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Search: WFRF:(Parkin Neil)

  • Result 1-4 of 4
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1.
  • Assimes, Themistocles L., et al. (author)
  • Lack of Association Between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies
  • 2010
  • In: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097. ; 56:19, s. 1552-1563
  • Journal article (peer-reviewed)abstract
    • Objectives We sought to replicate the association between the kinesin-like protein 6 (KIF6) Trp719Arg polymorphism (rs20455), and clinical coronary artery disease (CAD). Background Recent prospective studies suggest that carriers of the 719Arg allele in KIF6 are at increased risk of clinical CAD compared with noncarriers. Methods The KIF6 Trp719Arg polymorphism (rs20455) was genotyped in 19 case-control studies of nonfatal CAD either as part of a genome-wide association study or in a formal attempt to replicate the initial positive reports. Results A total of 17,000 cases and 39,369 controls of European descent as well as a modest number of South Asians, African Americans, Hispanics, East Asians, and admixed cases and controls were successfully genotyped. None of the 19 studies demonstrated an increased risk of CAD in carriers of the 719Arg allele compared with noncarriers. Regression analyses and fixed-effects meta-analyses ruled out with high degree of confidence an increase of >= 2% in the risk of CAD among European 719Arg carriers. We also observed no increase in the risk of CAD among 719Arg carriers in the subset of Europeans with early-onset disease (younger than 50 years of age for men and younger than 60 years of age for women) compared with similarly aged controls as well as all non-European subgroups. Conclusions The KIF6 Trp719Arg polymorphism was not associated with the risk of clinical CAD in this large replication study. (J Am Coll Cardiol 2010;56:1552-63) (C) 2010 by the American College of Cardiology Foundation
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2.
  • Lontok, Erik, et al. (author)
  • Hepatitis C virus drug resistance-associated substitutions : State of the art summary
  • 2015
  • In: Hepatology. - : Ovid Technologies (Wolters Kluwer Health). - 0270-9139 .- 1527-3350. ; 62:5, s. 1623-1632
  • Research review (peer-reviewed)abstract
    • Hepatitis C virus (HCV) drug development has resulted in treatment regimens composed of interferon-free, all-oral combinations of direct-acting antivirals. While the new regimens are potent and highly efficacious, the full clinical impact of HCV drug resistance, its implications for retreatment, and the potential role of baseline resistance testing remain critical research and clinical questions. In this report, we discuss the viral proteins targeted by HCV direct-acting antivirals and summarize clinically relevant resistance data for compounds that have been approved or are currently in phase 3 clinical trials. Conclusion: This report provides a comprehensive, systematic review of all resistance information available from sponsors' trials as a tool to inform the HCV drug development field.
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3.
  • Mazur, Mikael, 1990, et al. (author)
  • Continuous Fiber Sensing over Field-Deployed Metro Link using Real-Time Coherent Transceiver and DAS
  • 2022
  • In: 2022 European Conference on Optical Communication, ECOC 2022. - 9781957171159
  • Conference paper (peer-reviewed)abstract
    • We use an FPGA-based real-time coherent transceiver prototype with continuous μs-level state-of-polarization readouts and a commercial DAS system to perform fiber sensing. Link monitoring and active detection of link tampering is demonstrated using both systems, showing how SOP-based sensing complements DAS in metro environments.
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Type of publication
journal article (2)
conference paper (1)
research review (1)
Type of content
peer-reviewed (4)
Author/Editor
Lennerstrand, Johan (2)
Lenz, Oliver (2)
Miller, Veronica (2)
Salomaa, Veikko (1)
Melander, Olle (1)
Ouwehand, Willem H. (1)
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Cambien, Francois (1)
Deloukas, Panos (1)
Larsson-Edefors, Per ... (1)
Havulinna, Aki S. (1)
Thorleifsson, Gudmar (1)
Thorsteinsdottir, Un ... (1)
Stefansson, Kari (1)
Shah, Svati H. (1)
Rader, Daniel J. (1)
Granger, Christopher ... (1)
Wichmann, H. Erich (1)
Samani, Nilesh J. (1)
Peltonen, Leena (1)
Musunuru, Kiran (1)
Iqbal, Asif (1)
Daly, Mark J. (1)
Anand, Sonia S (1)
Elosua, Roberto (1)
Tang, Hua (1)
Waksman, Ron (1)
Hakonarson, Hakon (1)
Altshuler, David (1)
Guiducci, Candace (1)
Kathiresan, Sekar (1)
Hirschhorn, Joel N. (1)
O'Donnell, Christoph ... (1)
Li, Mingyao (1)
Braund, Peter S. (1)
Balmforth, Anthony J ... (1)
Hall, Alistair S. (1)
Hengstenberg, Christ ... (1)
Schunkert, Heribert (1)
Reilly, Muredach P. (1)
Assimes, Themistocle ... (1)
Holm, Hilma (1)
Voight, Benjamin F. (1)
Erdmann, Jeanette (1)
Willenborg, Christin ... (1)
Vaidya, Dhananjay (1)
Xie, Changchun (1)
Patterson, Chris C. (1)
Morgan, Thomas M. (1)
Burnett, Mary Susan (1)
Hlatky, Mark A. (1)
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University
Uppsala University (2)
Lund University (1)
Chalmers University of Technology (1)
Language
English (4)
Research subject (UKÄ/SCB)
Medical and Health Sciences (3)
Engineering and Technology (1)

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