| 1. |
- Chertkow, H., et al.
(author)
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An Action Plan to Face the Challenge of Dementia : INTERNATIONAL STATEMENT ON DEMENTIA from IAP for Health
- 2018
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In: The Journal of Prevention of Alzheimer's Disease. - : EDITIONS SERDI. - 2274-5807 .- 2426-0266. ; 5:3, s. 207-212
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Journal article (peer-reviewed)abstract
- An international committee set up through the IAP for Health met to develop an action plan for dementia. Comprehensive international and national initiatives should move forward with calls for action that include increased public awareness regarding brain health and dementia, support for a broad range of dementia research objectives, and investment in national health care systems to ensure timely competent person-centred care for individuals with dementia. The elements of such action plans should include: 1) Development of national plans including assessment of relevant lifecourse risk and protective factors; 2) Increased investments in national research programs on dementia with approximately 1% of the national annual cost of the disease invested; 3) Allocating funds to support a broad range of biomedical, clinical, and health service and systems research; 4) Institution of risk reduction strategies; 5) Building the required trained workforce (health care workers, teachers, and others) to deal with the dementia crisis; 6) Ensuring that it is possible to live well with dementia; and 7) Ensuring that all have access to prevention programs, care, and supportive living environments.
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| 2. |
- Davoudkhani, Mohsen, et al.
(author)
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The Validity and Reliability of a Persian Version of the Brief Community Screening Instrument for Dementia in the Elderly Patients with Dementia in Iran
- 2019
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In: Archives of neuroscience. - Tehran, Iran : Kowsar Corporation. - 2322-3944 .- 2322-5769. ; 6:3
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Journal article (peer-reviewed)abstract
- Background: The brief version of community screening instrument for dementia (CSI-D) is a neuropsychological tool, which can be used even by non-specialists in primary care settings following a short training. The CSI-D evaluates the cognitive and functional domains of the subjects and includes an informant interview. However, it should be adapted based on literacy level and sociocultural profile of population in each country.Objectives: The current study examined the validity and reliability of the Persian version of the brief CSI-D in elderly patients of Iran.Methods: The current descriptive, cross sectional study was conducted on people 60 and over from 16 provinces of Iran with seven different ethnicities and various levels of education (0 - 13 to >= 13 years). The participants consisted of subjects with normal cognition, subjective cognitive impairment (SCI), mild cognitive impairment (MCI), and different types of dementia. Cognitive impairment was diagnosed by a neurologist with expertise in dementia. The psychometric properties were assessed by comparing Persian version of brief CSI-D with the gold standard. Area under ROC curve, optimal cutoff point, and sensitivity and specificity were also calculated.Results: Data were collected from 262 participants. Of all the participants, 112 were diagnosed with dementia, 64 with MCI, 32 with SCI, and 53 with normal cognition. The best cutoff point for the test-regardless of gender and level of education-was 8.5 compared with 8 - 9 in the original version of CSI-D and also the cutoff point for patient with dementia was 5.5, while it was 4 in the original version.Conclusions: The Persian version of CSI-D seems to be an accurate and sensitive tool to screen dementia and MCI in primary care setting, especially among low-educated and illiterate people.
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| 3. |
- Noroozian, Maryam, et al.
(author)
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Hippocampal and motor regions contribute to memory benefits after enacted encoding : cross-sectional and longitudinal evidence
- 2023
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In: Cerebral Cortex. - : Oxford University Press. - 1047-3211 .- 1460-2199. ; 33:6, s. 3080-3097
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Journal article (peer-reviewed)abstract
- The neurobiological underpinnings of action-related episodic memory and how enactment contributes to efficient memory encoding are not well understood. We examine whether individual differences in level (n = 338) and 5-year change (n = 248) in the ability to benefit from motor involvement during memory encoding are related to gray matter (GM) volume, white matter (WM) integrity, and dopamine-regulating genes in a population-based cohort (age range = 25-80 years). A latent profile analysis identified 2 groups with similar performance on verbal encoding but with marked differences in the ability to benefit from motor involvement during memory encoding. Impaired ability to benefit from enactment was paired with smaller HC, parahippocampal, and putamen volume along with lower WM microstructure in the fornix. Individuals with reduced ability to benefit from encoding enactment over 5 years were characterized by reduced HC and motor cortex GM volume along with reduced WM microstructure in several WM tracts. Moreover, the proportion of catechol-O-methyltransferase-Val-carriers differed significantly between classes identified from the latent-profile analysis. These results provide converging evidence that individuals with low or declining ability to benefit from motor involvement during memory encoding are characterized by low and reduced GM volume in regions critical for memory and motor functions along with altered WM microstructure.
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