| 1. |
- Barack, Leor, et al.
(författare)
-
Black holes, gravitational waves and fundamental physics : a roadmap
- 2019
-
Ingår i: Classical and quantum gravity. - : IOP Publishing. - 0264-9381 .- 1361-6382. ; 36:14
-
Forskningsöversikt (refereegranskat)abstract
- The grand challenges of contemporary fundamental physics dark matter, dark energy, vacuum energy, inflation and early universe cosmology, singularities and the hierarchy problem all involve gravity as a key component. And of all gravitational phenomena, black holes stand out in their elegant simplicity, while harbouring some of the most remarkable predictions of General Relativity: event horizons, singularities and ergoregions. The hitherto invisible landscape of the gravitational Universe is being unveiled before our eyes: the historical direct detection of gravitational waves by the LIGO-Virgo collaboration marks the dawn of a new era of scientific exploration. Gravitational-wave astronomy will allow us to test models of black hole formation, growth and evolution, as well as models of gravitational-wave generation and propagation. It will provide evidence for event horizons and ergoregions, test the theory of General Relativity itself, and may reveal the existence of new fundamental fields. The synthesis of these results has the potential to radically reshape our understanding of the cosmos and of the laws of Nature. The purpose of this work is to present a concise, yet comprehensive overview of the state of the art in the relevant fields of research, summarize important open problems, and lay out a roadmap for future progress. This write-up is an initiative taken within the framework of the European Action on 'Black holes, Gravitational waves and Fundamental Physics'.
|
|
| 2. |
- Cerrato, Enrico, et al.
(författare)
-
Revascularization Deferral of Nonculprit Stenoses on the Basis of Fractional Flow Reserve : 1-Year Outcomes of 8,579 Patients
- 2020
-
Ingår i: JACC: Cardiovascular Interventions. - : Elsevier BV. - 1936-8798. ; 13:16, s. 1894-1903
-
Tidskriftsartikel (refereegranskat)abstract
- Background: Intracoronary physiology is increasingly used in nonculprit stenoses of patients with acute coronary syndromes (ACS). However, evidence regarding the safety of fractional flow reserve-based deferral in patients with ACS, compared with patients with stable angina pectoris (SAP), is scarce. Objectives: The aim of this study was to evaluate the safety of revascularization deferral on the basis of fractional flow reserve interrogation of nonculprit lesions in patients with ACS. Methods: A pooled analysis was performed of individual patient data included in 5 large international published studies on physiology-guided revascularization. The primary endpoint was major adverse cardiac events (MACE) (a composite of death, nonfatal myocardial infarction, or unplanned revascularization) at 1-year follow-up. Clinical outcomes of patients with ACS and SAP were compared in both the deferred and the revascularized groups. Results: A total of 8,579 patients were included in the analysis, 6,461 with SAP and 2,118 with ACS and nonculprit stenoses. Using fractional flow reserve, revascularization was deferred in 5,129 patients (59.8%) and performed in 3,450 patients (40.2%). In the deferred ACS group, a higher MACE rate was observed compared with the deferred SAP group (4.46% vs. 2.83%; adjusted hazard ratio [HR]: 1.72; 95% confidence interval [CI]: 1.17 to 2.53; p < 0.01). In particular, early unplanned revascularization (3.34% and 2.04% in ACS and SAP; adjusted HR: 1.81; 95% CI: 1.09 to 3.00; p = 0.02) contributed to this excess in MACE but the difference between the ACS and SAP groups did not reach statistical significance. On the contrary, no differences in outcomes linked to clinical presentation were found in treated patients (MACE rate 6.51% vs. 6.20%; adjusted HR: 1.21; 95% CI: 0.88 to 1.26; p = 0.24). Conclusions: Patients with ACS in whom revascularization of nonculprit lesions was deferred on the basis of fractional flow reserve have more MACE at 1 year compared with patients with SAP with deferred revascularization. Unplanned revascularization mainly contributed to this excess of MACE.
|
|
| 3. |
|
|
| 4. |
- Escaned, Javier, et al.
(författare)
-
Applied coronary physiology for planning and guidance of percutaneous coronary interventions. A clinical consensus statement from the European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the European Society of Cardiology
- 2023
-
Ingår i: EuroIntervention. - : Europa Digital & Publishing. - 1774-024X .- 1969-6213. ; 19:6, s. 464-
-
Tidskriftsartikel (refereegranskat)abstract
- The clinical value of fractional flow reserve and non-hyperaemic pressure ratios are well established in determining an indication for percutaneous coronary intervention (PCI) in patients with coronary artery disease (CAD). In addition, over the last 5 years we have witnessed a shift towards the use of physio-logy to enhance procedural planning, assess post-PCI functional results, and guide PCI optimisation. In this regard, clinical studies have reported compelling data supporting the use of longitudinal vessel analysis, obtained with pressure guidewire pullbacks, to better understand how obstructive CAD contributes to myocardial ischaemia, to establish the likelihood of functionally successful PCI, to identify the presence and location of residual flow-limiting stenoses and to predict long-term outcomes. The introduction of new functional coronary angiography tools, which merge angiographic information with fluid dynamic equations to deliver information equivalent to intracoronary pressure measurements, are now available and potentially also applicable to these endeavours. Furthermore, the ability of longitudinal vessel analysis to predict the functional results of stenting has played an integral role in the evolving field of simulated PCI. Nevertheless, it is important to have an awareness of the value and challenges of physiology-guided PCI in specific clinical and anatomical contexts. The main aim of this European Association of Percutaneous Cardiovascular Interventions clinical consensus statement is to offer up-to-date evidence and expert opin-ion on the use of applied coronary physiology for procedural PCI planning, disease pattern recognition and post-PCI optimisation.
|
|
| 5. |
- Garcia-Moreno, Hector, et al.
(författare)
-
Tau and neurofilament light-chain as fluid biomarkers in spinocerebellar ataxia type 3
- 2022
-
Ingår i: European Journal of Neurology. - : Wiley. - 1351-5101 .- 1468-1331. ; 29:8, s. 2439-2452
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND PURPOSE: Clinical trials in spinocerebellar ataxia type 3 (SCA3) will require biomarkers for use as outcome measures.METHODS: To evaluate total tau (t-tau), glial fibrillary acidic protein (GFAP), ubiquitin carboxy-terminal hydrolase L1 (UCHL1) and neurofilament light-chain (NfL) as fluid biomarkers in SCA3, ATXN3 mutation carriers (n = 143) and controls (n = 172) were clinically assessed, and the plasma concentrations of the four proteins were analysed on the Simoa HD-1 platform. Eleven ATXN3 mutation carrier cerebrospinal fluid samples were analysed for t-tau and phosphorylated tau (p-tau181 ). A transgenic SCA3 mouse model (MJDTg) was used to measure cerebellar t-tau levels.RESULTS: Plasma t-tau levels were higher in mutation carriers below the age of 50 compared to controls, and the Inventory of Non-Ataxia Signs was associated with t-tau in ataxic patients (p = 0.004). Pre-ataxic carriers showed higher cerebrospinal fluid t-tau and p-tau181 concentrations compared to ataxic patients (p = 0.025 and p = 0.014, respectively). Cerebellar t-tau was elevated in MJDTg mice compared to wild-type (p = 0.033) only in the early stages of the disease. GFAP and UCHL1 did not show higher levels in mutation carriers compared to controls. Plasma NfL concentrations were higher in mutation carriers compared to controls, and differences were greater for younger carriers. The Scale for the Assessment and Rating of Ataxia was the strongest predictor of NfL in ataxic patients (p < 0.001).CONCLUSION: Our results suggest that tau might be a marker of early disease stages in SCA3. NfL can discriminate mutation carriers from controls and is associated with different clinical variables. Longitudinal studies are required to confirm their potential role as biomarkers in clinical trials.
|
|
| 6. |
- Raposo, Hugo, et al.
(författare)
-
An integrated econometric model for bus replacement and determination of reserve fleet size based on predictive maintenance
- 2017
-
Ingår i: Eksploatacja i Niezawodność – Maintenance and Reliability. - : Polish Academy of Sciences. - 1507-2711 .- 2956-3860. ; 19:3, s. 358-368
-
Tidskriftsartikel (refereegranskat)abstract
- Maintenance policies influence equipment availability and, thus, they affect a company’s capacity for productivity and competitiveness. It is important to optimize the Life Cycle Cost (LCC) of assets, in this case, passenger bus fleets. The paper presents a predictive condition monitoring maintenance approach based on engine oil analysis, to assess the potential impact of this variable on the availability of buses. The approach has implications on maintenance costs during the life of a bus and, consequently, on the determination of the best time for bus replacement. The paper provides an overview of economic replacement models through a global model, with an emphasis on availability and its dependence on maintenance and maintenance costs. These factors help to determine the size of the reserve fleet and guarantee availability
|
|
| 7. |
- Raposo, Hugo David Nogueira, et al.
(författare)
-
Reserve Fleet Indexed To Exogenous Cost Variables
- 2019
-
Ingår i: Transport. - : VGTU Press. - 1648-4142 .- 1648-3480. ; 34:4, s. 437-454
-
Tidskriftsartikel (refereegranskat)abstract
- Identifying the optimal time to replace a passenger bus in a buses fleet has implications on the size of the reserve fleet. Such calculations rest on endogenous and exogenous economic variables: the former include operating and maintenance costs and bus depreciation; the latter include market imponderables such as the inflation and real discount rates, as well as energy costs, particularly fuel. The authors have created models for the withdrawal/replacement of buses using endogenous economic variables. The models include standard econometric models reflecting the influence of maintenance policies, especially Condition Monitoring (CM) or predictive maintenance, and the size of the reserve fleet. The paper deals with exogenous economic variables, specifically the influence of the cost of money, the inflation and real discount rates rate and the cost of fuel. Both variables fluctuate over time. The paper proposes analytical models for determining the influence of those variables on the withdrawal time and the size of the reserve fleet. It then comprehensively summarizes the variables in a global model, showing its relevance to the dimensioning of the reserve fleet and the withdrawal time.
|
|
| 8. |
- Raposo, Hugo, et al.
(författare)
-
Dimensioning reserve bus fleet using life cycle cost models and condition based/predictive maintenance: a case study
- 2018
-
Ingår i: Public Transport. - : Springer. - 1866-749X .- 1613-7159. ; 10:1, s. 169-190
-
Tidskriftsartikel (refereegranskat)abstract
- The paper demonstrates the dependence of a fleet reserve of buses on the maintenance policy of the whole fleet, in particular, condition-based maintenance using a motor oil degradation analysis. The paper discusses an approach to evaluate the oil degradation and the prediction of the next value for one relevant oil variable. The methodology to evaluate the reserve fleet is based on bus availability, estimated through the mean time between failures and the mean time to repair ratios. Through the use of econometric models, it is possible to determine the most rational size of the reserve fleet.
|
|
| 9. |
- Thim, Troels, et al.
(författare)
-
Evaluation and Management of Nonculprit Lesions in STEMI
- 2020
-
Ingår i: JACC: Cardiovascular Interventions. - : Elsevier BV. - 1936-8798. ; 13:10, s. 1145-1154
-
Forskningsöversikt (refereegranskat)abstract
- Nonculprit lesions are frequently observed in patients with ST-segment elevation myocardial infarction. Results from recent randomized clinical trials suggest that complete revascularization after ST-segment elevation myocardial infarction improves outcomes. In this state-of-the-art paper, the authors review these trials and consider how best to determine which nonculprit lesions require revascularization and when this should be performed.
|
|
