enriched in the Finnish population. A GWAS of 1,932 diseases also identified 2,733 genome-wide significant associations (893 phenome-wide significant (PWS), P < 2.6 × 10–11) at 2,496 (771 PWS) independent loci with 807 (247 PWS) end points. Among these, fine-mapping implicated 148 (73 PWS) coding variants associated with 83 (42 PWS) end points. Moreover, 91 (47 PWS) had an allele frequency of <5% in non-Finnish European individuals, of which 62 (32 PWS) were enriched by more than twofold in Finland. These findings demonstrate the power of bottlenecked populations to find entry points into the biology of common diseases through low-frequency, high impact variants.
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| 8. |
- Barnett, R., et al.
(author)
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Euclid preparation V. Predicted yield of redshift 7 < z < 9 quasars from the wide survey
- 2019
-
In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 631
-
Journal article (peer-reviewed)abstract
- We provide predictions of the yield of 7 < z < 9 quasars from the Euclid wide survey, updating the calculation presented in the Euclid Red Book in several ways. We account for revisions to the Euclid near-infrared filter wavelengths; we adopt steeper rates of decline of the quasar luminosity function (QLF; Phi) with redshift, Phi proportional to 10(k(z-6)), k = 0:72, and a further steeper rate of decline, k = 0:92; we use better models of the contaminating populations (MLT dwarfs and compact early-type galaxies); and we make use of an improved Bayesian selection method, compared to the colour cuts used for the Red Book calculation, allowing the identification of fainter quasars, down to J(AB) similar to 23. Quasars at z > 8 may be selected from Euclid OYJH photometry alone, but selection over the redshift interval 7 < z < 8 is greatly improved by the addition of z-band data from, e.g., Pan-STARRS and LSST. We calculate predicted quasar yields for the assumed values of the rate of decline of the QLF beyond z = 6. If the decline of the QLF accelerates beyond z = 6, with k = 0.92, Euclid should nevertheless find over 100 quasars with 7.0 < z < 7.5, and similar to 25 quasars beyond the current record of z = 7.5, including similar to 8 beyond z = 8.0. The first Euclid quasars at z > 7.5 should be found in the DR1 data release, expected in 2024. It will be possible to determine the bright-end slope of the QLF, 7 < z < 8, M-1450 < 25, using 8m class telescopes to confirm candidates, but follow-up with JWST or E-ELT will be required to measure the faint-end slope. Contamination of the candidate lists is predicted to be modest even at J(AB) similar to 23. The precision with which k can be determined over 7 < z < 8 depends on the value of k, but assuming k = 0.72 it can be measured to a 1 sigma uncertainty of 0.07.
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| 9. |
- Hamaus, N., et al.
(author)
-
Euclid : Forecasts from redshift-space distortions and the Alcock-Paczynski test with cosmic voids
- 2022
-
In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 658
-
Journal article (peer-reviewed)abstract
- Euclid is poised to survey galaxies across a cosmological volume of unprecedented size, providing observations of more than a billion objects distributed over a third of the full sky. Approximately 20 million of these galaxies will have their spectroscopy available, allowing us to map the three-dimensional large-scale structure of the Universe in great detail. This paper investigates prospects for the detection of cosmic voids therein and the unique benefit they provide for cosmological studies. In particular, we study the imprints of dynamic (redshift-space) and geometric (Alcock-Paczynski) distortions of average void shapes and their constraining power on the growth of structure and cosmological distance ratios. To this end, we made use of the Flagship mock catalog, a state-of-the-art simulation of the data expected to be observed with Euclid. We arranged the data into four adjacent redshift bins, each of which contains about 11000 voids and we estimated the stacked void-galaxy cross-correlation function in every bin. Fitting a linear-theory model to the data, we obtained constraints on f/b and DMH, where f is the linear growth rate of density fluctuations, b the galaxy bias, D-M the comoving angular diameter distance, and H the Hubble rate. In addition, we marginalized over two nuisance parameters included in our model to account for unknown systematic effects in the analysis. With this approach, Euclid will be able to reach a relative precision of about 4% on measurements of f/b and 0.5% on DMH in each redshift bin. Better modeling or calibration of the nuisance parameters may further increase this precision to 1% and 0.4%, respectively. Our results show that the exploitation of cosmic voids in Euclid will provide competitive constraints on cosmology even as a stand-alone probe. For example, the equation-of-state parameter, w, for dark energy will be measured with a precision of about 10%, consistent with previous more approximate forecasts.
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| 10. |
- Pezzotta, A., et al.
(author)
-
Euclid preparation XLI. Galaxy power spectrum modelling in real space
- 2024
-
In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 687
-
Journal article (peer-reviewed)abstract
- We investigate the accuracy of the perturbative galaxy bias expansion in view of the forthcoming analysis of the Euclid spectroscopic galaxy samples. We compare the performance of a Eulerian galaxy bias expansion using state-of-the-art prescriptions from the effective field theory of large-scale structure (EFTofLSS) with a hybrid approach based on Lagrangian perturbation theory and high-resolution simulations. These models are benchmarked against comoving snapshots of the flagship I N-body simulation at z = (0.9, 1.2, 1.5, 1.8), which have been populated with H alpha galaxies leading to catalogues of millions of objects within a volume of about 58 h(-3) Gpc(3). Our analysis suggests that both models can be used to provide a robust inference of the parameters (h, omega c) in the redshift range under consideration, with comparable constraining power. We additionally determine the range of validity of the EFTofLSS model in terms of scale cuts and model degrees of freedom. From these tests, it emerges that the standard third-order Eulerian bias expansion - which includes local and non-local bias parameters, a matter counter term, and a correction to the shot-noise contribution - can accurately describe the full shape of the real-space galaxy power spectrum up to the maximum wavenumber of k(max) = 0.45 h Mpc(-1), and with a measurement precision of well below the percentage level. Fixing either of the tidal bias parameters to physically motivated relations still leads to unbiased cosmological constraints, and helps in reducing the severity of projection effects due to the large dimensionality of the model. We finally show how we repeated our analysis assuming a volume that matches the expected footprint of Euclid, but without considering observational effects, such as purity and completeness, showing that we can get constraints on the combination (h, omega c) that are consistent with the fiducial values to better than the 68% confidence interval over this range of scales and redshifts.
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| 11. |
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| 12. |
- Contarini, S., et al.
(author)
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Euclid : cosmological forecasts from the void size function
- 2022
-
In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 667
-
Journal article (peer-reviewed)abstract
- The Euclid mission - with its spectroscopic galaxy survey covering a sky area over 15 000 deg(2) in the redshift range 0.9 < z < 1.8 - will provide a sample of tens of thousands of cosmic voids. This paper thoroughly explores for the first time the constraining power of the void size function on the properties of dark energy (DE) from a survey mock catalogue, the official Euclid Flagship simulation. We identified voids in the Flagship light-cone, which closely matches the features of the upcoming Euclid spectroscopic data set. We modelled the void size function considering a state-of-the art methodology: we relied on the volume-conserving (Vdn) model, a modification of the popular Sheth & van de Weygaert model for void number counts, extended by means of a linear function of the large-scale galaxy bias. We found an excellent agreement between model predictions and measured mock void number counts. We computed updated forecasts for the Euclid mission on DE from the void size function and provided reliable void number estimates to serve as a basis for further forecasts of cosmological applications using voids. We analysed two different cosmological models for DE: the first described by a constant DE equation of state parameter, w, and the second by a dynamic equation of state with coefficients w(0) and w(a). We forecast 1 sigma errors on w lower than 10% and we estimated an expected figure of merit (FoM) for the dynamical DE scenario FoM(w0,wa) = 17 when considering only the neutrino mass as additional free parameter of the model. The analysis is based on conservative assumptions to ensure full robustness, and is a pathfinder for future enhancements of the technique. Our results showcase the impressive constraining power of the void size function from the Euclid spectroscopic sample, both as a stand-alone probe, and to be combined with other Euclid cosmological probes.
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| 13. |
- Perdikari, A., et al.
(author)
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BATLAS: Deconvoluting Brown Adipose Tissue
- 2018
-
In: Cell Reports. - : Elsevier BV. - 2211-1247. ; 25:3
-
Journal article (peer-reviewed)abstract
- Recruitment and activation of thermogenic adipocytes have received increasing attention as a strategy to improve systemic metabolic control. The analysis of brown and brite adipocytes is complicated by the complexity of adipose tissue biopsies. Here, we provide an in-depth analysis of pure brown, brite, and white adipocyte transcriptomes. By combining mouse and human transcriptome data, we identify a gene signature that can classify brown and white adipocytes in mice and men. Using a machine-learning-based cell deconvolution approach, we develop an algorithm proficient in calculating the brown adipocyte content in complex human and mouse biopsies. Applying this algorithm, we can show in a human weight loss study that brown adipose tissue (BAT) content is associated with energy expenditure and the propensity to lose weight. This online available tool can be used for in-depth characterization of complex adipose tissue samples and may support the development of therapeutic strategies to increase energy expenditure in humans.
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| 14. |
- Pöntinen, M., et al.
(author)
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Euclid: Identification of asteroid streaks in simulated images using deep learning
- 2023
-
In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 679
-
Journal article (peer-reviewed)abstract
- The material composition of asteroids is an essential piece of knowledge in the quest to understand the formation and evolution of the Solar System. Visual to near-infrared spectra or multiband photometry is required to constrain the material composition of asteroids, but we currently have such data, especially in the near-infrared wavelengths, for only a limited number of asteroids. This is a significant limitation considering the complex orbital structures of the asteroid populations. Up to 150 000 asteroids will be visible in the images of the upcoming ESA Euclid space telescope, and the instruments of Euclid will offer multiband visual to near-infrared photometry and slitless near-infrared spectra of these objects. Most of the asteroids will appear as streaks in the images. Due to the large number of images and asteroids, automated detection methods are needed. A non-machine-learning approach based on the Streak Det software was previously tested, but the results were not optimal for short and/or faint streaks. We set out to improve the capability to detect asteroid streaks in Euclid images by using deep learning. We built, trained, and tested a three-step machine-learning pipeline with simulated Euclid images. First, a convolutional neural network (CNN) detected streaks and their coordinates in full images, aiming to maximize the completeness (recall) of detections. Then, a recurrent neural network (RNN) merged snippets of long streaks detected in several parts by the CNN. Lastly, gradient-boosted trees (XGBoost) linked detected streaks between different Euclid exposures to reduce the number of false positives and improve the purity (precision) of the sample. The deep-learning pipeline surpasses the completeness and reaches a similar level of purity of a non-machine-learning pipeline based on the StreakDet software. Additionally, the deep-learning pipeline can detect asteroids 0.25–0.5 magnitudes fainter than StreakDet. The deep-learning pipeline could result in a 50% increase in the number of detected asteroids compared to the StreakDet software. There is still scope for further refinement, particularly in improving the accuracy of streak coordinates and enhancing the completeness of the final stage of the pipeline, which involves linking detections across multiple exposures.
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| 15. |
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| 16. |
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| 17. |
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| 18. |
- Syvalahti, EKG, et al.
(author)
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Citalopram causes no significant alterations in plasma neuroleptic levels in schizophrenic patients
- 1997
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In: The Journal of international medical research. - : SAGE Publications. - 0300-0605 .- 1473-2300. ; 25:1, s. 24-32
-
Journal article (peer-reviewed)abstract
- Steady-state plasma concentrations of commonly used neuroleptic drugs were measured in 90 schizophrenic patients before and after adding placebo or citalopram (40 mg/day) to their treatment regimen. Plasma concentrations of citalopram and its main metabolite, desmethylcitalopram, were also measured. In addition, patients with exceptionally high neuroleptic levels or an increase in adverse effects during the 12-week study period were evaluated for their debrisoquine/sparteine hydroxylase (CYP2D6) genotype, an enzyme responsible for oxidative metabolism of several neuroleptics and selective serotonin re-uptake inhibitors. There were no significant changes in plasma concentrations of haloperidol, chlorpromazine, zuclopenthixol, levomepromazine, thioridazine or perphenazine during the study. Plasma concentrations of citalopram and desmethylcitalopram were well within the levels reported previously with monotherapy, and remained stable throughout the study. None of the 15 patients analysed for the CYP2D6 genotype was a poor metabolizer. It is concluded that clinically important pharmacokinetic drug interactions do not play a crucial role when citalopram is used as an augmentation therapy in neuroleptic-treated schizophrenic patients.
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| 19. |
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| 20. |
- Basirat, Farzad, et al.
(author)
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Modeling gas transport in the shallow subsurface in the Maguelone field experiment
- 2013
-
Conference paper (peer-reviewed)abstract
- Developing reliable monitoring techniques to detect and characterize CO2 leakage in shallow subsurface is necessary for the safety of any GCS project. To test different monitoring techniques, shallow injection-monitoring experiment have and are being carried out at the Maguelone, along the Mediterranean lido of the Gulf of Lions, near Montpellier, France. This experimental site was developed in the context of EU FP7 project MUSTANG and is documented in Lofi et al. (2012). Gas injection experiments are being carried out and three techniques of pressure, electrical resistivity and seismic monitoring have been used to detect the nitrogen and CO2 release in the near surface environment. In the present work we use the multiphase and multicomponent TOUGH2/EOS7CA model to simulate the gaseous nitrogen and CO2 transport of the experiments carried out so far. The objective is both to gain understanding of the system performance based on the model analysis as well as to further develop and validate modelling approaches for gas transport in the shallow subsurface, against the well-controlled data sets. Numerical simulation can also be used for the prediction of experimental setup limitations. We expect the simulations to represent the breakthrough time for the different tested injection rates. Based on the hydrogeological formation data beneath the lido, we also expect the vertical heterogeneities in grain size distribution create an effective capillary barrier against upward gas transport in numerical simulations.
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| 21. |
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| 22. |
- Danielsson, Ulf H., et al.
(author)
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Gauge field theory of chirally folded homopolymers with applications to folded proteins
- 2010
-
In: Physical Review E. - 1539-3755. ; 82:2, s. 021910-
-
Journal article (peer-reviewed)abstract
- We combine the principle of gauge invariance with extrinsic string geometry to develop a lattice model that can be employed to theoretically describe properties of chiral, unbranched homopolymers. We find that in its low temperature phase the model is in the same universality class with proteins that are deposited in the Protein Data Bank, in the sense of the compactness index. We apply the model to analyze various statistical aspects of folded proteins. Curiously we find that it can produce results that are a very good good match to the data in the Protein Data Bank.
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| 23. |
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| 24. |
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| 25. |
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| 26. |
- Fagerlund, Fritjof, 1974-, et al.
(author)
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Nonaqueous-phase liquid infiltration and immobilization in heterogeneous media : 2. Application to stochastically heterogeneous formations
- 2007
-
In: Vadose Zone Journal. - : Wiley. - 1539-1663. ; 6:3, s. 483-495
-
Journal article (peer-reviewed)abstract
- We performed a series of well-controlled laboratory experimentsinvestigating the infiltration and subsequent immobilizationof nonaqueous-phase liquid (NAPL) in saturated heterogeneousmedia. A system of two distinct aquifer zones separated by adipping interface was considered. Heterogeneity was representedby a spatially correlated random field with known geostatisticalparameters in one zone in combination with a homogenous packingof the other zone. The effects of heterogeneity on NAPL flowand entrapment in each of the two zones were investigated. Thetime-varying NAPL saturations were continuously monitored inspace and the final static entrapment–saturation distributionwas accurately measured. The immobilized-NAPL distribution contributesto plume generation from source zones. The results show thatcapillary barriers produced by the small-scale heterogeneitystrongly influenced the migration paths and the final distributionof NAPL both in space and across different saturation ranges.The NAPL was immobilized both by snap-off to discontinuous blobsand ganglia and by capillary barriers at textural interfaces.Heterogeneity generally increased entrapment, because spatialvariations in capillary properties caused NAPL to be entrappedat higher saturations. Heterogeneity in the finer formationprovided points of entry into this formation where the NAPLsubsequently could spread as the pressure built up. The NAPLwas immobilized at high saturations because high displacementpressures in the fine materials inhibited flow at low saturations.The accessibility for water flow through NAPL occurrences andthereby also the dissolution of NAPL is limited by (i) highentrapped NAPL saturations that decrease the aqueous-phase relativepermeability and (ii) the location of NAPL inside a formationwith low average permeability.
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| 27. |
- Fagerlund, Fritjof, 1974-, et al.
(author)
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Nonaqueous-phase liquid infiltration and immobilization in heterogeneous media : 1. Experimental methods and two-layered reference case
- 2007
-
In: Vadose Zone Journal. - : Wiley. - 1539-1663. ; 6:3, s. 471-482
-
Journal article (peer-reviewed)abstract
- Accurate data to understand the migration and entrapment ofnonaqueous-phase liquids (NAPLs) in heterogeneous formationsare presently lacking. A series of well-controlled laboratoryexperiments were conducted to investigate the infiltration andsubsequent immobilization of dense NAPLs in saturated heterogeneousmedia. The focus of this first study was the development ofa special experimental methodology for measuring the dynamicevolution of a NAPL plume in space and time. To demonstratethe method, a reference case of a two-layered formation consistingof two homogeneous sands separated by a dipping interface ispresented. The dipping formation in the reference case allowsthe study of NAPL behavior at texture interfaces under the influenceof both capillary and gravitational forces. The NAPL-saturationmeasurement methodology, based on a multiple-energy x-ray attenuationtechnique, correctly captured the known injected NAPL volumeas well as the general spreading and entrapment behavior inspace and time. Time-continuous measurements of NAPL saturationsallow the study of the history dependence of entrapped saturations.The Land model predicted the observed trend in the entrapmentbehavior well. The entrapment architecture was parameterizedusing spatial moments and moments of mass distribution at differentsaturations. The general features of the NAPL architecture weresuccessfully characterized by a simultaneous interpretationof these moments, while the domination of discontinuous or continuousNAPL was captured by the ganglia/pool ratio.
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| 28. |
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| 29. |
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| 30. |
- Hearn, Jeff, et al.
(author)
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Configurations of Europe
- 2006
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In: European Perspectives on Men and Masculinities. National and Transnational Approaches. - Houndmills, Basingstoke and New York : Palgrave macmillan. - 1403918139 ; , s. 184-199
-
Book chapter (peer-reviewed)
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| 31. |
- Hearn, Jeff, 1947-, et al.
(author)
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The state
- 2007. - 1
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In: Encyclopedia of Men and Masculinities. - London : Routledge. ; , s. 588-589
-
Book chapter (other academic/artistic)abstract
- The International Encyclopedia of Men and Masculinities offers a comprehensive guide to the current state of scholarship about men, masculinities, and gender around the world. The Encyclopedia's coverage is comprehensive across three dimensions: areas of personal and social life, academic disciplines, and cultural and historical contexts and formations.The Encyclopedia:examines every area of men's personal and social lives as shaped by gendercovers masculinity politics, the men's groups and movements that have tried to change men's rolespresents entries on working with particular groups of boys or men, from male patients to men in prisonincorporates cross-disciplinary perspectives on and examinations of men, gender and gender relationsgives comprehensive coverage of diverse cultural and historical formations of masculinity and the bodies of scholarship that have documented them.The Encyclopedia of Men and Masculinities is composed of over 350 free-standing entries written from their individual perspectives by eminent scholars in their fields. Entries are organized alphabetically for general ease of access but also listed thematically at the front of the encyclopedia, for the convenience of readers with specific areas of interest.
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| 32. |
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| 33. |
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| 34. |
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| 35. |
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| 36. |
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| 37. |
- Karlsson-Tuula, Marie, 1961-
(author)
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Rekonstruktion av företag inom insolvenslagstiftningens ramar : en jämförande studie av svensk och amerikansk insolvensrätt
- 2001
-
Doctoral thesis (other academic/artistic)abstract
- Insolvency law is the rooth of commercial and financial law because it obliges the legislator to chose. There is not enough money to go round so the law must chose who to pay. The law must always decide who is to bear the risk so there is always a winner and a loser. The insolvency law has been at the policy agenda in many countries in the last years. In France, Germany, Italy, Japan and other countries have the legal frameworks changed from liquidation procedures to reorganization business. The legal situation in Sweden has also changed from compositions to reorganization business, lagen om företagsrekonstruktion. The key issues are to encourage the formal proceeding by enlarging the debtors control of the business and by inroads creditors rights, in which case the proceeding is pro-debtor.This dissertation compares Swedish and American Bankruptcy Codes with respect to similarities and differences at macro- and micro perspectives. Chapter 11 Reorganization Business in America provides a corporate rehabilitation model, which has been used in other countries. The dissertation also compares the use of the concepts of - the purpose, - the function and - the direction of Swedish and American Bankruptcy Laws in order to establish whether the law is pro-debtor or pro-creditor. The key indicators of whether the rescue proceeding is pro-debtor or pro-creditor include; - How easy it is to enter the rescue proceeding. Debtor's incentives to commence proceeding, freeze on executions and liquidation petitions, impact on security, impact on title of finance, impact on set-off and netting, impact on contract rescissions and lease forfeitures. Disclaimer and abandonment, ability to replace the management, financing of the rescue, scope of the rehabilitation plan. It is argued that the optimal bankruptcy law can be achieved if the law purpose, the function and the law direction relate to each other in Sweden, in both reorganization business and in the liquidation code and it also compared with the American Bankruptcy Code. According to my opinion this is important both in a national and international context.The dissertation also deals with debtor's contract in an insolvency situation in reorganization business and in liquidation. Swedish Laws are compared to the American Bankruptcy Code and point out similarities and differences. In the American Bankruptcy Code there is a special section 365 § BC dealing with executory contract, this section is nearly the same for both the reorganization- and liquidationproceedings. The contracts must be unperformed which means the obligation of both the bankrupt and the other party in the contract are so far unperformed that the failure of either to complete performance would constitute a material breach excusing the performance of the other. If the contract is unperformed the debtor has the possibility to chose if the contracts shall be assumed, assumed and assigned or rejected. Section 365 § BC requires the court to consider whether assumption of the contract in question will further be needed in either rehabilitation or liquidation of the bankruptcy estate. The court reviews the financial impact of the estate and if it is benefiting becoming administratively obligated to perform. The court also review if is best to breach the contract. In Sweden we have different sections which regulate the situation. One section in our reorganization law, lagen om företagsrekonstruktion, we also have two special sections in the law of Sale of Goods, which deals with contract when a debtor became insolvent or file for reorganization business. But we don't have any section in our liquidation law, konkurslagstiftningen, which in my opinion is very strange. We also have a problem with the legislation about swaps and netting which are regulated in a special law, lagen om handel med finansiella intrument. Particular attention is given to the advantages and disadvantages of the existing rules in Swedish legal system compared with 365 § in American Bankruptcy Code. From a national point of view such section should preferably include all types of contract in only one section which is nearly the same as the American model of section 365 §.
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| 38. |
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| 39. |
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| 40. |
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| 41. |
- Lok, Veeleah, et al.
(author)
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Changes in anxiety and depression during the COVID-19 pandemic in the European population : A meta-analysis of changes and associations with restriction policies
- 2023
-
In: European psychiatry. - 0924-9338 .- 1778-3585. ; 66:1
-
Research review (peer-reviewed)abstract
- Background. Early studies of common mental disorders (CMDs) during the COVID-19 pandemic mainly report increases; however, more recent findings have been mixed. Also, studies assessing the effects of restriction measures on CMDs show varied results. The aim of this meta-analysis was to assess changes in levels of CMDs from pre-/early to during the pandemic and the effects of restriction policies in the European population.Methods. We searched for studies assessing both pre-pandemic and peri-pandemic self-reported emotional distress and symptoms of depression or anxiety among nationally/regionally representative samples in Europe and collected microdata from those studies. Estimates of corona containment index were related to changes in CMDs using random-effects meta-regression.Results. Our search strategy resulted in findings from 15 datasets drawn from 8 European countries being included in the meta-analysis. There was no evidence of change in the prevalence of emotional distress, anxiety, or depression from before to during the pandemic; but from early pandemic periods to later periods, there were significant decreases in emotional distress and anxiety. Increased school restrictions and social distancing were associated with small increases in self-reported emotional distress.Conclusions. Despite initial concerns of increased emotional distress and mental illness due to the COVID-19 pandemic, the results from this meta-analysis indicate that there was a decrease in emotional distress and no change in anxiety or depression in the general population in Europe. Overall, our findings support the importance of strong governance when implementing periodic and robust restriction measures to combat the spread of COVID-19.
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| 42. |
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| 43. |
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| 44. |
- Moghadasi, Ramin, et al.
(author)
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Pore-scale characterization of residual gas remobilization in CO2 geological storage
- 2023
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In: Advances in Water Resources. - : Elsevier. - 0309-1708 .- 1872-9657. ; 179
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Journal article (peer-reviewed)abstract
- A decrease in reservoir pressure can lead to remobilization of residually trapped CO2. In this study, the pore-scale processes related to trapped CO2 remobilization under pressure depletion were investigated with the use of highresolution 3D X-ray microtomography. The distribution of CO2 in the pore space of Bentheimer sandstone was measured after waterflooding at a fluid pressure of 10 MPa, and then at pressures of 8, 6 and 5 MPa. At each stage CO2 was produced, implying that swelling of the gas phase and exsolution allowed the gas to reconnect and flow. After production, the gas reached a new position of equilibrium where it may be trapped again. At the end of the experiment, we imaged the sample again after 30 hours. Firstly, the results showed that an increase in saturation beyond the residual value was required to remobilize the gas, which is consistent with earlier field-scale results. Additionally, Ostwald ripening and continuing exsolution lead to a significant change in fluid saturation: transport of dissolved gas in the aqueous phase to equilibriate capillary pressure led to reconnection of the gas and its flow upwards under gravity. The implications for CO2 storage are discussed: an increase in saturation beyond the residual value is required to mobilize the gas, but Ostwald ripening can allow local reconnection of hitherto trapped gas, thus enhancing migration and may reduce the amount of CO2 that can be capillary trapped in storage operations.
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| 46. |
- Nakanishi, Tomoko, et al.
(author)
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Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
- 2021
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In: Journal of Clinical Investigation. - : American Society For Clinical Investigation. - 0021-9738 .- 1558-8238. ; 131:23
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Journal article (peer-reviewed)abstract
- BACKGROUND. There is considerable variability in COVID-19 outcomes among younger adults, and some of this variation may be due to genetic predisposition. METHODS. We combined individual level data from 13,888 COVID-19 patients (n = 7185 hospitalized) from 17 cohorts in 9 countries to assess the association of the major common COVID-19 genetic risk factor (chromosome 3 locus tagged by rs10490770) with mortality, COVID-19-related complications, and laboratory values. We next performed metaanalyses using FinnGen and the Columbia University COVID-19 Biobank. RESULTS. We found that rs10490770 risk allele carriers experienced an increased risk of all-cause mortality (HR, 1.4; 95% CI, 1.2-1.7). Risk allele carriers had increased odds of several COVID-19 complications: severe respiratory failure (OR, 2.1; 95% CI, 1.6-2.6), venous thromboembolism (OR, 1.7; 95% CI, 1.2-2.4), and hepatic injury (OR, 1.5; 95% CI, 1.2-2.0). Risk allele carriers age 60 years and younger had higher odds of death or severe respiratory failure (OR, 2.7; 95% CI, 1.8-3.9) compared with those of more than 60 years (OR, 1.5; 95% CI, 1.2-1.8; interaction, P = 0.038). Among individuals 60 years and younger who died or experienced severe respiratory failure, 32.3% were risk-variant carriers compared with 13.9% of those not experiencing these outcomes. This risk variant improved the prediction of death or severe respiratory failure similarly to, or better than, most established clinical risk factors. CONCLUSIONS. The major common COVID-19 genetic risk factor is associated with increased risks of morbidity and mortality, which are more pronounced among individuals 60 years or younger. The effect was similar in magnitude and more common than most established clinical risk factors, suggesting potential implications for future clinical risk management.
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| 47. |
- Nakanishi, T, et al.
(author)
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Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality
- 2021
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In: medRxiv : the preprint server for health sciences. - : Cold Spring Harbor Laboratory.
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Journal article (other academic/artistic)abstract
- BackgroundThere is considerable variability in COVID-19 outcomes amongst younger adults—and some of this variation may be due to genetic predisposition. We characterized the clinical implications of the major genetic risk factor for COVID-19 severity, and its age-dependent effect, using individual-level data in a large international multi-centre consortium.MethodThe major common COVID-19 genetic risk factor is a chromosome 3 locus, tagged by the marker rs10490770. We combined individual level data for 13,424 COVID-19 positive patients (N=6,689 hospitalized) from 17 cohorts in nine countries to assess the association of this genetic marker with mortality, COVID-19-related complications and laboratory values. We next examined if the magnitude of these associations varied by age and were independent from known clinical COVID-19 risk factors.FindingsWe found that rs10490770 risk allele carriers experienced an increased risk of all-cause mortality (hazard ratio [HR] 1·4, 95% confidence interval [CI] 1·2–1·6) and COVID-19 related mortality (HR 1·5, 95%CI 1·3–1·8). Risk allele carriers had increased odds of several COVID-19 complications: severe respiratory failure (odds ratio [OR] 2·0, 95%CI 1·6-2·6), venous thromboembolism (OR 1·7, 95%CI 1·2-2·4), and hepatic injury (OR 1·6, 95%CI 1·2-2·0). Risk allele carriers ≤ 60 years had higher odds of death or severe respiratory failure (OR 2·6, 95%CI 1·8-3·9) compared to those > 60 years OR 1·5 (95%CI 1·3-1·9, interaction p-value=0·04). Amongst individuals ≤ 60 years who died or experienced severe respiratory COVID-19 outcome, we found that 31·8% (95%CI 27·6-36·2) were risk variant carriers, compared to 13·9% (95%CI 12·6-15·2%) of those not experiencing these outcomes. Prediction of death or severe respiratory failure among those ≤ 60 years improved when including the risk allele (AUC 0·82 vs 0·84, p=0·016) and the prediction ability of rs10490770 risk allele was similar to, or better than, most established clinical risk factors.InterpretationThe major common COVID-19 risk locus on chromosome 3 is associated with increased risks of morbidity and mortality—and these are more pronounced amongst individuals ≤ 60 years. The effect on COVID-19 severity was similar to, or larger than most established risk factors, suggesting potential implications for clinical risk management.FundingFunding was obtained by each of the participating cohorts individually.
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| 48. |
- Niemi, Auli, et al.
(author)
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Chapter 7: Site Characterization
- 2017
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In: Geological Storage Of Co<sub>2</sub> in Deep Saline Formations. - Dordrecht : Springer Netherlands. - 9789402409949 - 9789402409963 ; , s. 309-380
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Book chapter (peer-reviewed)abstract
- A necessary first step in qualifying a specific site for CO2 storage and for quantifying its relevant properties is a proper site characterization. Site characterization provides the ultimate input data for reservoir modeling and for all the predictions concerning the storage complex and its surroundings. It also provides baseline information for monitoring the behavior of injected CO2. It also incorporates input from laboratory experiments described in Chap.6. This chapter gives an overview of site characterization procedures with respect to geological storage of CO2, by starting from regulatory requirements and guidelines and proceeding to specific methodologies for assessing the sites properties in terms of CO2 geological storage.
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| 49. |
- Niemi, Auli, et al.
(author)
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Characterizing CO2 residual trapping in-situ by means of single-well push-pull experiments at Heletz, Israel, pilot injection site : experimental procedures and results of the experiments
- 2020
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In: International Journal of Greenhouse Gas Control. - : Elsevier BV. - 1750-5836 .- 1878-0148. ; 101
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Journal article (peer-reviewed)abstract
- Two dedicated field experiments have been carried out at the Heletz, Israel pilot CO2 injection site. The objective has been to quantify the CO2 residual trapping in-situ, based on two distinctly different methods. Both experiments are based on the principle of a combination of hydraulic, thermal and/or tracer tests before and after creating the residually trapped zone of CO2 and using the difference in the responses of these tests to estimate the in-situ residual trapping. In Residual Trapping Experiment I (RTE I), carried out in autumn 2016, the main characterization test before and after the creation of the residually trapped zone were hydraulic withdrawal tests. In this experiment, the residually trapped zone was also created by fluid withdrawal, by first injecting CO2, then withdrawing fluids until CO2 was at residual saturation. The second experiment, Residual Trapping Experiment II (RTE II), was carried out autumn 2017. In this experiment, the residually trapped CO2 zone was created by CO2 injection, followed by the injection of CO2-saturated water, to push away the mobile CO2 and leave the residually trapped CO2 behind. In this test, the main reference test carried out before and after creating the residually trapped zone was injection and recovery of gas partitioning tracer Krypton. This paper presents the experimental procedures and results of these experiments. A hydraulic withdrawal test as a characterization method was robust and gave a clear signal. Given the difficulties in injecting water optimally saturated with CO2, in order not to dissolve the residually trapped CO2 or to create situations with excess mobile gas, withdrawal test may also be a generally preferable hydraulic testing method, in comparison to injection. The limitation of any hydraulic test is that it only gives an averaged value over the test section. At Heletz additional information about CO2 distribution was obtained based on thermal measurements and by monitoring the pressure difference between the two sensors in the bolehole. The latter could be used to estimate the amount of mobile CO2 in the well test section. Tracer experiments with gas partitioning tracers can in principle give more detailed information of CO2 residual distribution in the reservoir than hydraulic tests can, but are also far more complicated to carry out, involving sophisticated and sensitive equipment. In the Heletz case the optimal injection of CO2-saturated water turned out to be difficult to achieve. Creating the zone of residual saturation by means of fluid withdrawal rather than by injecting CO2-saturated water seemed a more robust approach. Monitoring the gas contents in the test interval gave good guidance on the state of the system. Model interpretations of the two experiments to obtain values for CO2 residual saturation are presented in companion papers in this same Special Edition.
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