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1.	Goel, HL, et al. (author) GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation 2013 In: EMBO molecular medicine. - : EMBO. - 1757-4684 .- 1757-4676. ; 5:4, s. 488-508 Journal article (peer-reviewed)
2.	Oksvold, MP, et al. (author) Karonudib has potent anti-tumor effects in preclinical models of B-cell lymphoma 2021 In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 11:1, s. 6317- Journal article (peer-reviewed)abstract Chemo-immunotherapy has improved survival in B-cell lymphoma patients, but refractory/relapsed diseases still represent a major challenge, urging for development of new therapeutics. Karonudib (TH1579) was developed to inhibit MTH1, an enzyme preventing oxidized dNTP-incorporation in DNA. MTH1 is highly upregulated in tumor biopsies from patients with diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma, hence confirming a rationale for targeting MTH1. Here, we tested the efficacy of karonudib in vitro and in preclinical B-cell lymphoma models. Using a range of B-cell lymphoma cell lines, karonudib strongly reduced viability at concentrations well tolerated by activated normal B cells. In B-cell lymphoma cells, karonudib increased incorporation of 8-oxo-dGTP into DNA, and prominently induced prometaphase arrest and apoptosis due to failure in spindle assembly. MTH1 knockout cell lines were less sensitive to karonudib-induced apoptosis, but were displaying cell cycle arrest phenotype similar to the wild type cells, indicating a dual inhibitory role of the drug. Karonudib was highly potent as single agent in two different lymphoma xenograft models, including an ABC DLBCL patient derived xenograft, leading to prolonged survival and fully controlled tumor growth. Together, our preclinical findings provide a rationale for further clinical testing of karonudib in B-cell lymphoma.
3.	Fougner, C, et al. (author) Claudin-low-like mouse mammary tumors show distinct transcriptomic patterns uncoupled from genomic drivers 2019 In: Breast cancer research : BCR. - : Springer Science and Business Media LLC. - 1465-542X. ; 21:1, s. 85- Journal article (peer-reviewed)
4.	Goel, HL, et al. (author) Regulated splicing of the α6 integrin cytoplasmic domain determines the fate of breast cancer stem cells 2014 In: Cell reports. - : Elsevier BV. - 2211-1247. ; 7:3, s. 747-761 Journal article (peer-reviewed)
5.	Linderholm, BK, et al. (author) VEGF and downstream mitogen activated protein kinases (MAPK's) signalling is invoved in resistance to tamoxifen in breast cancer cell lines. 2006 In: BREAST CANCER RESEARCH AND TREATMENT. - 0167-6806. ; 100, s. S193-S193 Conference paper (other academic/artistic)
6.	Norum, JH, et al. (author) A conditional transgenic mouse line for targeted expression of the stem cell marker LGR5 2015 In: Developmental biology. - : Elsevier BV. - 1095-564X .- 0012-1606. ; 404:2, s. 35-48 Journal article (peer-reviewed)
7.	Norum, JH, et al. (author) GLI1-induced mammary gland tumours are transplantable and maintain major molecular features 2020 In: International journal of cancer. - : Wiley. - 1097-0215 .- 0020-7136. ; 146:4, s. 1125-1138 Journal article (peer-reviewed)
8.	Norum, JH, et al. (author) Long-term GLI1 expression induces mammary gland tumour formation in nulliparous transgenic mice 2010 In: EJC SUPPLEMENTS. - 1359-6349. ; 8:5, s. 219-219 Conference paper (other academic/artistic)
9.	Norum, JH, et al. (author) Mammary Gland Tumour Formation in Conditional Transgenic Mice Expressing GLI1 2011 In: EUROPEAN JOURNAL OF CANCER. - 0959-8049. ; 47, s. S99-S100 Conference paper (other academic/artistic)
10.	Norum, JH, et al. (author) The effect of a tankyrase inhibitor on the small intestine tissue homeostasis 2014 In: CANCER RESEARCH. - 0008-5472. ; 74:19 Conference paper (other academic/artistic)
11.	Norum, JH, et al. (author) The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology 2018 In: Biological research. - : Springer Science and Business Media LLC. - 0717-6287. ; 51:1, s. 3- Journal article (peer-reviewed)
12.	Norum, JH, et al. (author) The tankyrase inhibitor G007-LK inhibits small intestine Lgr5+stem cell proliferation without altering tissue morphology 2016 In: CANCER RESEARCH. - 0008-5472. ; 76 Conference paper (other academic/artistic)
13.	Roswell, P, et al. (author) Signaling by PDGF-CC in the maintenance of a protumorigenic breast cancer microenvironment 2013 In: CANCER RESEARCH. - 0008-5472. ; 73 Conference paper (other academic/artistic)

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Result 1-13 of 13

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Type of publication: journal article (7); conference paper (6)

Type of content: peer-reviewed (7); other academic/artistic (6)

Author/Editor: Norum, JH (13); Toftgard, R (7); Sorlie, T. (6); Kuiper, R (5); Kasper, M (3); Skarpen, E (3); show more...; Brech, A (3); Chang, C (2); Bergstrom, A (2); Jaks, V (2); Bergholtz, H. (2); Goel, HL (2); Pursell, B (2); Shultz, LD (2); Greiner, DL (2); Mercurio, AM (2); Shaw, LM (2); Li, H. (1); Eriksson, U (1); Kumar, P. (1); Andersson, A (1); Aesoy, R. (1); Viktorsson, K. (1); Helleday, T (1); Petersson, A. (1); Linderholm, BK (1); Pietras, K (1); Haller, K (1); Anderberg, C. (1); Andersson, AB (1); Sanjiv, K (1); Frings, O (1); Bai, BY (1); Smeland, EB (1); Myklebust, JH (1); Pham, T (1); Gad, H (1); Berglund, UW (1); Fredlund, E (1); Stokke, T (1); Mao, JH (1); Chavez Sanchez, B (1); Fougner, C (1); Kuiper, RV (1); Simin, K (1); Vander Kooi, CW (1); Kuperwasser, C (1); Gritsko, T (1); Oy, GF (1); Hoelzl, MA (1); show less...

University: Karolinska Institutet (13)

Language: English (13)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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