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- Braun, M, et al.
(author)
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The CD6 scavenger receptor is differentially expressed on a CD56 natural killer cell subpopulation and contributes to natural killer-derived cytokine and chemokine secretion
- 2011
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In: Journal of innate immunity. - : S. Karger AG. - 1662-8128 .- 1662-811X. ; 3:4, s. 420-434
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Journal article (peer-reviewed)abstract
- The CD6 scavenger receptor is known to be expressed on virtually all T cells and is supposed to be involved in costimulation, synapse formation, thymic selection and leukocyte migration. Here, we demonstrate that CD6 is differentially expressed by a subpopulation of peripheral CD56<sup>dim</sup> natu- ral killer (NK) cells and absent on CD56<sup>bright</sup> NK cells. CD56<sup>dim</sup>CD16<sup>+</sup> cells represent the major NK subset in the periphery, and most cells within this group are positive for CD6. Most killer immunoglobulin-like receptor- and immunoglobulin-like transcript-positive cells also belong to the CD6<sup>+</sup> subpopulation, as expected from their restricted expression on CD56<sup>dim</sup> NK cells. In addition, CD6<sup>+</sup> NK cells are similar to the newly identified CD94<sup>low</sup>CD56<sup>dim</sup> NK subpopulation and most distant from the recently defined CD27<sup>+</sup> NK subpopulation based on the reverse correlation of expression between CD6 and CD27, a marker associated primarily with CD56<sup>bright</sup> NK cells. With respect to CD6 function on NK cells, direct CD6 triggering did not result in degranulation but induced secretion of cytokines (interferon-γ and tumor necrosis factor-α) and chemokines [CXCL10 (IP-10), CXCL1 (GRO-α)]. Thus, CD6 expression on peripheral NK cells marks a novel CD56<sup>dim</sup> subpopulation associated with distinct patterns of cytokine and chemokine secretion.
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