| 1. |
- Kehoe, Laura, et al.
(author)
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Make EU trade with Brazil sustainable
- 2019
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 364:6438, s. 341-
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Journal article (other academic/artistic)
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| 2. |
- Dormann, Carsten F., et al.
(author)
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Components of uncertainty in species distribution analysis: a case study of the Great Grey Shrike
- 2008
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In: Ecology. - : Wiley. - 0012-9658. ; 89:12, s. 3371-3386
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Journal article (peer-reviewed)abstract
- Sophisticated statistical analyses are common in ecological research, particularly in species distribution modeling. The effects of sometimes arbitrary decisions during the modeling procedure on the final outcome are difficult to assess, and to date are largely unexplored. We conducted an analysis quantifying the contribution of uncertainty in each step during the model-building sequence to variation in model validity and climate change projection uncertainty. Our study system was the distribution of the Great Grey Shrike in the German federal state of Saxony. For each of four steps (data quality, collinearity method, model type, and variable selection), we ran three different options in a factorial experiment, leading to 81 different model approaches. Each was subjected to a fivefold cross-validation, measuring area under curve (AUC) to assess model quality. Next, we used three climate change scenarios times three precipitation realizations to project future distributions from each model, yielding 729 projections. Again, we analyzed which step introduced most variability (the four model-building steps plus the two scenario steps) into predicted species prevalences by the year 2050. Predicted prevalences ranged from a factor of 0.2 to a factor of 10 of present prevalence, with the majority of predictions between 1.1 and 4.2 (inter-quartile range). We found that model type and data quality dominated this analysis. In particular, artificial neural networks yielded low cross-validation robustness and gave very conservative climate change predictions. Generalized linear and additive models were very similar in quality and predictions, and superior to neural networks. Variations in scenarios and realizations had very little effect, due to the small spatial extent of the study region and its relatively small range of climatic conditions. We conclude that, for climate projections, model type and data quality were the most influential factors. Since comparison of model types has received good coverage in the ecological literature, effects of data quality should now come under more scrutiny.
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| 4. |
- Molina, Berengere, et al.
(author)
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Dupilumab for relapsing or refractory sinonasal and/or asthma manifestations in eosinophilic granulomatosis with polyangiitis : a European retrospective study
- 2023
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In: Annals of the Rheumatic Diseases. - : BMJ Publishing Group Ltd. - 0003-4967 .- 1468-2060. ; 82:12, s. 1587-1593
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Journal article (peer-reviewed)abstract
- Background Eosinophilic granulomatosis with polyangiitis (EGPA) is often associated with glucocorticoid-dependent asthma and/or ear, nose and throat (ENT) manifestations. When immunosuppressants and/or mepolizumab are ineffective, dupilumab could be an option. We describe the safety and efficacy of off-label use of dupilumab in relapsing and/or refractory EGPA.Patients and methods We conducted an observational multicentre study of EGPA patients treated with dupilumab. Complete response was defined by Birmingham Vasculitis Activity Score (BVAS)=0 and prednisone dose ≤4 mg/day, and partial response by BVAS=0 and prednisone dose >4 mg/day. Eosinophilia was defined as an eosinophil count >500/mm3.Results Fifty-one patients were included. The primary indication for dupilumab was disabling ENT symptoms in 92%. After a median follow-up of 13.1 months, 18 patients (35%) reported adverse events (AEs), including two serious AEs. Eosinophilia was reported in 34 patients (67%), with a peak of 2195/mm3 (IQR 1268–4501) occurring at 13 weeks (IQR 4–36) and was associated with relapse in 41%. Twenty-one patients (41%) achieved a complete response and 12 (24%) a partial response. Sixteen (31%) patients experienced an EGPA relapse while on dupilumab, which was associated with blood eosinophilia in 14/16 (88%) patients. The median eosinophil count at the start of dupilumab was significantly lower in relapsers than in non-relapsers, as was the median time between stopping anti-IL-5/IL-5R and switching to dupilumab.Conclusion These results suggest that dupilumab may be effective in treating patients with EGPA-related ENT manifestations. However, EGPA flares occurred in one-third of patients and were preceded by eosinophilia in 88%, suggesting that caution is required.
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| 5. |
- Phillips, Helen R. P., et al.
(author)
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Global distribution of earthworm diversity
- 2019
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 366:6464, s. 480-
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Journal article (peer-reviewed)abstract
- Soil organisms, including earthworms, are a key component of terrestrial ecosystems. However, little is known about their diversity, their distribution, and the threats affecting them. We compiled a global dataset of sampled earthworm communities from 6928 sites in 57 countries as a basis for predicting patterns in earthworm diversity, abundance, and biomass. We found that local species richness and abundance typically peaked at higher latitudes, displaying patterns opposite to those observed in aboveground organisms. However, high species dissimilarity across tropical locations may cause diversity across the entirety of the tropics to be higher than elsewhere. Climate variables were found to be more important in shaping earthworm communities than soil properties or habitat cover. These findings suggest that climate change may have serious implications for earthworm communities and for the functions they provide.
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