| 1. |
|
|
| 2. |
- Bravo, L, et al.
(author)
-
- 2021
-
swepub:Mat__t
|
|
| 3. |
- Tabiri, S, et al.
(author)
-
- 2021
-
swepub:Mat__t
|
|
| 4. |
- Thomas, HS, et al.
(author)
-
- 2019
-
swepub:Mat__t
|
|
| 5. |
|
|
| 6. |
- Khatri, C, et al.
(author)
-
Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
- 2021
-
In: BMJ open. - : BMJ. - 2044-6055. ; 11:11, s. e050830-
-
Journal article (peer-reviewed)abstract
- Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis.SettingProspective, international, multicentre, observational cohort study.ParticipantsPatients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative).Primary outcome30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality.ResultsThis study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p<0.001), age >80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787).ConclusionsPatients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups.Trial registration numberNCT04323644
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
- Hyde, K. D., et al.
(author)
-
Global consortium for the classification of fungi and fungus-like taxa
- 2023
-
In: MYCOSPHERE. - : Mushroom Research Foundation. - 2077-7000 .- 2077-7019. ; 14:1, s. 1960-2012
-
Journal article (peer-reviewed)abstract
- The Global Consortium for the Classification of Fungi and fungus-like taxa is an international initiative of more than 550 mycologists to develop an electronic structure for the classification of these organisms. The members of the Consortium originate from 55 countries/regions worldwide, from a wide range of disciplines, and include senior, mid-career and early-career mycologists and plant pathologists. The Consortium will publish a biannual update of the Outline of Fungi and fungus-like taxa, to act as an international scheme for other scientists. Notes on all newly published taxa at or above the level of species will be prepared and published online on the Outline of Fungi website (https://www.outlineoffungi.org/), and these will be finally published in the biannual edition of the Outline of Fungi and fungus-like taxa. Comments on recent important taxonomic opinions on controversial topics will be included in the biannual outline. For example, 'to promote a more stable taxonomy in Fusarium given the divergences over its generic delimitation', or 'are there too many genera in the Boletales?' and even more importantly, 'what should be done with the tremendously diverse 'dark fungal taxa?' There are undeniable differences in mycologists' perceptions and opinions regarding species classification as well as the establishment of new species. Given the pluralistic nature of fungal taxonomy and its implications for species concepts and the nature of species, this consortium aims to provide a platform to better refine and stabilise fungal classification, taking into consideration views from different parties. In the future, a confidential voting system will be set up to gauge the opinions of all mycologists in the Consortium on important topics. The results of such surveys will be presented to the International Commission on the Taxonomy of Fungi (ICTF) and the Nomenclature Committee for Fungi (NCF) with opinions and percentages of votes for and against. Criticisms based on scientific evidence with regards to nomenclature, classifications, and taxonomic concepts will be welcomed, and any recommendations on specific taxonomic issues will also be encouraged; however, we will encourage professionally and ethically responsible criticisms of others' work. This biannual ongoing project will provide an outlet for advances in various topics of fungal classification, nomenclature, and taxonomic concepts and lead to a community-agreed classification scheme for the fungi and fungus-like taxa. Interested parties should contact the lead author if they would like to be involved in future outlines.
|
|
| 10. |
-
- 2019
-
Journal article (peer-reviewed)
|
|
| 11. |
|
|
| 12. |
|
|
| 13. |
|
|
| 14. |
- Young, William J., et al.
(author)
-
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
- 2022
-
In: Nature Communications. - : Springer Nature. - 2041-1723. ; 13
-
Journal article (peer-reviewed)abstract
- The QT interval is a heritable electrocardiographic measure associated with arrhythmia risk when prolonged. Here, the authors used a series of genetic analyses to identify genetic loci, pathways, therapeutic targets, and relationships with cardiovascular disease. The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identify associations with Mendelian disease genes. Enrichments are observed in established pathways for QT and JT, and previously unreported genes indicated in insulin-receptor signalling and cardiac energy metabolism. In contrast for QRS, connective tissue components and processes for cell growth and extracellular matrix interactions are significantly enriched. We demonstrate polygenic risk score associations with atrial fibrillation, conduction disease and sudden cardiac death. Prioritization of druggable genes highlight potential therapeutic targets for arrhythmia. Together, these results substantially advance our understanding of the genetic architecture of ventricular depolarization and repolarization.
|
|
| 15. |
- Combe, B, et al.
(author)
-
2016 update of the EULAR recommendations for the management of early arthritis
- 2017
-
In: Annals of the rheumatic diseases. - : BMJ. - 1468-2060 .- 0003-4967. ; 76:6, s. 948-959
-
Journal article (peer-reviewed)abstract
- Since the 2007 recommendations for the management of early arthritis have been presented, considerable research has been published in the field of early arthritis, mandating an update of the 2007 European League Against Rheumatism (EULAR) recommendations for management of early arthritis.MethodsIn accordance with the 2014 EULAR Standardised Operating Procedures, the expert committee pursued an approach that was based on evidence in the literature and on expert opinion. The committee involved 20 rheumatologists, 2 patients and 1 healthcare professional representing 12 European countries. The group defined the focus of the expert committee and target population, formulated a definition of ‘management’ and selected the research questions. A systematic literature research (SLR) was performed by two fellows with the help of a skilled librarian. A set of draft recommendations was proposed on the basis of the research questions and the results of the SLR. For each recommendation, the categories of evidence were identified, the strength of recommendations was derived and the level of agreement was determined through a voting process.ResultsThe updated recommendations comprise 3 overarching principles and 12 recommendations for managing early arthritis. The selected statements involve the recognition of arthritis, referral, diagnosis, prognostication, treatment (information, education, pharmacological and non-pharmacological interventions), monitoring and strategy. Eighteen items were identified as relevant for future research.ConclusionsThese recommendations provide rheumatologists, general practitioners, healthcare professionals, patients and other stakeholders with an updated EULAR consensus on the entire management of early arthritis.
|
|
| 16. |
|
|
| 17. |
- Afzal, Muhammad, et al.
(author)
-
Synthesis of Ba0.3Ca0.7Co0.8Fe0.2O3-δ composite material as novel catalytic cathode for ceria-carbonate electrolyte fuel cells
- 2015
-
In: Electrochimica Acta. - : Pergamon Press. - 0013-4686 .- 1873-3859. ; 178, s. 385-391
-
Journal article (peer-reviewed)abstract
- This work reports a new composite BaxCa1-xCoyFe1-yO3-delta (BCCF) cathode material for advanced and low temperature solid oxide fuel cells (SOFCs). The BCCF-based composite material was synthesized by sol gel method and investigated as a catalytic cathode for low temperature (LT) SOFCs. XRD analysis of the as-prepared material revealed the dominating BCCF perovskite structure as the main phase accompanied with cobalt and calcium oxides as the secondary phases resulting into an overall composite structure. Structure and morphology of the sample was observed by Field Emission Scanning Electron Microscope (FE-SEM). In particular, the Ba0.3Ca0.7Co0.8Fe0.2O3-delta (BCCF37) showed a maximum conductivity of 143 S cm(-1) in air at 550 degrees C measured by DC 4 probe method. The BCCF at the optimized composition exhibited much higher electrical conductivities than the commercial Ba0.5Sr0.5Co0.8Fe0.2O3-delta (BSCF) perovskite cathode material. A maximum power density of 325 mW cm(-2) at 550 degrees C is achieved for the ceria-carbonate electrolyte fuel cell with BCCF37 as the cathode material.
|
|
| 18. |
- Ahmed, Anisuddin, et al.
(author)
-
Measuring the effectiveness of an integrated intervention package to improve the level of infection prevention and control : a multi-centre study in Bangladesh
- 2024
-
In: Journal of Hospital Infection. - : Elsevier. - 0195-6701 .- 1532-2939. ; 145, s. 22-33
-
Journal article (peer-reviewed)abstract
- Background: Infection prevention and control (IPC) is a critical component of delivering safe, effective and high -quality healthcare services, and eliminating avoidable healthcare -associated infections (HAIs) in health facilities, predominantly in populationdense settings such as Bangladesh.Aim: Our study aimed to assess the effect of an integrated intervention package in improving the IPC level of the health facilities in Bangladesh.Methods: We conducted a pre -post intervention study in six district hospitals (DHs) and 13 Upazila Health Complexes (UHCs) in the six districts of Bangladesh. Baseline and endline assessments were conducted between March and December 2021 using the adapted World Health Organization Infection Prevention and Control Assessment Framework (WHO-IPCAF) tool. The IPCAF score, ranging from 0-800, was calculated by adding the scores of eight components, and the IPC promotion and practice level was categorized as Inadequate (0 -200), Basic (201-400), Intermediate (401-600) and Advanced (601-800). The integrated intervention package including IPC committee formation, healthcare provider training, logistics provision, necessary guidelines distribution, triage/flu corners establishment, and infrastructure development was implemented in all facilities.Results: The average IPCAF score across all the facilities showed a significant increase from 16% (95% CI: 11.5-20.65%) to 54% (95% CI: 51.4-57.1%). Overall, the IPCAF score increased by 34 percentage points (P<0.001) in DHs and 40 percentage points (P<0.001) in UHCs. Following the intervention, 12 (three DHs, nine UHCs) of 19 facilities progressed from inadequate to intermediate, and another three DHs upgraded from basic to intermediate in terms of IPC level.Conclusion: The integrated intervention package improved IPCAF score in all facilities.
|
|
| 19. |
|
|
| 20. |
|
|
| 21. |
|
|
| 22. |
- Reinert, Line S, et al.
(author)
-
Brain immune cells undergo cGAS-STING-dependent apoptosis during herpes simplex virus type 1 infection.
- 2020
-
In: The Journal of clinical investigation. - 1558-8238. ; 131:1
-
Journal article (peer-reviewed)abstract
- Protection of the brain from viral infections involves the type I interferon (IFN-I) system, defects in which renders humans susceptible to herpes simplex encephalitis (HSE). However, excessive cerebral IFN-I levels leads to pathologies, suggesting the need for tight regulation of responses. Based on data from mouse models, human HSE cases, and primary cell culture systems, we here show that microglia and other immune cells undergo apoptosis in the HSV-1-infected brain through a mechanism dependent on the cyclic GMP-AMP synthase (cGAS) - stimulator of interferon genes (STING) pathway, but independent of IFN-I. HSV-1 infection of microglia induced cGAS-dependent apoptosis at high viral doses, while lower viral doses led to IFN-I responses. Importantly, inhibition of caspase activity prevented microglial cell death and augmented IFN-I responses. Accordingly, HSV-1-infected organotypic brain slices, or mice treated with caspase inhibitor, exhibited lower viral load and improved outcome of infection. Collectively, we identify an activation-induced apoptosis program in brain immune cells which down-modulates local immune responses.
|
|
| 23. |
|
|
| 24. |
- Afzal, Muhammad, et al.
(author)
-
Charge transfer, transportation, and simulation
- 2020
-
In: Solid Oxide Fuel Cells. - : Wiley. ; , s. 319-246
-
Book chapter (peer-reviewed)abstract
- This chapter discusses charge transfer and transportation in energy materials and devices, especially focusing on single layer or electrolyte-free fuel cells (EFFCs). Here, charge means electrons and both positive and negative ions, e.g. H+ and O2-. We will study the factors that affect the charges resulting in conduction either externally for electrons or internally for both electrons and ions in EFFCs. Theoretical simulations are carried out by considering specific characteristics EFFC processes. Moreover, the enhancement in ionic conductivity is discussed leading to superionic conduction.
|
|
| 25. |
- Ali, Amjad, et al.
(author)
-
A potential electrolyte (Ce1-x CaxO2-delta) for fuel cells:Theoretical andexperimental study
- 2018
-
In: Ceramics International. - : ELSEVIER SCI LTD. - 0272-8842 .- 1873-3956. ; 44:11, s. 12676-12683
-
Journal article (peer-reviewed)abstract
- First-principles calculations are performed using density function theory to explore the effects of dopant Ca in ceria (Ce1-x CaxO2-delta). The impact of oxygen vacancy on band gap and density of states is examined in doped ceria using generalized gradient approximations. Vacancy association and vacancy formation energies of the doped ceria are calculated to reveal the effect of dopant on ion conduction. The experimental study of the sample Ce0.875Ca0.125O2-delta) was performed to compare with the theoretical results. The obtained results from theoretical calculation and experimental techniques show that oxygen vacancy increases the volume, lattice constant (5.47315 angstrom) but decrease the band gap (1.72 eV) and bulk modulus. The dopant radius (1.173 angstrom) and lattice constant (5.4718 angstrom) are also calculated by equations which is close to the DFT lattice parameter. The result shows that oxygen vacancy shifts the density of states to lower energy region. Band gap is decreased due to shifting of valence states to conduction band. Vacancy formation shows a significance increase in density of states near the Fermi level. Density of states at Fermi level is proportional to the conductivity, so an increase in density of states near the Fermi level increases the conductivity. The experimental measured ionic conductivity is found to 0.095 S cm(-1) at 600 degrees C. The microstructural studies is also reported in this work.
|
|
| 26. |
|
|
| 27. |
- De Souza, S, et al.
(author)
-
PATIENT AND PUBLIC INVOLVEMENT IN CLINICAL TRIAL DESIGN
- 2020
-
In: ANNALS OF THE RHEUMATIC DISEASES. - : BMJ. - 0003-4967 .- 1468-2060. ; 79, s. 1285-1286
-
Conference paper (other academic/artistic)abstract
- Patient and public involvement (PPI) is gaining increasing recognition as important in ensuring research is relevant and acceptable to participants. Rheuma Tolerance for Cure (RTCure) is a 5 year international collaboration between academia and industry; focusing on earlier detection and prevention of rheumatoid arthritis (RA) through the use of immune-tolerising treatments.Objectives:To bring lived experience and insight into scientific discussions; and to evolve collaboration between lay representatives and academia/industry.Methods:9 Patient Research Partners (PRPs) from 5 European countries were recruited via the EULAR PARE Network and institutions within the RTCure Consortium (8 PRPs with RA and 1 ‘at risk’). They were asked to enter into a legal agreement with the Consortium. PRPs participated in teleconferences (TCs) and were invited to attend face-to-face (F2F) meetings at least annually. Requests for input/feedback were sent from researchers to PRPs via the project’s Patient Engagement Expert [SK].Results:PRP involvement has given researchers and industry partners a new perspective on patient priorities, and focused thought on the ethics of recruitment for and participation in clinical trials of people ‘at risk’ of developing RA. PRPs have helped define the target populations, given their thoughts on what types of treatments are acceptable to people ‘at risk’ and have aided the development of a survey (sent to EULAR PARE members) regarding the use of animal models in biomedical research. Positive informal feedback has been received from researchers and industry regarding the contribution of PRPs to the ongoing project (formal evaluation of PPI in RTCure will be carried out in 2020 and at the project end in 2022).Challenges:Legal agreements- Many PRPs refused to sign the Consortium’s complex PRP Agreement; feeling it unnecessary, incomprehensible and inequitable. After extensive consultation with various parties (including EULAR and the Innovative Medicines Initiative) no similar contract was found. Views for its requirement even varied between legal experts. After 2 years of intense discussion, a simple non-disclosure agreement was agreed upon. Ideally any contract, if required, should be approved prior to project onset.Meeting logistics- Other improvements identified were to locate the meeting venue and accommodation on the same site to minimise travel, and to make it easier for PRPs to take breaks when required. This also facilitates informal discussions and patient inclusivity. We now have agreed a policy to fund PRPs extra nights before and after meetings, and to bring a carer if needed.Enabling understanding– Future annual meetings will start with a F2F meeting between PRPs and Work Package Leads. Researchers will be encouraged to start presentations with a summary slide in lay language. Additionally, an RTCure Glossary is in development.Enabling participation– SK will provide monthly project updates and PRP TCs will be held in the evening (as some PRPs remain employed). PRPs will be invited to all project TCs and F2F meetings. Recruitment is underway to increase the number of ‘at risk’ PRPs as their viewpoint is vital to this study.Conclusion:Currently PPI in RTCure is an ongoing mutual learning process. Universal guidance regarding what types of contracts are needed for PPI would be useful. Communication, trust and fruitful discussions have evolved through F2F meetings (both formal and informal) between PRPs, academia and industry. It is important that all parties can be open with each other in order to make PPI more meaningful.Acknowledgments:This work has received support from the EU/EFPIA Innovative Medicines Initiative 2 Joint Undertaking RTCure grant number 777357.Disclosure of Interests:Savia de Souza: None declared, Ruth Williams: None declared, Eva Johansson: None declared, Codruta Zabalan: None declared, Tom Esterine: None declared, Margôt Bakkers: None declared, Wolfgang Roth: None declared, Neil Mc Carthy: None declared, Meryll Blake: None declared, Susanne Karlfeldt: None declared, Martina Johannesson: None declared, Karim Raza Grant/research support from: KR has received research funding from AbbVie and Pfizer, Consultant of: KR has received honoraria and/or consultancy fees from AbbVie, Sanofi, Lilly, Bristol-Myers Squibb, UCB, Pfizer, Janssen and Roche Chugai, Speakers bureau: KR has received honoraria and/or consultancy fees from AbbVie, Sanofi, Lilly, Bristol-Myers Squibb, UCB, Pfizer, Janssen and Roche Chugai
|
|
| 28. |
- Figueiredo, S., et al.
(author)
-
ARCADIAN-IoT - Enabling Autonomous Trust, Security and Privacy Management for IoT
- 2022
-
In: Lect. Notes Comput. Sci. 5th The Global IoT Summit, GIoTS 2022. Dublin 20 June 2022 through 23 June 2022. - Cham : Springer Science and Business Media Deutschland GmbH. - 9783031209352 ; , s. 348-359
-
Conference paper (peer-reviewed)abstract
- Cybersecurity incidents have been growing both in number and associated impact, as a result from society’s increased dependency in information and communication technologies - accelerated by the recent pandemic. In particular, IoT. technologies, which enable significant flexibility and cost-efficiency, but are also associated to more relaxed security mechanisms, have been quickly adopted across all sectors of the society, including critical infrastructures (e.g. smart grids) and services (e.g. eHealth). Gaps such as high dependence on 3rd party IT suppliers and device manufacturers increase the importance of trustworthy and secure solutions for future digital services. This paper presents ARCADIAN-IoT, a framework aimed at holistically enabling trust, security, privacy and recovery in IoT systems, and enabling a Chain of Trust between the different IoT entities (persons, objects and services). It builds on features such as federated AI for effective and privacy-preserving cybersecurity, distributed ledger technologies for decentralized management of trust, or transparent, user-controllable and decentralized privacy. © 2022, The Author(s)
|
|
| 29. |
- Freedman, Kevin J., et al.
(author)
-
Nonequilibrium Capture Rates Induce Protein Accumulation and Enhanced Adsorption to Solid-State Nanopores
- 2014
-
In: ACS Nano. - : American Chemical Society (ACS). - 1936-0851 .- 1936-086X. ; 8:12, s. 12238-12249
-
Journal article (peer-reviewed)abstract
- Single molecule capturing of analytes using an electrically biased nanopore is the fundamental mechanism in which nearly all nanopore experiments are conducted. With pore dimensions being on the order of a single molecule, the spatial zone of sensing only contains approximately a zeptoliter of volume. As a result, nanopores offer high precision sensing within the pore but provide little to no information about the analytes outside the pore. In this study, we use capture frequency and rate balance theory to predict and study the accumulation of proteins at the entrance to the pore. Protein accumulation is found to have positive attributes such as capture rate enhancement over time but can additionally lead to negative effects such as long-term blockages typically attributed to protein adsorption on the surface of the pore. Working with the folded and unfolded states of the protein domain PDZ2 from SAP97, we show that applying short (e.g., 3-25 s in duration) positive voltage pulses, rather than a constant voltage, can prevent long-term current blockades (i.e., adsorption events). By showing that the concentration of proteins around the pore can be controlled in real time using modified voltage protocols, new experiments can be explored which study the role of concentration on single molecular kinetics including protein aggregation, folding, and protein binding.
|
|
| 30. |
- Gerlag, Danielle M., et al.
(author)
-
EULAR recommendations for terminology and research in individuals at risk of rheumatoid arthritis : report from the Study Group for Risk Factors for Rheumatoid Arthritis
- 2012
-
In: Annals of the Rheumatic Diseases. - : BMJ. - 0003-4967 .- 1468-2060. ; 71:5, s. 638-641
-
Journal article (peer-reviewed)abstract
- The Study Group for Risk Factors for Rheumatoid Arthritis was established by the EULAR Standing Committee on Investigative Rheumatology to facilitate research into the preclinical and earliest clinically apparent phases of rheumatoid arthritis (RA). This report describes the recommendation for terminology to be used to define specific subgroups during different phases of disease, and defines the priorities for research in this area. Terminology was discussed by way of a three-stage structured process: A provisional list of descriptors for each of the possible phases preceding the diagnosis of RA were circulated to members of the study group for review and feedback. Anonymised comments from the members on this list were fed back to participants before a 2-day meeting. 18 participants met to discuss these data, agree terminologies and prioritise important research questions. The study group recommended that, in prospective studies, individuals without RA are described as having: genetic risk factors for RA; environmental risk factors for RA; systemic autoimmunity associated with RA; symptoms without clinical arthritis; unclassified arthritis; which may be used in a combinatorial manner. It was recommended that the prefix 'pre-RA with:' could be used before any/any combination of the five points above but only to describe retrospectively a phase that an individual had progressed through once it was known that they have developed RA. An approach to dating disease onset was recommended. In addition, important areas for research were proposed, including research of other tissues in which an adaptive immune response may be initiated, and the identification of additional risk factors and biomarkers for the development of RA, its progression and the development of extra-articular features. These recommendations provide guidance on approaches to describe phases before the development of RA that will facilitate communication between researchers and comparisons between studies. A number of research questions have been defined, requiring new cohorts to be established and new techniques to be developed to image and collect material from different sites.
|
|
| 31. |
- Hussain, F., et al.
(author)
-
Electrochemical investigation of multi-fuel based low temperature nano-composite anode for solid oxide fuel cell
- 2019
-
In: Journal of Power Sources. - : Elsevier B.V.. - 0378-7753 .- 1873-2755. ; 425, s. 147-152
-
Journal article (peer-reviewed)abstract
- Extensive efforts have been made in order to develop multi-fuel-based low temperature solid oxide fuel cell for direct conversion of hydrocarbons to electric power. It is extremely difficult to operate due to the C–H activation and its tremendously sluggish oxidation reduction in the low temperature range from 300 to 600 °C. The structural and electrochemical properties of novel anode material Ni 0.6 (Ba 0.3 Ce 0.2 Zn 0.5 ) 0.4 have been investigated in the presence of hydrogen, natural gas, ethanol, glucose, and sugar-cane at low temperature of 600 °C. Through sol-gel method the proposed oxide material is synthesized. The composite average crystalline size has been found 25–90 nm by both scanning electron microscopy and X-ray diffraction techniques. The ultraviolet– visible and Fourier transform infrared techniques are used to determine band gap and absorption spectrum respectively. The power density of the cell at various fuels has been observed and measurements indicate that it varies from 57 to 315 mWcm −2 at 600 °C among different fuels at anode side. The current study reveals that proposed anode Ni 0.6 (Ba 0.3 Ce 0.2 Zn 0.5 ) 0.4 is promising multi-fuel anode material for low-temperature solid oxide fuel cell, and it does not need to reform hydrocarbon fuels in order to fully utilize the advantage of these cells.
|
|
| 32. |
- Khan, M. Ajmal, et al.
(author)
-
Effect of titania concentration on the grain boundary conductivity of calcium-doped ceria electrolyte
- 2014
-
In: Ceramics International. - : Elsevier BV. - 0272-8842 .- 1873-3956. ; 40:7, s. 9775-9781
-
Journal article (peer-reviewed)abstract
- A solid-state technique was used to synthesize ceria-based (CDC-xT, in which x=0-1 mol%) solid electrolyte ceramics. The effects of doping the ceramic solid electrolyte (CDC) with titanium oxide were studied with regard to densification, crystal structure, morphology, electro-impedance spectroscopy and fuel cell performance. TiO2 doping afforded materials a 95% relative density at 940 degrees C, approximately 200 degrees C lower than the temperature required without titanium oxide. The addition of titanium oxide (TiO2) reduced the CDC sintering temperature and significantly improved the grain boundary conduction. The minimum grain boundary resistivity was obtained at 0.8 mol% TiO2. X-ray diffraction (XRD) results showed that the lattice parameters enhanced with increased titanium oxide concentrations up to 0.8 mol%, revealing the solubility limit for Caria's fluorite structure. The optimum doping level (0.8 mol%) is provided maximum conductivity. Conductivities were measured using EIS (Electrochemical Impedance Spectroscopy) with a two-probe method, and the activation energies were calculated using the Arrhenius plots. The maximum power density (660 mW/cm(2)) was achieved with CDC 0.8T electrolyte at 650 degrees C using LiCuZnNi oxide electrodes.
|
|
| 33. |
- Knitza, J, et al.
(author)
-
Toward Earlier Diagnosis Using Combined eHealth Tools in Rheumatology: The Joint Pain Assessment Scoring Tool (JPAST) Project
- 2020
-
In: JMIR mHealth and uHealth. - : JMIR Publications Inc.. - 2291-5222. ; 8:5, s. e17507-
-
Journal article (peer-reviewed)abstract
- Outcomes of patients with inflammatory rheumatic diseases have significantly improved over the last three decades, mainly due to therapeutic innovations, more timely treatment, and a recognition of the need to monitor response to treatment and to titrate treatments accordingly. Diagnostic delay remains a major challenge for all stakeholders. The combination of electronic health (eHealth) and serologic and genetic markers holds great promise to improve the current management of patients with inflammatory rheumatic diseases by speeding up access to appropriate care. The Joint Pain Assessment Scoring Tool (JPAST) project, funded by the European Union (EU) European Institute of Innovation and Technology (EIT) Health program, is a unique European project aiming to enable and accelerate personalized precision medicine for early treatment in rheumatology, ultimately also enabling prevention. The aim of the project is to facilitate these goals while at the same time, reducing cost for society and patients.
|
|
| 34. |
|
|
| 35. |
- Mushtaq, N., et al.
(author)
-
Perovskite SrFe1-xTixO3-δ (x < = 0.1) cathode for low temperature solid oxide fuel cell
- 2018
-
In: Ceramics International. - : Elsevier. - 0272-8842 .- 1873-3956. ; 44:9, s. 10266-10272
-
Journal article (peer-reviewed)abstract
- Stable and compatible cathode materials are a key factor for realizing the low-temperature (LT, ≤600 °C) operation and practical implementations of solid oxide fuel cells (SOFCs). In this study, perovskite oxides SrFe1-xTixO3-δ (x < = 0.1), with various ratios of Ti doping, are prepared by a sol-gel method for cathode material for LT-SOFCs. The structure, morphology and thermo-gravimetric characteristics of the resultant SFT powders are investigated. It is found that the Ti is successfully doped into SrFeO3-δ to form a single phase cubic perovskite structure and crystal structure of SFT shows better stability than SrFeO3-δ. The dc electrical conductivity and electrochemical properties of SFT are measured and analysed by four-probe and electrochemical impedance spectra (EIS) measurements, respectively. The obtained SFT exhibits a very low polarization resistance (Rp),.01 Ωcm2 at 600◦C. The SFT powders using as cathode in fuel cell devices, exhibit maximum power density of 551 mW cm−2 with open circuit voltage (OCV) of 1.15 V at 600◦C. The good performance of the SFT cathode indicates a high rate of oxygen diffusion through the material at cathode. By enabling operation at low temperatures, SFT cathodes may result in a practical implementation of SOFCs.
|
|
| 36. |
- Naqvi, Salman Raza, et al.
(author)
-
Pyrolysis of high-ash sewage sludge : Thermo-kinetic study using TGA and artificial neural networks
- 2018
-
In: Fuel. - Oxon, UK : Elsevier Ltd. - 0016-2361 .- 1873-7153. ; 233, s. 529-538
-
Journal article (peer-reviewed)abstract
- Pyrolysis of high-ash sewage sludge (HASS) is a considered as an effective method and a promising way for energy production from solid waste of wastewater treatment facilities. The main purpose of this work is to build knowledge on pyrolysis mechanisms, kinetics, thermos-gravimetric analysis of high-ash (44.6%) sewage sludge using model-free methods & results validation with artificial neural network (ANN). TG-DTG curves at 5,10 and 20 °C/min showed the pyrolysis zone was divided into three zone. In kinetics, E values of models ranges are; Friedman (10.6–306.2 kJ/mol), FWO (45.6–231.7 kJ/mol), KAS (41.4–232.1 kJ/mol) and Popescu (44.1–241.1 kJ/mol) respectively. ΔH and ΔG values predicted by OFW, KAS and Popescu method are in good agreement and ranged from (41–236 kJ/mol) and 53–304 kJ/mol, respectively. Negative value of ΔS showed the non-spontaneity of the process. An artificial neural network (ANN) model of 2 * 5 * 1 architecture was employed to predict the thermal decomposition of high-ash sewage sludge, showed a good agreement between the experimental values and predicted values (R2 ⩾ 0.999) are much closer to 1. Overall, the study reflected the significance of ANN model that could be used as an effective fit model to the thermogravimetric experimental data. © 2018 Elsevier Ltd
|
|
| 37. |
- Phukhamsakda, Chayanard, et al.
(author)
-
The numbers of fungi: contributions from traditional taxonomic studies and challenges of metabarcoding
- 2022
-
In: Fungal diversity. - : Springer Science and Business Media LLC. - 1560-2745 .- 1878-9129. ; 114:1, s. 327-386
-
Journal article (peer-reviewed)abstract
- The global diversity of fungi has been estimated using several different approaches. There is somewhere between 2–11 million estimated species, but the number of formally described taxa is around 150,000, a tiny fraction of the total. In this paper, we examine 12 ascomycete genera as case studies to establish trends in fungal species descriptions, and introduce new species in each genus. To highlight the importance of traditional morpho-molecular methods in publishing new species, we introduce novel taxa in 12 genera that are considered to have low species discovery. We discuss whether the species are likely to be rare or due to a lack of extensive sampling and classification. The genera are Apiospora, Bambusicola, Beltrania, Capronia, Distoseptispora, Endocalyx, Neocatenulostroma, Neodeightonia, Paraconiothyrium, Peroneutypa, Phaeoacremonium and Vanakripa. We discuss host-specificity in selected genera and compare the number of species epithets in each genus with the number of ITS (barcode) sequences deposited in GenBank and UNITE. We furthermore discuss the relationship between the divergence times of these genera with those of their hosts. We hypothesize whether there might be more species in these genera and discuss hosts and habitats that should be investigated for novel species discovery.
|
|
| 38. |
|
|
| 39. |
|
|
| 40. |
- Raza, Karim, et al.
(author)
-
Delays in assessment of patients with rheumatoid arthritis: variations across Europe
- 2011
-
In: Annals of the Rheumatic Diseases. - London : BMJ. - 1468-2060 .- 0003-4967. ; 70:10, s. 1822-1825
-
Journal article (peer-reviewed)abstract
- Objective The first 3 months after symptom onset represent an important therapeutic window for rheumatoid arthritis (RA). This study investigates the extent and causes of delay in assessment of patients with RA in eight European countries. Method Data on the following levels of delay were collected from 10 centres (Berlin, Birmingham, Heraklion, Lund, Prague, Stockholm, Umea, Vienna, Warsaw and Zurich): (1) from onset of RA symptoms to request to see healthcare professional (HCP); (2) from request to see HCP to assessment by that HCP; (3) from initial assessment by HCP to referral to rheumatologist; and (4) from referral to rheumatologist to assessment by that rheumatologist. Results Data were collected from 482 patients with RA. The median delay across the 10 centres from symptom onset to assessment by the rheumatologist was 24 weeks, with the percentage of patients seen within 12 weeks of symptom onset ranging from 8% to 42%. There were important differences in the levels underlying the total delays at individual centres. Conclusions This research highlights the contribution of patients, professionals and health systems to treatment delay for patients with RA in Europe. Although some centres have strengths in minimising certain types of delay, interventions are required in all centres to ensure timely treatment for patients.
|
|
| 41. |
- Raza, Muhammad Liaquat, et al.
(author)
-
Therapeutic Potential of Iridoid Derivatives: Patent Review.
- 2019
-
In: Inventions. - : MDPI AG. - 2411-5134. ; 4:2
-
Research review (peer-reviewed)abstract
- Iridoids belong to a family of monoterpenoids comprising the cyclopentan[c]-pyran system; this class of compounds offers a wide range of biological effects, namely antileishmanial, anticancer, antiplasmodial, and anti-inflammatory potency. To date, a large number of biologically active iridoid derivatives have been reported from various plant families, including Rubiaceae, Plantaginaceae, Scrophulariaceae, and Verbenaceae. Furthermore, iridoids have the potential to form conjugates with other anticancer, antidiabetic, antileishmanial, and antimalarial drugs which synergistically have the potential to increase their effects. Additionally, future research should focus on the synthesis of halo analogs as well as preparing homo dimers or heterodimers of iridoids, since these might quite conceivably possess an increased bioactivity.
|
|
| 42. |
- Raza, Rizwan, et al.
(author)
-
Fuel cell technology for sustainable development in Pakistan - An over-view
- 2016
-
In: Renewable & sustainable energy reviews. - : Elsevier. - 1364-0321 .- 1879-0690. ; 53, s. 450-461
-
Journal article (peer-reviewed)abstract
- Fuel cell technology holds the combination of benefits, which are barely offered by any other energy generating technology. Because the fuel used in this technology is found in abundance in nature and can also be renewed/sustained. Pakistan is blessed with renewable energy resources which are suitable for fuel cell technology. Therefore, fuel cell technology offers a great opportunity to meet the demand of energy and for the sustainable development of Pakistan. The energy research group at COMSATS Institute of Information Technology (CIIT), Lahore has made efforts to study the technical aspects of fuel cell technology and its commercial benefits. The research group is interested in finding ways and means of generating and storing the energy produced by using fuel cells. In this paper, the research activities on fuel cell technology in Pakistan have been reviewed and it is also discussed how this technology can resolve the current energy crises in Pakistan and can be the source of sustainable energy. It has been also reviewed that the country would greatly benefit from fuel cells and fuel cell hybrid system (environmental friendly technology), which could be the best solution for electricity production as well for automobile industry.
|
|
| 43. |
- Raza-Ullah, Tatbeeq, et al.
(author)
-
The nature, consequences, and management of emotions in interfirm paradoxical relationships - A conceptual framework
- 2020
-
In: Scandinavian Journal of Management. - : Elsevier. - 0956-5221 .- 1873-3387. ; 36:4
-
Journal article (peer-reviewed)abstract
- We develop a theory of emotions in interfirm paradoxical relationships with a focus on coopetition and emotional ambivalence. We suggest that appraisals of paradoxical coopetition situations lead to the arousal of multiple, oppositely valenced emotions of various intensities, combinations of which correspond to different states of emotional ambivalence. We explicate how emotional ambivalence, through managers’ appraisal and emotional contagion processes becomes collective and how it impacts coopetition performance. We further theorize how the negative effect of ambivalence on performance could be minimized and the positive effect could be amplified through emotional capability. Our theory provides a nuanced understanding of the complex nature of emotions, and how they arise, manifest, and impact outcomes in interfirm paradoxical relationships.
|
|
| 44. |
- Saeed, Aamer, et al.
(author)
-
Identification of novel C-2 symmetric Bis-Azo-Azamethine molecules as competitive inhibitors of mushroom tyrosinase and free radical scavengers : synthesis, kinetics, and molecular docking studies
- 2022
-
In: Journal of Biomolecular Structure and Dynamics. - : Taylor & Francis. - 0739-1102 .- 1538-0254. ; 40:10, s. 4419-4428
-
Journal article (peer-reviewed)abstract
- Tyrosinase is a multi-copper enzyme found in plants, animals and microorganisms, plays a critical role in the melanogenesis and browning process critical to cosmetics and food industries. Many natural, semi-synthetic and synthetic inhibitors have been discovered. To this end, a small library of symmetrical Bis-Azo-Azamethine hybrids 5a–j was synthesized and characterized through spectroscopic and analytical data and explored for mushroom tyrosinase and free radical scavenging activity. All of the molecules 5a–j explicated better potential compared to the standard Kojic acid. On the whole, compound 5i having IC50 value 0.002 ± 0.004 µM was found to be the most potent derivative. The Kinetic studies were performed for 5i and indicating the mode of inhibition in a competitive manner. Structure Activity Relationship (SAR) analysis and docking studies were carried out. Thus compound 5i bearing bulky naphthyl groups was most potent and, The molecular docking indicated formation of two hydrogen bonds with Arg268 and one hydrophobic interaction with Glu322. The carbonyl oxygen of 5i interacts with Arg268 and form two hydrogen bonds having lengths 2.44 and 2.62 Å, respectively. In the same way, compounds 5a–j were appraised for DPPH free radical scavenging ability and five of them 5d, 5e, 5h, 5i and 5j were found to exhibit higher % scavenging potency compared with vitamin C, as the standard. Interesting compound 5i was again the most potent in the series. The current investigation points towards the role of naphthyl group in design of new inhibitors of melanogenesis and the antioxidants with improved efficacy.
|
|
| 45. |
- Saeed, Aamer, et al.
(author)
-
Novel N-(benzo[d]oxazol-2-yl)alkanamides : synthesis and carbonic anhydrase II inhibition studies
- 2020
-
In: Journal of Heterocyclic Chemistry. - : WILEY. - 0022-152X .- 1943-5193. ; 57:7, s. 2831-2843
-
Journal article (peer-reviewed)abstract
- Carbonic anhydrase (CA II) inhibitors are very important therapeutic targets in drug design for treatment of neuropathic pain and in eradication of glaucoma, cancer, epilepsy, ulcer and obesity. In this study, some two2-substituted benzoxazoles (3a-j) were developed as a new family of carbonic anhydrase II inhibitors by employing acyl thiourea chemistry via a simple and expedient protocol and evaluated for CA II inhibitor activity and radical scavenging ability. Compounds 3f and 3j were found to be the most potent inhibitors, with IC50 values of 0.00564 and 0.00596 mu M, respectively which are several times better than that of the standard, acetazolamide (IC50 value 0.997 +/- 0.0586 mu M). Docking experiments were carried out against the carbonic anhydrase II crystal structure to better rationalize the inhibitory activities of these new structures. Moreover, the results of a DPPH radical scavenging assay showed that the antioxidant profile of compound 3i is superior to those of other derivatives. The results have revealed that derivatives 3f and 3j behave as CA-II inhibitors significantly better than standard and 3i has good anti-oxidation potential.
|
|
| 46. |
- Senanayake, Indunil C., et al.
(author)
-
Fungal diversity notes 1611–1716: taxonomic and phylogenetic contributions on fungal genera and species emphasis in south China
- 2023
-
In: Fungal Diversity. - 1560-2745 .- 1878-9129. ; 122, s. 161-403
-
Journal article (peer-reviewed)abstract
- This article is the 15th contribution in the Fungal Diversity Notes series, wherein 115 taxa from three phyla, nine classes, 28 orders, 48 families, and 64 genera are treated. Fungal taxa described and illustrated in the present study include a new family, five new genera, 61 new species, five new combinations, one synonym, one new variety and 31 records on new hosts or new geographical distributions. Ageratinicolaceae fam. nov. is introduced and accommodated in Pleosporales. The new genera introduced in this study are Ageratinicola, Kevinia, Pseudomultiseptospora (Parabambusicolaceae), Marasmiellomycena, and Vizzinia (Porotheleaceae). Newly described species are Abrothallus altoandinus, Ageratinicola kunmingensis, Allocryptovalsa aceris, Allophoma yuccae, Apiospora cannae, A. elliptica, A. pallidesporae, Boeremia wisteriae, Calycina papaeana, Clypeococcum lichenostigmoides, Coniochaeta riskali-shoyakubovii, Cryphonectria kunmingensis, Diaporthe angustiapiculata, D. campylandrae, D. longipapillata, Diatrypella guangdongense, Dothiorella franceschinii, Endocalyx phoenicis, Epicoccum terminosporum, Fulvifomes karaiensis, F. pannaensis, Ganoderma ghatensis, Hysterobrevium baoshanense, Inocybe avellaneorosea, I. lucida, Jahnula oblonga, Kevinia lignicola, Kirschsteiniothelia guangdongensis, Laboulbenia caprina, L. clavulata, L. cobiae, L. cosmodisci, L. nilotica, L. omalii, L. robusta, L. similis, L. stigmatophora, Laccaria rubriporus, Lasiodiplodia morindae, Lyophyllum agnijum, Marasmiellomycena pseudoomphaliiformis, Melomastia beihaiensis, Nemania guangdongensis, Nigrograna thailandica, Nigrospora ficuum, Oxydothis chinensis, O. yunnanensis, Petriella thailandica, Phaeoacremonium chinensis, Phialocephala chinensis, Phytophthora debattistii, Polyplosphaeria nigrospora, Pronectria loweniae, Seriascoma acutispora, Setoseptoria bambusae, Stictis anomianthi, Tarzetta tibetensis, Tarzetta urceolata, Tetraploa obpyriformis, Trichoglossum beninense, and Tricoderma pyrrosiae. We provide an emendation for Urnula ailaoshanensis Agaricus duplocingulatoides var. brevisporus introduced as a new variety based on morphology and phylogeny.
|
|
| 47. |
- Usman, Muhammad, et al.
(author)
-
Evaluation of the chronic intoxication of fluoride on human serum metabolome using untargeted metabolomics
- 2022
-
In: Arabian Journal of Chemistry. - : Elsevier BV. - 1878-5352 .- 1878-5379. ; 15:7
-
Journal article (peer-reviewed)abstract
- Drinking water is the main source of fluoride intake for the human body and its regulated consumption helps in decreasing dental caries. However, excessive fluoride consumption over a prolonged time period causes fluorosis disease which adversely affects many tissues and organs of the body. This paper describes the evaluation of chronic intoxication of fluoride on human serum metabolome. The untargeted metabolomics approach using UPLC-QTOF-MS/MS is applied for metabolomic profiling, whereas the estimation of fluoride in serum samples was carried out using the ion-selective electrode (ISE). Fluoride concentration was found to be 0.16–1.25 mg/L in serum samples of 39 fluorosis patients and 0.008–0.045 mg/L in 20 healthy samples. A total of 47 metabolites were identified based on the high-resolution mass spectrometry analysis. A volcano plot was generated to discriminate features that are significantly different between the fluorosis and healthy groups at the probability of 0.05 and fold change ≥ 2. Among all identified metabolites, intensities of ten differential identified metabolites including inosine, α-linolenic acid, guanosine, octanoyl-L-carnitine, His-Trp, phytosphingosine, lauroyl-L-carnitine, hydrocortisone, deoxyinosine and dodecanedioic acid have been found altered in disease samples compared to healthy controls. Major pathways identified based on these metabolites include energy metabolism, fatty acid oxidation, purine degradation pathway, elevated protein degradation, and increased ω-6 fatty acid linoleate signatures were observed.
|
|
| 48. |
- Wu, Y., et al.
(author)
-
Electrolyte-free fuel cell : Principles and crosslink research
- 2020
-
In: Solid Oxide Fuel Cells. - : Wiley. ; , s. 347-378
-
Book chapter (peer-reviewed)abstract
- Semiconductors and the associated methodologies applied to electrochemistry have recently grown as an emerging field in energy materials and technologies. Fuel cells have been developed in line with traditional electrochemistry employing three basic functional components: anode, electrolyte and cathode. The electrolyte is a key component to the device performance by providing an ionic charge flow pathway between the anode and cathode but preventing electron conduction. By contrast, semiconductors and the derived heterostructures with electronic (hole) conducting materials have been strongly developed with much better ionic conductors instead of a conventional ionic electrolyte for novel fuel cells. Energy band structures and alignments, band-bending and built-in-field are all important parameters in this context to accomplish the necessary fuel cell functionalities. This chapter extends widely the semiconductor-based electrochemical energy conversion and storage technologies, describing their fundamentals and working principles, with an intention to advance the understanding of the semiconductors and energy bands role in electrochemical devices of energy conversion and storage, as well as applications for emerging demands, widely involving in energy applications, such as photo catalysis/water splitting; battery and solar cell etc. It provides new ideas and new solutions to the problems beyond the conventional electrochemistry and presents new inter-disciplinary approaches to develop clean energy conversion and storage technologies.
|
|
| 49. |
- Yasin, A., et al.
(author)
-
Can serious gaming tactics bolster spear-phishing and phishing resilience? : Securing the human hacking in Information Security
- 2024
-
In: Information and Software Technology. - : Elsevier B.V.. - 0950-5849 .- 1873-6025. ; 170
-
Journal article (peer-reviewed)abstract
- Context: In the digital age, there is a notable increase in fraudulent activities perpetrated by social engineers who exploit individuals’ limited knowledge of digital devices. These actors strategically manipulate human psychology, targeting IT devices to gain unauthorized access to sensitive data. Objectives: Our study is centered around two distinct objectives to be accomplished through the utilization of a serious game: (i) The primary objective entails delivering training and educational content to participants with a focus on phishing attacks; (ii) The secondary objective aims to heighten participants’ awareness regarding the perils associated with divulging excessive information online. Methodology: To address these objectives, we have employed the following techniques and methods: (i) A comprehensive literature review was conducted to establish foundational knowledge in areas such as social engineering, game design, learning principles, human interaction, and game-based learning; (ii) We meticulously aligned the game design with the philosophical concept of social engineering attacks; (iii) We devised and crafted an advanced hybrid version of the game, incorporating the use of QR codes to generate game card data; (iv) We conducted an empirical evaluation encompassing surveys, observations, discussions, and URL assessments to assess the effectiveness of the proposed hybrid game version. Results: Quantitative data and qualitative observations suggest the “PhishDefend Quest” game successfully improved players’ comprehension of phishing threats and how to detect them through an interactive learning experience. The results highlight the potential of serious games to educate people about social engineering risks. Conclusion: Through the evaluation, we can readily arrive at the following conclusions: (i) Game-based learning proves to be a viable approach for educating participants about phishing awareness and the associated risks tied to the unnecessary disclosure of sensitive information online; (ii) Furthermore, game-based learning serves as an effective means of disseminating awareness among participants and players concerning prevalent phishing attacks.
|
|
