| 1. |
- Ruilope, LM, et al.
(author)
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Design and Baseline Characteristics of the Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease Trial
- 2019
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In: American journal of nephrology. - : S. Karger AG. - 1421-9670 .- 0250-8095. ; 50:5, s. 345-356
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Journal article (peer-reviewed)abstract
- <b><i>Background:</i></b> Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. <b><i>Patients and</i></b> <b><i>Methods:</i></b> The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate ≥25 mL/min/1.73 m<sup>2</sup> and albuminuria (urinary albumin-to-creatinine ratio ≥30 to ≤5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level α = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. <b><i>Conclusions:</i></b> FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049.
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| 2. |
- Hurth, A., et al.
(author)
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Assessment of Central Sensitization in Breast Cancer Survivors: Convergent Validity and Use of the Central Sensitization Inventory (CSI) and Its Short-Form as a Clustering Tool
- 2021
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In: Clinics and Practice. - : MDPI AG. - 2039-7275 .- 2039-7283. ; 11:3, s. 607-618
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Journal article (peer-reviewed)abstract
- The Central Sensitization Inventory (CSI) measurement properties in patients having nonspecific, noncancer pain are well-established. However, studies examining the reliability and validity of either the CSI or the Central Sensitization Inventory short-form version (CSI-9) in breast cancer survivors (BCS) are scarce. The purpose was to evaluate convergent validity and internal consistency of the CSI and CSI-9. Additionally, the relevance of a new cluster calculator using the CSI was explored. The cross-sectional multi-center study included 65 BCS and 37 healthy volunteers. Patients filled out multiple questionnaires assessing pain, number of painful areas, anxiety, depression and quality of life. The relevance of a cluster calculator was explored by known-group comparisons and boxplot description. All hypotheses were formulated before data analysis. The majority of hypotheses on the correlations between the CSI or CSI-9 and other health outcomes were confirmed (22 out of 27). The CSI and CSI-9 have excellent (alpha = 0.92) and good (alpha = 0.86) internal consistency, respectively. The CSI cluster calculator might be an interesting tool to use to have a patient's overall condition snapshot. Generally, the study findings support the construct validity and internal consistency of the CSI, which underline the use of this self-reported instrument in BCS. The CSI-9 shows promising results, but should be further evaluated.
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| 3. |
- Zeng, Qiao-Shi, et al.
(author)
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Substitutional alloy of Ce and Al
- 2009
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 106:8, s. 2515-2518
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Journal article (peer-reviewed)abstract
- The formation of substitutional alloys has been restricted to elements with similar atomic radii and electronegativity. Using high-pressure at 298 K, we synthesized a face-centered cubic disordered alloy of highly dissimilar elements (large Ce and small Al atoms) by compressing the Ce3Al intermetallic compound > 15 GPa or the Ce3Al metallic glass > 25 GPa. Synchrotron X-ray diffraction, Ce L-3-edge absorption spectroscopy, and ab initio calculations revealed that the pressure-induced Kondo volume collapse and 4f electron delocalization of Ce reduced the differences between Ce and Al and brought them within the Hume-Rothery (HR) limit for substitutional alloying. The alloy remained after complete release of pressure, which was also accompanied by the transformation of Ce back to its ambient 4f electron localized state and reversal of the Kondo volume collapse, resulting in a non-HR alloy at ambient conditions.
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| 4. |
- Mao, Wendy L., et al.
(author)
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Distortions and stabilization of simple-cubic calcium at high pressure and low temperature
- 2010
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In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424 .- 1091-6490. ; 107:22, s. 9965-9968
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Journal article (peer-reviewed)abstract
- Ca-III, the first superconducting calcium phase under pressure, was identified as simple-cubic (sc) by previous X-ray diffraction (XRD) experiments. In contrast, all previous theoretical calculations showed that sc had a higher enthalpy than many proposed structures and had an imaginary (unstable) phonon branch. By using our newly developed submicrometer high-pressure single-crystal XRD, cryogenic high-pressure XRD, and theoretical calculations, we demonstrate that Ca-III is neither exactly sc nor any of the lower-enthalpy phases, but sustains the sc-like, primitive unit by a rhombohedral distortion at 300 K and a monoclinic distortion below 30 K. This surprising discovery reveals a scenario that the high-pressure structure of calcium does not go to the zero-temperature global enthalpy minimum but is dictated by high-temperature anharmonicity and low-temperature metastability fine-tuned with phonon stability at the local minimum.
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| 5. |
- Nilsson, Hans, et al.
(author)
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Birth of a comet magnetosphere : A spring of water ions
- 2015
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In: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 347:6220
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Journal article (peer-reviewed)abstract
- The Rosetta mission shall accompany comet 67P/Churyumov-Gerasimenko from a heliocentric distance of >3.6 astronomical units through perihelion passage at 1.25 astronomical units, spanning low and maximum activity levels. Initially, the solar wind permeates the thin comet atmosphere formed from sublimation, until the size and plasma pressure of the ionized atmosphere define its boundaries: A magnetosphere is born. Using the Rosetta Plasma Consortium ion composition analyzer, we trace the evolution from the first detection of water ions to when the atmosphere begins repelling the solar wind (~3.3 astronomical units), and we report the spatial structure of this early interaction. The near-comet water population comprises accelerated ions (
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| 6. |
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| 7. |
- Nordström, T., et al.
(author)
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Venus ion outflow estimates at solar minimum : Influence of reference frames and disturbed solar wind conditions
- 2013
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In: Journal of Geophysical Research - Space Physics. - : John Wiley & Sons. - 2169-9380 .- 2169-9402. ; 118:6, s. 3592-3601
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Journal article (peer-reviewed)abstract
- Recent estimates of ion escape rates from Venus, based on ASPERA-4 data, differ by more than a factor of 4. Whereas the ASPERA-4 instrument provides state-of-the art observations, the limited field of view of the instrument and the strongly limited geographical coverage of the spacecraft orbit means that significant assumptions must be used in the interpretation of the data. We complement previous studies by using a method of average distribution functions to obtain as good statistics as possible while taking the limited field of view into account. We use more than 3 years of data, more than any of the previous studies, and investigate how the choice of a geographical reference frame or a solar wind electric field oriented reference frame affects the results. We find that the choice of reference frame cannot explain the difference between the previously published reports. Our results, based on a larger data set, fall in between the previous studies. Our conclusion is that the difference between previous studies is caused by the large variability of ion outflow at Venus. It matters significantly for the end result which data are selected and which time period is used. The average escape rates were found to be 5.2±1.0×1024 s−1for heavy ions (m/q ≥16) and 14±2.6×1024 s−1for protons. We also discuss the spatial distribution of the planetary ion outflow in the solar wind electric field reference frame.
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| 8. |
- Persson, Moa, 1991-, et al.
(author)
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Heavy Ion Flows in the Upper Ionosphere of the Venusian North Pole
- 2019
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In: Journal of Geophysical Research - Space Physics. - : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 124:6, s. 4597-4607
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Journal article (peer-reviewed)abstract
- We investigate the heavy ion density and velocity in the Venusian upper ionosphere near the North Pole, using the Ion Mass Analyzer, a part of the Analyzer of Space Plasmas and Energetic Atoms 4, together with the magnetic field instruments on Venus Express. The measurements were made during June-July 2014, covering the aerobraking campaign with lowered altitude measurements (similar to 130 km). The plasma scale heights are similar to 15 km below 150-km altitude and similar to 200 km at 150-400-km altitude. A clear trend of dusk-to-dawn heavy ion flow across the polar ionosphere was found, with speeds of similar to 2-10 km/s. In addition, the flow has a significant downward radial velocity component. The flow pattern does not depend on the interplanetary magnetic field directions nor the ionospheric magnetization states. Instead, we suggest a thermal pressure gradient between the equatorial and polar terminator regions, induced by the decrease in density between the regions, as the dominant mechanism driving the ion flow. Plain Language Summary We have calculated the ion density and velocities in the Venusian polar ionosphere using measurements from the Ion Mass Analyzer on board the Venus Express spacecraft. During June-July 2014 the periapsis was lowered to similar to 130 km, which allowed for measurements down to low altitudes of the ionosphere near the North Pole. The plasma scale heights are similar to 15 km below 150-km altitude and similar to 200 km at 150-400 km, which is similar to what was found near the equatorial region by the Pioneer Venus mission. In addition, there is a clear trend of dusk-to-dawn flow, along the terminator, for the heavy ions. This is surprising, as a general flow from day-to-night is expected for the Venusian ionosphere due to the long nights and significant heating of the dayside upper atmosphere. The interplanetary magnetic field direction does not appear to affect the ion flow pattern. Instead, we propose a thermal pressure gradient as the dominant accelerating mechanism, induced by the decrease in density from the equator toward the pole.
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| 9. |
- Reijers, S. J. M., et al.
(author)
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Variation in response rates to isolated limb perfusion in different soft-tissue tumour subtypes: an international multi-centre study
- 2023
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In: European Journal of Cancer. - 0959-8049. ; 190
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Journal article (peer-reviewed)abstract
- Objective: The aim of this study was to investigate the response rates of different extremity soft-tissue sarcoma subtypes (eSTS) after isolated limb perfusion (ILP), based on an international multi-centre study. Materials and methods: The retrospective cohort comprised eSTS patients from 17 specialised ILP centres that underwent melphalan-based ILP, with or without recombinant human tumour necrosis factor (rhTNF & alpha;) (TM-ILP and M-ILP, respectively). Response was measured on imaging (magnetic resonance imaging) and/or clinical response, for which M-ILPs were excluded. Results: A total of 1109 eSTS patients were included. The three most common histological subtypes were undifferentiated pleomorphic sarcoma (17%, n = 184), synovial sarcoma (16%, n = 175) and myxofibrosarcoma (8%, n = 87). rhTNF & alpha; was used in 93% (TM-ILP) and resulted in a significantly better overall response rate (ORR, p = 0.031) and complete responses (CR, p < 0.001) in comparison to M-ILP, without significant differences among histological subgroups. The ORR of TM-ILP was 68%, including 17% CR. Also, 80% showed progressive disease. Significantly higher response rates were shown for Kaposi sarcoma (KS) with 42% CR and 96% ORR (both p < 0.001), and significantly higher CR rates for angiosarcoma (AS, 45%, p < 0.001) and clear cell sarcoma (CCS, 31%, p = 0.049). ILP was followed by resection & LE; 6 months in 80% of the patients. The overall limb salvage rate was 88%, without significant differences among histological subgroups, but was significantly higher for ILP responders compared to non-responders (93% versus 76%, p < 0.001). Conclusion: ILP resulted in high response and LRS among all eSTS subtypes, however, with significant differences between subtypes with most promising results for KS, AS and CCS.
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