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| 9. |
- Ahmed, M., et al.
(author)
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Search for the lepton-family-number nonconserving decay μ +→e +γ
- 2002
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In: Physical Review D. - : American Physical Society. - 1550-7998 .- 1550-2368. ; 65:11
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Journal article (peer-reviewed)abstract
- The MEGA experiment, which searched for the muon- and electron-number violating decay μ +→e + γ, is described. The spectrometer system, the calibrations, the data taking procedures, the data analysis, and the sensitivity of the experiment are discussed. The most stringent upper limit on the branching ratio, B(μ + →e + γ)<1.2×10 -11 with 90% confidence, is derived from a likelihood analysis.
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| 10. |
- Amann, F., et al.
(author)
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A search for murarregamma at the level of 10-13
- 1991
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In: Proceedings of the 25th International Conference on High Energy Physics. - 9810024347 ; , s. 1070-1071
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Conference paper (peer-reviewed)abstract
- The MEGA experiment, which is a search for the decay murarregamma with a branching ratio sensitivity of about 10-13, employs highly modular, fast detectors, state-of-the-art electronics, and a staged trigger with on-line filters. The detectors are contained in a 1.5-T solenoidal field produced by a superconducting magnet. Positrons are confined to the central region and are measured by a set of thin MWPCs. Photons are measured by one of four layers of pair spectrometers in the outer region. Most aspects of the design have been validated in engineering runs; data taking will begin in 1990 with much of the electron arm and one pair spectrometer layer installed.
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| 11. |
- Ginsburg, A., et al.
(author)
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Dense gas in the Galactic central molecular zone is warm and heated by turbulence
- 2016
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In: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 586, s. Art nr A50-
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Journal article (peer-reviewed)abstract
- Context. The Galactic center is the closest region where we can study star formation under extreme physical conditions like those in high-redshift galaxies. Aims. We measure the temperature of the dense gas in the central molecular zone (CMZ) and examine what drives it. Methods. We mapped the inner 300 pc of the CMZ in the temperature-sensitive J = 3-2 para-formaldehyde (p-H2CO) transitions. We used the 3(2,1)-2(2,0)/3(0,3)-2(0,2) line ratio to determine the gas temperature in n similar to 10(4) - 10(5) cm(-3) gas. We have produced temperature maps and cubes with 30 0 0 and 1 km s(-1) resolution and published all data in FITS form. Results. Dense gas temperatures in the Galactic center range from similar to 60 K to > 100 K in selected regions. The highest gas temperatures T-G > 100 K are observed around the Sgr B2 cores, in the extended Sgr B2 cloud, the 20 km s(-1) and 50 km s(-1) clouds, and in "The Brick" (G0.253 + 0.016). We infer an upper limit on the cosmic ray ionization rate zeta(CR)
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| 12. |
- Kennedy, S. A., et al.
(author)
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Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D
- 2020
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In: Nature Communications. - : Springer Nature. - 2041-1723. ; 11:1
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Journal article (peer-reviewed)abstract
- Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRASG13D) affects PPIN structure and function of the Epidermal Growth Factor Receptor (EGFR) network in colorectal cancer (CRC) cells. Mapping >6000 PPIs shows that this network is extensively rewired in cells expressing transforming levels of KRASG13D (mtKRAS). The factors driving PPIN rewiring are multifactorial including changes in protein expression and phosphorylation. Mathematical modelling also suggests that the binding dynamics of low and high affinity KRAS interactors contribute to rewiring. PPIN rewiring substantially alters the composition of protein complexes, signal flow, transcriptional regulation, and cellular phenotype. These changes are validated by targeted and global experimental analysis. Importantly, genetic alterations in the most extensively rewired PPIN nodes occur frequently in CRC and are prognostic of poor patient outcomes.
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| 13. |
- Mariz, FC, et al.
(author)
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Peak neutralizing and cross-neutralizing antibody levels to human papillomavirus types 6/16/18/31/33/45/52/58 induced by bivalent and quadrivalent HPV vaccines
- 2020
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In: NPJ vaccines. - : Springer Science and Business Media LLC. - 2059-0105. ; 5:1, s. 14-
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Journal article (peer-reviewed)abstract
- We performed an independent comparison of neutralizing and cross-neutralizing antibody (ab) levels seven months after initiation of three-dose, six-month vaccination schedules with the bivalent and quadrivalent human papillomavirus (HPV) vaccines in adolescent Finnish and Indian females, respectively. We used a semi-automated Pseudovirion-Based Neutralization Assay and observed significantly higher HPV16/18 peak ab-levels in bivalent as compared to quadrivalent vaccine recipients. Bivalent vaccine induced cross-neutralizing HPV31/33/45/52/58 antibodies significantly more frequently and to higher levels than the quadrivalent vaccine. The correlation of bivalent vaccine-induced HPV45 ab-levels with HPV16/18 ab-levels was stronger than that of corresponding quadrivalent vaccine-induced ab-levels, suggesting a qualitatively different cross-reactive response. Our findings on the comparison of the immunogenicity of two HPV vaccine tested in two different populations indicate that further head-to-head studies are warranted.
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| 14. |
- Szymanski, J. J., et al.
(author)
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A study of the decay mu –> e gamma by the MEGA experiment
- 1996
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In: Proceedings, 9th Meeting, DPF'96, Minneapolis, USA, August 11-15, 1996. Vol. 1, 2.. ; , s. 1450-1452
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Conference paper (peer-reviewed)
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| 15. |
- Szymanski, J. J., et al.
(author)
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MEGA : A search for the decay mu –> e gamma
- 1994
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In: Intersections between particle and nuclear physics. Proceedings, 5th Conference, St. Petersburg, USA, May 31-June 6, 1994. ; , s. 789-792
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Conference paper (peer-reviewed)
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| 17. |
- Chyrkin, Anton, 1984, et al.
(author)
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Stability of External alpha-Al2O3 Scales on Alloy 602 CA at 1100-1200 A degrees C
- 2018
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In: Oxidation of Metals. - : Springer Science and Business Media LLC. - 1573-4889 .- 0030-770X. ; 90:1-2, s. 119-133
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Journal article (peer-reviewed)abstract
- An external ultrathin alpha-Al2O3 scale grown on the Ni-base alloy 602 CA during air oxidation at 800 A degrees C was characterized by means of high-resolution TEM/EDX and electron diffraction. Alloy samples pre-oxidized at 800 A degrees C were subsequently exposed at 1100, 1150 and 1200 A degrees C for up to 100 h. Whereas the external alumina remained stable at 1100 A degrees C, with the increasing exposure temperature, the pre-grown alumina scale tended to break down resulting in an external chromia scale accompanied by internal alumina precipitation. The transition from external to internal Al oxidation was investigated using SEM/EDX/EBSD. The critical Al depletion at the scale-alloy interface during the post-exposure at 1100-1200 A degrees C was modeled using the CALPHAD-based thermodynamic-kinetic approach.
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| 20. |
- Frosi, Y, et al.
(author)
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Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex
- 2022
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1, s. 4854-
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Journal article (peer-reviewed)abstract
- An attractive approach to target intracellular macromolecular interfaces and to model putative drug interactions is to design small high-affinity proteins. Variable domains of the immunoglobulin heavy chain (VH domains) are ideal miniproteins, but their development has been restricted by poor intracellular stability and expression. Here we show that an autonomous and disufhide-free VH domain is suitable for intracellular studies and use it to construct a high-diversity phage display library. Using this library and affinity maturation techniques we identify VH domains with picomolar affinity against eIF4E, a protein commonly hyper-activated in cancer. We demonstrate that these molecules interact with eIF4E at the eIF4G binding site via a distinct structural pose. Intracellular overexpression of these miniproteins reduce cellular proliferation and expression of malignancy-related proteins in cancer cell lines. The linkage of high-diversity in vitro libraries with an intracellularly expressible miniprotein scaffold will facilitate the discovery of VH domains suitable for intracellular applications.
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| 21. |
- Galiullin, T., et al.
(author)
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Effect of alloying elements in Ni-base substrate material on interdiffusion processes in MCrAlY-coated systems
- 2018
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In: Surface and Coatings Technology. - : Elsevier BV. - 0257-8972. ; 350, s. 359-368
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Journal article (peer-reviewed)abstract
- he effect of alloying elements in the substrate on the interdiffusion processes between a NiCoCrAlY-coating and model Ni-base superalloys was studied. Four single-crystal substrates Ni-10Cr-8Al-X (wt%, X = 10Co, 9Ta, 6 W) were coated with a conventional NiCoCrAlY-coating and exposed to air for up to 1000 h at 1050 °C. The microstructural analyses (LOM/SEM/EDX) revealed a strong dependence of the coating degradation rate on the substrate composition. The coating applied to the ternary base Ni-10Cr-8Al alloy and to the quaternary Co-containing substrate degraded most rapidly while the Ta addition to the substrate effectively suppressed interdiffusion. The degradation phenomena such as β-NiAl depletion and propagation of the secondary reaction zone (SRZ) were interpreted in terms of a thermodynamical analysis in Thermo-Calc and by using a CALPHAD-based thermodynamic-kinetic diffusion model.
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| 23. |
- Nyenswah, TG, et al.
(author)
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Ebola and Its Control in Liberia, 2014-2015
- 2016
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In: Emerging infectious diseases. - : Centers for Disease Control and Prevention (CDC). - 1080-6059 .- 1080-6040. ; 22:2, s. 169-177
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Journal article (peer-reviewed)
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| 25. |
- Swami, Viren, et al.
(author)
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The Attractive Female Body Weight and Female Body Dissatisfaction in 26 Countries Across 10 World Regions : Results of the International Body Project I
- 2010
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In: Personality and Social Psychology Bulletin. - : Sage Publications. - 0146-1672 .- 1552-7433. ; 36:3, s. 309-325
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Journal article (peer-reviewed)abstract
- This study reports results from the first International Body Project (IBP-I), which surveyed 7,434 individuals in 10 major world regions about body weight ideals and body dissatisfaction. Participants completed the female Contour Drawing Figure Rating Scale (CDFRS) and self-reported their exposure to Western and local media. Results indicated there were significant cross-regional differences in the ideal female figure and body dissatisfaction, but effect sizes were small across high-socioeconomic-status (SES) sites. Within cultures, heavier bodies were preferred in low-SES sites compared to high-SES sites in Malaysia and South Africa (ds = 1.94-2.49) but not in Austria. Participant age, body mass index (BMI), and Western media exposure predicted body weight ideals. BMI and Western media exposure predicted body dissatisfaction among women. Our results show that body dissatisfaction and desire for thinness is commonplace in high-SES settings across world regions, highlighting the need for international attention to this problem.
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| 26. |
- Vernet, Nicolas, et al.
(author)
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Experimental determination of the permeability of engineering textiles : Benchmark II
- 2014
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In: Composites. Part A, Applied science and manufacturing. - : Elsevier Ltd. - 1359-835X .- 1878-5840. ; 61, s. 172-184
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Journal article (peer-reviewed)abstract
- In this second international permeability benchmark, the in-plane permeability values of a carbon fabric were studied by twelve research groups worldwide. One participant also investigated the deformation of the tested carbon fabric. The aim of this work was to obtain comparable results in order to make a step toward standardization of permeability measurements. Unidirectional injections were thus conducted to determine the unsaturated in-plane permeability tensor of the fabric. Procedures used by participants were specified in the guidelines defined for this benchmark. Participants were asked to use the same values for parameters such as fiber volume fraction, injection pressure and fluid viscosity to minimize sources of scatter. The comparison of the results from each participant was encouraging. The scatter between data obtained while respecting the guidelines was below 25%. However, a higher dispersion was observed when some parameters differed from the recommendations of this exercise.
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| 27. |
- Wang, Chao, et al.
(author)
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The role of turbulence in high-mass star formation: Subsonic and transonic turbulence are ubiquitously found at early stages
- 2024
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In: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 681
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Journal article (peer-reviewed)abstract
- Context. Traditionally, supersonic turbulence is considered to be one of the most likely mechanisms slowing the gravitational collapse in dense clumps, thereby enabling the formation of massive stars. However, several recent studies have raised differing points of view based on observations carried out with sufficiently high spatial and spectral resolution. These studies call for a re-evaluation of the role turbulence plays in massive star-forming regions. Aims. Our aim is to study the gas properties, especially the turbulence, in a sample of massive star-forming regions with sufficient spatial and spectral resolution, which can both resolve the core fragmentation and the thermal line width. Methods. We observed NH3 metastable lines with the Very Large Array (VLA) to assess the intrinsic turbulence. Results. Analysis of the turbulence distribution histogram for 32 identified NH3 cores reveals the presence of three distinct components. Furthermore, our results suggest that (1) sub-and transonic turbulence is a prevalent (21 of 32) feature of massive star-forming regions and those cold regions are at early evolutionary stage. This investigation indicates that turbulence alone is insufficient to provide the necessary internal pressure required for massive star formation, necessitating further exploration of alternative candidates; and (2) studies of seven multi-core systems indicate that the cores within each system mainly share similar gas properties and masses. However, two of the systems are characterized by the presence of exceptionally cold and dense cores that are situated at the spatial center of each system. Our findings support the hub-filament model as an explanation for this observed distribution.
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