| 1. |
- Sliz, E., et al.
(author)
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Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata
- 2023
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 14:1
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Journal article (peer-reviewed)abstract
- Uterine leiomyomata (UL) are the most common tumours of the female genital tract and the primary cause of surgical removal of the uterus. Genetic factors contribute to UL susceptibility. To add understanding to the heritable genetic risk factors, we conduct a genome-wide association study (GWAS) of UL in up to 426,558 European women from FinnGen and a previous UL meta-GWAS. In addition to the 50 known UL loci, we identify 22 loci that have not been associated with UL in prior studies. UL-associated loci harbour genes enriched for development, growth, and cellular senescence. Of particular interest are the smooth muscle cell differentiation and proliferation-regulating genes functioning on the myocardin-cyclin dependent kinase inhibitor 1A pathway. Our results further suggest that genetic predisposition to increased fat-free mass may be causally related to higher UL risk, underscoring the involvement of altered muscle tissue biology in UL pathophysiology. Overall, our findings add to the understanding of the genetic pathways underlying UL, which may aid in developing novel therapeutics.
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| 2. |
- Tabassum, R, et al.
(author)
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Genetic architecture of human plasma lipidome and its link to cardiovascular disease
- 2019
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 4329-
-
Journal article (peer-reviewed)abstract
- Understanding genetic architecture of plasma lipidome could provide better insights into lipid metabolism and its link to cardiovascular diseases (CVDs). Here, we perform genome-wide association analyses of 141 lipid species (n = 2,181 individuals), followed by phenome-wide scans with 25 CVD related phenotypes (n = 511,700 individuals). We identify 35 lipid-species-associated loci (P <5 ×10−8), 10 of which associate with CVD risk including five new loci-COL5A1, GLTPD2, SPTLC3, MBOAT7 and GALNT16 (false discovery rate<0.05). We identify loci for lipid species that are shown to predict CVD e.g., SPTLC3 for CER(d18:1/24:1). We show that lipoprotein lipase (LPL) may more efficiently hydrolyze medium length triacylglycerides (TAGs) than others. Polyunsaturated lipids have highest heritability and genetic correlations, suggesting considerable genetic regulation at fatty acids levels. We find low genetic correlations between traditional lipids and lipid species. Our results show that lipidomic profiles capture information beyond traditional lipids and identify genetic variants modifying lipid levels and risk of CVD.
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| 3. |
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| 4. |
- Kurki, MI, et al.
(author)
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FinnGen provides genetic insights from a well-phenotyped isolated population
- 2023
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In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 613:7944, s. 508-
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Journal article (peer-reviewed)abstract
- Population isolates such as those in Finland benefit genetic research because deleterious alleles are often concentrated on a small number of low-frequency variants (0.1% ≤ minor allele frequency < 5%). These variants survived the founding bottleneck rather than being distributed over a large number of ultrarare variants. Although this effect is well established in Mendelian genetics, its value in common disease genetics is less explored1,2. FinnGen aims to study the genome and national health register data of 500,000 Finnish individuals. Given the relatively high median age of participants (63 years) and the substantial fraction of hospital-based recruitment, FinnGen is enriched for disease end points. Here we analyse data from 224,737 participants from FinnGen and study 15 diseases that have previously been investigated in large genome-wide association studies (GWASs). We also include meta-analyses of biobank data from Estonia and the United Kingdom. We identified 30 new associations, primarily low-frequency variants, enriched in the Finnish population. A GWAS of 1,932 diseases also identified 2,733 genome-wide significant associations (893 phenome-wide significant (PWS), P < 2.6 × 10–11) at 2,496 (771 PWS) independent loci with 807 (247 PWS) end points. Among these, fine-mapping implicated 148 (73 PWS) coding variants associated with 83 (42 PWS) end points. Moreover, 91 (47 PWS) had an allele frequency of <5% in non-Finnish European individuals, of which 62 (32 PWS) were enriched by more than twofold in Finland. These findings demonstrate the power of bottlenecked populations to find entry points into the biology of common diseases through low-frequency, high impact variants.
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| 5. |
- Zhou, Wei, et al.
(author)
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Global Biobank Meta-analysis Initiative : Powering genetic discovery across human disease
- 2022
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In: Cell Genomics. - : Elsevier. - 2666-979X. ; 2:10
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Journal article (peer-reviewed)abstract
- Biobanks facilitate genome-wide association studies (GWASs), which have mapped genomic loci across a range of human diseases and traits. However, most biobanks are primarily composed of individuals of European ancestry. We introduce the Global Biobank Meta-analysis Initiative (GBMI)-a collaborative network of 23 biobanks from 4 continents representing more than 2.2 million consented individuals with genetic data linked to electronic health records. GBMI meta-analyzes summary statistics from GWASs generated using harmonized genotypes and phenotypes from member biobanks for 14 exemplar diseases and endpoints. This strategy validates that GWASs conducted in diverse biobanks can be integrated despite heterogeneity in case definitions, recruitment strategies, and baseline characteristics. This collaborative effort improves GWAS power for diseases, benefits understudied diseases, and improves risk prediction while also enabling the nomination of disease genes and drug candidates by incorporating gene and protein expression data and providing insight into the underlying biology of human diseases and traits.
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| 6. |
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| 7. |
- Briselet, R., et al.
(author)
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Production cross section and decay study of Es 243 and Md 249
- 2019
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In: Physical Review C. - 2469-9985. ; 99:2
-
Journal article (peer-reviewed)abstract
- In the study of the odd-Z, even-N nuclei Es243 and Md249, performed at the University of Jyväskylä, the fusion-evaporation reactions Au197(Ca48,2n)Es243 and Tl203(Ca48,2n)Md249 have been used for the first time. Fusion-evaporation residues were selected and detected using a gas-filled separator coupled with its focal-plane spectrometer. For Es243, the recoil decay correlation analysis yielded a half-life of 24±3s and a maximum production cross section of 37±10nb. In the same way, a half-life of 26±1s, an α-branching ratio of 75±5%, and a maximum production cross section of 300±80nb were determined for Md249. The decay properties of Es245, the daughter of Md249, were also measured: an α-branching ratio of 54±7% and a half-life of 65±6s. Experimental cross sections were compared to the results of calculations performed using the kewpie2 statistical fusion-evaporation code.
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| 8. |
- Hilton, J., et al.
(author)
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α -spectroscopy studies of the new nuclides Pt 165 and Hg 170
- 2019
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In: Physical Review C. - 2469-9985. ; 100:1
-
Journal article (peer-reviewed)abstract
- The new nuclides Pt165 and Hg170 were produced in the reactions Mo92(Kr78,5n) and Ru96(Kr78,4n) at bombarding energies of 418 MeV and 390 MeV, respectively. For Hg170 an α-particle energy of Eα=7590(30)keV and half-life of t1/2=0.08-0.04+0.40ms were deduced, while for Pt165 the corresponding values were 7272(14) keV and 0.26-0.09+0.26ms. Comparison of the reduced α-decay widths with systematics indicates that both α decays are unhindered. Although combining the measured α-decay Q values with extrapolated masses suggests that both new nuclides are unbound to two-proton emission by more than 1 MeV, their α-decay half-lives are too short for this decay mode to compete. Improved data were also obtained for Pt166,167, produced via the Ru96(Kr78,α4n) and Ru96(Kr78,α3n) reactions at bombarding energies of 390 MeV and 418 MeV.
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| 9. |
- Lewis, M. C., et al.
(author)
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Decay of a 19(-) isomeric state in Lu-156
- 2018
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In: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 98:2
-
Journal article (peer-reviewed)abstract
- A multiparticle spin-trap isomeric state having a half-life of 179(4) ns and lying 2601 keV above the yrast 10(+) state in Lu-156 has been discovered. The Lu-156 nuclei were produced by bombarding isotopically enriched Cd-106 targets with beams of Ni-58 ions, separated in flight using the gas-filled separator RITU and their decays were measured using the GREAT spectrometer. Analysis of the main decay path that populates yrast states observed previously suggests a spin-parity assignment of 19(-) for the isomeric state, which is consistent with isomeric states identified in the N = 85 isotones. Comparison with other decay paths in Lu-156 indicates that the [pi h(11/)(2)(-1) circle times nu h(9/2)]10(+) state at the bottom of the yrast sequence is likely to be the a-decaying isomeric state, with the [pi h(11/)(2)(-1) circle times nu f(7/2)]9(+) state lying 62 keV above it. The relative ordering of the lowest-lying 9(+) and 10(+) states is inverted in Lu-156 compared with its odd-odd isotones.
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| 10. |
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| 11. |
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| 12. |
- Parr, E., et al.
(author)
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Fine structure in the alpha decay of high-spin isomers in Lu-155 and Hf-156
- 2018
-
In: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 98:2
-
Journal article (peer-reviewed)abstract
- Fine structure in the a decay of high-spin isomers in Lu-155( 25/2(-)) and Hf-156(8(+))has been studied for the first time using alpha gamma- coincidence analysis. Three new a decays from Lu-155(25/2(-)) and two from Hf-156(8(+)) have been identified, populating seniority s > 1 states in the N = 82 nuclei Tm-151 and Yb-152, respectively. The reduced hindrance factors of the a decays support the previous configuration assignments of the populated states. This is the first observation of states with excitation energy greater than 1.5 MeV being populated following a decay in nuclei outside of the Pb-208 region.
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| 13. |
- Parr, E., et al.
(author)
-
Identification of the J(pi)=1(-) state in Ra-218 populated via alpha decay of Th-222
- 2016
-
In: PHYSICAL REVIEW C. - 2469-9985. ; 94:1
-
Journal article (peer-reviewed)abstract
- The alpha decay of Th-222 populating the low-lying J(pi) = 3(-) state, and also a proposed 1(-) state, in Ra-218 has been observed. The observations suggest an excitation energy of 853 keV for the 1(-) state, which is 60 keV above the 3(-) state. The hindrance factors of these alpha decays give a possible boundary to the region of ground-state octupole deformation in the light-actinide nuclei. The relative positions of the J(pi) = 1(-) and 3(-) states suggest they are produced by an octupole-vibrational mechanism, as opposed to alpha clustering or rotations of a reflection-asymmetric octupole-deformed shape.
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| 14. |
- Parr, E., et al.
(author)
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Single-particle states and parity doublets in odd- Z Ac 221 and Pa 225 from α -decay spectroscopy
- 2022
-
In: Physical Review C. - 2469-9985. ; 105:3
-
Journal article (peer-reviewed)abstract
- Low-lying states in the odd-Z isotopes Ac13289221 and Pa13491225 have been studied using α-particle and αγ-coincidence spectroscopy in the Pa225→Ac221→Fr217 decay chain. Ground-state spin and parity assignments of Iπ = 5/2- are proposed for both Ac221 and Pa225, with the odd proton occupying the ω = 5/2 orbital of the quadrupole-octupole deformed shell model in both nuclei. In Ac221, excited states in the bands based on the ω = 5/2 and ω = 3/2 orbitals have been identified, including proposed parity-doublet states. The results suggest that reflection-asymmetric deformation of the ground state persists in the odd-A members of the isotope chains down to N = 132 for Ac and N = 134 for Pa, before reaching the transitional region at N = 130.
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| 15. |
- Saygi, B., et al.
(author)
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Reduced transition probabilities along the yrast line in W-166
- 2017
-
In: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 96:2
-
Journal article (peer-reviewed)abstract
- Lifetimes of excited states in the yrast band of the neutron-deficient nuclide W-166 have been measured utilizing the DPUNS plunger device at the target position of the JUROGAM II gamma-ray spectrometer in conjunction with the RITU gas-filled separator and the GREAT focal-plane spectrometer. Excited states in W-166 were populated in the Mo-92(Kr-78, 4p) reaction at a bombarding energy of 380 MeV. The measurements reveal a low value for the ratio of reduced transitions probabilities for the lowest-lying transitions B(E2; 4(+)-> 2(+)) / B(E2; 2(+)-> 0(+)) = 0.33(5), compared with the expected ratio for an axially deformed rotor (B-4/2 = 1.43).
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| 16. |
- Taylor, M. J., et al.
(author)
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Competing single-particle and collective states in the low-energy structure of I-113
- 2013
-
In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 88:5, s. 054307-
-
Journal article (peer-reviewed)abstract
- To understand the low-energy structure of the neutron deficient iodine isotopes, lifetimes for the low-lying 9/2(+) and 11/2(+) positive-parity states in I-113 have been measured as tau = 28(4) ps and tau = 3.7(7) ps, respectively. The lifetime for the 11/2(-) state, which feeds the 9/2(+) and 11/2(+) states, was remeasured with improved accuracy as tau = 216(7) ps. The reduced transition probability, B(E2) = 32(5) W.u., for the 9/2(+) -> 5/2(+) transition agrees with that calculated within the shell model using a Hamiltonian based on the charge-dependent Bonn nucleon-nucleon interaction. In contrast, the much larger transition probability, B(E2) = 209(39) W.u., measured for the 11/2(+) -> 7/2(+) transition has been interpreted, with the aid of configuration-constrained total Routhian surface calculations, as resulting from a slightly gamma-soft rotor with an associated quadrupole deformation of beta(2) approximate to 0.18. Remarkably similar reduced E1 transition probabilities of 5.5(5) x 10(-4) and 4.9(5) x 10(-4) W.u. were deduced for the 11/2(-) -> 9/2(+) and 11/2(-) -> 11/2(+) transitions, respectively, which feed apparently dissimilar but competing structures.
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| 17. |
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| 18. |
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| 19. |
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| 20. |
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| 21. |
- Doncel, Maria, et al.
(author)
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Lifetime measurements of excited states in W-162 and W-164 and the evolution of collectivity in rare-earth nuclei
- 2017
-
In: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 95:4
-
Journal article (peer-reviewed)abstract
- Lifetimes of the first excited 2(+) states in the extremely neutron- deficient W-162 and W-164 nuclei have been measured using the recoil distance Doppler shift technique. Experimental B(E2) data for the isotopic chains of hafnium, tungsten, and osmium, from the midshell region near the beta-stability line towards the N = 82 closed shell and the most neutron-deficient nuclides, are compared with predictions of nuclear deformations and 2(1)(+) -> 0(g.s)(.+) reduced transition strengths from different classes of state-of-the-art theoretical model calculations. The results reveal striking differences and deficiencies in the predictive power of current nuclear structure models.
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| 22. |
- Ertoprak, Aysegul, et al.
(author)
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Evidence for octupole collectivity in 172Pt
- 2020
-
In: European Physical Journal A. - : Springer. - 1434-6001 .- 1434-601X. ; 56:2
-
Journal article (peer-reviewed)abstract
- Excited states in the extremely neutron-deficient nucleus 172Pt were populated via 96Ru(78Kr,2p) and 92Mo(83Kr,3n) reactions. The level scheme has been extended up to an excitation energy of ~ 5 MeV and tentative spin-parity assignments up to Iπ = 18+. Linear polarization and angular distribution measurements were used to determine the electromagnetic E1 character of the dipole transitions connecting the positive-parity ground-state band with an excited side-band, firmly establishing it as a negative-parity band. The lowest member of this negative-parity structure was firmly assigned spin-parity 3-. In addition, we observed an E3 transition from this 3- state to the ground state, providing direct evidence for octupole collectivity in 172Pt. Large-scale shell model (LSSM) and total Routhian surface (TRS) calculations have been performed, supporting the interpretation of the 3- state as a collective octupole-vibrational state.
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| 23. |
- Gillespie, S. A., et al.
(author)
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Identification of a 6.6 μ s isomeric state in Ir 175
- 2019
-
In: Physical Review C. - 2469-9985. ; 99:6
-
Journal article (peer-reviewed)abstract
- An experiment has been performed to study excited states in the neutron-deficient nucleus Ir175 via the use of the JUROGAM II high-purity germanium detector array and the RITU gas-filled separator at JYFL, Jyväskylä. By using isomer tagging, an isomeric state with a half-life of 6.58(15) μs has been observed in Ir175 for the first time. It has been established that the isomer decays via a 45.2 (E1)-26.1 (M1) keV cascade to new states below the previously reported ground state in Ir175 with Iπ=(5/2-). We now reassign this (5/2-) state to the isomeric state discovered in this study.
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| 24. |
- Gillespie, S. A., et al.
(author)
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Identification of sub- μ s isomeric states in the odd-odd nucleus Au 178
- 2021
-
In: Physical Review C. - 2469-9985. ; 103:4
-
Journal article (peer-reviewed)abstract
- The neutron-deficient gold (Z=79) isotopes in the vicinity of the neutron midshell N=104 provide prolific examples of shape coexistence and isomerism at low excitation energy. They can be probed via a number of different experimental techniques. In this study, two new isomeric states with half-lives of 294(7) and 373(9) ns have been observed in the neutron-deficient odd-odd nuclide Au178 (N=99) in an experiment at the RITU gas-filled separator at JYFL, Jyväskylä. This result was achieved due to the use of a segmented planar germanium detector with a high efficiency at low energies. By applying the recoil-decay tagging technique, they were assigned to decay to two different long-lived α-decaying states in Au178.
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| 25. |
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| 26. |
- Irestorm, Elin, et al.
(author)
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The development of fatigue after treatment for pediatric brain tumors does not differ between tumor locations
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In: Pediatric Blood & Cancer. - 1545-5017. ; , s. 1-9
-
Journal article (peer-reviewed)abstract
- BackgroundChildren and adolescents treated for a brain tumor suffer from more fatigue than survivors of other types of childhood cancer. As tumor location might be predictive of fatigue, our aim was to investigate the longitudinal development of fatigue in children with brain tumors and risk factors for fatigue separately for different tumor locations.MethodsFatigue was assessed 1235 times for 425 participants. Self-report versions of PedsQL Multidimensional Fatigue Scale were used to repeatedly assess fatigue from the end of treatment up to 8 years later. Mixed models were used to analyze fatigue over time and determinants separately for infratentorial (N = 205), supratentorial hemispheric (N = 91), and supratentorial midline tumors (N = 129).ResultsCognitive fatigue worsened with time, while sleep-rest and general fatigue first decreased and then increased. There was no difference in fatigue between the tumor locations, but the risk factors differed when stratified by location. Radiotherapy was associated with more fatigue for infratentorial tumors, and centralization of care was associated with less fatigue for the supratentorial midline tumors. For supratentorial hemispheric tumors, female sex was associated with more fatigue. Higher parental education was associated with less fatigue regardless of tumor location.ConclusionsThe development of fatigue seems to be more related to sociodemographic and treatment variables than to tumor location. Healthcare providers need to be aware that fatigue may develop in the years following end of treatment, and that patients with a low/middle educational family background might be more vulnerable and in need of targeted support.
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| 27. |
- Li, Hongjie, et al.
(author)
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First identification of rotational band structures in Re-166(75)91
- 2015
-
In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 92:1
-
Journal article (peer-reviewed)abstract
- Excited states in the odd-odd, highly neutron-deficient nucleus Re-166 have been investigated via the Mo-92(Kr-78, 3p1n)Re-166 reaction. Prompt gamma rays were detected by the JUROGAM II. gamma-ray spectrometer, and the recoiling fusion-evaporation products were separated by the recoil ion transport unit (RITU) gas-filled recoil separator and implanted into the Gamma Recoil Electron Alpha Tagging spectrometer located at the RITU focal plane. The tagging and coincidence techniques were applied to identify the gamma-ray transitions in Re-166, revealing two collective, strongly coupled rotational structures, for the first time. The more strongly populated band structure is assigned to the pi h(11/2)[514]9/2(-) circle times vi(13/2)[660]1/2(+) Nilsson configuration, while the weaker structure is assigned to be built on a two-quasiparticle state of mixed pi h(11/2)[514]9/2(-) circle times v[h(9/2)f(7/2)]3/2(-) character. The configuration assignments are based on the electromagnetic characteristics and rotational properties, in comparison with predictions from total Routhian surface and particle-rotor model calculations.
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| 28. |
- Li, Hongjie, et al.
(author)
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Recoil-decay tagging spectroscopy of W-162(74)88
- 2015
-
In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 92:1
-
Journal article (peer-reviewed)abstract
- Excited states in the highly neutron-deficient nucleus W-162 have been investigated via the Mo-92(Kr-78, 2 alpha) W-162 reaction. Prompt gamma rays were detected by the JUROGAM II high-purity germanium detector array and the recoiling fusion-evaporation products were separated by the recoil ion transport unit (RITU) gas-filled recoil separator and identified with the gamma recoil electron alpha tagging (GREAT) spectrometer at the focal plane of RITU. gamma rays from W-162 were identified uniquely using mother-daughter and mother-daughter-granddaughter alpha-decay correlations. The observation of a rotational-like ground-state band is interpreted within the framework of total Routhian surface (TRS) calculations, which suggest an axially symmetric ground-state shape with a gamma-soft minimum at beta(2) approximate to 0.15. Quasiparticle alignment effects are discussed based on cranked shell model calculations. New measurements of the W-162 ground-state alpha-decay energy and half-life were also performed. The observed alpha-decay energy agrees with previous measurements. The half-life of W-162 was determined to be t(1/2) = 990(30) ms. This value deviates significantly from the currently adopted value of t(1/2) = 1360(70) ms. In addition, the alpha-decay energy and half-life of Os-166 were measured and found to agree with the adopted values.
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| 29. |
- Lundström, Staffan, et al.
(author)
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In-plane permeability measurements : a Nordic round-robin study
- 2000
-
In: Composites. Part A, Applied science and manufacturing. - 1359-835X .- 1878-5840. ; 31:1, s. 29-43
-
Journal article (peer-reviewed)abstract
- Three methods to measure the in-plane permeability are compared. The methods are based on the wetting and saturated parallel flow techniques and the wetting radial flow technique. It is found that the stability of all three methods is very good. The best repeatability in the results is obtained with the wetting parallel flow technique. A main drawback of this method is, however, that the samples are not saturated hence, the saturated parallel flow method is suggested for continued evaluation. The standard deviation from repeatable measurements of this method is 14 and 20% for the two fabrics tested. By a round-robin comparison at three laboratories it is found that the reproducibility of the saturated parallel flow technique is in the same range as the repeatability of the method. Furthermore, it is shown that the liquid tested and the pressure applied have very small influence on the results. It is clear that most of the scatter is due to the sample preparation and variations in the material. Accordingly, a continued work should be concentrated on improvements of the sample preparation, and development of methods to reduce the influence, from small errors, in sample preparation on the results.
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| 30. |
- Lundström, Staffan, et al.
(author)
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In-plane permeability measurements : stability, repeatability and reproducibility
- 1999
-
In: ICCM-12 Europe. - Tours : ICCM. - 2951452624
-
Conference paper (peer-reviewed)abstract
- Three methods to measure the in-plane permeability have been compared by theoretical analysis and repeated measurements. Based on this comparison the saturated parallel flow technique is suggested for continued evaluation. The stability of this method is better than 1%. However when doing repeatable measurements with new samples the averaged standard deviation increases to 14 % and 20 % for the two fabrics tested. By a round-robin comparison at three laboratories it is found that the reproducibility of the saturated parallel flow technique is in the same range as the repeatability of the method. It is clear that the scatter is due to the sample preparation, variations in the material and the method of loading the sample. Accordingly, a continued work should be concentrated on improvements of the sample preparation, and developments of methods to reduce the influence, from small errors, in sample preparation and sample loading on the results.
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| 31. |
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| 32. |
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| 33. |
- Ahlgren Cederlöf, Ebba, et al.
(author)
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Lifetime measurement of the yrast 2+ state in 118Te
- 2023
-
In: European Physical Journal A. - : Springer. - 1434-6001 .- 1434-601X. ; 59:12
-
Journal article (peer-reviewed)abstract
- The electromagnetic transition probabilities of the yrast 2+ states in the midshell Te isotopes, two protons above the closed shell at Sn, are of great importance for the understanding of nuclear collectivity in these isotopes and the role played by the neutron-proton interactions and cross-shell excitations. However, the large uncertainty of the experimental data for the midshell nucleus 118Te and the missing data for 116Te make it difficult to pin down the general trend of the evolution of transition probabilities as a function of the neutron number. In this work, the lifetime of the yrast 2+ state in 118Te was measured, with the aim of reducing the uncertainty of the previous measurement. The result is τ2+ = 7.46(19) ps. In addition, the lifetime of the 4+ state was measured to be τ4+ = 4.25(23) ps. The experimental transition rates are extracted from the measured lifetimes and compared with systematic large-scale shell-model calculations. The trend of the B(E2; 0+ → 2+) values in the midshell area is in good agreement with the calculations and the calculated B4/2 ratio provide evidence for 118Te as a near perfect harmonic vibrator.
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| 34. |
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| 35. |
- Auranen, K., et al.
(author)
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Experimental study of isomeric intruder 1/2(+) states in At-197,At-203
- 2017
-
In: Physical Review C. - : AMER PHYSICAL SOC. - 2469-9985 .- 2469-9993. ; 95:4
-
Journal article (peer-reviewed)abstract
- A newly observed isomeric intruder 1/2(+) state [T-1/2 = 3.5( 6) ms] is identified in At-203 using a gas-filled recoil separator and fusion-evaporation reactions. The isomer is depopulated through a cascade of E3 and mixed M1/E2 transitions to the 9/2(-) ground state, and it is suggested to originate from the pi(s(1/2))(-1) configuration. In addition, the structures above the 1/2(+) state in At-203 and At-197 are studied using in-beam gamma-ray spectroscopy, recoil-decay tagging, and recoil-isomer decay tagging methods. The 1/2(+) state is fed from 3/2(+) and 5/2(+) states, and the origin of these states are discussed.
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| 36. |
- Auranen, K., et al.
(author)
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Prompt and delayed spectroscopy of At-203 : Observation of a shears band and a 29/2(+) isomeric state
- 2018
-
In: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 97:2
-
Journal article (peer-reviewed)abstract
- Using fusion-evaporation reactions, a gas-filled recoil separator, recoil-gating technique and recoil-isomer decay tagging technique we have extended the level scheme of At-203 (N = 118) significantly. We have observed an isomeric [tau = 14.1(3) mu s] state with a spin and parity of 29/2(+). The isomeric state is suggested to originate from the pi(h(9/2)) circle times |Po-202; 11(-)> coupling, and it is depopulated through 286 keV E2 and 366 keV E3 transitions. In addition, we have observed a cascade of magnetic-dipole transitions which is suggested to be generated by the shears mechanism.
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| 37. |
- Badran, H., et al.
(author)
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Confirmation of the new isotope Pb-178
- 2016
-
In: PHYSICAL REVIEW C. - 2469-9985. ; 94:5
-
Journal article (peer-reviewed)abstract
- The extremely neutron-deficient isotope Pb-178 has been produced. The GREAT spectrometer at the focal plane position of the gas-filled separator RITU was used to study the alpha decay of Pb-178 and its alpha-decay chain through alpha-alpha correlations. The alpha decay was measured to have an energy and half-life of E-alpha = 7610(30) keV and t(1/2) = 0.21(-0.08)(+0.21) ms, respectively. The half-life is consistent with recent theoretical calculations using the Coulomb and proximity potential model. The alpha-decay reduced width and hindrance factor for Pb-178 were deduced and correspond to an unhindered Delta l = 0 transition. In addition, the mass excess of Pb-178 and the alpha-decay Q value were calculated from the experimental results and compared to theoretical values.
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| 38. |
- Badran, H., et al.
(author)
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Decay spectroscopy of Pb-179(82)97 and evidence for a 9/2(-) intruder state in Tl-179(81)98
- 2017
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In: Physical Review C. - 2469-9985 .- 2469-9993. ; 96:6
-
Journal article (peer-reviewed)abstract
- The very neutron-deficient isobars Pb-179 and Tl-179 have been produced using the fusion-evaporation reactions Pd-104(Kr-78,xpyn), where x <= 1 and y >= 2. The gas-filled separator RITU was employed to transport and separate the recoiling nuclei of interest from the scattered beam and unwanted products. The GREAT spectrometer was used to study the decay properties through alpha-alpha and alpha-gamma correlations, which has allowed the ground state of Pb-179 to be assigned as I-pi = 9/2(-). The decay of Pb-179 was measured to have an alpha-particle energy and half-life of E-alpha = 7348(5) keV and t(1/2) = 2.7(2) ms, respectively. A search for a nu i(13/2) state in Pb-179 was performed, but only a limit of excitation energy and half-life was obtained. In Tl-179 a t(1/2) = 114(-10)(+18) ns isomeric state, likely at an excitation energy of 904.5(9) keV, was identified and is tentatively assigned to be a 9/2(-) proton intruder state.
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| 39. |
- Cederwall, Bo, 1964-, et al.
(author)
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Lifetime Measurements of Excited States in Pt-172 and the Variation of Quadrupole Transition Strength with Angular Momentum
- 2018
-
In: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 121:2
-
Journal article (peer-reviewed)abstract
- Lifetimes of the first excited 2(+) and 4(+) states in the extremely neutron -deficient nuclide Pt-172 have been measured for the first time using the recoil-distance Doppler shift and recoil-decay tagging techniques. An unusually low value of the ratio B(E2: 4(1)(+) -> 2(1)(+)/B(E2: 2(1)(+) -> 0(gs)(+)) = 0.55(19) was found, similar to a handful of other such anomalous cases observed in the entire Segre chart. The observation adds to a cluster of a few extremely neutron -deficient nuclides of the heavy transition metals with neutron numbers N approximate to 90-94 featuring the effect. No theoretical model calculations reported to date have been able to explain the anomalously low B(E2: 4(1)(+) -> 2(1)(+)/B(E2: 2(1)(+) -> 0(gs)(+)) ratios observed in these cases. Such low values cannot, e.g., be explained within the framework of the geometrical collective model or by algebraic approaches within the interacting boson model framework. It is proposed that the group of B(E2: 4(1)(+) -> 2(1)(+)/B(E2: 2(1)(+) -> 0(gs)(+)) ratios in the extremely neutron-deficient even-even W, Os, and Pt nuclei around neutron numbers N approximate to 90-94 reveal a quantum phase transition from a seniority-conserving structure to a collective regime as a function of neutron number. Although a system governed by seniority symmetry is the only theoretical framework for which such an effect may naturally occur, the phenomenon is highly unexpected for these nuclei that are not situated near closed shells.
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| 40. |
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| 41. |
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| 42. |
- Doncel, Maria, et al.
(author)
-
Lifetime measurement of the first excited 2(+) state in Te-112
- 2015
-
In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 91:6
-
Journal article (peer-reviewed)abstract
- The lifetime of the 2(+) --> 0(g.s.)(+) transition in the neutron-deficicient nucleus Te-112 has been measured for the first time using the DPUNS plunger and the recoil distance Doppler shift technique. The deduced value for the reduced transition probability is B(E2 :0(g.s.)(+) --> 2(+)) = 0.46 +/- 0.04 e(2)b(2), indicating that there is no unexpected enhancement of the B(E2 :0(g.s.)(+) --> 2(+)) values in Te isotopes below the midshell. The result is compared to and discussed in the framework of large-scale shell-model calculations.
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| 43. |
- Doncel, Maria, et al.
(author)
-
Spin-dependent evolution of collectivity in Te 112
- 2017
-
In: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 96:5
-
Journal article (peer-reviewed)abstract
- The evolution of collectivity with spin along the yrast line in the neutron-deficient nucleus Te112 has been studied by measuring the reduced transition probability of excited states in the yrast band. In particular, the lifetimes of the 4+ and 6+ excited states have been determined by using the recoil distance Doppler-shift method. The results are discussed using both large-scale shell-model and total Routhian surface calculations.
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| 44. |
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| 45. |
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| 46. |
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| 47. |
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| 48. |
- Herzan, A., et al.
(author)
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Detailed spectroscopy of Bi-195
- 2017
-
In: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 96:1
-
Journal article (peer-reviewed)abstract
- An experiment focused on the study of shape coexistence and new high-spin structures in Bi-195 has been performed. The nucleus is in a transitional region of the bismuth isotope chain. A large number of new states have been found, resulting in a significant extension of the previously known level scheme. Several new collective structures have been identified. A strongly coupled rotational band built upon the 13/2(+) isomeric state was extended up to I-pi = (49/2(+)) and an energy of 5706 keV. The I-pi = 31/2(+) member of the pi i(13/2) band was also found to feed a new long-lived isomeric state with an excitation energy of 2616 keV and a spin and parity of I-pi = 29/2(+). The half-life of the 29/2+ isomeric state was determined to be 1.49(1) mu s. It decays via the emission of 457-keV E2 and 236-keV E1 transitions, respectively. A low-energy 46-keV E2 transition has been identified to depopulate the (29/(2-)) isomeric state, with a measured half-life of T-1/2 = 614(5) ns. This transition allows the excitation energy of the isomeric state to be determined as 2381 keV. The feeding patterns of both 29/2(+) and (29/2(-)) isomeric states have also been described. This is the first time collective structures have also been observed up to high spins and excitation energies in the neutron-deficient Bi-195 nucleus. Evidence for the manifestation of shape coexistence in Bi-195 is also discussed.
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| 49. |
- Hodge, D., et al.
(author)
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Identification of a dipole band above the Iπ=31/2- isomeric state in Pb 189
- 2015
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In: Physical Review C. Nuclear Physics. - : American Physical Society. - 0556-2813 .- 1089-490X. ; 92:5
-
Journal article (peer-reviewed)abstract
- A dipole band of six transitions built upon a firmly established Iπ=31/2- isomeric state has been identified in Pb189 using recoil-isomer tagging. This is the lightest odd-mass Pb nucleus in which a dipole band is known. The dipole nature of the new transitions has been confirmed through angular-intensity arguments. The evolution of the excitation energy and the aligned-angular momentum of the states in the new dipole band are compared with those of dipole bands in heavier, odd-mass lead isotopes. This comparison suggests that the new band in Pb189 is based upon a π[s1/2-2h9/2i13/2]11- - ν[i13/2+-1]13/2+ configuration. However, the increased aligned-angular momentum in Pb189 may suggest evidence for a reduced repulsive proton/neutron-hole interaction compared to dipole bands in the heavier mass isotopes.
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| 50. |
- Hyvärinen, Kati, et al.
(author)
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A machine-learning method for biobank-scale genetic prediction of blood group antigens
- 2024
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In: PLoS Computational Biology. - 1553-734X. ; 20:3
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Journal article (peer-reviewed)abstract
- A key element for successful blood transfusion is compatibility of the patient and donor red blood cell (RBC) antigens. Precise antigen matching reduces the risk for immunization and other adverse transfusion outcomes. RBC antigens are encoded by specific genes, which allows developing computational methods for determining antigens from genomic data. We describe here a classification method for determining RBC antigens from genotyping array data. Random forest models for 39 RBC antigens in 14 blood group systems and for human platelet antigen (HPA)-1 were trained and tested using genotype and RBC antigen and HPA-1 typing data available for 1,192 blood donors in the Finnish Blood Service Biobank. The algorithm and models were further evaluated using a validation cohort of 111,667 Danish blood donors. In the Finnish test data set, the median (interquartile range [IQR]) balanced accuracy for 39 models was 99.9 (98.9-100)%. We were able to replicate 34 out of 39 Finnish models in the Danish cohort and the median (IQR) balanced accuracy for classifications was 97.1 (90.1-99.4)%. When applying models trained with the Danish cohort, the median (IQR) balanced accuracy for the 40 Danish models in the Danish test data set was 99.3 (95.1-99.8)%. The RBC antigen and HPA-1 prediction models demonstrated high overall accuracies suitable for probabilistic determination of blood groups and HPA-1 at biobank- scale. Furthermore, population-specific training cohort increased the accuracies of the models. This stand-alone and freely available method is applicable for research and screening for antigen-negative blood donors.
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