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1.	Wilhelmson, Anna S K, et al. (author) Testosterone is an endogenous regulator of BAFF and splenic B cell number 2018 In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 9:1 Journal article (peer-reviewed)abstract Testosterone deficiency in men is associated with increased risk for autoimmunity and increased B cell numbers through unknown mechanisms. Here we show that testosterone regulates the cytokine BAFF, an essential survival factor for B cells. Male mice lacking the androgen receptor have increased splenic B cell numbers, serum BAFF levels and splenic Baff mRNA. Testosterone deficiency by castration causes expansion of BAFF-producing fibro-blastic reticular cells (FRCs) in spleen, which may be coupled to lower splenic noradrenaline levels in castrated males, as an alpha-adrenergic agonist decreases splenic FRC number in vitro. Antibody-mediated blockade of the BAFF receptor or treatment with the neurotoxin 6-hydroxydopamine revert the increased splenic B cell numbers induced by castration. Among healthy men, serum BAFF levels are higher in men with low testosterone. Our study uncovers a previously unrecognized regulation of BAFF by testosterone and raises important questions about BAFF in testosterone-mediated protection against autoimmunity.
2.	Ceredig, R, et al. (author) Effect of deregulated IL-7 transgene expression on B lymphocytel receptors. 1999 In: Eur J Immunol. ; 29, s. 2797- Journal article (peer-reviewed)
3.	Ceredig, R, et al. (author) Fetal liver organ cultures allow the proliferative expansion of pre-B receptor-expressing pre-B-II cells and the differentiation of immature and mature B cells in vitro 1998 In: Int Immunol. ; 10, s. 49- Journal article (peer-reviewed)
4.	Engel, H, et al. (author) Expression level of a transgenic 12 chain results in isotype exclusion and commitment to Bl cells 1998 In: Eur J Immunol. ; 28, s. 2289- Journal article (peer-reviewed)
5.	Kienzler, AK, et al. (author) Human BAFF-R Deficiency is Associated with Primary Antibody Deficiency Syndrome 2009 In: CLINICAL IMMUNOLOGY. - : Elsevier BV. - 1521-6616. ; 131, s. S123-S123 Conference paper (other academic/artistic)
6.	Melchers, F, et al. (author) The roles of preB and B cell receptors in the stepwise allelic exclusion of mouse IgH and L chain gene loci [In Process Citation] 1999 In: Semin Immunol. ; 11, s. 307- Journal article (peer-reviewed)
7.	Pieper, K, et al. (author) A common single nucleotide polymorphism impairs B-cell activating factor receptor's multimerization, contributing to common variable immunodeficiency 2014 In: The Journal of allergy and clinical immunology. - : Elsevier BV. - 1097-6825 .- 0091-6749. ; 133:4, s. 1222-1225 Journal article (other academic/artistic)
8.	Rolink, A, et al. (author) Molecular mechanisms guiding B cell development 1999 In: In: Primary Immunodeficiency Diseases, a Molecular and Genetic Approach (HD Ochs, CIE Smith, J Puck, eds). - : Oxford Univ Press Inc, New York. ; , s. 55- Book chapter (other academic/artistic)
9.	Yamagami, T, et al. (author) Four of five RAG-expressing JCkappa-/- small pre-BII cells have no Liency single cell PCR [In Process Citation] 1999 In: Immunity. ; 11, s. 309- Journal article (peer-reviewed)
10.	Yamagami, T, et al. (author) Frequencies of multiple IgL chain gene rearrangements in single normalient B lineage cells [In Process Citation] 1999 In: Immunity. ; 11, s. 317- Journal article (peer-reviewed)

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Type of publication: journal article (8); conference paper (1); book chapter (1)

Type of content: peer-reviewed (7); other academic/artistic (3)

Author/Editor: Rolink, A (8); Andersson, J (7); Melchers, F (6); Ten Boekel, E (5); Yamagami, T (3); EIBEL, H (2); show more...; Hammarstrom, L (2); Warnatz, K (2); Grimbacher, B (2); Ceredig, R (2); Salzer, U (2); Engel, H. (1); Rizzi, M. (1); Kraus, H. (1); Notarangelo, LD (1); Pan-Hammarstrom, Q (1); Lougaris, V (1); Plebani, A (1); Johansson, Maria E, ... (1); Ghia, P (1); Schneider, P (1); Wilhelmson, Anna S K (1); Nissbrandt, Hans, 19 ... (1); Carlsten, Hans, 1954 (1); Mårtensson, Inga-Lil ... (1); Stubelius, Alexandra ... (1); Fogelstrand, Per, 19 ... (1); Tivesten, Åsa, 1969 (1); Fagman, Johan Bourgh ... (1); Camponeschi, Alessan ... (1); Weiss, S (1); Recher, M (1); Smulski, CR (1); Speletas, M (1); Oka, Y. (1); Rolink, AG (1); Karlsson, M. C. I. (1); Kienzler, AK (1); Bogen, B (1); Duhlin, A (1); Myller, J (1); PETER, HH (1); Schamel, WW (1); Johansson, Inger, 19 ... (1); Kalberer, C (1); Winkler, TH (1); Lantero Rodriguez, M ... (1); Pieper, K. (1); Porse, B. T. (1); Sic, H (1); show less...

University: Uppsala University (7); Karolinska Institutet (3); University of Gothenburg (1)

Language: English (10)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

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