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1.	Diaz, T, et al. (author) A call for standardised age-disaggregated health data 2021 In: The lancet. Healthy longevity. - 2666-7568. ; 2:7, s. e436-e443 Journal article (peer-reviewed)
2.	Kulane, A, et al. (author) Human immune responses to the highly repetitive Plasmodium falciparum antigen Pf332 1999 In: The American journal of tropical medicine and hygiene. - : American Society of Tropical Medicine and Hygiene. - 0002-9637 .- 1476-1645. ; 61:1, s. 141-148 Journal article (peer-reviewed)
3.	Kulane, A, et al. (author) T- and B-cell responses of malaria immune individuals to synthetic peptides corresponding to non-repeat sequences in the N-terminal region of the Plasmodium falciparum antigen Pf155/RESA 1997 In: Acta tropica. - 0001-706X. ; 68:1, s. 37-51 Journal article (peer-reviewed)
4.	Siddique, AB, et al. (author) Antibodies to a non-repeat region of Plasmodium falciparum antigen Pf155/RESA in individuals from malaria-endemic areas 1999 In: Clinical and experimental immunology. - : Oxford University Press (OUP). - 0009-9104 .- 1365-2249. ; 116:3, s. 493-499 Journal article (peer-reviewed)abstract Human antibodies to the repeat regions of the Plasmodium falciparum asexual blood stage antigen Pf155/RESA interfere with parasite growth in vitro, but the significance in this respect of antibodies to non-repetitive epitopes is less clear. In this study the levels of antibodies to a non-repetitive part of Pf155/RESA (residue 199–221) in malaria-exposed individuals were analysed, as was the parasite-inhibitory capacity of such antibodies. Residue 199–221 is of particular interest since it includes a sequence homologous to a cytoadherence-related motif from band 3. Sera from donors in Liberia and Tanzania were analysed for reactivity in ELISA with synthetic peptides together overlapping this part of Pf155/RESA. High antibody reactivity was observed in most of the sera with two peptides including residues 199–211 and 202–214, respectively. Specific antibodies were affinity-purified from selected sera using these peptide sequences and were shown to react with Pf155/RESA by immunofluorescence and Western blotting. The purified antibodies were furthermore shown to inhibit parasite growth in vitro. The results suggest that both repeat and non-repeat epitopes in Pf155/RESA elicit antibodies with potential to protect against malaria infection.

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Type of publication: journal article (4)

Type of content: peer-reviewed (4)

Author/Editor: Ahlborg, N (2); Perlmann, P (2); Kulane, A (2); aut (1); Azzopardi, PS (1); Hanson, C (1); show more...; Pereira, R (1); Schellenberg, J (1); English, M (1); Siddique, R (1); Noor, A (1); Banerjee, A (1); Troye-Blomberg, M (1); Amouzou, A (1); Vaz, LME (1); Cao, B. (1); Requejo, J (1); Moller, AB (1); Moran, AC (1); Dastgiri, S. (1); Diaz, T (1); Hosseinpoor, AR (1); Glaziou, P (1); Carvajal, L (1); Morgan, AP (1); Chatterji, S (1); Strong, KL (1); Guthold, R (1); Sadana, R (1); Thiyagarajan, JA (1); Adebayo, E (1); Akwara, E (1); Aponte Varon, JJ (1); Boschi-Pinto, C (1); Chandra-Mouli, V (1); Crofts, S (1); Dery, JS (1); Elnakib, S (1); Fagan, L (1); Jane Ferguson, B (1); Fitzner, J (1); Friedman, HS (1); Hagell, A (1); Jongstra, E (1); Kann, L (1); Marsh, A (1); Munos, MK (1); Pavlin, BI (1); Porth, TA (1); You, D (1); show less...

University: Karolinska Institutet (4)

Language: English (4)

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