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- Jonsson, Stefan, et al.
(author)
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Identification of sequence variants influencing immunoglobulin levels
- 2017
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 49:8, s. 1182-1191
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Journal article (peer-reviewed)abstract
- Immunoglobulins are the effector molecules of the adaptive humoral immune system. In a genome-wide association study of 19,219 individuals, we found 38 new variants and replicated 5 known variants associating with IgA, IgG or IgM levels or with composite immunoglobulin traits, accounted for by 32 loci. Variants at these loci also affect the risk of autoimmune diseases and blood malignancies and influence blood cell development. Notable associations include a rare variant at RUNX3 decreasing IgA levels by shifting isoform proportions (rs188468174[C>T]: P = 8.3 × 10(-55), β = -0.90 s.d.), a rare in-frame deletion in FCGR2B abolishing IgG binding to the encoded receptor (p.Asn106del: P = 4.2 × 10(-8), β = 1.03 s.d.), four IGH locus variants influencing class switching, and ten new associations with the HLA region. Our results provide new insight into the regulation of humoral immunity.
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3. |
- Jorgensen, Palle, et al.
(author)
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Operator algebras and representation theory : frames, wavelets and fractals
- 2011
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In: Oberwolfach Reports. - 1660-8933 .- 1660-8941. ; 8:1, s. 901-978
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Journal article (peer-reviewed)abstract
- Operator Algebras and Representation Theory: Frames, Wavelets and Fractals Organized by: Palle E.T. Jorgensen (1), Gitta Kutyniok (2), Gestur Olafsson (3) and Sergei Silvestrov (4) (1) Department of Mathematics, University of Iowa, IA 52242-1466, IOWA CITY, UNITED STATES(2) Fachbereich Mathematik / Informatik, Universität Osnabrück, Albrechtstr. 28a, 49069, OSNABRÜCK, GERMANY(3) Department of Mathematics, Louisiana State University, LA 70803-4918, BATON ROUGE, UNITED STATES(4) Centre for Mathematical Sciences, Lund University, P.O. Box 118, 22100, LUND, SWEDEN The central focus of the workshop was Kadison-Singer conjecture and its connection to operator algebras, harmonic analysis, representation theory and the theory of fractals. The program was intrinsically interdisciplinary and represented areas with much recent progress. The workshop includes talks on operator theory, wavelets, shearlets, frames, fractals, representations theory and compressed sensing.
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