| 1. |
- Carninci, P, et al.
(author)
-
The transcriptional landscape of the mammalian genome
- 2005
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In: Science (New York, N.Y.). - : American Association for the Advancement of Science (AAAS). - 1095-9203 .- 0036-8075. ; 309:5740, s. 1559-1563
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Journal article (peer-reviewed)abstract
- This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5′ and 3′ boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.
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| 2. |
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| 3. |
- Jeppesen, H. B., et al.
(author)
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Multi-quasiparticle states in (256)Rf
- 2009
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In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 79:3, s. 031303-
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Journal article (peer-reviewed)abstract
- Excited states in (256)Rf were populated via the Pb-208(Ti-50,2n) fusion-evaporation reaction. Delayed gamma-ray and electron decay spectroscopy was performed and three isomeric states in (256)Rf have been identified. A fourth low-energy nonyrast state was identified from the gamma-ray decay of one of the higher lying isomers. The states are interpreted as multi-quasiparticle excitations.
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| 4. |
- Gadea, A., et al.
(author)
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Observation of Ni-54 : Cross-conjugate symmetry in f(7/2) mirror energy differences
- 2006
-
In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 97:15, s. 152501-
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Journal article (peer-reviewed)abstract
- Gamma decays from excited states up to J(pi)=6(+) in the N=Z-2 nucleus Ni-54 have been identified for the first time. Level energies are compared with those of the isobars Co-54 and Fe-54 and of the cross-conjugate nuclei of mass A=42. The good but puzzling f(7/2) cross-conjugate symmetry in mirror and triplet energy differences is analyzed. Shell model calculations reproduce the new data but the necessary nuclear charge-dependent phenomenology is not fully explained by modern nucleon-nucleon potentials.
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| 5. |
- Gadea, A., et al.
(author)
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Spectroscopy at N=Z with EUROBALL III
- 1999
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In: AIP Conference Proceedings. - : AIP. - 1551-7616 .- 0094-243X. ; 495, s. 195-198
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Conference paper (peer-reviewed)abstract
- A complete study of the nuclear structure by means of gamma spectroscopy requires, in addition to the high resolution gamma measurement and accurate DCO's or angular distributions, the information concerning the Electric or Magnetic character of the transition. This information for transitions in nuclei far from stability valley is now reachable in the new generation of Ge-arrays based in composite detectors. EUROBALL III is a good example with the high polarization sensitivity of the 90 degrees ring of Clovers. The Polarization correlations PCO's measured in coincidence with the Cluster detectors permits to investigate transitions in weakly populated nuclei. In this contribution we present results on medium mass N=Z nuclei measured with EUROBALL III coupled with light particle ancillary detectors.
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| 6. |
- Spolaore, P., et al.
(author)
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Identification and study of the very neutron deficient nuclide I-111 : search for octupole correlations in the region of N approximate to Z approximate to 56
- 2001
-
In: Nuclear Physics A. - 0375-9474 .- 1873-1554. ; 682, s. 387C-393C
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Journal article (peer-reviewed)abstract
- High-spin states in the neutron-deficient nuclide I-111 have been populated with the fusion reaction Ni-58 + Ni-58 at a beam energy of 210 MeV, in an experiment performed at the Tandem Accelerator of the Laboratori Nazionali di Legnaro. The gamma spectrometer GASP was used in time coincidence with the ISIS Si-ball and the CAMEL recoil mass spectrometer for the positive identification of the nuclide. Gamma transitions and structure details previously attributed to I-111 by Other authors are only partially confirmed. The obtained level scheme includes new rotational bands and a new low lying structure which suggests the presence of octupole correlations at predicted rotational frequency values.
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| 7. |
- Algora, A., et al.
(author)
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Pronounced Shape Change Induced by Quasiparticle Alignment
- 2000
-
In: Physical Review C (Nuclear Physics). - 0556-2813 .- 1089-490X. ; 61:3
-
Journal article (peer-reviewed)abstract
- Mean lifetimes of high-spin states of Kr-74 have been determined using the Doppler-shift attenuation method. The high-spin states were studied using the Ca-40(Ca-40, alpha 2p) reaction at a beam energy of 160 MeV with the GASP gamma-ray spectrometer. The ground-state band and negative parity side band show the presence of three different configurations in terms of transitional quadrupole deformations. A dramatic shape change was found along the ground-state band after the S-band crossing. The deduced quadrupole deformation changes are well reproduced by cranked Woods-Saxon Strutinsky calculations.
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| 8. |
- De Angelis, G., et al.
(author)
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Collective Excitations in the Vicinity of N=Z
- 1999. - 1 SUPPL. 1
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In: Proceedings INPC 1998. - 0375-9474. ; 654, s. 659-662
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Conference paper (peer-reviewed)abstract
- In our contribution to the INPC98 conference we reported on the experimental investigation of high spin collective states in medium and heavy mass N≈Z nuclei at LNL. The main purpose is to set light on the role of the proton-neutron interaction in the collective behavior of the nucleus. In medium mass N=Z nuclei, in contrast with the stable nuclei, valence protons and neutrons occupy the same orbitals and one may expect a reinforcement of neutron-proton T=0 (np) pairing correlations[1]. In this interesting subject, the medium mass N=Z=36 72Kr has been studied and completely reported in [2]. In this proceedings we will concentrate in unpublished results concerning the onset of collectivity on nearly spherical nuclei in the 100Sn region. In nuclei with Z=50 and Z=49 dipole bands have been found indicating the presence of "Magnetic Rotation" [3].
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| 9. |
- Gadea, A, et al.
(author)
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Magnetic rotation in the Sn-105 nucleus
- 1997
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In: PHYSICAL REVIEW C-NUCLEAR PHYSICS. - : AMER INST PHYSICS. ; 55:1, s. R1-R4
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Journal article (other academic/artistic)abstract
- The structure of Sn-105 has been investigated through the Cr-50(Ni-58,2pn) reaction at a beam energy of 210 MeV. In addition to an extension of the spherical level scheme a regular sequence of dipole transitions has been found. The states of the dipole ba
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| 10. |
- Gadea, A, et al.
(author)
-
Shears band in the Sn-105 nucleus
- 1997
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In: ZEITSCHRIFT FUR PHYSIK A-HADRONS AND NUCLEI. - : SPRINGER VERLAG. ; 358:2, s. 193-194
-
Journal article (other academic/artistic)abstract
- The structure of Sn-105 has been investigated through the Cr-50(Ni-58, 2pn) reaction at a beam energy of 210 MeV. In addition to an extension of the spherical level scheme, a regular sequence of dipole transitions has been found. The experimental results
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| 11. |
- Zhang, Tongwu, et al.
(author)
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Cell-type-specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes
- 2018
-
In: Genome Research. - : Cold Spring Harbor Laboratory. - 1088-9051 .- 1549-5469. ; 28:11, s. 1621-1635
-
Journal article (peer-reviewed)abstract
- Most expression quantitative trait locus (eQTL) studies to date have been performed in heterogeneous tissues as opposed to specific cell types. To better understand the cell-type-specific regulatory landscape of human melanocytes, which give rise to melanoma but account for <5% of typical human skin biopsies, we performed an eQTL analysis in primary melanocyte cultures from 106 newborn males. We identified 597,335 cis-eQTL SNPs prior to linkage disequilibrium (LD) pruning and 4997 eGenes (FDR < 0.05). Melanocyte eQTLs differed considerably from those identified in the 44 GTEx tissue types, including skin. Over a third of melanocyte eGenes, including key genes in melanin synthesis pathways, were unique to melanocytes compared to those of GTEx skin tissues or TCGA melanomas. The melanocyte data set also identified trans-eQTLs, including those connecting a pigmentation-associated functional SNP with four genes, likely through cis-regulation of IRF4. Melanocyte eQTLs are enriched in cis-regulatory signatures found in melanocytes as well as in melanoma-associated variants identified through genome-wide association studies. Melanocyte eQTLs also colocalized with melanoma GWAS variants in five known loci. Finally, a transcriptome-wide association study using melanocyte eQTLs uncovered four novel susceptibility loci, where imputed expression levels of five genes (ZFP90, HEBP1, MSC, CBWD1, and RP11-383H13.1) were associated with melanoma at genome-wide significant P-values. Our data highlight the utility of lineage-specific eQTL resources for annotating GWAS findings, and present a robust database for genomic research of melanoma risk and melanocyte biology.
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| 12. |
- Andrighetto, Giulia, et al.
(author)
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Changes in social norms during the early stages of the COVID-19 pandemic across 43 countries
- 2024
-
In: Nature Communications. - : NATURE PORTFOLIO. - 2041-1723. ; 15:1
-
Journal article (peer-reviewed)abstract
- The emergence of COVID-19 dramatically changed social behavior across societies and contexts. Here we study whether social norms also changed. Specifically, we study this question for cultural tightness (the degree to which societies generally have strong norms), specific social norms (e.g. stealing, hand washing), and norms about enforcement, using survey data from 30,431 respondents in 43 countries recorded before and in the early stages following the emergence of COVID-19. Using variation in disease intensity, we shed light on the mechanisms predicting changes in social norm measures. We find evidence that, after the emergence of the COVID-19 pandemic, hand washing norms increased while tightness and punishing frequency slightly decreased but observe no evidence for a robust change in most other norms. Thus, at least in the short term, our findings suggest that cultures are largely stable to pandemic threats except in those norms, hand washing in this case, that are perceived to be directly relevant to dealing with the collective threat. Tightness-looseness theory predicts that social norms strengthen following threat. Here the authors test this and find that, after the emergence of the COVID-19 pandemic, hand washing norms increased, but no evidence was observed for a robust change in most other norms.
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| 13. |
- de Angelis, G., et al.
(author)
-
Coherent proton-neutron contribution to octupole correlations in the neutron-deficient Xe-114 nucleus
- 2002
-
In: Physics Letters B. - 0370-2693 .- 1873-2445. ; 535:04-jan, s. 93-102
-
Journal article (peer-reviewed)abstract
- Gamma ray linear polarization and picosecond lifetimes have been measured for levels in the neutron deficient nucleus Xe-114 using the EUROBALL IV spectrometer and the Cologne plunger device. The EUCLIDES Si-ball was used to improve the reaction channel selectivity. The linear polarization results have, for the first time, unambiguously determined the electromagnetic character of the dipole transitions de-exciting the negative parity level sequence, providing clear evidence for enhanced octupole collectivity. The discovery of two E3 transitions and the measurement of the lifetimes of the states depopulated by these transitions have allowed a quantitative determination of the octupole collectivity in the A approximate to 112 mass region. The large measured B(E3) values, close to approximate to 70 W.u., are among the strongest observed hitherto and indicate a coherent proton-neutron contribution to the octupole moment.
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| 14. |
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| 15. |
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| 16. |
- Canton, Martina, et al.
(author)
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Improving Fatigue Resistance of Dihydropyrene by Encapsulation within a Coordination Cage
- 2020
-
In: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 1520-5126 .- 0002-7863. ; 142:34, s. 14557-14565
-
Journal article (peer-reviewed)abstract
- Photochromic molecules undergo reversible isomerization upon irradiation with light at different wavelengths, a process that can alter their physical and chemical properties. For instance, dihydropyrene (DHP) is a deep-colored compound that isomerizes to light-brown cyclophanediene (CPD) upon irradiation with visible light. CPD can then isomerize back to DHP upon irradiation with UV light or thermally in the dark. Conversion between DHP and CPD is thought to proceed via a biradical intermediate; bimolecular events involving this unstable intermediate thus result in rapid decomposition and poor cycling performance. Here, we show that the reversible isomerization of DHP can be stabilized upon confinement within a (PdIIL4)-L-6 coordination cage. By protecting this reactive intermediate using the cage, each isomerization reaction proceeds to higher yield, which significantly decreases the fatigue experienced by the system upon repeated photocycling. Although molecular confinement is known to help stabilize reactive species, this effect is not typically employed to protect reactive intermediates and thus improve reaction yields. We envisage that performing reactions under confinement will not only improve the cyclic performance of photochromic molecules, but may also increase the amount of product obtainable from traditionally low-yielding organic reactions.
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| 17. |
- de, Angelis G, et al.
(author)
-
Band crossing phenomena in N = Z nuclei - A probe to T = 0 pairing correlations?
- 1997
-
In: ACTA PHYSICA HUNGARICA NEW SERIES-HEAVY ION PHYSICS. - : AKADEMIAI KIADO. ; 6:1-4, s. 269-273
-
Journal article (other academic/artistic)abstract
- The structure of the N = Z nuclei Zn-60, Ga-62, Ge-64 and Kr-72 has been investigated at GASP. Total Routhian surface (TRS) calculations have been performed for the N = 36, 38 and 40 Kr isotones. In the case of Kr-72 the four quasi-particle g(9/2) alignme
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| 18. |
- de, Angelis G, et al.
(author)
-
Rotation induced octupole correlations in the neutron-deficient Te-109 nucleus
- 1998
-
In: Physics Letters B. - 0370-2693 .- 1873-2445. ; 437:3-4, s. 236-242
-
Journal article (peer-reviewed)abstract
- High spin states in the neutron deficient nucleus 109Te have been populated with the 58Ni+54Fe reaction at 220 MeV and investigated through γ-spectroscopy methods at the GASP spectrometer making use of reaction channel selection with the ISIS Si-ball. The level scheme has been extended up to an excitation energy of ≈12.1 MeV. The spins and parities of the observed levels are assigned tentatively supporting the identification of two bands of opposite parity connected by strong dipole transitions inferred to be of E1 character. Octupole correlations in 109Te induced by rotation are suggested as the cause of this effect.
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| 19. |
- de, Angelis G, et al.
(author)
-
T=0 pairing correlations and band crossing phenomena in N=Z nuclei
- 1998
-
In: NUCLEAR PHYSICS A. - : ELSEVIER SCIENCE BV. ; 630:1-2, s. 426C-433C
-
Journal article (other academic/artistic)abstract
- The structure of the N=Z nuclei Zn-60, Ga-62, Ge-64 and Kr-72 has been investigated at GASP spectrometer through the S-32 + Ca-40 and Ca-40 + Ca-40 reactions at 140 and 160 MeV, respectively, using reaction channel selection with the ISIS Si-ball. The hig
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| 20. |
- Ek, Gustav, et al.
(author)
-
Elucidating the Effects of the Composition on Hydrogen Sorption in TiVZrNbHf-Based High-Entropy Alloys
- 2021
-
In: Inorganic Chemistry. - : American Chemical Society (ACS). - 0020-1669 .- 1520-510X. ; 60:2, s. 1124-1132
-
Journal article (peer-reviewed)abstract
- A number of high-entropy alloys (HEAs) in the TiVZrNbHf system have been synthesized by arc melting and systematically evaluated for their hydrogen sorption characteristics. A total of 21 alloys with varying elemental compositions were investigated, and 17 of them form body-centered-cubic (bcc) solid solutions in the as-cast state. A total of 15 alloys form either face-centered-cubic (fcc) or body-centered-tetragonal (bct) hydrides after exposure to gaseous hydrogen with hydrogen per metal ratios (H/M) as high as 2.0. Linear trends are observed between the volumetric expansion per metal atom [(V/Z)fcc/bct – (V/Z)bcc/hcp]/(V/Z)bcc/hcp with the valence electron concentration and average Pauling electronegativity (χp) of the alloys. However, no correlation was observed between the atomic size mismatch, δ, and any investigated hydrogen sorption property such as the maximum storage capacity or onset temperature for hydrogen release.
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| 21. |
- Fridner, Ann, et al.
(author)
-
The research collaboration HOUPE: Health and Organisation among University Hospital Physcians in four European countries: Sweden, Norway, Iceland and Italy
- 2008
-
In: BMA – AMA – CMA International conference on Doctors Health, London, 18-20th of November 2008.
-
Conference paper (peer-reviewed)abstract
- Background: Hospital statistics show increased pre-pensioning and sickness absence among physicians in Sweden. In addition, female physicians experience unconstructive work conditions, inequality of pay, and less career advancement than their male counterparts in university hospitals despite increased share of women in medical education. Signs of ill-health among physicians might have severe consequences for people involved, patients, hospital economy and for health service provided. HOUPE is a research collaboration between four University Hospitals in Europe; Karolinska University Hospital, Stockholm, Landspitali University Hospital, Reykjavik, St Olavs University Hospital, Trondheim and University Hospital Azienda Ospedaliera, Padova.Objective: In 2002 national research groups anchored at four University Hospitals in Sweden, Norway, Iceland and Italy started a comprehensive research program abbreviated: The HOUPE project intended to provide a systematic comparison of university hospitals in Europe and how the structure and organization of these hospitals affected the research activity, work load, work satisfaction, gender equality, career advancement, health, and wellbeing of physicians. Next phase in our longitudinal design will include the university hospital in Budapest, Hungary.Funding: Medical Association in Iceland and Sweden, SLS - Swedish Physician Society, NorFA, Vinnova, Stockholm City Council, the four University Hospitals.Method: Three level of data collection were executed: Document analysis concerning national frameworks, register data/hospital statistics and a cross sectional survey in 2005/2006 (N = 2095/3867) among permanently employed university hospital physicians in each country.Results: Numerous research projects are scheduled in each country based on these data in different national research project. Preliminary results will be presented based on these ongoing analyzes on differences in the prevalence of harassment level, suicide ideation, hospitals emphasize of clinical research, and the tension between work load and interaction between career and role as caregivers at home, inequality of pay between men and women, and between medical and academic position.Intervention and prevention: Survey feedback seminars (Fridner & Pingel, 2006) with physicians in each clinic and Occupational Stress Index (OSI) for physicians (Belkic, 2003).Conclusions: The lack of studies that address organisational and psychosocial work conditions for physicians in Iceland and Italy makes HOUPE data important for this purpose. Numerous research projects were scheduled in each country based on these data. In addition, HOUPE data will be able to identify existing practices in management systems of university hospitals and trough comparison between the university hospitals highlight best practice.
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| 22. |
- Gannimani, Ramesh, et al.
(author)
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Acetal containing polymers as pH-responsive nano-drug delivery systems
- 2020
-
In: Journal of Controlled Release. - : Elsevier BV. - 0168-3659 .- 1873-4995. ; 328, s. 736-761
-
Research review (peer-reviewed)abstract
- Utilization of unique acidic environment in various disease sites has been quite advantageous in targeted drug delivery. Among the widely explored pH-sensitive moieties such as hydrazone, orthoester, imine, vinylether, etc., the acetal bearing compounds are one of the most explored entities in targeted and improved drug delivery to treat disease conditions at the preclinical stage. This review addresses the design and synthesis of various acetalbased polymers as pH-responsive nano-drug delivery systems in the form of micelles, polymersomes, nanoplexes and polymeric and solid lipid nanoparticles for biomedical applications. The review will identify potential advantages, key challenges and future prospects of acetal-based pH-responsive drug delivery systems. The novel developments, strategies and suggestions described may guide the formulation scientists to optimize acetalbased pH-responsive drug delivery systems as an approach to treat various diseases.
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| 23. |
- Habchi, Johnny, et al.
(author)
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Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer's disease
- 2017
-
In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 114:2, s. 200-208
-
Journal article (peer-reviewed)abstract
- The aggregation of the 42-residue form of the amyloid-β peptide (Aβ42) is a pivotal event in Alzheimer's disease (AD). The use of chemical kinetics has recently enabled highly accurate quantifications of the effects of small molecules on specific microscopic steps in Aβ42 aggregation. Here, we exploit this approach to develop a rational drug discovery strategy against Aβ42 aggregation that uses as a readout the changes in the nucleation and elongation rate constants caused by candidate small molecules. We thus identify a pool of compounds that target specific microscopic steps in Aβ42 aggregation. We then test further these small molecules in human cerebrospinal fluid and in a Caenorhabditis elegans model of AD. Our results show that this strategy represents a powerful approach to identify systematically small molecule lead compounds, thus offering an appealing opportunity to reduce the attrition problem in drug discovery.
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| 24. |
- Limbocker, Ryan, et al.
(author)
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Trodusquemine enhances Aβ42 aggregation but suppresses its toxicity by displacing oligomers from cell membranes
- 2019
-
In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1
-
Journal article (peer-reviewed)abstract
- Transient oligomeric species formed during the aggregation process of the 42-residue form of the amyloid-β peptide (Aβ42) are key pathogenic agents in Alzheimer’s disease (AD). To investigate the relationship between Aβ42 aggregation and its cytotoxicity and the influence of a potential drug on both phenomena, we have studied the effects of trodusquemine. This aminosterol enhances the rate of aggregation by promoting monomer-dependent secondary nucleation, but significantly reduces the toxicity of the resulting oligomers to neuroblastoma cells by inhibiting their binding to the cellular membranes. When administered to a C. elegans model of AD, we again observe an increase in aggregate formation alongside the suppression of Aβ42-induced toxicity. In addition to oligomer displacement, the reduced toxicity could also point towards an increased rate of conversion of oligomers to less toxic fibrils. The ability of a small molecule to reduce the toxicity of oligomeric species represents a potential therapeutic strategy against AD.
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| 25. |
- Lona-Durazo, Frida, et al.
(author)
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Meta-analysis of GWA studies provides new insights on the genetic architecture of skin pigmentation in recently admixed populations
- 2019
-
In: BMC Genetics. - : BMC. - 1471-2156. ; 20
-
Journal article (peer-reviewed)abstract
- Background: Association studies in recently admixed populations are extremely useful to identify the genetic architecture of pigmentation, due to their high genotypic and phenotypic variation. However, to date only four Genome-Wide Association Studies (GWAS) have been carried out in these populations.Results: We present a GWAS of skin pigmentation in an admixed sample from Cuba (N=762). Additionally, we conducted a meta-analysis including the Cuban sample, and admixed samples from Cape Verde, Puerto Rico and African-Americans from San Francisco. This meta-analysis is one of the largest efforts so far to characterize the genetic basis of skin pigmentation in admixed populations (N=2,104). We identified five genome-wide significant regions in the meta-analysis, and explored if the markers observed in these regions are associated with the expression of relevant pigmentary genes in human melanocyte cultures. In three of the regions identified in the meta-analysis (SLC24A5, SLC45A2, and GRM5/TYR), the association seems to be driven by non-synonymous variants (rs1426654, rs16891982, and rs1042602, respectively). The rs16891982 polymorphism is strongly associated with the expression of the SLC45A2 gene. In the GRM5/TYR region, in addition to the rs1042602 non-synonymous SNP located on the TYR gene, variants located in the nearby GRM5 gene have an independent effect on pigmentation, possibly through regulation of gene expression of the TYR gene. We also replicated an association recently described near the MFSD12 gene on chromosome 19 (lead variant rs112332856). Additionally, our analyses support the presence of multiple signals in the OCA2/HERC2/APBA2 region on chromosome 15. A clear causal candidate is the HERC2 intronic variant rs12913832, which has a profound influence on OCA2 expression. This variant has pleiotropic effects on eye, hair, and skin pigmentation. However, conditional and haplotype-based analyses indicate the presence of other variants with independent effects on melanin levels in OCA2 and APBA2. Finally, a follow-up of genome-wide signals identified in a recent GWAS for tanning response indicates that there is a substantial overlap in the genetic factors influencing skin pigmentation and tanning response.Conclusions: Our meta-analysis of skin pigmentation GWAS in recently admixed populations provides new insights about the genetic architecture of this complex trait.
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| 26. |
- Lunardi, S, et al.
(author)
-
Highly deformed band in Nd-138
- 2004
-
In: Physical Review C (Nuclear Physics). - 0556-2813. ; 69:5
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Journal article (peer-reviewed)abstract
- High-spin states in Nd-138 have been investigated with the reaction Zr-94(Ca-48,4n), using the GASP array. A new rotational band has been identified, which has close similarities with the well known highly deformed bands of the lighter Nd isotopes, and is therefore interpreted as built on the second minimum of the nuclear potential energy surface. From comparison with calculations a configuration is suggested which involves two neutrons in the i(13/2) deformation driving orbital.
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| 27. |
- Pavan, C., et al.
(author)
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Generation of the iPSC line FINi002-A from a male Parkinson's disease patient carrying compound heterozygous mutations in the PRKN gene
- 2023
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In: Stem Cell Research. - 1873-5061. ; 73
-
Journal article (peer-reviewed)abstract
- The most common cause of autosomal recessive familial Parkinson's disease (PD) are mutations in the PRKN/PARK2 gene encoding an E3 ubiquitin protein-ligase PARKIN. We report the generation of an iPSC cell line from the fibroblasts of a male PD patient carrying a common missense variant in exon 7 (p.Arg275Trp), and a 133 kb deletion encompassing exon 8, using transiently-present Sendai virus. The established line displays typical human primed iPSC morphology and expression of pluripotency-associated markers, normal karyotype without SNP array-detectable copy number variations and can give rise to derivatives of all three embryonic germ layers. We envisage the usefulness of this iPSC line, carrying a common and well-studied missense mutation in the RING1 domain of the PARKIN protein, for the elucidation of PARKIN-dependent mechanisms of PD using in vitro and in vivo models.
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| 28. |
- Pavan, J, et al.
(author)
-
Lifetime measurements and terminating structures in Nb-87
- 2003
-
In: Physical Review C (Nuclear Physics). - 0556-2813. ; 67:3: 034316
-
Journal article (peer-reviewed)abstract
- Two experiments have been performed using the Ni-58(S-32,3p) reaction at 135 MeV with Gammasphere and the Microball to study the high-spin structure of the transitional nucleus Nb-87. The first experiment using a thin target provided a considerable extension and refinement of the level scheme, as well as firm spin assignments from directional correlation of oriented nuclei. Sub-picosecond lifetimes were measured in the second backed-target experiment using the Doppler-shift attenuation method. The lifetimes imply a rather modest average deformation of beta(2)similar to0.1, but with considerable variation from state to state. Strong alternations were observed in the B(M1) strengths of transitions between some pairs of bands. The experimental results were compared with calculations performed within the cranked Nilsson-Strutinsky approach. The calculations generally reproduce the irregularities in the structure of the yrast lines and plunging transition quadrupole moments Q(t) within the bands explaining them as reflections of configuration changes and an approach of band termination, respectively.
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| 29. |
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| 30. |
- Pipinato, A., et al.
(author)
-
Prolonging the service life of steel truss bridges
- 2018
-
In: Maintenance, Safety, Risk, Management and Life-Cycle Performance of Bridges. - : Taylor & Francis. ; , s. 489-496
-
Conference paper (peer-reviewed)abstract
- Prolonging the life of existing steel trusses all over the world is a incoming necessity for all managing authorities wherever these structures have reached a particular state of use. The unsatisfactory behavior of these structures under the current type and increasing number of loads make clearer that innovative solutions are needed. For this purpose, the realization of different techniques are presented, in order to retrofit the actual load onto a structure conceived with historical codes, characterized by lower design live loads. The possibilities of retrofitting bridges with different solution studied in a recent research program are presented and compared in this study.
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| 31. |
- Pipinato, A., et al.
(author)
-
Steel bridge structural retrofit : Innovative and light-weight solutions
- 2018
-
In: Life Cycle Analysis and Assessment in Civil Engineering: Towards an Integrated Vision. - : Taylor & Francis. ; , s. 2857-2867
-
Conference paper (peer-reviewed)abstract
- Prolonging the life of existing steel trusses all over the world is a incoming necessity for all managing authorities wherever these structures have reached a particular state of use. The unsatisfactory behavior of these structures under the current type and increasing number of loads make clearer that innovative solutions are needed. For this purpose, the realization of different techniques are presented, in order to retrofit the actual load onto a structure conceived with historical codes, characterized by lower design live loads. The possibilities of retrofitting bridges with different solution studied in a recent research program are presented and compared in this study.
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| 32. |
- Rambabu, D., et al.
(author)
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Pd/C-mediated synthesis of (Z)-3-alkylidenephthalides of potential pharmacological interest
- 2013
-
In: Tetrahedron Letters. - Oxford, England : PERGAMON-ELSEVIER SCIENCE LTD. - 0040-4039 .- 1359-8562. ; 54:23, s. 2989-2995
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Journal article (peer-reviewed)abstract
- The coupling of o-bromobenzoic acid with terminal alkynes using 10% Pd/C-Et3N-CuI-PPh3 as a catalyst system leads to the synthesis of (Z)-3-alkylidenephthalides as the major product along with the traces of isocoumarin when the reaction was performed in 1,4-dioxane. The methodology afforded a range of compounds including (Z)-3-(4-(methylsulfonyl)benzylidene)isobenzofuran-1(3H)-one of potential pharmacological interest. (C) 2013 Elsevier Ltd. All rights reserved.
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| 36. |
- Tap, J., et al.
(author)
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Effects of the long-term storage of human fecal microbiota samples collected in RNAlater
- 2019
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9
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Journal article (peer-reviewed)abstract
- The adequate storage of fecal samples from clinical trials is crucial if analyses are to be performed later and in long-term studies. However, it is unknown whether the composition of the microbiota is preserved during long-term stool storage (>1 year). We therefore evaluated the influence of long-term storage on the microbiota composition of human stool samples collected in RNAlater and stored for approximately five years at -80 degrees C. We compared storage effects on stool samples from 24 subjects with the effects of technical variation due to different sequencing runs and biological variation (intra-and inter-subject), in another 101 subjects, based on alpha-diversity, beta-diversity and taxonomic composition. We also evaluated the impact of initial alpha-diversity and fecal microbiota composition on beta-diversity instability upon storage. Overall, long-term stool storage at -80 degrees C had only limited effects on the microbiota composition of human feces. The magnitude of changes in alpha-and betadiversity and taxonomic composition after long-term storage was similar to inter-sequencing variation and smaller than biological variation (both intra- and inter-subject). The likelihood of fecal samples being affected by long-term storage correlated with the initial relative abundance of some genera and tend to be affected by initial taxonomic richness.
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| 37. |
- Valentino, F., et al.
(author)
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Valuable Routes for Sewage Sludge Utilization: Effect of Temperature and Hydraulic Retention Time in the Acidogenic Fermentation Process
- 2022
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In: Chemical Engineering Transactions. - 2283-9216. ; 93, s. 193-198
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Journal article (peer-reviewed)abstract
- The disposal of sewage sludge potentially reaches the 50-60% of WWTP’s total operation cost. Such stream can be considered a renewable carbon source to produce added-value products. Different pre-treatment methods have been applied on thickened sewage sludge (SS) coming from the domestic wastewater treatment plant (WWTP) of Treviso (northeast Italy) to favour its acidogenic fermentability. Alkaline (pH 9-11) and thermal (50-70°C) hydrolysis were applied separately and in combination The following fermentation process was addressed to the recovery of volatile fatty acids (VFA) as valuable building blocks substances. Batch fermentation tests were conducted at lab-scale under controlled temperature (T): 20, 37, 55 and 70°C by using an available mixed fermentative consortium as inoculum. Thermophilic T (55°C) was chosen in the following semi-continuous fermentation process (fill and draw), carried out with three different hydraulic retention time (HRT; 4-5-6 days). In terms of organic matter solubilisation, the thermal hydrolysis (70°C) allowed to obtain a soluble chemical oxygen demand (CODSOL) concentration around 10.0 g/L, with no additional benefits from the combined alkaline treatment. The batch acidogenic fermentation tests highlighted the T effect on acidification performances; thermophilic trials (55°C) showed the highest CODVFA/CODSOL ratio (0.81). The three semi-continuous tests (HRT 4-5-6 days) were followed for 45 days (roughly), under the chosen thermophilic condition (55°C). The highest fermentation rate was obtained at 4.0 d as HRT (22 mgCODVFA/gVS d); on the contrary, the highest fermentation yield (0.30 gCODVFA/gVS) and CODVFA/CODSOL ratio (0.73) were obtained at 6.0 d as HRT. In practice, low HRT selected for a mixed consortium with high fermentation rate, but less efficient in the conversion of the organic matter into VFA. No HRT’s effect was instead observed in the VFA composition, always rich in acetic (29-31% COD basis) and butyric acid (31-32%), and poorer in propionic (14-15%), valeric (12-13%) and caproic acid (11-12%). Copyright © 2022, Aidic Servizi S.R.L.
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