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| 5. |
- Eriksson, Ulf G, et al.
(author)
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Pharmacokinetics of melagatran and the effect on ex vivo coagulation time in orthopaedic surgery patients receiving subcutaneous melagatran and oral ximelagatran : a population model analysis
- 2003
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In: Clinical Pharmacokinetics. - 0312-5963 .- 1179-1926. ; 42:7, s. 687-701
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Research review (peer-reviewed)abstract
- OBJECTIVE: Ximelagatran, an oral direct thrombin inhibitor, is rapidly bioconverted to melagatran, its active form. The objective of this population analysis was to characterise the pharmacokinetics of melagatran and its effect on activated partial thromboplastin time (APTT), an ex vivo measure of coagulation time, in orthopaedic surgery patients sequentially receiving subcutaneous melagatran and oral ximelagatran as prophylaxis for venous thromboembolism. To support the design of a pivotal dose-finding study, the impact of individualised dosage based on bodyweight and calculated creatinine clearance was examined. DESIGN AND METHODS: Pooled data obtained in three small dose-guiding studies were analysed. The patients received twice-daily administration, with either subcutaneous melagatran alone or a sequential regimen of subcutaneous melagatran followed by oral ximelagatran, for 8-11 days starting just before initiation of surgery. Nonlinear mixed-effects modelling was used to evaluate rich data of melagatran pharmacokinetics (3326 observations) and the pharmacodynamic effect on APTT (2319 observations) in samples from 216 patients collected in the three dose-guiding trials. The pharmacokinetic and pharmacodynamic models were validated using sparse data collected in a subgroup of 319 patients enrolled in the pivotal dose-finding trial. The impact of individualised dosage on pharmacokinetic and pharmacodynamic variability was evaluated by simulations of the pharmacokinetic-pharmacodynamic model. RESULTS: The pharmacokinetics of melagatran were well described by a one-compartment model with first-order absorption after both subcutaneous melagatran and oral ximelagatran. Melagatran clearance was correlated with renal function, assessed as calculated creatinine clearance. The median population clearance (creatinine clearance 70 mL/min) was 5.3 and 22.9 L/h for the subcutaneous and oral formulations, respectively. The bioavailability of melagatran after oral ximelagatran relative to subcutaneous melagatran was 23%. The volume of distribution was influenced by bodyweight. For a patient with a bodyweight of 75kg, the median population estimates were 15.5 and 159L for the subcutaneous and oral formulations, respectively. The relationship between APTT and melagatran plasma concentration was well described by a power function, with a steeper slope during and early after surgery but no influence by any covariates. Simulations demonstrated that individualised dosage based on creatinine clearance or bodyweight had no clinically relevant impact on the variability in melagatran pharmacokinetics or on the effect on APTT. CONCLUSIONS: The relatively low impact of individualised dosage on the pharmacokinetic and pharmacodynamic variability of melagatran supported the use of a fixed-dose regimen in the studied population of orthopaedic surgery patients, including those with mild to moderate renal impairment.
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| 6. |
- Flys, Olena, 1971-, et al.
(author)
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Piston ring topography variation and robust characterization
- 2014
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Conference paper (peer-reviewed)abstract
- It is a constant challenge for the automotive industry to reduce friction losses and oil consumption in automobile engine. The piston ring friction accounts for approximately 20% of the total mechanical energy losses in a modern engine. Oil control rings limit and control the oil consumption of the engine as well. They scrape off excess lubricating oil from the cylinder walls and return it to the crank case. Piston rings are designed to distribute the thin oil film evenly to ensure piston and ring lubrication. The surface topography of a piston ring is an efficient variable in the control of the oil consumption and friction losses. In places where the interacting surfaces come in contact, the oil film thickness is extremely thin and the surface asperities may deform because of the high pressures. There are different types of oil control rings.The most common one is the twin land oil control ring, which consists of two narrow lands that scrape off the oil on the liner and a spring on the back that exerts the load. In this paper, the surfaces of the two lands were investigated, since they play the key role in its function. The goal is to map the variation in surface roughness of piston rings that appear at different scales from form and waviness to micro and nano roughness. Areal topography measurements were made by white light interferometer designed at the Halmstad University able to measure and scan the total functional area of a piston ring. An significant amount of oil control piston rings of heavy duty truck engines were examined and 24 measurements were made in circumferential direction and on each ring land. The results show both the variation and uncertainty of the ring topography and discuss the instrument and measuring methodology uncertainty. The most stable parameters were found and recommended for an effective quality control. Comparisons between established coherence scanning interferometer and the instrument built in Halmstad were made. To ensure a good quality, the measurements were made both on calibration standards and on piston ring surfaces. Finally the influence on function and energy losses in the final engine assembly is discussed to indicate future design and metrology improvements.
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| 7. |
- Graham, Jinko, et al.
(author)
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Negative association between type 1 diabetes and HLA DQB1*0602-DQA1*0102 is attenuated with age at onset
- 1999
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In: European Journal of Immunogenetics. - : Wiley. - 0960-7420 .- 1365-2370. ; 26, s. 117-
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Journal article (peer-reviewed)abstract
- HLA-associated relative risks of type 1 (insulin-dependent) diabetes mellitus were analysed in population-based Swedish patients and controls aged 0-34 years. The age dependence of HLA-associated relative risks was assessed by likelihood ratio tests of regression parameters in separate logistic regression models for each HLA category. The analyses demonstrated an attenuation with increasing age at onset in the relative risk for the positively associated DQB1*0201-A1*0502/B1*0302-A1*0301 (DQ2/8) genotype (P = 0.02) and the negatively associated DQB1*0602-A1*0102 (DQ6.2) haplotype (P = 0.004). At birth, DQ6.2-positive individuals had an estimated relative risk of 0.03, but this increased to 1.1 at age 35 years. Relative risks for individuals with DQ genotype 8/8 or 8/X or DQ genotype 2/2 or 2/X, where X is any DQ haplotype ether than 2, 8 or 6.2, were not significantly age-dependent. An exploratory analysis of DQ haplotypes other than 2, 8 and 6.2 suggested that the risk of type 1 diabetes increases with age for DQB1*0604-A1*0102 (DQ6.4) and that the peak risk for the negatively associated DQB1*0301-A1*0501 haplotype is at age 18 years. There was also weak evidence that the risk for DQB1*0303-A1*0301 (DQ9), which has a positive association in the Japanese population, may decrease with age. We speculate that HLA-DQ alleles have a significant effect on the rate of beta cell destruction, which is accelerated in DQ2/8-positive individuals and inhibited, but not completely blocked, in DQ6.2-positive individuals.
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| 11. |
- Hansson, Karna, et al.
(author)
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Carbon and nitrogen pools and fluxes above and below ground in spruce, pine and birch stands in southern Sweden
- 2013
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In: Forest Ecology and Management. - : Elsevier BV. - 0378-1127 .- 1872-7042. ; 309, s. 28-35
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Journal article (peer-reviewed)abstract
- We synthesised results on soil carbon (C) and nitrogen (N) fluxes and the accumulation of soil organic C and N under adjacent 50-year-old Norway spruce, Scots pine and silver birch stands growing on similar soils and evaluated the different processes involved. C and N budgets were calculated. Spruce stands had larger stocks of C and N in biomass and soil than birch stands, with pine intermediate. The differences in soil stocks were mainly found in the organic layer, whereas differences in the mineral soil were small. The study showed that there is no simple answer to what is causing the differences in soil C and N stocks, because several processes are interacting. Spruce and pine trees had higher biomass and litter production than birch trees, but total litter inputs showed no significant difference between stands, because the rich ground vegetation under pine and birch contributed with substantial litter inputs, in contrast to the poor ground vegetation under spruce. Decomposition rate (per g of C) was markedly higher under birch than under spruce and pine resulting in lower C and N stocks in the organic layer. This effect was amplified by higher abundance and biomass of earthworms, favoured by higher pH and palatable litter under birch. Earthworm bioturbation probably both increased decomposition rate and damaged the ectomycorrhizal network with negative consequences for the formation of mycorrhizal litter and C storage. In conclusion, the direct effects of spruce, pine and birch litter on C and N pools and fluxes were modified by indirect effects of understorey structure, pH and earthworm responses. (C) 2013 Elsevier B.V. All rights reserved.
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| 12. |
- Hansson, Karna, et al.
(author)
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Differences in soil properties in adjacent stands of Scots pine, Norway spruce and silver birch in SW Sweden
- 2011
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In: Forest Ecology and Management. - : Elsevier BV. - 0378-1127 .- 1872-7042. ; 262, s. 522-530
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Journal article (peer-reviewed)abstract
- Soil properties were compared in adjacent 50-year-old Norway spruce, Scots pine and silver birch stands 26 growing on similar soils in south-west Sweden. The effects of tree species were most apparent in the 27 humus layer and decreased with soil depth. At 20–30 cm depth in the mineral soil, species differences 28 in soil properties were small and mostly not significant. Soil C, N, K, Ca, Mg, and Na content, pH, base sat- 29 uration and fine root biomass all significantly differed between humus layers of different species. Since 30 the climate, parent material, land use history and soil type were similar, the differences can be ascribed to 31 tree species. Spruce stands had the largest amounts of carbon stored down to 30 cm depth in mineral soil 32 (7.3 kg C m??2), whereas birch stands, with the lowest production, smallest amount of litterfall and lowest 33 C:N ratio in litter and humus, had the smallest carbon pool (4.1 kg C m??2), with pine intermediate 34 (4.9 kg C m??2). Similarly, soil nitrogen pools amounted to 349, 269, and 240 g N m??2 for spruce, pine, 35 and birch stands, respectively. The humus layer in birch stands was thin and mixed with mineral soil, 36 and soil pH was highest in the birch stands. Spruce had the thickest humus layer with the lowest pH
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| 13. |
- Köping Olsson, Bengt, 1963-
(author)
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Beskrivningsspråk i och för kreativ praxis : Idéutveckling under gruppsession
- 2008
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Doctoral thesis (other academic/artistic)abstract
- Generating and developing ideas constitute centerpieces for innovations processes, idea creation methods and techniques most urgent in their initial phases processes, though the need is no less in subsequent phases. Those early phases, however, allow for more deviant ideas, characterized by more of ambiguity and uncertainty. This is an innovation process theme that is recognized as among those least understood.Through comparative studies of seven groups from three different practices, their interactions in idea development and problem solving, a deeper understanding of descriptive languages and modus operandi has been acquired. The research was carried out in three settings: brainstorming in industrial design, musical improvisation and dialogue seminars with participants representing industrial design and music, respectively. The compilation of the three practices’ contributions results in a conceptual framework. It includes such concepts as, for example, ‘momentary formation’, ‘temporary epistemology’ and ‘the play with semantic key signature’. Those concepts give examples of the reconsidering of creative group processes, relative to previous frameworks, that is a result of these studies. From the perspective of group idea, individuals’ creative processes might be perceived as the searching for the different or the deviant while we suggest that group creativity is enhanced throughits members’ abilities to preserve their own perspectives and thought styles. Group creativity is based on a willingness to focus on the central group idea while simultaneously maintaining individual thought styles.A creative group’s way of forming and mediating ideas, its modus operandi, is referred to as its description language. The importance of descriptive languages driving mechanism for creative group processes should be seen in the perspective of fundamental social cognition processes.The problem area is mapped through the strategic use of different descriptive modus. Groups employ iteration as a strategy for stimulating collective reflection, that is, to think about the problem again but in other ways. We argue that critical thinking and the ability to make critical judgements is an important driving force in the creative groups’ iterative processes: criticism makes reconsideration meaningful. Different types of criticism are discussed, as is how they interact with groups’ idea development and creative processes.This research project has resulted in a deeper understanding of the relay race of initiatives that characterizes the interactions in groups solving problems and developing ideas. The project has developed an awareness of which descriptions that stimulate group creativity.
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| 14. |
- Landin-Olsson, Mona, et al.
(author)
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Appearance of islet cell autoantibodies after clinical diagnosis of diabetes mellitus
- 1999
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In: Autoimmunity. - : Informa UK Limited. - 0891-6934 .- 1607-842X. ; 29:1, s. 57-63
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Journal article (peer-reviewed)abstract
- Islet cell antibodies (ICA) and glutamic acid decarboxylase antibodies (GAD65Ab) are often present at diagnosis of insulin dependent diabetes mellitus (type I diabetes) and are supposed to decline in level and frequency during the first years of disease. We have analysed ICA and GAD65Ab at onset and after one gear in 395 population based randomly selected 15-34 year old patients newly diagnosed with diabetes mellitus, to study how these autoantibodies persist, disappear and appear and their relation to C-peptide levels. Of the 395 samples 212 (54%) were positive for ICA, 250 (63%) were positive for GAD65Ab and 170 (43%) were positive for both. At follow up after one year, 27/183 (15%) of the ICA negative patients and 25/145 (17%) of the GAD65Ab negative patients had converted to positivity. Among the 103 patients negative for both ICA and GAD65Ab, 16 turned positive for one or both antibodies after one year. Patients converting to positivity for one or the other antibody after one year, had lower C-peptide levels after one year than patients who initially were and remained negative, supporting the hypothesis that these patients have a genuine type I diabetes. In conclusion, newly diagnosed patients may be negative for autoantibodies at diagnosis but develop these antibodies later on during the disease.
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| 15. |
- Littorin, Bengt, et al.
(author)
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Family characteristics and life events before the onset of autoimmune type 1 diabetes in young adults : A nationwide study
- 2001
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In: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 24:6, s. 1033-1037
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Journal article (peer-reviewed)abstract
- OBJECTIVE - To elucidate whether family characteristics and stressful life events were associated with onset of autoimmune type 1 diabetes in young adults. RESEARCH DESIGN AND METHODS - This investigation was based on a nationwide study (Diabetes Incidence Study in Sweden) of newly diagnosed patients aged 15-34 years. Patients clinically classified as type 1 diabetic with antibodies to islet cells and/or to GAD65 were compared with age- and sex-matched control subjects via questionnaire. The questionnaire covered diabetes heredity, social environment, educational level, and life events experienced during the 12 months before diagnosis. RESULTS - The rate of response was 82% for the diabetic patients and 65% for the control subjects. Questionnaires from 349 diabetic patients and 979 control subjects were considered. Diabetes in relatives was more frequent in the patients (odds ratio [OR] 2.6) who were born in Sweden and whose mothers were of Swedish origin. No major stress factors were detected in the diabetic patients, however, in comparison with the control subjects, the diabetic patients had experienced fewer conflicts with their parents and had less often broken contacts with friends. CONCLUSIONS - Young adults with recent-onset type 1 diabetes were more exposed to heredity for diabetes, but no major prediabetic stress factors were detected. Our study does not directly support the concept that psychosocial stressful life events are involved in the development of autoimmune type 1 diabetes in young adults.
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| 16. |
- Littorin, Bengt, et al.
(author)
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Islet cell and glutamic acid decarboxylase antibodies present at diagnosis of diabetes predict the need for insulin treatment : A cohort study in young adults whose disease was initially labeled as type 2 or unclassifiable diabetes
- 1999
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In: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 22:3, s. 409-412
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Journal article (peer-reviewed)abstract
- OBJECTIVE:To clarify the predictive value of islet cell antibody (ICA) and GAD65 antibody (GADA) present at diagnosis with respect to the need for insulin treatment 6 years after diagnosis in young adults initially considered to have type 2 or unclassifiable diabetes.RESEARCH DESIGN AND METHODS:The patient material was representative of the entire Swedish population, consisting of patients who were 15-34 years old at diagnosis of diabetes in 1987-1988 but were not considered to have type 1 diabetes at onset. At follow-up, 6 years after the diagnosis, it was noted whether the patient was treated with insulin. The presence of ICA was determined by an immunofluorescence assay, and GADAs were measured by a radioligand assay.RESULTS:Six years after diagnosis, 70 of 97 patients were treated with insulin, and 27 of 97 patients were treated with oral drugs or diet alone. At diagnosis, ICAs and GADAs were present in 41 (59%) of 70 patients and 41 (60%) of 68 patients, respectively, of those now treated with insulin, compared with only 1 (4%) of 26 patients and 2 (7%) of 27 patients who were still not treated with insulin. For either ICA or GADA, the corresponding frequencies were 50 (74%) of 68 for patients who were later treated with insulin and 3 (12%) of 26 for those who were still not treated with insulin, respectively. The sensitivity for later insulin treatment was highest (74%) for the presence of ICA or GADA, and the specificity was highest (100%) for ICA and GADA. The positive predictive value was 100% for the combination of ICA and GADA, 98% for ICA alone, and approximately 95% for GADA alone.CONCLUSIONS:Determination of the presence of ICA and GADA at diagnosis of diabetes improves the classification of diabetes and predicts the future need of insulin in young adults.
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| 19. |
- Olsson, Emma, 1974-
(author)
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Many-body Problems in the Theory of Stellar Collapse and Neutron Stars
- 2004
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Doctoral thesis (other academic/artistic)abstract
- When modelling the collapse of massive stars leading to supernova explosions and the cooling of neutron stars, understanding the microphysical processes, such as the interaction of neutrinos within a dense medium are of vital importance. The interaction of neutrinos with nucleons (neutrons and protons) is altered by the presence of the medium, compared to the same process with free nucleons. Neutrino scattering and production processes may be characterized in terms of the excitations that are created or destroyed in the nuclear medium. One way to analyse the effects of the medium is by using Landau's theory of normal Fermi liquids. This theory gives simple relationships between physical quantities such as the spin susceptibility or the response to a weak interaction probe in terms of Landau parameters, that are measures of the interaction between quasiparticles. One problem when using Landau Fermi liquid theory for nucleon matter is that the interaction has a tensor component. The tensor interaction does not conserve the total spin and, as a consequence, there are generally contributions to long-wavelength response functions from states that have more than one quasiparticle-quasihole pair in the intermediate state. Such contributions cannot be calculated in terms of Landau parameters alone, since in the usual formulation of Landau theory, only singlepair excitations are considered. In this thesis three problems are addressed. First, we obtain bounds on the contributions from more than one quasiparticle-quasihole pair by using sum-rule arguments. Second, we derive expressions for static response functions allowing for the tensor components of the interaction. We analyse which the most important effects are on the static response of nucleon matter, and find that the major contributions comes from renormalization of coupling constants and transitions to states with more than one quasiparticle-quasihole pair. Third, we show how contributions to the dynamical response coming from states containing two quasiparticle-quasihole pairs may be evaluated in terms of Landau theory if one allows for the effect of collisions in the Landau kinetic equation. We consider the case of asymmetric nuclear matter, and our work goes beyond earlier works in that they contain the effects of collisions in addition to those of the mean field.
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| 21. |
- Simonsson, Bengt, et al.
(author)
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Intensive treatment and stem cell transplantation in chronic myelogenous leukemia : long-term follow-up
- 2005
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In: Acta Haematologica. - : S. Karger AG. - 0001-5792 .- 1421-9662. ; 113:3, s. 155-162
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Journal article (peer-reviewed)abstract
- In the present study we combined interferon (IFN) and hydroxyurea (HU) treatment, intensive chemotherapy and autologous stem cell transplantation (SCT) in newly diagnosed chronic myelogenous leukemia patients aged below 56 years, not eligible for allogeneic SCT. Patients who had an HLA-identical sibling donor and no contraindication went for an allogeneic SCT (related donor, RD). After diagnosis, patients not allotransplanted received HU and IFN to keep WBC and platelet counts low. After 6 months patients with Ph-positive cells still present in the bone marrow received 1–3 courses of intensive chemotherapy. Those who became Ph-negative after IFN + HU or after 1–3 chemotherapy courses underwent autologous SCT. Some patients with poor cytogenetic response were allotransplanted with an unrelated donor (URD). IFN + HU reduced the percentage of Ph-positive metaphases in 56% of patients, and 1 patient became Ph-negative. After one or two intensive cytotherapies 86 and 88% had a Ph reduction, and 34 and 40% became Ph-negative, respectively. In patients receiving a third intensive chemotherapy 92% achieved a Ph reduction and 8% became Ph-negative. The median survival after auto-SCT (n = 46) was 7.5 years. The chance of remaining Ph-negative for up to 10 years after autologous SCT was around 20%. The overall survival for allo-SCT RD (n = 91) and URD (n = 28) was almost the same, i.e. ≈60% at 10 years. The median survival for all 251 patients registered was 8 years (historical controls 3.5 years). The role of the treatment schedule presented in the imatinib era is discussed.
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| 22. |
- Törn, Carina, et al.
(author)
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Combinations of beta cell specific autoantibodies at diagnosis of diabetes in young adults reflects different courses of beta cell damage
- 2001
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In: Autoimmunity. - 0891-6934. ; 33:2, s. 115-120
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Journal article (peer-reviewed)abstract
- To explore the natural course of beta cell function in recent onset diabetes, a subgroup (n = 157) of all incident cases (n = 879) 15-34 years old. 1992-1993 in Sweden. and with positivity for at least one autoantibody of islet cell antibodies (ICA), glutamic acid decarboxylase antibodies (GADA) or tyrosine phosphatase antibodies (1A-2A) were followed prospectively thr the first four years with annual analysis of C-peptide. The aim was to relate the course of beta cell function, measured as C-peptide, in early diabetes with the presence of different islet autoantibodies at diagnosis. We found that patients positive for ICA alone (n = 11 ) had significantly higher C-peptide levels both at diagnosis and during the first three years compared with the other patients (n = 146; p = 0.022, p < 0.001, p = 0.004 and p = 0.0022). Patients positive for GADA alone or in combination with other antibodies (n = 125) had significantly lower C-peptide during the first three years after diagnosis compared with the other patients (n = 32. p < 0.001, p = 0.0011 and p = 0.0136). Patients with two or three autoantibodies had C-peptide levels similar to levels found in patients positive only for GADA. However. after four years, there were no significant differences between any of the groups of different autoantibody combinations. At diagnosis. 55% (86/157) of the patients had C-peptide: levels above the lower normal range of 0.25 nmol/l, but the frequency of patients with beta cell Function above this level decreased after two years to 41% (65/157; p = 0.035) and after four years to 22% (35/157; p = 0.0041).
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| 23. |
- Törn, Carina, et al.
(author)
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Glutamic acid decarboxylase antibodies (GADA) is the most important factor for prediction of insulin therapy within 3 years in young adult diabetic patients not classified as Type 1 diabetes on clinical grounds
- 2000
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In: Diabetes/Metabolism Research and Reviews. - 1520-7552 .- 1520-7560. ; 16:6, s. 442-447
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Journal article (peer-reviewed)abstract
- Background Differentiation between Type 1 and Type 2 diabetes in adults is difficult at diagnosis. In this study we tested the hypothesis that autoantibodies at diagnosis are predictive for insulin treatment within 3 years in patients initially not classified as Type 1 diabetes. Methods In a nationwide population-based study, blood samples were obtained from 764 patients, all diagnosed with diabetes during a 2-year period. At diagnosis, 583 (76%) were classified as Type 1, 110 (14%) as Type 2 and 71 (9.3%) could not be classified. Results Among patients not classified as Type 1 diabetes, 52 (47%) of Type 2 and 42 (59%) of unclassified patients were positive for islet cell antibodies CICA), glutamic acid decarboxylase antibodies (GADA) or tyrosine phosphatase antibodies (IA-2A). These patients (n=94) had lower body mass index (BMI) (p<0.001) and lower C-peptide (p<0.001) compared to the autoantibody negative patients (n=87). Compared to clinically classified Type 1 diabetes patients positive for autoantibodies (n=477), they have higher BMI (p<0.001), higher C-peptide (p<0.001) and the same levels of ICA, GADA and IA-2A. After 3 years, 93% of autoantibody positive patients initially not classified as Type 1 were on insulin. When ICA, GADA, IA-2A, BMI and C-peptide were tested in a multiple logistic regression, only GADA was signiificant for insulin treatment within 3 years (OR = 18.8; 95% CI 1.8-191) in patients treated with diet or oral drugs at diagnosis. Conclusions A correct classification is difficult in adult diabetic patients. The presence of pancreatic autoantibodies, especially GADA, at diagnosis of diabetes are highly predictive for insulin therapy within 3 years from diagnosis.
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| 24. |
- Ager, Bengt
(author)
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Skogsarbetets humanisering och rationalisering från 1900 och framåt
- 2014
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Doctoral thesis (other academic/artistic)abstract
- Rapporten belyser skogsarbetets förändring i storskogsbruket under perioden 1900 – 2013 under inflytande av rationalisering och humanisering som förändringsprocesser. Utgångsläget var ett ytterst slitsamt, riskabelt och lågbetalt säsongsarbete i kyla och snö, med bortaliggning i undermåliga kojor.I periodens början fullbordades en spontan rationalisering som inletts i slutet av 1800-talet och som bestod av att effektivare handredskap – olika typer av sågar, barkspadar och hanteringsdon - ersatte yxan som universalredskap. Organiserad rationalisering av skogsarbetet kom igång först i slutet på 30-talet. Den hämtade då sin inspiration från industrin som vid det laget hade anpassat amerikanen F W Taylors rationaliseringskoncept till den svenska arbetsmarknaden och kulturen. Arbetsstudier blev grund för effektivisering av det manuella skogsarbetet och för en rättvisare lön. Men skogsbruket kom sedan att finna egna vägar, som ledde till en världsunik teknisk och organisatorisk utveckling med början på 1950-talet och kulmen kring 1990. Under de senaste två årtiondena har rationaliseringen i skogsbruket anslutit sig till ”mainstream” i näringslivets utveckling, som styrs allt mera av dels den globaliserade marknadens mekanismer samt dels ”Lean”, ett hopkok av amerikanska och japanska organisationskoncept, och med ”outsourcing” som främsta verktyg. Under perioden 1940-2005 utvecklades produktiviteten kraftigt, med särskilt stora språng 1960-75 och 1990-2005. Efter 2005 skedde en stagnation.Humaniseringen av skogsarbetet inleddes med provinsialläkaren Hasslers larm 1907. Starten blev trög men skogsarbetarnas boende och mathållning kom att förbättras på många håll fram till 1930-talets slut. Då blev humanisering en integrerad del av den systematiska rationaliseringen, vilket innebar radikala förbättringar av det manuella skogsarbetet. När mekaniseringen tog fart under 50- och 60-talet kom människan i produktionssystemet bort ett tag, vilket ledde till omtag på humaniseringsprocessen. Ergonomin utvecklades som redskap och som vetenskap. Från slutet av 70-talet till slutet av 90-talet blev humaniseringen, stödd av flera aktörer, åter en integrerad del av rationaliseringen, nu underbyggd av det ”sociotekniska” organisationskoncept som utvecklats av engelska och norska arbetsforskare. Arbetets organisation kom i fokus. Den totala humankvaliteten kulminerade åren kring 1990. Skogsarbetet nådde då en höjdpunkt vad gäller mångsidighet, kontaktrikedom, variation, självbestämmande, ansvar och uppmärksamhet. Sedan inleddes en viss avhumanisering. Humaniseringsaktörerna försvagades eller försvann. Marknadens ”osynliga hand” tog alltmera över utvecklingen. Humankvaliteten försämrades på en rad punkter som i huvudsak kan hänföras till organisationsmiljön – färre personliga kontakter, längre arbetsresor, sämre skiftformer, kortare framförhållning och sämre kvalitet i planeringen samt sänkt relativ lönenivå. Försämringarna kompenseras delvis av att maskinernas förarmiljö och driftssäkerhet förbättrats avsevärt, men generellt har skogsarbetet förlorat i attraktivitet. Historiken summeras utförligt i kapitel 11.I kapitlet 12 om framtidens arbetsliv nationellt och i skogsbruket hävdar författaren att det behövs ett tidsanpassat humaniseringskoncept av samma dignitet som det på 60-talet lanserade sociotekniska konceptet. En skiss på ett sådant ”socioekonomiskt” koncept presenteras, inklusive en begreppsapparat som gör anspråk på att vara innovativ, samt en rad åtgärdsförslag. Därvid beaktas lärdomar från det förgångna.
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| 25. |
- Ahlgren, Benjamin, et al.
(author)
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A simplified model for linear correlation between annual yield and DNI for parabolic trough collectors
- 2018
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In: Energy Conversion and Management. - : Elsevier. - 0196-8904 .- 1879-2227. ; 174, s. 295-308
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Journal article (peer-reviewed)abstract
- This paper proposes a simple method for estimating annual thermal performance of parabolic trough collectors (PTCs) based on a linear relation with annual DNI for a certain latitude. A case study with simulations for a novel concentrating solar collector in 316 locations for three operating temperature scenarios worldwide was carried out and showed promising results for the latitudes and continents investigated. For a certain latitude and mean operating temperature, the annual yield of a PTC was found to be linearly proportional to yearly DNI. The proposed method will serve as a simplified alternative to the steady-state and quasi-dynamic methods already used. Estimating performance based on yearly DNI can be used by design engineers to do quick preliminary planning of solar plants. Customers can also use this method to evaluate existing solar collector installations. A TRNSYS/TRNSED tool that uses a steady-state model has been developed to carry out the simulations and it has been validated against a PTC array at Technical University of Denmark (DTU). The results show that the simplified method can give reliable estimates of long-term performance of parabolic trough collectors.
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| 26. |
- Akselsson, Cecilia, et al.
(author)
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Weathering rates in Swedish forest soils
- 2019
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In: Biogeosciences. - : Copernicus GmbH. - 1726-4170 .- 1726-4189. ; 16:22, s. 4429-4450
-
Research review (peer-reviewed)abstract
- Soil and water acidification was internationally recognised as a severe environmental problem in the late 1960s. The interest in establishing “critical loads” led to a peak in weathering research in the 1980s and 1990s, since base cation weathering is the long-term counterbalance to acidification pressure. Assessments of weathering rates and associated uncertainties have recently become an area of renewed research interest, this time due to demand for forest residues to provide renewable bioenergy. Increased demand for forest fuels increases the risk of depleting the soils of base cations produced in situ by weathering. This is the background to the research programme Quantifying Weathering Rates for Sustainable Forestry (QWARTS), which ran from 2012 to 2019. The programme involved research groups working at different scales, from laboratory experiments to modelling. The aims of this study were to (1) investigate the variation in published weathering rates of base cations from different approaches in Sweden, with consideration of the key uncertainties for each method; (2) assess the robustness of the results in relation to sustainable forestry; and (3) discuss the results in relation to new insights from the QWARTS programme and propose ways to further reduce uncertainties. In the study we found that the variation in estimated weathering rates at single-site level was large, but still most sites could be placed reliably in broader classes of weathering rates. At the regional level, the results from the different approaches were in general agreement. Comparisons with base cation losses after stem-only and whole-tree harvesting showed sites where whole-tree harvesting was clearly not sustainable and other sites where variation in weathering rates from different approaches obscured the overall balance. Clear imbalances appeared mainly after whole-tree harvesting in spruce forests in southern and central Sweden. Based on the research findings in the QWARTS programme, it was concluded that the PROFILE/ForSAFE family of models provides the most important fundamental understanding of the contribution of weathering to long-term availability of base cations to support forest growth. However, these approaches should be continually assessed against other approaches. Uncertainties in the model approaches can be further reduced, mainly by finding ways to reduce uncertainties in input data on soil texture and associated hydrological parameters but also by developing the models, e.g. to better represent biological feedbacks under the influence of climate change.
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| 27. |
- Alevronta, Eleftheria, et al.
(author)
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Dose-response relationships for an atomized symptom of fecal incontinence after gynecological radiotherapy.
- 2013
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In: Acta oncologica (Stockholm, Sweden). - : Taylor & Francis. - 1651-226X .- 0284-186X. ; 52:4, s. 719-26
-
Journal article (peer-reviewed)abstract
- Purpose. The aim of this study was to investigate what bowel organ and delivered dose levels are most relevant for the development of 'emptying of all stools into clothing without forewarning' so that the related dose-responses could be derived as an aid in avoiding this distressing symptom in the future. Material and methods. Of the 77 gynecological cancer survivors treated with radiotherapy (RT) for gynecological cancer, 13 developed the symptom. The survivors were treated between 1991 and 2003. The anal-sphincter region, the rectum, the sigmoid and the small intestines were all delineated and the dose-volume histograms were exported for each patient. The dose-volume parameters were estimated fitting the data to the Relative Seriality (RS), the Lyman and the generalized Equivalent Uniform Dose (gEUD) model. Results. The dose-response parameters for all three models and four organs at risk (OARs) were estimated. The data from the sigmoid fits the studied models best: D50 was 58.8 and 59.5 Gy (RS, Lyman), γ50 was 1.60 and 1.57 (RS, Lyman), s was 0.32, n was 0.13 and a was 7.7 (RS, Lyman, gEUD). The estimated volume parameters indicate that the investigated OARs behave serially for this endpoint. Our results for the three models studied indicate that they have the same predictive power (similar LL values) for the symptom as a function of the dose for all investigated OARs. Conclusions. In our study, the anal-sphincter region and sigmoid fit our data best, but all OARs were found to have steep dose-responses for 'emptying of all stools into clothing without forewarning' and thus, the outcome can be predicted with an NTCP model. In addition, the dose to the four studied OARs may be considered when minimizing the risk of the symptom.
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| 28. |
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| 29. |
- Alström, Per, Professor, et al.
(author)
-
Multiple species delimitation approaches applied to the avian lark genus Alaudala
- 2021
-
In: Molecular Phylogenetics and Evolution. - : Elsevier BV. - 1055-7903 .- 1095-9513. ; 154
-
Journal article (peer-reviewed)abstract
- Species delimitation has advanced from a purely phenotypic exercise to a branch of science that integrates multiple sources of data to identify independently evolving lineages that can be treated as species. We here test species limits in the avian Lesser Short-toed Lark Alaudala rufesens-Sand Lark A. raytal complex, which has an intricate taxonomic history, ranging from a single to three recognised species, with different inclusiveness in different treatments. Our integrative taxonomic approach is based on a combination of DNA sequences, plumage, biometrics, songs, song-flights, geographical distributions, habitat, and bioclimatic data, and using various methods including a species delimitation program (STACEY) based on the multispecies coalescent model. We propose that four species should be recognised: Lesser Short-toed Lark A. rufescens (sensu stricto), Heine's Short-toed Lark A. heinei, Asian Short-toed Lark A. cheleensis and Sand Lark A. raytal. There is also some evidence suggesting lineage separation within A. cheleensis and A. raytal, but additional data are required to evaluate this. The species delimitation based on STACEY agrees well with the non-genetic data. Although computer-based species delimitation programs can be useful in identifying independently evolving lineages, we stress that whenever possible, species hypotheses proposed by these programs should be tested by independent, non-genetic data. Our results highlight the difficulty and subjectivity of delimiting lineages and species, especially at early stages in the speciation process.
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| 30. |
- Andermann, Tobias, et al.
(author)
-
Allele Phasing Greatly Improves the Phylogenetic Utility of Ultraconserved Elements
- 2019
-
In: Systematic Biology. - : Oxford University Press (OUP). - 1063-5157 .- 1076-836X. ; 68:1, s. 32-46
-
Journal article (peer-reviewed)abstract
- Advances in high-throughput sequencing techniques now allow relatively easy and affordable sequencing of large portions of the genome, even for nonmodel organisms. Many phylogenetic studies reduce costs by focusing their sequencing efforts on a selected set of targeted loci, commonly enriched using sequence capture. The advantage of this approach is that it recovers a consistent set of loci, each with high sequencing depth, which leads to more confidence in the assembly of target sequences. High sequencing depth can also be used to identify phylogenetically informative allelic variation within sequenced individuals, but allele sequences are infrequently assembled in phylogenetic studies. Instead, many scientists perform their phylogenetic analyses using contig sequences which result from the de novo assembly of sequencing reads into contigs containing only canonical nucleobases, and this may reduce both statistical power and phylogenetic accuracy. Here, we develop an easy-to-use pipeline to recover allele sequences from sequence capture data, and we use simulated and empirical data to demonstrate the utility of integrating these allele sequences to analyses performed under the multispecies coalescent model. Our empirical analyses of ultraconserved element locus data collected from the South American hummingbird genus Topaza demonstrate that phased allele sequences carry sufficient phylogenetic information to infer the genetic structure, lineage divergence, and biogeographic history of a genus that diversified during the last 3 myr. The phylogenetic results support the recognition of two species and suggest a high rate of gene flow across large distances of rainforest habitats but rare admixture across the Amazon River. Our simulations provide evidence that analyzing allele sequences leads to more accurate estimates of tree topology and divergence times than the more common approach of using contig sequences.
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| 31. |
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| 32. |
- Andersson, Agneta, et al.
(author)
-
Effects of physical exercise on phospholipid fatty acid composition in skeletal muscle
- 1998
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In: American Journal of Physiology. Endocrinology and Metabolism. - 0193-1849 .- 1522-1555. ; 274:37, s. E432-E438
-
Journal article (peer-reviewed)abstract
- The effects of low-intensity exercise on the fatty acid composition in skeletal muscle and in serum were studied in 19 sedentary, middle-aged Swedish men. During a 10-wk period, all subjects were given a standardized diet with an identical fat composition. After 4 wk on this diet, they were randomly allocated to a daily exercise program (55% peak oxygen uptake) or to continue to live a sedentary life for the remaining 6 wk. Aerobic capacity (submaximal bicycle test) and peripheral insulin sensitivity (hyperinsulinemic euglycemic clamp) improved with training, whereas the body weight as well as the body composition (underwater weighing and bioimpedance) were unchanged. The proportions of palmitic acid (16:0) and linoleic acid [18:2(n-6)] and the sum of n-6 fatty acids [18:2(n-6), 20:3(n-6), 20:4(n-6)] were decreased in skeletal muscle phospholipids, whereas the proportion of oleic acid [18:1(n-9)] was increased, by training. The fatty acid profile in skeletal muscle triglycerides remained unchanged. We conclude that regular low-intensity exercise influences the fatty acid composition of the phospholipids in skeletal muscle, which hypothetically may contribute to changes of the skeletal muscle membrane fluidity and influence the peripheral insulin sensitivity.
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| 33. |
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| 34. |
- Andersson, Agneta, et al.
(author)
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Fatty acid profile of skeletal muscle phospholipids in trained and untrained young men
- 2000
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In: American Journal of Physiology. Endocrinology and Metabolism. - 0193-1849 .- 1522-1555. ; 279:4, s. E744-E751
-
Journal article (peer-reviewed)abstract
- Endurance trained (n = 14) and untrained young men (n = 15) were compared regarding the fatty acid profile of the vastus lateralis muscle after 8 wk on diets with a similar fatty acid composition. The skeletal muscle phospholipids in the trained group contained lower proportions of palmitic acid (16:0) (-12.4%, P < 0.001) and di-homo-gamma-linolenic acid [20:3(n-6)] (-15.3%, P = 0.018), a lower n-6-to-n-3 ratio (-42.0%, P = 0.015), higher proportions of stearic acid (18:0) (+9.8%, P = 0.004) and sum of n-3 polyunsaturated fatty acids (+33.8%, P = 0.009), and a higher ratio between 20:4(n-6) to 20:3(n-6) (+18.4%, P = 0.006) compared with those in the untrained group. The group differences in 16:0, 20:3(n-6), 18:0/16:0, and 20:4(n-6)/20:3(n-6) were independent of fiber-type distribution. The trained group also showed a lower proportion of 16:0 (-7.9%, P < 0.001) in skeletal muscle triglycerides irrespective of fiber type. In conclusion, the fatty acid profile of the skeletal muscle differed between trained and untrained individuals, although the dietary fatty acid composition was similar. This difference was not explained by different fiber-type distribution alone but appears to be a direct consequence of changes in fatty acid metabolism due to the higher level of physical activity.
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| 35. |
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| 36. |
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| 37. |
- Andersson, Jonas, et al.
(author)
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Left ventricular remodelling changes without concomitant loss of myocardial fat after long-term dietary intervention
- 2016
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In: International Journal of Cardiology. - : Elsevier BV. - 0167-5273 .- 1874-1754. ; 216, s. 92-96
-
Journal article (peer-reviewed)abstract
- Background: Accumulation of myocardial triglycerides (MTG) is associated with impaired left ventricular (LV) remodelling and function in obese and diabetic subjects. The role of MTG accumulation in development of heart failure in this group of patients is unknown. Short-term studies suggest that diets that lead to weight loss could mobilize MTG, with a favourable effect on cardiac remodelling. In a 24-month, randomized, investigator-blinded study, we assessed the effect of two different diets and subsequent weight loss on cardiac function and MTG in postmenopausal women. Methods: Sixty-eight healthy postmenopausal women with body mass index [BMI] >= 27 kg/m(2) were randomized to an ad libitum Palaeolithic diet (PD) or a Nordic Nutrition Recommendation (NNR) diet for 24 months. Morphology, cardiac function, and MTG levels were measured using magnetic resonance (MR) scanning, including proton spectroscopy at baseline and 6 and 24 months. Results: Despite mean weight losses of 4.9 (1.0) kg (NNR) and 7.8 (1.1) kg (PD), the MTG content did not change over time (p = 0.98 in the NNR and p = 0.11 in the PD group at 24 months). Reduced left ventricular mass was observed in both diet groups over 24 months. Blood pressure was reduced at 6 months, but returned to baseline levels at 24 months. End diastolic volume, stroke volume, and cardiac output decreased over time. No differences between diet groups were observed. Conclusions: Diet intervention and moderate weight loss over 24 months improved LV remodelling but did not alter MTG levels in overweight/obese postmenopausal women. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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| 38. |
- Andersson, Lena, et al.
(author)
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Hydrolysis of galactolipids by human pancreatic lipolytic enzymes and duodenal contents
- 1995
-
In: Journal of Lipid Research. - 1539-7262. ; 36:6, s. 1392-1400
-
Journal article (peer-reviewed)abstract
- Monogalactosyldiacylglycerols (MGDG), digalactosyldiacylglycerols (DGDG) and sulfoquinovosyldiacylglycerols (SQDG) are major lipids in vegetable food. Their digestion and absorption are unknown. This study examines the hydrolysis of galactolipids in vitro with human duodenal contents, pancreatic juice, and purified human pancreatic lipases. Galactolipids were incubated with human duodenal contents, pancreatic juice, pure pancreatic carboxyl ester lipase (CEL), and colipase-dependent lipase with colipase (Lip-Col). Hydrolysis was estimated as release of free fatty acids and by the use of [3H]galactose or [3H]fatty acid-labeled DGDG. Pancreatic juice and duodenal contents hydrolyzed DGDG to fatty acids, digalactosylmonoacylglycerol (DGMG) and water-soluble galactose-containing compounds. The hydrolysis of DGDG was bile salt-dependent and had a pH optimum at 6.5-7.5. Human pancreatic juice released fatty acids from MGDG, DGDG, and SQDG. Purified CEL hydrolyzed all three substrates; the hydrolysis rate was MGDG > SQDG > DGDG. Pure Lip-Col had activity toward MGDG but had little activity against DGDG. Separation of pancreatic juice by Sephadex G100 gel filtration chromatography revealed two peaks with galactolipase activity that coincided with CEL (molecular mass 100 kD) and lipase (molecular mass 50 kD) peaks. In contrast to pure Lip-Col enzymes of the latter peak were as active against DGDG as against MGDG. Thus, DGDG is hydrolyzed both by CEL and by a pancreatic enzyme(s) with a molecular mass of 40-50 kD to fatty acids and lyso DGDG. MGDG, DGDG, and SQDG are all hydrolyzed by human pancreatic juice. Pure CEL hydrolyzed all three substrates.
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| 39. |
- Andersson, Mats, et al.
(author)
-
Road Friction Estimation
- 2007
-
Reports (other academic/artistic)abstract
- This project is part of the Swedish IVSS program. The aim of IVSS is to stimulate research and development for the road safety of the future. Road conditions with low friction have been identified as a frequent cause of traffic accidents. Therefore, technology to automaticallydetect changes in road conditions and alert the driver or take proper actions with active driver support systems would be a key contribution to increased road safety.The aim of this project was to investigate the possibilities to estimate the tire to road friction.Three different approaches have been developed and evaluated, from concept to early prototypes in test vehicles. In the first method, the estimation of the coefficient of friction is based on the forces and torques that are produced at the front tires at cornering maneuvers.The second method is based on a physical model of the tire behavior and estimates road friction from information on the forces that are produced at straight driving. The third method is based on an optical sensor that classifies the road surface ahead of the vehicle.The three methods have been successfully evaluated in proving ground and public road tests in summer and winter conditions with different tires, and have been compared with reference measurements. The conclusion is that all three methods can be used for tire to road frictionestimation and are recommended for further development and industrialization.
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| 40. |
- Ares, Mikko, et al.
(author)
-
Decreased inducibility of TNF expression in lipid-loaded macrophages.
- 2002
-
In: BMC Immunology. - 1471-2172. ; 3:1, s. 13-13
-
Journal article (peer-reviewed)abstract
- BACKGROUND: Inflammation and immune responses are considered to be very important in the pathogenesis of atherosclerosis. Lipid accumulation in macrophages of the arterial intima is a characteristic feature of atherosclerosis which can influence the inflammatory potential of macrophages. We studied the effects of lipid loading on the regulation of TNF expression in human monocyte-derived macrophages. RESULTS: In macrophages incubated with acetylated low density lipoprotein (ac-LDL) for 2 days, mRNA expression of TNF in cells stimulated with TNF decreased by 75%. In cell cultures stimulated over night with IL-1beta, lipid loading decreased secretion of TNF into culture medium by 48%. These results suggest that lipid accumulation in macrophages makes them less responsive to inflammatory stimuli. Decreased basal activity and inducibility of transcription factor AP-1 was observed in lipid-loaded cells, suggesting a mechanism for the suppression of cytokine expression. NF-kappaB binding activity and inducibility were only marginally affected by ac-LDL. LDL and ac-LDL did not activate PPARgamma. In contrast, oxidized LDL stimulated AP-1 and PPARgamma but inhibited NF-kappaB, indicating that the effects of lipid loading with ac-LDL were not due to oxidation of lipids. CONCLUSIONS: Accumulation of lipid, mainly cholesterol, results in down-regulation of TNF expression in macrophages. Since monocytes are known to be activated by cell adhesion, these results suggest that foam cells in atherosclerotic plaques may contribute less potently to an inflammatory reaction than newly arrived monocytes/macrophages.
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| 41. |
- Arnqvist, Goran, et al.
(author)
-
Falsk marknadsföring om hållbart skogsbruk
- 2022
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In: Svenska Dagbladet Debatt. - 1101-2412.
-
Journal article (pop. science, debate, etc.)abstract
- Dagens svenska skogsbruk är inte ekologiskt hållbart. Att saluföra det som hållbart är därför – för att tala klarspråk – falsk marknadsföring, skriver forskare.
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| 42. |
- Aronsson, Per, et al.
(author)
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An operational decision support tool for stump harvest
- 2011
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Conference paper (other academic/artistic)abstract
- A multi-criteria decision support tool was developed to optimise stump harvesting for energy in Sweden. The decision tool takes account of multiple, sometimes conflicting, criteria relating to stump harvest; energy and climate, economics, biodiversity, and soil and water. Data on harvested stems are used as primary input data in the tool. Such data are routinely collected in harvester computers. The tool effectively deals with mixed sets of data; quantitative harvest data are re-calculated to metric (e.g. stump biomass), and qualitative data (e.g. biodiversity implications) are incorporated. A digital terrain map derived from air-borne laser scanning provides basic data for estimating soil wetness, while digital maps of water courses, key habitats and protected areas, or other sensitive habitats, are used to identify potentially and practically harvestable stumps.In four sub-models, an index from 0 to 10 is calculated for each stump, with 0 representing ‘Not at all suitable’ and 10 ‘Highly suitable for extraction’. Through this, a stump of high value for wood-living species is assigned a low index in the biodiversity sub-model and a large, easily accessible stump is assigned a high index in the economic sub-model. When calculating the net index, the sub-indices can be weighted according to the preferences of the end-user.An energy and climate sub-model incorporates greenhouse gas (GHG) emissions from forest operations and the effect of advancing GHG emissions when stump biomass is incinerated instead of being left to decompose. In the economic sub-model the potential monetary return from each stump is calculated based on estimated revenue from harvested stump biomass and the costs of stump harvesting and forwarding operations (based on cost functions and GIS calculations of transport distances).The biodiversity sub-model considers four types of wood-dependent organisms (lichens, mosses, insects and fungi) in terms of their habitat requirements, vulnerability, sun exposure preferences, locality, etc. A panel of external experts has drawn up a grading scale of stump values for the different taxonomic groups. The proximity to key habitats and exposure to sunlight are derived from a spatial model.Soil and water issues are handled within a sub-model estimating the consequences for long-term soil fertility (nutrient cycling and soil compaction) and water (leaching of plant nutrients and mercury, and particle transport due to soil damage by heavy machinery).The tool offers the end-user possibilities to prioritise and plan for cost-effective stump harvesting, while minimising negative environmental impacts.
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| 43. |
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| 44. |
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| 45. |
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| 46. |
- Backström, Tomas, et al.
(author)
-
Den hållbara och kreativa organisationen
- 2010
-
In: Sociala relationer i arbetslivet. - Malmö : Gleerup utbildning. - 9789140668233
-
Book chapter (other academic/artistic)abstract
- Detta kapitel behandlar hur social interaktion samverkar med och påverkas av organiserande strukturer – interaktion skapar strukturen relation samtidigt som denna relation påverkar interaktionen. Vi studerar inte interaktionen genom att beskriva enskilda samtal i detalj, utan genom att studera vilka mönster eller organiserande strukturer som växer fram i interaktioner. Det gäller både de temporära strukturer som organiserar interaktionen och arbetsorganisationens mer stabila strukturer, det vill säga sociala ordningsparametrar.
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| 47. |
- Backström, Tomas, et al.
(author)
-
Kaikaku - a complement to emergence based development.
- 2010
-
In: DS 66-2: Proceedings of the 1st International Conference on Design Creativity, ICDC 2010. - 9780857292230
-
Conference paper (peer-reviewed)abstract
- Radical change, or Kaikaku, is typically organized as a top-down change project based on a design process strategy. Creative processes are emergent and tend to refuse goal-steering. Still, group creativity and emergence could play an important part in Kaikaku projects. A vision formulated in a creative process, may be an order parameter in emergence and continuously direct, align and commit the actions of the people involved in the Kaikaku.
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| 48. |
- Backström, Tomas, et al.
(author)
-
Manager's task to support integrated autonomy at the workplace : Results from an intervention
- 2013
-
In: International Journal of Business and Management. - Bayswater, W.A. : Canadian Center of Science and Education. - 1833-3850 .- 1833-8119. ; 8:22, s. 20-31
-
Journal article (peer-reviewed)abstract
- A new managerial task arises in today’s working life: to provide conditions for and influence interaction between actors and thus to enable the emergence of organizing structure in tune with a changing environment. We call this the enabling managerial task. The goal of this paper is to study whether training first line managers in the enabling managerial task could lead to changes in the work for the subordinates. This paper presents results from questionnaires answered by the subordinates of the managers before and after the training. The training was organized as a learning network and consisted of eight workshops carried out over a period of one year (September 2009–June 2010), where the managers met with each other and the researchers once a month. Each workshop consisted of three parts, during three and a half hours. The first hour was devoted to joint reflection on a task that had been undertaken since the last workshop; some results were presented from the employee pre-assessments, followed by relevant theory and illuminating practices, finally the managers created new tasks for themselves to undertake during the following month. The subordinates’ answers show positive change in all of the seventeen scales used to assess it. The improvements are significant in scales measuring the relationship between the manager and the employees, as well as in those measuring interaction between employees. It is concluded that the result was a success for all managers that had the possibility of using the training in their management work.
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| 49. |
- Backström, Tomas, et al.
(author)
-
Managers' task to supportintegrated autonomy at the workplace. Results from an intervention. : International Journal of Business and Management; Vol. 8, No. 22; 2013
- 2013
-
In: International Journal of Business and Management. - Canada : Canadian centrer of science and education. - 1833-3850 .- 1833-8119. ; 8:22, s. 20-31
-
Journal article (peer-reviewed)abstract
- A new managerial task arises in today’s working life: to provide conditions for and influence interaction between actors and thus to enable the emergence of organizing structure in tune with a changing environment. We call this the enabling managerial task. The goal of this paper is to study whether training first line managers in the enabling managerial task could lead to changes in the work for the subordinates. This paper presents results from questionnaires answered by the subordinates of the managers before and after the training. The training was organized as a learning network and consisted of eight workshops carried out over a period of one year (September 2009 – June 2010), where the managers met with each other and the researchers once a month. Each workshop consisted of three parts, during three and a half hours. The first hour was devoted to joint reflection on a task that had been undertaken since the last workshop; some results were presented from the employee pre-assessments, followed by relevant theory and illuminating practices, finally the managers created new tasks for themselves to undertake during the following month. The subordinates’ answers show positive change in all of the seventeen scales used to assess it. The improvements are significant in scales measuring the relationship between the manager and the employees, as well as in those measuring interaction between employees. It is concluded that the result was a success for all managers that had the possibility of using the training in their management work.
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| 50. |
- Backström, Tomas, et al.
(author)
-
The manager´s directing task
- 2011
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Conference paper (other academic/artistic)abstract
- The manager has great influence over the talks in the workplace. A manager as usesthe appropriate tools can help employees become more democratic in meetings andmore receptive to what colleagues are saying. This in turn leads to increased learningand better working environment for employees. This is shown in a project withtwenty managers from different businesses. From the public sector participatedcounty council, state administration and municipal activity. From private industryparticipated small service companies, banking, automobile, and an additionalmanufacturing industry. The managers had during a year to participate in eightworkshops with different themes related to communication and collaboration,conducted by researchers from Mälardalen University, Dalarna University andStockholm University (Sweden). The employees were requested to answerquestionnaires before and after this year, to study the extent to which they have beeninfluenced by the fact that managers attended the training.The results show that the working groups not only become more competent,employees have also been more attached to their work group and working groupshave also become more involved in decisions regarding their work and workplaces.Results point at the importance of the manager to support integrated autonomy amongthe employees who then become responsible and empowered actors.The ideal that this project seeks is called integrated autonomy. This means that theactor at the same time should be both independent and belonging. Employees andwork groups, should as far as possible, be permitted and develop competence todecide how the work should be carried out. The employees belonging enables thedecision to be made within the framework of the practices, the culture and theobjectives that the group and the organization has developed. Belonging is both asupport to staff and ensures that the action is strongly influenced by the organization.The manager task is about providing conditions for interaction and to influence theemergence of collective competence and coordination in tune with a changingenvironment. This way of working, we describe as the managers' directing task.
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