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| 2. |
- la Marca, Giancarlo, et al.
(author)
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Diagnosis of immunodeficiency caused by a purine nucleoside phosphorylase defect by using tandem mass spectrometry on dried blood spots.
- 2014
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In: Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 1097-6825 .- 0091-6749. ; 134:1, s. 155-155
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Journal article (peer-reviewed)abstract
- Purine nucleoside phosphorylase (PNP) deficiency is a rare form of autosomal recessive combined primary immunodeficiency caused by a enzyme defect leading to the accumulation of inosine, 2'-deoxy-inosine (dIno), guanosine, and 2'-deoxy-guanosine (dGuo) in all cells, especially lymphocytes. Treatments are available and curative for PNP deficiency, but their efficacy depends on the early approach. PNP-combined immunodeficiency complies with the criteria for inclusion in a newborn screening program.
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| 3. |
- Mittone, Alberto, et al.
(author)
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Multiscale pink-beam microCT imaging at the ESRF-ID17 biomedical beamline
- 2020
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In: Journal of Synchrotron Radiation. - : INT UNION CRYSTALLOGRAPHY. - 0909-0495 .- 1600-5775. ; 27:5, s. 1347-1357
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Journal article (peer-reviewed)abstract
- Recent trends in hard X-ray micro-computed tomography (microCT) aim at increasing both spatial and temporal resolutions. These challenges require intense photon beams. Filtered synchrotron radiation beams, also referred to as 'pink beams', which are emitted by wigglers or bending magnets, meet this need, owing to their broad energy range. In this work, the new microCT station installed at the biomedical beamline ID17 of the European Synchrotron is described and an overview of the preliminary results obtained for different biomedical-imaging applications is given. This new instrument expands the capabilities of the beamline towards sub-micrometre voxel size scale and simultaneous multi-resolution imaging. The current setup allows the acquisition of tomographic datasets more than one order of magnitude faster than with a monochromatic beam configuration.
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| 4. |
- Barbaud, Annick, et al.
(author)
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Allergies and COVID-19 vaccines : An ENDA/EAACI Position paper
- 2022
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In: Allergy. European Journal of Allergy and Clinical Immunology. - : John Wiley & Sons. - 0105-4538 .- 1398-9995. ; 77:8, s. 2292-2312
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Journal article (peer-reviewed)abstract
- Background Anaphylaxis, which is rare, has been reported after COVID-19 vaccination, but its management is not standardized.Method Members of the European Network for Drug Allergy and the European Academy of Allergy and Clinical Immunology interested in drug allergy participated in an online questionnaire on pre-vaccination screening and management of allergic reactions to COVID-19 vaccines, and literature was analysed.Results No death due to anaphylaxis to COVID-19 vaccines has been confirmed in scientific literature. Potential allergens, polyethylene glycol (PEG), polysorbate and tromethamine are excipients. The authors propose allergy evaluation of persons with the following histories: 1-anaphylaxis to injectable drug or vaccine containing PEG or derivatives; 2-anaphylaxis to oral/topical PEG containing products; 3-recurrent anaphylaxis of unknown cause; 4-suspected or confirmed allergy to any mRNA vaccine; and 5-confirmed allergy to PEG or derivatives. We recommend a prick-to-prick skin test with the left-over solution in the suspected vaccine vial to avoid waste. Prick test panel should include PEG 4000 or 3500, PEG 2000 and polysorbate 80. The value of in vitro test is arguable.Conclusions These recommendations will lead to a better knowledge of the management and mechanisms involved in anaphylaxis to COVID-19 vaccines and enable more people with history of allergy to be vaccinated.
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| 5. |
- Bousquet, Jean, et al.
(author)
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ARIA digital anamorphosis : Digital transformation of health and care in airway diseases from research to practice
- 2021
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In: Allergy. European Journal of Allergy and Clinical Immunology. - : John Wiley & Sons. - 0105-4538 .- 1398-9995. ; 76:1, s. 168-190
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Research review (peer-reviewed)abstract
- Digital anamorphosis is used to define a distorted image of health and care that may be viewed correctly using digital tools and strategies. MASK digital anamorphosis represents the process used by MASK to develop the digital transformation of health and care in rhinitis. It strengthens the ARIA change management strategy in the prevention and management of airway disease. The MASK strategy is based on validated digital tools. Using the MASK digital tool and the CARAT online enhanced clinical framework, solutions for practical steps of digital enhancement of care are proposed.
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| 6. |
- De Lauretis, Maria, 1987-, et al.
(author)
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On the rectangular mesh and the decomposition of a Green’s-function-based quadruple integral into elementary integrals
- 2022
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In: Engineering analysis with boundary elements. - Oxford : Elsevier. - 0955-7997 .- 1873-197X. ; 134, s. 419-434
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Journal article (peer-reviewed)abstract
- Computational electromagnetic problems require evaluating the electric and magnetic fields of the physical object under investigation, divided into elementary cells with a mesh. The partial element equivalent circuit (PEEC) method has recently received attention from academic and industry communities because it provides a circuit representation of the electromagnetic problem. The surface formulation, known as S-PEEC, requires computing quadruple integrals for each mesh patch. Several techniques have been developed to simplify the computational complexity of quadruple integrals but limited to triangular meshes as used in well-known methods such as the Method of Moments (MoM). However, in the S-PEEC method, the mesh can be rectangular and orthogonal, and new approaches must be investigated to simplify the quadruple integrals. This work proposes a numerical approach that treats the singularity and reduces the computational complexity of one of the two quadruple integrals used in the S-PEEC method. The accuracy and computational time are tested for representative parallel and orthogonal meshes.
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| 7. |
- Di Murro, Francesca, et al.
(author)
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Efficient Computation of Partial Elements in the Full-Wave Surface-PEEC Method
- 2021
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In: IEEE transactions on electromagnetic compatibility (Print). - : IEEE. - 0018-9375 .- 1558-187X. ; 63:4, s. 1189-1201
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Journal article (peer-reviewed)abstract
- The partial element equivalent circuit (PEEC) method provides an electromagnetic model of interconnections and packaging structures in terms of standard circuit elements. The surface-based PEEC (S-PEEC) formulation can reduce the number of unknowns compared to the standard volume-based PEEC (V-PEEC) method. This reduction is of particular use in the case of high-speed circuits and high-switching power electronics, where the bandwidth extends from low frequencies to the GHz range. In this article, the S-PEEC formulation is revised and cast in a matrix form. The main novelty is that the interaction integrals involving the curl of the magnetic and electric vector potentials are computed through the Taylor series expansion of the full-wave Green’s function, leading to analytical forms that are rigorously derived. Therefore, the numerical integration is avoided, with a consequent reduction of the computation time. The proposed formulas are studied in terms of the frequency, size of the mesh, and distance between the basis function domains. Three examples are presented, confirming the accuracy of the proposed method compared to the V-PEEC method and surface-based numerical methods from literature.
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| 8. |
- Di Murro, Francesca, et al.
(author)
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Semi-analytical form of full-wave self-interaction integrals over rectangles
- 2020
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In: Proceedings of the 2020 International Symposium on Electromagnetic Compatibility – EMC EUROPE. - : IEEE.
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Conference paper (peer-reviewed)abstract
- The Partial Element Equivalent Circuit (PEEC) method is widely used to model a large variety of electrical systems ranging from interconnects to antennas and packaging. A key aspect in the development of the method is the computation of interaction integrals, namely partial inductances and coefficients of potential. In this work, a novel semi-analytical approach to the computation of the self-interaction integral over rectangular domains is proposed for the zero thickness case as it occurs in the case of the coefficients of potential and partial inductances of very thin conductors and in the surface integral equation based formulation. The proposed semi-analytical formula is verified by comparison with more standard integration schemes.
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| 9. |
- Iovino, Maria Rosa, et al.
(author)
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Archaeological volcanic glass from the site of Rocchicella (Sicily, Italy)
- 2008
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In: Archaeometry. - : Wiley-Blackwell. - 0003-813X .- 1475-4754. ; 50:3, s. 474-494
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Journal article (peer-reviewed)abstract
- The site of Rocchicella, near Catania, in eastern Sicily, has yielded important archaeological evidence from prehistoric times to the Middle Ages. Extensive archaeological investigations of cultural layers dating from the Palaeo-Mesolithic to the Copper Age have recently been undertaken, and volcanic glass, mainly obsidian, has been collected in the course of excavation. To determine the provenance of this volcanic glass, a non-destructive elemental analysis was carried out to measure the concentration of characteristic trace elements. The analysis was carried out using a new XRF spectrometer equipped with a beam stability controller and a quantitative method developed at the LANDIS laboratory of the INFN–CNR Institutes of Catania. In addition to the obsidian, it was demonstrated for the first time that a local vitreous material similar to obsidian, but displaying a completely different composition, was used during all the investigated periods. This material was identified as a basaltic glass, characterized by a superficial product of devitrification called palagonite. Analysis of the obsidians has led to the identification of the island of Lipari as the provenance source. High- and low-power microscopic use-wear analysis on obsidian and basaltic glass artefacts indicated that soft wood and plant matter might have been processed at the site.
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| 10. |
- Jung, Christian, et al.
(author)
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A comparison of very old patients admitted to intensive care unit after acute versus elective surgery or intervention
- 2019
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In: Journal of critical care. - : W B SAUNDERS CO-ELSEVIER INC. - 0883-9441 .- 1557-8615. ; 52, s. 141-148
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Journal article (peer-reviewed)abstract
- Background: We aimed to evaluate differences in outcome between patients admitted to intensive care unit (ICU) after elective versus acute surgery in a multinational cohort of very old patients (80 years; VIP). Predictors of mortality, with special emphasis on frailty, were assessed.Methods: In total, 5063 VIPs were induded in this analysis, 922 were admitted after elective surgery or intervention, 4141 acutely, with 402 after acute surgery. Differences were calculated using Mann-Whitney-U test and Wilcoxon test. Univariate and multivariable logistic regression were used to assess associations with mortality.Results: Compared patients admitted after acute surgery, patients admitted after elective surgery suffered less often from frailty as defined as CFS (28% vs 46%; p < 0.001), evidenced lower SOFA scores (4 +/- 5 vs 7 +/- 7; p < 0.001). Presence of frailty (CFS >4) was associated with significantly increased mortality both in elective surgery patients (7% vs 12%; p = 0.01), in acute surgery (7% vs 12%; p = 0.02).Conclusions: VIPs admitted to ICU after elective surgery evidenced favorable outcome over patients after acute surgery even after correction for relevant confounders. Frailty might be used to guide clinicians in risk stratification in both patients admitted after elective and acute surgery.
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| 11. |
- Lazaridis, Iosif, et al.
(author)
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Ancient human genomes suggest three ancestral populations for present-day Europeans
- 2014
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In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 513:7518, s. 409-
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Journal article (peer-reviewed)abstract
- We sequenced the genomes of a similar to 7,000-year-old farmer from Germany and eight similar to 8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes(1-4) with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations: west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians(3), who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry. We model these populations' deep relationships and show that early European farmers had similar to 44% ancestry from a 'basal Eurasian' population that split before the diversification of other non-African lineages.
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