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1.	2021 swepub:Mat__t
2.	Fernandez-Perez, L, et al. (author) Congenital hypothyroidism causes altered lipogenic response to thyroid hormones in adult rat liver 2006 In: FEBS JOURNAL. - 1742-464X. ; 273, s. 219-220 Conference paper (other academic/artistic)
3.	Fernandez-Perez, L, et al. (author) Functional exploration of liver genome by using cDNA microarrays in a model of estrogen-induced cholestasis 2005 In: FEBS JOURNAL. - 1742-464X. ; 272, s. 122-122 Conference paper (other academic/artistic)
4.	Fernandez-Perez, L, et al. (author) The effect of in vivo growth hormone treatment on blood gene expression in adults with growth hormone deficiency reveals potential biomarkers to monitor growth hormone therapy 2010 In: Clinical endocrinology. - : Wiley. - 1365-2265 .- 0300-0664. ; 72:6, s. 800-806 Journal article (peer-reviewed)
5.	Henriquez-Hernandez, L. A., et al. (author) Role of pituitary hormones on 17 alpha-ethinylestradiol-induced cholestasis in rat 2007 In: Journal of Pharmacology and Experimental Therapeutics. - : American Society for Pharmacology & Experimental Therapeutics (ASPET). - 0022-3565 .- 1521-0103. ; 320:2, s. 695-705 Journal article (peer-reviewed)abstract Estrogens cause intrahepatic cholestasis in susceptible women during pregnancy, after administration of oral contraceptives, or during postmenopausal hormone replacement therapy. 17 alpha-Ethinylestradiol ( EE) is a synthetic estrogen widely used to cause experimental cholestasis in rodents with the aim of examining molecular mechanisms involved in this disease. EE actions on the liver are thought to be mediated by estrogen receptor alpha ( ER alpha) and pituitary hormones. We tested this hypothesis by analyzing metabolic changes induced by EE in livers from hypophysectomized ( HYPOX) and hypothyroid rats. Microarray studies revealed that the number of genes regulated by EE was increased almost 4-fold in HYPOX rat livers compared with intact males. Little overlap was apparent between the effects of EE in intact and HYPOX rats, demonstrating that pituitary hormones play a critical role in the hepatic effects of EE. Consistently, hypophysectomy protects the liver against induction by EE of serum bilirubin and alkaline phosphatase, two markers of cholestasis and hepatotoxicity and modulates the effects of EE on several genes involved in bile acid homeostasis ( e. g., FXR, SHP, BSEP, and Cyp8b1). Finally, we demonstrate a novel mechanism of action of EE through binding and negative regulation of glucocorticoid receptor-mediated transcription. In summary, pituitary- and ER alpha- independent mechanisms contribute to development of EE-induced changes in liver transcriptome. Such mechanisms may be relevant when this model of EE-induced cholestasis is evaluated. The observation that the pharmacological effects of estrogen in liver differ in the absence or presence of the pituitary could be clinically relevant, because different drugs that block actions of pituitary hormones are now available.
6.	Santana-Farre, R, et al. (author) Influence of neonatal hypothyroidism on hepatic gene expression and lipid metabolism in adulthood 2012 In: PloS one. - : Public Library of Science (PLoS). - 1932-6203. ; 7:5, s. e37386- Journal article (peer-reviewed)
7.	Zadjali, F, et al. (author) Liver X receptor agonist downregulates growth hormone signaling in the liver 2011 In: Hormone molecular biology and clinical investigation. - 1868-1883. ; 8:2, s. 471-8 Journal article (peer-reviewed)
8.	Zadjali, F, et al. (author) SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice 2012 In: FASEB journal : official publication of the Federation of American Societies for Experimental Biology. - : Wiley. - 1530-6860. ; 26:8, s. 3282-3291 Journal article (peer-reviewed)

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Type of publication: journal article (5); conference paper (2)

Type of content: peer-reviewed (5); other academic/artistic (2)

Author/Editor: Chen, L (1); Brown, J. (1); Chen, S. (1); Davies, M. (1); Gupta, S. (1); King, M. (1); show more...; Lopes, L. (1); Losada, M. (1); Moss, J. (1); Nayyar, R. (1); Negri, G. (1); Qureshi, A. (1); Rao, K. (1); Robson, A. (1); Romano, M. (1); Taylor, W. (1); Zhang, H. (1); Liu, J. (1); Morton, A. (1); Davies, E. (1); Horn, C. (1); Valente, P. (1); Gupta, A. (1); Kelly, M. (1); Liu, T. (1); Bertoli, G (1); Coe, P. (1); Smith, M. (1); Price, S (1); Martin, J. (1); Aytac, E (1); Campain, N (1); Ceelen, W (1); Davies, RJ (1); Domingo, S (1); Ghosh, A (1); Golda, T (1); Hompes, R (1); Kumar, S (1); Lago, (1); Lakkis, Z (1); Maciel, J (1); Park, J (1); Rottoli, M (1); Shaikh, (1); Tsarkov, P (1); Wilson, M (1); Baker, A. (1); Brown, A. (1); James, A. (1); show less...

University: Karolinska Institutet (8); Royal Institute of Technology (1)

Language: English (8)

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