| 1. |
|
|
| 2. |
- Das, A., et al.
(author)
-
Genomic predictors of response to PD-1 inhibition in children with germline DNA replication repair deficiency
- 2022
-
In: Nature Medicine. - : Springer Science and Business Media LLC. - 1078-8956 .- 1546-170X. ; 28:1, s. 125-135
-
Journal article (peer-reviewed)abstract
- Cancers arising from germline DNA mismatch repair deficiency or polymerase proofreading deficiency (MMRD and PPD) in children harbour the highest mutational and microsatellite insertion–deletion (MS-indel) burden in humans. MMRD and PPD cancers are commonly lethal due to the inherent resistance to chemo-irradiation. Although immune checkpoint inhibitors (ICIs) have failed to benefit children in previous studies, we hypothesized that hypermutation caused by MMRD and PPD will improve outcomes following ICI treatment in these patients. Using an international consortium registry study, we report on the ICI treatment of 45 progressive or recurrent tumors from 38 patients. Durable objective responses were observed in most patients, culminating in a 3 year survival of 41.4%. High mutation burden predicted response for ultra-hypermutant cancers (>100 mutations per Mb) enriched for combined MMRD + PPD, while MS-indels predicted response in MMRD tumors with lower mutation burden (10–100 mutations per Mb). Furthermore, both mechanisms were associated with increased immune infiltration even in ‘immunologically cold’ tumors such as gliomas, contributing to the favorable response. Pseudo-progression (flare) was common and was associated with immune activation in the tumor microenvironment and systemically. Furthermore, patients with flare who continued ICI treatment achieved durable responses. This study demonstrates improved survival for patients with tumors not previously known to respond to ICI treatment, including central nervous system and synchronous cancers, and identifies the dual roles of mutation burden and MS-indels in predicting sustained response to immunotherapy. © 2022, The Author(s).
|
|
| 3. |
- Dickstein, D. L., et al.
(author)
-
Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure
- 2021
-
In: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 26, s. 5940-5954
-
Journal article (peer-reviewed)abstract
- Traumatic brain injury (TBI) is a risk factor for the later development of neurodegenerative diseases that may have various underlying pathologies. Chronic traumatic encephalopathy (CTE) in particular is associated with repetitive mild TBI (mTBI) and is characterized pathologically by aggregation of hyperphosphorylated tau into neurofibrillary tangles (NFTs). CTE may be suspected when behavior, cognition, and/or memory deteriorate following repetitive mTBI. Exposure to blast overpressure from improvised explosive devices (IEDs) has been implicated as a potential antecedent for CTE amongst Iraq and Afghanistan Warfighters. In this study, we identified biomarker signatures in rats exposed to repetitive low-level blast that develop chronic anxiety-related traits and in human veterans exposed to IED blasts in theater with behavioral, cognitive, and/or memory complaints. Rats exposed to repetitive low-level blasts accumulated abnormal hyperphosphorylated tau in neuronal perikarya and perivascular astroglial processes. Using positron emission tomography (PET) and the [F-18]AV1451 (flortaucipir) tau ligand, we found that five of 10 veterans exhibited excessive retention of [F-18]AV1451 at the white/gray matter junction in frontal, parietal, and temporal brain regions, a typical localization of CTE tauopathy. We also observed elevated levels of neurofilament light (NfL) chain protein in the plasma of veterans displaying excess [F-18]AV1451 retention. These findings suggest an association linking blast injury, tauopathy, and neuronal injury. Further study is required to determine whether clinical, neuroimaging, and/or fluid biomarker signatures can improve the diagnosis of long-term neuropsychiatric sequelae of mTBI.
|
|
| 4. |
|
|
| 5. |
|
|
| 6. |
|
|
| 7. |
- Garmabaki, Amir H. Soleimani, et al.
(author)
-
Modeling two-dimensional software multi-upgradation and related release problem : a multi attribute utility approach
- 2012
-
In: International Journal of Reliability, Quality and Safety Engineering (IJRQSE). - 0218-5393. ; 19:3
-
Journal article (peer-reviewed)abstract
- The today's fast-paced, competitive environment in the field of Science and Technology, demands highly reliable hardware and software in order to achieve new breakthroughs in quality and productivity. In this scenario, first release of software products includes enough features and functionality to make it useful for the customers. Later, software companies have to come up with upgradation or add-ons in their software to survive in the market through a series of releases. Each succeeding upgradation offers some innovative performance or new functionality, distinguishing itself from the past releases. In one-dimensional Software Reliability Growth Models (SRGM) researcher used one factor such as Testing-Time, Testing-Effort or Coverage, etc. but within a two-dimensional SRGM environment, the process depends on two-types of reliability growth factors like Testing-time and Testing-effort. In addition, we also consider the combined effect of bugs encountered during testing of present release and user reported bugs from the operational phase. The model developed in the paper takes into consideration the testing and the operational phase where fault removal phenomenon follows, logistic and Weibull model, respectively. The paper also comprises of formulating an optimal release problem based on Multi-Attribute Utility Theory (MAUT). Lastly, the model validation is done on real dataset of software already released in the market with successive generations.
|
|
| 8. |
- Garmabaki, Amir H. Soleimani, et al.
(author)
-
The Impact of Bugs Reported from Operational Phase on Successive Software Releases
- 2014
-
In: International Journal of Productivity and Quality Management. - 1746-6474 .- 1746-6482. ; 14:4, s. 423-440
-
Journal article (peer-reviewed)abstract
- Software testing is a necessary part of software development life cycle (SDLC) to achieve a high reliable software system. In today’s software environment of global competition where each company is trying to prove itself better than its competitors, software companies have to continually do up-gradation or add-ons in their software to survive in the market. Each succeeding up-gradation offers some innovative performance or new functionality, distinguishing itself from the past release. We consider the combined effect of bugs encountered during testing of present release and user reported bug from operational phase. The model developed in the paper takes into consideration the testing and the operational phase where fault removal phenomenon follows Kapur-Garg model and Weibull-model respectively. The model developed is validated on real datasets for software which has been released in the market with new features.
|
|
| 9. |
|
|
| 10. |
|
|
| 11. |
- Petrovic, S, et al.
(author)
-
Identification of a basolateral Cl-/HCO3- exchanger specific to gastric parietal cells
- 2003
-
In: American journal of physiology. Gastrointestinal and liver physiology. - : American Physiological Society. - 0193-1857 .- 1522-1547. ; 284:6, s. G1093-G1103
-
Journal article (peer-reviewed)abstract
- The basolateral Cl−/HCO[Formula: see text] exchanger in parietal cells plays an essential role in gastric acid secretion mediated via the apical gastric H+-K+-ATPase. Here, we report the identification of a new Cl−/HCO[Formula: see text]exchanger, which shows exclusive expression in mouse stomach and kidney, with expression in the stomach limited to the basolateral membrane of gastric parietal cells. Tissue distribution studies by RT-PCR and Northern hybridizations demonstrated the exclusive expression of this transporter, also known as SLC26A7, to stomach and kidney, with the stomach expression significantly more abundant. No expression was detected in the intestine. Cellular distribution studies by RT-PCR and Northern hybridizations demonstrated predominant localization of SLC26A7 in gastric parietal cells. Immunofluorescence labeling localized this exchanger exclusively to the basolateral membrane of gastric parietal cells, and functional studies in oocytes indicated that SLC26A7 is a DIDS-sensitive Cl−/HCO[Formula: see text] exchanger that is active in both acidic and alkaline pHi. On the basis of its unique expression pattern and function, we propose that SLC26A7 is a basolateral Cl−/HCO[Formula: see text] exchanger in gastric parietal cells and plays a major role in gastric acid secretion.
|
|
| 12. |
|
|
| 13. |
- Petrovic, S, et al.
(author)
-
SLC26A7: a basolateral Cl-/HCO3- exchanger specific to intercalated cells of the outer medullary collecting duct
- 2004
-
In: American journal of physiology. Renal physiology. - : American Physiological Society. - 1931-857X .- 1522-1466. ; 286:1, s. F161-F169
-
Journal article (peer-reviewed)abstract
- The outer medullary collecting duct (OMCD) plays an important role in bicarbonate reabsorption and acid-base regulation. An apical V-type H+-ATPase and a basolateral [Formula: see text] exchanger, located in intercalated cells of OMCD, mediate the bicarbonate reabsorption. Here we report the identification of a new basolateral [Formula: see text] exchanger in OMCD intercalated cells in rat kidney. Northern hybridizations demonstrated the predominant expression of this transporter, also known as SLC26A7, in the outer medulla, with lower expression levels in the inner medulla. SLC26A7 was recognized as a ∼90-kDa band in the outer medulla by immunoblot analysis and was localized on the basolateral membrane of a subset of OMCD cells by immunocytochemical staining. No labeling was detected in the cortex. Double-immunofluorescence labeling with the aquaporin-2 and SLC26A7 antibodies or anion exchanger-1 and SLC26A7 antibodies identified the SLC26A7-expressing cells as α-intercalated cells. Functional studies in oocytes demonstrated that increasing the osmolality of the media (to simulate the physiological milieu in the medulla) increased the [Formula: see text] exchanger activity mediated via SLC26A7 by about threefold ( P < 0.02 vs. normal condition). We propose that SLC26A7 is a basolateral [Formula: see text] exchanger in intercalated cells of the OMCD and may play an important role in bicarbonate reabsorption in medullary collecting duct.
|
|
| 14. |
- Adie, Bailey Ashton, et al.
(author)
-
Careers, citations, bibliometrics, and impact : perspectives of new and emerging researchers
- 2024
-
In: How to get published in the best tourism journals. - Cheltenham : Edward Elgar Publishing. - 9781035300600 - 9781035300594 ; , s. 211-238
-
Book chapter (peer-reviewed)abstract
- This chapter brings together invited contributions from new and emerging academics with respect to their experiences and how publishing demands affect their careers and life, and vice versa. The provision of such experiences is important as it conveys the reality of publishing from a real-world context with respect to the pressures we face, especially when starting on the academic ladder. Authors were given a broad scope with respect to their contributions and the results are provided with only very minor editing. They have also been presented anonymously, or rather collectively, because although there are clearly different perspectives, emphasises, and interpretations, there are also commonalities in the contributors’ experiences. Nevertheless, as the reader will see, there are a number of common themes that emerge. Following the perspectives of the different contributions the chapter will discuss some of the main issues that emerge and their implications, including some of the darker aspects of the pressures of publishing.
|
|
| 15. |
|
|
| 16. |
- Derakhshandeh, J., et al.
(author)
-
Fabrication of 100 nm gate length MOSFET's using a novel carbon nanotube-based nano-lithography
- 2005
-
In: Materials Science & Engineering. - : Elsevier BV. - 0921-5107 .- 1873-4944. ; 124, s. 354-358
-
Journal article (peer-reviewed)abstract
- PECVD-grown carbon nanotubes on (100)silicon substrates have been studied and exploited for electron emission applications. After the growth of vertical CNT's [Y. Abdi, J. Koohsorkhi, J. Derakhshandeh, S. Mohajerzadeh, H. Hosseinzadegan, M.D. Robertson, C. Benet, EMRS Spring Meeting, Strasbourg, France, May 2005] the grown nanotubes are encapsulated by means of an insulating TiO(2) layer, leading to beam-shape emission of electrons from the cathode towards the opposite anode electrode. The electron emission occurs using an anode-cathode voltage of 100 V with ability of direct writing on a photo-resist-coated substrates. Straight lines with widths between 50 and 200 nm have been successfully drawn. This technique has been applied on P-type (100)silicon substrates for the formation of the gate of N-MOSFET devices. The successful realization of MOSFET devices indicates its usefulness for applications in nano-electronic devices. This device has inversion Cox exceeding 0.7 mu F/cm(2), drive current equal to 3 10 mu A/mu m.
|
|
| 17. |
|
|
| 18. |
- Gharipour, Mojgan, et al.
(author)
-
Socioeconomic determinants and metabolic syndrome : Results from the Isfahan Healthy Heart Program
- 2016
-
In: Acta Biomedica. - 0392-4203. ; 87:3, s. 291-298
-
Journal article (peer-reviewed)abstract
- Introduction: The prevalence of metabolic syndrome (MetS) is increasing in Iran. We assessed the relationship between socioeconomic status (SES) and Mets components in the Iranian population. Materi- als and Methods: The sample for this study comprised a random cross-section of men and women from two province districts who participated in the Isfahan Healthy Heart Program (IHHP) in 2007. Each participant completed a questionnaire, underwent anthropometric testing and blood pressure measurements, and pro- vided a blood sample. Mets was defined based on ATPIII criteria. Several SES dimensions, such as education, occupation, and number of children, as well as home, car, and personal computer ownership, were assessed to determine the participant’s SES. Results: A higher-than-average income, car ownership, owning or renting a private home, and having a computer are increasing towards increment in SES. All MetS components were more prevalent in participants defined as having a lower SES, while low HDL levels were more common in participants having an SES II (P>0.001). A multivariate analysis showed that having the lowest SES (I) increased the risk of MetS by 1.72 [1.44-2.07], whereas subjects having an SES III had a 1.23 [1.04-1.47] lower risk for MetS. Conclusions: The relationship between SES and Mets is due largely to behavioural factors, such as practicing unhealthy eating habits. Given the high prevalence of Mets in Iran, we propose that regular health check-ups may be useful in the early detection of the syndrome and, consequently, in the prevention of its effects. In addition, the early detection of MetS may result in the early diagnosis and prevention of car- diovascular diseases. (www.actabiomedica.it)
|
|
| 19. |
|
|
| 20. |
- Kharrazi, S. M., et al.
(author)
-
Pretreatment of lignocellulosic waste as a precursor for synthesis of high porous activated carbon and its application for Pb (II) and Cr (VI) adsorption from aqueous solutions
- 2021
-
In: International Journal of Biological Macromolecules. - : Elsevier. - 0141-8130 .- 1879-0003. ; 180, s. 299-310
-
Journal article (peer-reviewed)abstract
- Effects of Elm tree sawdust pretreatments using alkali and alkaline earth metals (NaCl, KCl, CaCl2, MgCl2 and Elm tree ash) and deashing solutions (water, HCl, HNO3 and aqua regia) before the carbonization process on the porosity of produced activated carbons and Pb (II) and Cr (VI) adsorption were studied. The activated carbons were characterized by pore size distribution, surface area, FTIR, and SEM-EDX analysies. Based on the results, HCl leaching pretreatment of the biomass increased the activated carbon adsorption capacity of Cr (VI) from 114 to 190 mg g−1. The treatment of biomass with alkali and alkali earth metal salts, especially MgCl2, remarkably increased the activated carbon adsorption capacity of Pb (II) from 233 to 1430 mg g−1. The results indicated that Pb (II) adsorption was attributed to both the mesoporous structure of activated carbon and the abundance of Mg on the activated carbon's surface. On the other hand, the micropores played a major role in Cr (VI) adsorption capacity. The development of the micro- or mesoporous structure of activated carbons through pretreatment of lignocellulosic precursor could be an approach for providing high performance activated carbons for Pb (II) and Cr (VI) removal from aqueous solutions.
|
|
| 21. |
|
|
| 22. |
- Mead, Gillian E., et al.
(author)
-
Fluoxetine for stroke recovery : Meta-analysis of randomized controlled trials
- 2020
-
In: International Journal of Stroke. - : SAGE Publications. - 1747-4930 .- 1747-4949. ; 15:4, s. 365-376
-
Journal article (peer-reviewed)abstract
- OBJECTIVE: To determine whether fluoxetine, at any dose, given within the first year after stroke to patients who did not have to have mood disorders at randomization reduced disability, dependency, neurological deficits and fatigue; improved motor function, mood, and cognition at the end of treatment and follow-up, with the same number or fewer adverse effects.METHODS: Searches (from 2012) in July 2018 included databases, trials registers, reference lists, and contact with experts. Co-primary outcomes were dependence and disability. Dichotomous data were synthesized using risk ratios (RR) and continuous data using standardized mean differences (SMD). Quality was appraised using Cochrane risk of bias methods. Sensitivity analyses explored influence of study quality.RESULTS: The searches identified 3414 references of which 499 full texts were assessed for eligibility. Six new completed RCTs (n = 3710) were eligible, and were added to the seven trials identified in a 2012 Cochrane review (total: 13 trials, n = 4145). There was no difference in the proportion independent (3 trials, n = 3249, 36.6% fluoxetine vs. 36.7% control; RR 1.00, 95% confidence interval 0.91 to 1.09, p = 0.99, I2 = 78%) nor in disability (7 trials n = 3404, SMD 0.05, -0.02 to 0.12 p = 0.15, I2 = 81%) at end of treatment. Fluoxetine was associated with better neurological scores and less depression. Among the four (n = 3283) high-quality RCTs, the only difference between groups was lower depression scores with fluoxetine.CONCLUSION: This class I evidence demonstrates that fluoxetine does not reduce disability and dependency after stroke but improves depression.
|
|
| 23. |
- Soleimani, M., et al.
(author)
-
A multiphysics-based artificial neural networks model for atherosclerosis
- 2023
-
In: Heliyon. - 2405-8440. ; 9
-
Journal article (peer-reviewed)abstract
- Atherosclerosis is a medical condition involving the hardening and/or thickening of arteries' walls. Mathematical multi-physics models have been developed to predict the development of atherosclerosis under different conditions. However, these models are typically computationally expensive. In this study, we used machine learning techniques, particularly artificial neural networks (ANN), to enhance the computational efficiency of these models. A database of multi-physics Finite Element Method (FEM) simulations was created and used for training and validating an ANN model. The model is capable of quick and accurate prediction of atherosclerosis development. A remarkable computational gain is obtained using the ANN model compared to the original FEM simulations.
|
|
