| 1. |
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
- Lyons, PA, et al.
(author)
-
Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status
- 2019
-
In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 5120-
-
Journal article (peer-reviewed)abstract
- Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare inflammatory disease of unknown cause. 30% of patients have anti-neutrophil cytoplasmic antibodies (ANCA) specific for myeloperoxidase (MPO). Here, we describe a genome-wide association study in 676 EGPA cases and 6809 controls, that identifies 4 EGPA-associated loci through conventional case-control analysis, and 4 additional associations through a conditional false discovery rate approach. Many variants are also associated with asthma and six are associated with eosinophil count in the general population. Through Mendelian randomisation, we show that a primary tendency to eosinophilia contributes to EGPA susceptibility. Stratification by ANCA reveals that EGPA comprises two genetically and clinically distinct syndromes. MPO+ ANCA EGPA is an eosinophilic autoimmune disease sharing certain clinical features and an HLA-DQ association with MPO+ ANCA-associated vasculitis, while ANCA-negative EGPA may instead have a mucosal/barrier dysfunction origin. Four candidate genes are targets of therapies in development, supporting their exploration in EGPA.
|
|
| 8. |
- Haberle, R. M., et al.
(author)
-
Secular Climate Change on Mars : An Update Using MSL Pressure Data
- 2013
-
Conference paper (peer-reviewed)abstract
- The South Polar Residual Cap (SPRC) on Mars is an icy reservoir of CO2. If all the CO2 trapped in the SPRC were released to the atmosphere the mean annual global surface pressure would rise by ~20 Pa. Repeated MOC and HiRISE imaging of scarp retreat rates within the SPRC have led to the suggestion that the SPRC is losing mass. Estimates for the loss rate vary between 0. 5 Pa per Mars Decade to 13 Pa per Mars Decade. Assuming 80% of this loss goes directly into the atmosphere, and that the loss is monotonic, the global annual mean surface pressure should have increased between ~1-20 Pa since the Viking mission (19 Mars years ago). Surface pressure measurements by the Phoenix Lander only 2 Mars years ago were found to be consistent with these loss rates. Here we compare surface pressure data from the MSL mission with that from Viking Lander 2 (VL-2) to determine if the trend continues. We use VL-2 because it is at the same elevation as MSL (-4500 m). However, based on the first 100 sols of data there does not appear to be a significant difference between the dynamically adjusted pressures of the two landers. This result implies one of several possibilities: (1) the cap is not losing mass and the difference between the Viking and Phoenix results is due to uncertainties in the measurements; (2) the cap has lost mass between the Viking and Phoenix missions but it has since gone back to the cap or into the regolith; or (3) that our analysis is flawed. The first possibility is real since post-mission analysis of the Phoenix sensor has shown that there is a 3 (±2) Pa offset in the data and there may also be uncertainties in the Viking data. The loss/gain scenario for the cap seems unlikely since scarps continue retreating, and regolith uptake implies something unique about the past several Mars years. That our analysis is flawed is certainly possible owing to the very different environments of the Viking and MSL landers. MSL is at the bottom of a deep crater in the southern tropics (~5°S), whereas VL-2 is at a high latitude (~48°N) in the northern plains. And in spite of the fact that the two landers are at nearly identical elevations, they are in very different thermal environments (e.g., MSL is warm when VL-2 is cold), which can have a significant affect on pressures. For these reasons, our confidence in the comparison will increase as more MSL data become available. We will report the results up through sol 360 at the meeting.
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
- Alimena, Juliette, et al.
(author)
-
Searching for long-lived particles beyond the Standard Model at the Large Hadron Collider
- 2020
-
In: Journal of Physics G. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 47:9
-
Journal article (peer-reviewed)abstract
- Particles beyond the Standard Model (SM) can generically have lifetimes that are long compared to SM particles at the weak scale. When produced at experiments such as the Large Hadron Collider (LHC) at CERN, these long-lived particles (LLPs) can decay far from the interaction vertex of the primary proton-proton collision. Such LLP signatures are distinct from those of promptly decaying particles that are targeted by the majority of searches for new physics at the LHC, often requiring customized techniques to identify, for example, significantly displaced decay vertices, tracks with atypical properties, and short track segments. Given their non-standard nature, a comprehensive overview of LLP signatures at the LHC is beneficial to ensure that possible avenues of the discovery of new physics are not overlooked. Here we report on the joint work of a community of theorists and experimentalists with the ATLAS, CMS, and LHCb experiments-as well as those working on dedicated experiments such as MoEDAL, milliQan, MATHUSLA, CODEX-b, and FASER-to survey the current state of LLP searches at the LHC, and to chart a path for the development of LLP searches into the future, both in the upcoming Run 3 and at the high-luminosity LHC. The work is organized around the current and future potential capabilities of LHC experiments to generally discover new LLPs, and takes a signature-based approach to surveying classes of models that give rise to LLPs rather than emphasizing any particular theory motivation. We develop a set of simplified models; assess the coverage of current searches; document known, often unexpected backgrounds; explore the capabilities of proposed detector upgrades; provide recommendations for the presentation of search results; and look towards the newest frontiers, namely high-multiplicity 'dark showers', highlighting opportunities for expanding the LHC reach for these signals.
|
|
| 12. |
|
|
| 13. |
- Harri, A.-M., et al.
(author)
-
Mars Science Laboratory relative humidity observations: Initial results
- 2014
-
In: Journal of Geophysical Research - Planets. - 2169-9097 .- 2169-9100. ; 119:9, s. 2132-2147
-
Journal article (peer-reviewed)abstract
- The Mars Science Laboratory (MSL) made a successful landing at Gale crater early August 2012. MSL has an environmental instrument package called the Rover Environmental Monitoring Station (REMS) as a part of its scientific payload. REMS comprises instrumentation for the observation of atmospheric pressure, temperature of the air, ground temperature, wind speed and direction, relative humidity (REMS-H), and UV measurements. We concentrate on describing the REMS-H measurement performance and initial observations during the first 100 MSL sols as well as constraining the REMS-H results by comparing them with earlier observations and modeling results. The REMS-H device is based on polymeric capacitive humidity sensors developed by Vaisala Inc., and it makes use of transducer electronics section placed in the vicinity of the three humidity sensor heads. The humidity device is mounted on the REMS boom providing ventilation with the ambient atmosphere through a filter protecting the device from airborne dust. The final relative humidity results appear to be convincing and are aligned with earlier indirect observations of the total atmospheric precipitable water content. The water mixing ratio in the atmospheric surface layer appears to vary between 30 and 75 ppm. When assuming uniform mixing, the precipitable water content of the atmosphere is ranging from a few to six precipitable micrometers.
|
|
