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- Gilchrist, Annalyn, et al.
(author)
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Quantitative proteomics analysis of the secretory pathway.
- 2006
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In: Cell. - : Elsevier BV. - 0092-8674. ; 127:6, s. 1265-81
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Journal article (peer-reviewed)abstract
- We report more than 1400 proteins of the secretory-pathway proteome and provide spatial information on the relative presence of each protein in the rough and smooth ER Golgi cisternae and Golgi-derived COPI vesicles. The data support a role for COPI vesicles in recycling and cisternal maturation, showing that Golgi-resident proteins are present at a higher concentration than secretory cargo. Of the 1400 proteins, 345 were identified as previously uncharacterized. Of these, 230 had their subcellular location deduced by proteomics. This study provides a comprehensive catalog of the ER and Golgi proteomes with insight into their identity and function.
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