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1.
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2.
  • Romagnoni, A, et al. (author)
  • Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data
  • 2019
  • In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 9:1, s. 10351-
  • Journal article (peer-reviewed)abstract
    • Crohn Disease (CD) is a complex genetic disorder for which more than 140 genes have been identified using genome wide association studies (GWAS). However, the genetic architecture of the trait remains largely unknown. The recent development of machine learning (ML) approaches incited us to apply them to classify healthy and diseased people according to their genomic information. The Immunochip dataset containing 18,227 CD patients and 34,050 healthy controls enrolled and genotyped by the international Inflammatory Bowel Disease genetic consortium (IIBDGC) has been re-analyzed using a set of ML methods: penalized logistic regression (LR), gradient boosted trees (GBT) and artificial neural networks (NN). The main score used to compare the methods was the Area Under the ROC Curve (AUC) statistics. The impact of quality control (QC), imputing and coding methods on LR results showed that QC methods and imputation of missing genotypes may artificially increase the scores. At the opposite, neither the patient/control ratio nor marker preselection or coding strategies significantly affected the results. LR methods, including Lasso, Ridge and ElasticNet provided similar results with a maximum AUC of 0.80. GBT methods like XGBoost, LightGBM and CatBoost, together with dense NN with one or more hidden layers, provided similar AUC values, suggesting limited epistatic effects in the genetic architecture of the trait. ML methods detected near all the genetic variants previously identified by GWAS among the best predictors plus additional predictors with lower effects. The robustness and complementarity of the different methods are also studied. Compared to LR, non-linear models such as GBT or NN may provide robust complementary approaches to identify and classify genetic markers.
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5.
  • Craddock, Nick, et al. (author)
  • Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
  • 2010
  • In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7289, s. 713-720
  • Journal article (peer-reviewed)abstract
    • Copy number variants (CNVs) account for a major proportion of human genetic polymorphism and have been predicted to have an important role in genetic susceptibility to common disease. To address this we undertook a large, direct genome-wide study of association between CNVs and eight common human diseases. Using a purpose-designed array we typed,19,000 individuals into distinct copy-number classes at 3,432 polymorphic CNVs, including an estimated similar to 50% of all common CNVs larger than 500 base pairs. We identified several biological artefacts that lead to false-positive associations, including systematic CNV differences between DNAs derived from blood and cell lines. Association testing and follow-up replication analyses confirmed three loci where CNVs were associated with disease-IRGM for Crohn's disease, HLA for Crohn's disease, rheumatoid arthritis and type 1 diabetes, and TSPAN8 for type 2 diabetes-although in each case the locus had previously been identified in single nucleotide polymorphism (SNP)-based studies, reflecting our observation that most common CNVs that are well-typed on our array are well tagged by SNPs and so have been indirectly explored through SNP studies. We conclude that common CNVs that can be typed on existing platforms are unlikely to contribute greatly to the genetic basis of common human diseases.
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6.
  • Bianco, L., et al. (author)
  • Discovery of W-157 and Os-161
  • 2010
  • In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 690:1, s. 15-18
  • Journal article (peer-reviewed)abstract
    • The nuclides W-157 and Os-161 have been discovered ill reactions of Ni-58 ion beams with a Cd-106 target. The Os-161 alpha-decay energy and half-life were 6890 +/- 12 keV and 640 +/- 60 mu s. The daughter W-157 nuclei beta-decayed with a half-life of 275 +/- 40 ms, populating both low-lying alpha-decaying states in Ta-157, which is consistent with a 7/2(-) ground state in W-157. Fine structure observed in the alpha decay of Os-161 places the lowest excited state in W-157 with 1(pi) = 9/2(-) at 318 +/- 30 key. The branching ratio of 5.5(-2.2)(+3.1)% indicates that Os-161 also has a 7/2(-) ground state. Shell-model calculations analysing the effects of monopole shifts and a tensor force on the relative energies of 2f(7/2) and 1h(9/2) neutron states in N = 83 isotones are presented. (C) 2010 Elsevier B.V. All rights reserved.
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7.
  • Downey, Harriet, et al. (author)
  • Training future generations to deliver evidence-based conservation and ecosystem management
  • 2021
  • In: Ecological Solutions and Evidence. - : Wiley. - 2688-8319. ; 2:1
  • Research review (peer-reviewed)abstract
    • 1. To be effective, the next generation of conservation practitioners and managers need to be critical thinkers with a deep understanding of how to make evidence-based decisions and of the value of evidence synthesis.2. If, as educators, we do not make these priorities a core part of what we teach, we are failing to prepare our students to make an effective contribution to conservation practice.3. To help overcome this problem we have created open access online teaching materials in multiple languages that are stored in Applied Ecology Resources. So far, 117 educators from 23 countries have acknowledged the importance of this and are already teaching or about to teach skills in appraising or using evidence in conservation decision-making. This includes 145 undergraduate, postgraduate or professional development courses.4. We call for wider teaching of the tools and skills that facilitate evidence-based conservation and also suggest that providing online teaching materials in multiple languages could be beneficial for improving global understanding of other subject areas.
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8.
  • Grodner, E., et al. (author)
  • Hindered Gamow-Teller Decay to the Odd-Odd N=Z 62Ga: Absence of Proton-Neutron T=0 Condensate in A=62
  • 2014
  • In: Physical Review Letters. - 1079-7114. ; 113:9
  • Journal article (peer-reviewed)abstract
    • Search for a new kind of superfluidity built on collective proton-neutron pairs with aligned spin is performed studying the Gamow-Teller decay of the T=1, Jπ=0+ ground state of Ge62 into excited states of the odd-odd N=Z nucleus Ga62. The experiment is performed at GSI Helmholtzzentrum für Schwerionenforschung with the Ge62 ions selected by the fragment separator and implanted in a stack of Si-strip detectors, surrounded by the RISING Ge array. A half-life of T1/2=82.9(14) ms is measured for the Ge62 ground state. Six excited states of Ga62, populated below 2.5 MeV through Gamow-Teller transitions, are identified. Individual Gamow-Teller transition strengths agree well with theoretical predictions of the interacting shell model and the quasiparticle random phase approximation. The absence of any sizable low-lying Gamow-Teller strength in the reported beta-decay experiment supports the hypothesis of a negligible role of coherent T=0 proton-neutron correlations in Ga62.
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9.
  • Hurst, A. M., et al. (author)
  • Measurement of the sign of the spectroscopic quadrupole moment for the 2(1)(+) state in Se-70: No evidence for oblate shape
  • 2007
  • In: Physical Review Letters. - 1079-7114. ; 98:7
  • Journal article (peer-reviewed)abstract
    • Using a method whereby molecular and atomic ions are independently selected, an isobarically pure beam of Se-70 ions was postaccelerated to an energy of 206 MeV using REX-ISOLDE. Coulomb-excitation yields for states in the beam and target nuclei were deduced by recording deexcitation gamma rays in the highly segmented MINIBALL gamma-ray spectrometer in coincidence with scattered particles in a silicon detector. At these energies, the Coulomb-excitation yield for the first 2(+) state is expected to be strongly sensitive to the sign of the spectroscopic quadrupole moment through the nuclear reorientation effect. Experimental evidence is presented here for a prolate shape for the first 2(+) state in Se-70, reopening the question over whether there are, as reported earlier, deformed oblate shapes near to the ground state in the light selenium isotopes.
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10.
  • Ketelhut, S., et al. (author)
  • gamma-Ray Spectroscopy at the Limits : First Observation of Rotational Bands in Lr-255
  • 2009
  • In: Physical Review Letters. - 0031-9007 .- 1079-7114. ; 102:21, s. 212501-
  • Journal article (peer-reviewed)abstract
    • The rotational band structure of Lr-255 has been investigated using advanced in-beam gamma-ray spectroscopic techniques. To date, Lr-255 is the heaviest nucleus to be studied in this manner. One rotational band has been unambiguously observed and strong evidence for a second rotational structure was found. The structures are tentatively assigned to be based on the 1/2(-)[521] and 7/2(-)[514] Nilsson states, consistent with assignments from recently obtained alpha decay data. The experimental rotational band dynamic moment of inertia is used to test self-consistent mean-field calculations using the Skyrme SLy4 interaction and a density-dependent pairing force.
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11.
  • Page, R. D., et al. (author)
  • alpha decay of Re-159 and proton emission from Ta-155
  • 2007
  • In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 75:6, s. 061302-
  • Journal article (peer-reviewed)abstract
    • The alpha decay of Re-159 has been observed for the first time in reactions of 300 MeV Ni-58 ions with an isotopically enriched Cd-106 target. The Re-159 ions were separated in-flight using the RITU separator and implanted into the GREAT spectrometer. The alpha decay emanates from the proton-emitting pi h(11/2) state in Re-159 with an energy of E-alpha=6776 +/- 26 keV and a branching ratio of 7.5 +/- 3.5%. This alpha decay populates a state in the closed neutron shell nucleus Ta-155, which decays by emitting 1444 +/- 15 keV protons with a half-life of 2.9(-1.1)(+1.5) ms. These values are consistent with the emission of the proton from a pi h(11/2) orbital. These results fit in with the systematics of proton and alpha-particle separation energies in the region, but disagree with the previously reported decay properties of Ta-155.
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12.
  • Page, R. D., et al. (author)
  • Probing single-particle structures beyond the proton drip line
  • 2007
  • In: Proton Emitting Nuclei and Related Topics. - : American Institute of Physics (AIP). - 9780735404755 ; , s. 137-142
  • Conference paper (peer-reviewed)abstract
    • Single-particle energies have been investigated in the closed neutron shell proton emitter 155Ta. The 155Ta nuclei were populated through the α decay of 159Re, which has been observed for the first time. The 159Re nuclei were produced in reactions of 300 MeV 58Ni ions with an isotopically enriched 106Cd target, separated in-flight using the RITU separator and implanted into the GREAT spectrometer. The 159Re α decay emanates from the proton-emitting πh11/2 state and populates a state in 155Ta which decays by the emission of a proton from a πh 11/2 orbital. The results fit in with the systematics of proton and α-particle separation energies in the region, but disagree with the previously reported decay properties of 155Ta.
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13.
  • Saunders, N. R., et al. (author)
  • Age-Dependent Transcriptome and Proteome Following Transection of Neonatal Spinal Cord of Monodelphis domestica (South American Grey Short-Tailed Opossum)
  • 2014
  • In: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 9:6
  • Journal article (peer-reviewed)abstract
    • This study describes a combined transcriptome and proteome analysis of Monodelphis domestica response to spinal cord injury at two different postnatal ages. Previously we showed that complete transection at postnatal day 7 (P7) is followed by profuse axon growth across the lesion with near-normal locomotion and swimming when adult. In contrast, at P28 there is no axon growth across the lesion, the animals exhibit weight-bearing locomotion, but cannot use hind limbs when swimming. Here we examined changes in gene and protein expression in the segment of spinal cord rostral to the lesion at 24 h after transection at P7 and at P28. Following injury at P7 only forty genes changed (all increased expression); most were immune/inflammatory genes. Following injury at P28 many more genes changed their expression and the magnitude of change for some genes was strikingly greater. Again many were associated with the immune/inflammation response. In functional groups known to be inhibitory to regeneration in adult cords the expression changes were generally muted, in some cases opposite to that required to account for neurite inhibition. For example myelin basic protein expression was reduced following injury at P28 both at the gene and protein levels. Only four genes from families with extracellular matrix functions thought to influence neurite outgrowth in adult injured cords showed substantial changes in expression following injury at P28: Olfactomedin 4 (Olfm4, 480 fold compared to controls), matrix metallopeptidase (Mmp1, 104 fold), papilin (Papln, 152 fold) and integrin alpha 4 (Itga4, 57 fold). These data provide a resource for investigation of a priori hypotheses in future studies of mechanisms of spinal cord regeneration in immature animals compared to lack of regeneration at more mature stages.
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14.
  • Wadsworth, R., et al. (author)
  • Spin-gap Isomer in 96Cd
  • 2012
  • In: Journal of Physics: Conference Series. - : IOP Publishing. - 1742-6596 .- 1742-6588. ; 381:1
  • Journal article (peer-reviewed)abstract
    • Evidence has been obtained for the existence of the long predicted 16+ spin-gap isomer in 96Cd. The decay of the isomer was identified and studied following the use of an 850 MeV/u beam of 124Xe impinging on a Be target and the fragment recoil separator at the GSI Laboratory. Gamma decays from the fragments were detected using the RISING gamma ray array, in its stopped beam configuration, plus a silicon active stopper. The data obtained have been compared with shell model predictions, which indicate that the isoscalar neutron-proton interaction plays a key role in the formation of the isomer.
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15.
  • Al-Dahan, N., et al. (author)
  • Multiple beta(-) decaying states in Re-194: Shape evolution in neutron-rich osmium isotopes
  • 2012
  • In: Physical Review C (Nuclear Physics). - 0556-2813. ; 85:3
  • Journal article (peer-reviewed)abstract
    • beta decays from heavy, neutron-rich nuclei with A similar to 190 have been investigated following their production via the relativistic projectile fragmentation of an E/A = 1 GeV Pb-208 primary beam on a similar to 2.5 g/cm(2) Be-9 target. The reaction products were separated and identified using the GSI FRagment Separator (FRS) and stopped in the RISING active stopper. gamma decays were observed and correlated with these secondary ions on an event-by-event basis such that gamma-ray transitions following from both internal (isomeric) and beta decays were recorded. A number of discrete, beta-delayed gamma-ray transitions associated with beta decays from Re-194 to excited states in Os-194 have been observed, including previously reported decays from the yrast I-pi = (6(+)) state. Three previously unreported gamma-ray transitions with energies 194, 349, and 554 keV are also identified; these transitions are associated with decays from higher spin states in Os-194. The results of these investigations are compared with theoretical predictions from Nilsson multi-quasiparticle (MQP) calculations. Based on lifetime measurements and the observed feeding pattern to states in Os-194, it is concluded that there are three beta(-)-decaying states in Re-194.
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16.
  • Al-Dahan, N., et al. (author)
  • Structure of N≥126 Nuclei Produced in Fragmentation of 238U
  • 2009
  • In: Proceedings of the 13th International Symposium on Capture Gamma‐Ray Spectroscopy and Related Topics. - : AIP. - 0094-243X. ; 1090, s. 145-148
  • Conference paper (peer-reviewed)abstract
    • The nuclear structure of neutron-rich N≥126 nuclei have been investigated following their production via relativistic projectile fragmentation of a E/A=l GeV 238U beam on a Be target. The cocktail of secondary beam products were separated and identified using the GSI FRagment Separator (FRS). The nuclei of interest were implanted in a high-granularity active stopper detector set-up consisting of 6 double sided silicon strip detectors. The associated gamma-ray transitions were detected with the RISING array, consisting of 15 Euroball cluster Ge-detectors. Time-correlated gamma decays from individually identified nuclear species have been recorded, allowing the clean identification of isomeric decays.
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17.
  • Bacelar, A. M. Denis, et al. (author)
  • Angular Momentum Population In Fragmentation Reactions
  • 2009
  • In: Acta Physica Polonica. Series B: Elementary Particle Physics, Nuclear Physics, Statistical Physics, Theory of Relativity, Field Theory. - 0587-4254. ; 40:3, s. 889-892
  • Journal article (peer-reviewed)abstract
    • Neutron-deficient nuclei with N = 126 have been populated following projectile fragmentation of a U-238 beam with energy 1 GeV/A. The decay of several previously reported isomers has been measured. This will allow us to calculate high-spin isomeric ratios and compare them with model calculations to allow a better understanding of the reaction mechanism.
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18.
  • Darby, I. G., et al. (author)
  • Decay of the high-spin isomer in Re-160 : Changing single-particle structure beyond the proton drip line
  • 2011
  • In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 695:1-4, s. 78-81
  • Journal article (peer-reviewed)abstract
    • A new high-spin isomeric state (t(1/2) = 2.8 +/- 0.1 mu s) in Re-160 has been identified. This high-spin isomer is unique in that it only decays by gamma-decay and not by proton or alpha-particle emission as is the case in every other proton emitter between Z = 64 and 80. Shell model calculations indicate how the convergence of the h(9/2) and f(7/2) neutron levels in this region could open up a gamma-decay path from the high-spin isomer to the low-spin ground state of 160Re. providing a natural explanation for this anomalous absence of charged-particle emission. The consequences of these observations for future searches for proton emission from even more exotic nuclei and in-beam spectroscopic studies are considered.
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19.
  • Darby, I. G., et al. (author)
  • Precision measurements of proton emission from the ground states of Ta-156 and Re-160
  • 2011
  • In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 83:6, s. 064320-
  • Journal article (peer-reviewed)abstract
    • The decays of the pi d(3/2) ground states of Ta-156 and Re-160 have been studied in detail using the GREAT spectrometer. More than 7000 Re-160 nuclei were produced in reactions of 290- and 300-MeV Ni-58 ions with an isotopically enriched Cd-106 target and separated in flight using the RITU separator. The proton and alpha decays of the pi d(3/2) level were confirmed and the half-life and branching ratios of this state were determined with improved precision to be t(1/2) = 611 +/- 7 mu s and b(p) = 89 +/- 1% and b(alpha) = 11 +/- 1%, respectively. The alpha-decay branch populated the ground state of Ta-156, allowing improved values for the proton-decay energy and half-life to be obtained (E-p = 1011 +/- 5 keV; t(1/2) = 106 +/- 4 ms). The beta decay of this level was identified for the first time and a branching ratio of b(beta) = 29 +/- 3% was deduced. The spectroscopic factors deduced from these measurements are compared with predictions.
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20.
  • Denis Bacelar, A.M., et al. (author)
  • The population of metastable states as a probe of relativistic-energy fragmentation reactions
  • 2013
  • In: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 723:4–5, s. 302-306
  • Journal article (peer-reviewed)abstract
    • Isomeric ratios have been measured for high-spin states in Po-198,200,206,208(84), At-208,209,210,211(85), Rn-210,211,212,213,214(86), Fr-208,211,212,213,214(87), Ra-210,211,212,214,215(88), and Ac-215(89) following the projectile fragmentation of a 1 AGeV U-238 beam by a Be-9 target at GSI Helmholtzzentrum fur Schwerionenforschung. The fragments were separated in the fragment separator (FRS) and identified by means of energy loss and time-of-flight techniques. They were brought to rest at the centre of the RISING gamma-ray detector array and intensities of gamma rays emitted in the decay of isomeric states with half-lives between 100 ns and 40 mu s and spin values up to 55/2 (h) over bar were used to obtain the corresponding isomeric ratios. The data are compared to theoretical isomeric ratios calculated in the framework of the abrasion-ablation model. Large experimental enhancements are obtained for high-spin isomers in comparison to expected values. (C) 2013 Elsevier B.V. All rights reserved.
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21.
  • Herzberg, R-D, et al. (author)
  • Isomer spectroscopy in No-254
  • 2006
  • In: Physica Scripta. - 0031-8949 .- 1402-4896. ; T125, s. 73-77
  • Journal article (peer-reviewed)abstract
    • Isomeric states in No-254 were investigated using a calorimetric method. Two different isomers were found with half-lives of T-1/2 = 266 +/- 2 ms and T-1/2 = 184 +/- 3 mu s, respectively. The dominant decay path of the 184 mu s isomer proceeds via states feeding the longer-lived 266 ms isomer. The 266 ms isomer in turn decays via a two-quasi-particle K = 3 band to the ground-state band. The full decay path was observed with the GREAT spectrometer located at the focal plane of the gas-filled separator RITU at the Accelerator Laboratory in Jyvskyl. This work sheds light on the two-quasi-particle structure in this transfermium nucleus.
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22.
  • Joss, D. T., et al. (author)
  • Discovery of the proton emitting nucleus 159Re
  • 2007
  • In: Proton Emitting Nuclei and Related Topics. - : American Institute of Physics (AIP). - 9780735404755 ; , s. 28-33
  • Conference paper (peer-reviewed)abstract
    • The observation of the new nuclide 159Re provides important insights into the evolution of single-particle structure in heavy nuclei beyond the proton drip line. The nuclide 159Re was synthesised in the reaction 106Cd(58Ni, p4n) and identified via its proton radioactivity using the RITU gas-filled separator and the GREAT focal-plane spectrometer. Comparisons of the measured proton energy (Ep = 1805±20 keV) and decay half-life (t1/2 = 21±4 μs) with values calculated using the WKB method indicate that the proton is emitted from an h11/2 state. The implications of these results for future experimental investigations into even more proton unbound Re isotopes using in-flight separation techniques are considered.
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23.
  • Joss, D. T., et al. (author)
  • Probing the limit of nuclear existence : Proton emission from Re-159
  • 2006
  • In: Physics Letters B. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 641:1, s. 34-37
  • Journal article (peer-reviewed)abstract
    • The observation of the new nuclide Re-159(75)84 provides important insights into the evolution of single-particle structure and the mass surface in heavy nuclei beyond the proton drip line. This nuclide, 26 neutrons away from the nearest stable rhenium isotope, was synthesised in the reaction Cd-106(Ni-58, p4n) and identified via its proton radioactivity using the RITU gas-filled separator and the GREAT focal-plane spectrometer. Comparisons of the measured proton energy (E-p = 1805 +/- 20 keV) and decay half-life (t(1/2) = 21 +/- 4 mu s) with values calculated using the WKB method indicate that the proton is emitted from an h(11/2) state. The implications of these results for future experimental investigations into even more proton unbound nuclei using in-flight separation techniques are considered.
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24.
  • Morales, A. I., et al. (author)
  • beta -Delayed gamma -Ray Spectroscopy of Heavy Neutron Rich Nuclei "South" of Lead
  • 2009
  • In: Acta Physica Polonica B. - 0587-4254. ; 40:3, s. 867-870
  • Conference paper (peer-reviewed)abstract
    • Relativistic projectile fragmentation of a Pb-208 primary beam has been used to produce neutron-rich nuclei with proton-holes relative to the Z = 82 shell closure, i.e., "south" of Pb. beta-delayed gamma-ray spectroscopy allows to investigate the structural properties of such nuclei with A similar to 195 -> 205. The current work presents transitions de-exciting excited states in Au-204, which are the first spectroscopic information on this N = 125 isotone.
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25.
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26.
  • Söderström, Pär-Anders, et al. (author)
  • Spectroscopy of neutron-rich Dy-168,Dy-170 : Yrast band evolution close to the NpNn valence maximum
  • 2010
  • In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 81:3, s. 034310-
  • Journal article (peer-reviewed)abstract
    • The yrast sequence of the neutron-rich dysprosium isotope Dy-168 has been studied using multinucleon transfer reactions following collisions between a 460-MeV Se-82 beam and an Er-170 target. The reaction products were identified using the PRISMA magnetic spectrometer and the gamma rays detected using the CLARA HPGe-detector array. The 2(+) and 4(+) members of the previously measured ground-state rotational band of Dy-168 have been confirmed and the yrast band extended up to 10(+). A tentative candidate for the 4(+) -> 2(+) transition in Dy-170 was also identified. The data on these nuclei and on the lighter even-even dysprosium isotopes are interpreted in terms of total Routhian surface calculations and the evolution of collectivity in the vicinity of the proton-neutron valence product maximum is discussed.
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27.
  • Wadsworth, R., et al. (author)
  • THE NORTHWEST FRONTIER : SPECTROSCOPY OF N similar to Z NUCLEI BELOW MASS 100
  • 2009
  • In: Acta Physica Polonica B. - 0587-4254 .- 1509-5770. ; 40:3, s. 611-620
  • Journal article (peer-reviewed)abstract
    • The spectroscopy and structure of excited states of N similar to Z nuclei in the mass 70-100 region has been investigated using two techniques. In the A similar to 70-80 region fusion evaporation reactions coupled with the recoil-beta-tagging method have been employed at Jyvaskyla to study low-lying states in odd-odd N = Z nuclei. Results from these and other data for known odd-odd nuclei above mass 60 will be discussed. In the heavier mass 90 region a fragmentation experiment has been performed using the RIS-ING/FRS setup at GSI. This experiment was primarily aimed at searching for spin gap isomers in nuclei around A similar to 96. The objectives of the latter experiment will be discussed.
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28.
  • Wang, F., et al. (author)
  • Reinvestigation of the excited states in the proton emitter Lu-151 : Particle-hole excitations across the N = Z=64 subshell
  • 2017
  • In: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 96:6
  • Journal article (peer-reviewed)abstract
    • The excited states of the proton emitter Lu-151 were reinvestigated in a recoil-decay tagging experiment at the Accelerator Laboratory of the University of Jyvaskyla (JYFL). The level scheme built on the ground state of 151Lu was updated with five new y-ray transitions. Large-scale shell model calculations were carried out in the model space consisting of the neutron and proton orbitals 0g(7/2), Id(5/2), Id(3/2), 2s(1/2), and Oh(1/2) with the optimized monopole interaction in order to interpret the experimental level scheme of Lu-151. It is found that the excitation energies of states above the 27/2(-) and 23/2(+) isomeric levels in Lu-151 can be sensitive to excitations from g(7/2) and d(5/2) to single-particle orbitals above N = Z = 64.
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29.
  • Wang, F., et al. (author)
  • Spectroscopic factor and proton formation probability for the d3/2 proton emitter 151mLu
  • 2017
  • In: Physics Letters B. - : Elsevier. - 0370-2693 .- 1873-2445. ; 770, s. 83-87
  • Journal article (peer-reviewed)abstract
    • The quenching of the experimental spectroscopic factor for proton emission from the short-lived d3/2 isomeric state in 151mLu was a long-standing problem. In the present work, proton emission from this isomer has been reinvestigated in an experiment at the Accelerator Laboratory of the University of Jyväskylä. The proton-decay energy and half-life of this isomer were measured to be 1295(5) keV and 15.4(8) μs, respectively, in agreement with another recent study. These new experimental data can resolve the discrepancy in the spectroscopic factor calculated using the spherical WKB approximation. Using the R-matrix approach it is found that the proton formation probability indicates no significant hindrance for the proton decay of 151mLu.
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30.
  • Al-Dahan, N., et al. (author)
  • Isomeric States In 208Hg And 209Tl Populated In Fragmentation Of 238U
  • 2009
  • In: Acta Physica Polonica. Series B: Elementary Particle Physics, Nuclear Physics, Statistical Physics, Theory of Relativity, Field Theory. - 0587-4254. ; 40:3, s. 871-874
  • Journal article (peer-reviewed)abstract
    • The nuclear structure of neutron-rich N > 126 nuclei has been investigated following their production via relativistic projectile fragmentation of a E/A = 1 GeV U-238 beam on a Be target. The preliminary analysis indicates the presence of previously unreported isomeric states in the N = 128 isotones Hg-208 and Tl-209.
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31.
  • Al-Dahan, N., et al. (author)
  • Nuclear Structure "Southeast" of 208Pb: Isomeric states in 208Hg and 209Tl
  • 2009
  • In: Physical Review C (Nuclear Physics). - 0556-2813. ; 80:6
  • Journal article (peer-reviewed)abstract
    • The nuclear structure of neutron-rich N>126 nuclei has been investigated following their production via relativistic projectile fragmentation of a E/A=1 GeV U-238 beam. Metastable states in the N=128 isotones Hg-208 and Tl-209 have been identified. Delayed gamma-ray transitions are interpreted as arising from the decay of I-pi=(8(+)) and (17/2(+)) isomers, respectively. The data allow for the so far most comprehensive verification of the shell-model approach in the region determined by magic numbers Z < 82 and N>126.
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32.
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33.
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34.
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35.
  • Bull, Philip, et al. (author)
  • Beyond ΛCDM : Problems, solutions, and the road ahead
  • 2016
  • In: Physics of the Dark Universe. - : Elsevier BV. - 2212-6864. ; 12, s. 56-99
  • Journal article (peer-reviewed)abstract
    • Despite its continued observational successes, there is a persistent (and growing) interest in extending cosmology beyond the standard model, Lambda CDM. This is motivated by a range of apparently serious theoretical issues, involving such questions as the cosmological constant problem, the particle nature of dark matter, the validity of general relativity on large scales, the existence of anomalies in the CMB and on small scales, and the predictivity and testability of the inflationary paradigm. In this paper, we summarize the current status of Lambda CDM as a physical theory, and review investigations into possible alternatives along a number of different lines, with a particular focus on highlighting the most promising directions. While the fundamental problems are proving reluctant to yield, the study of alternative cosmologies has led to considerable progress, with much more to come if hopes about forthcoming high-precision observations and new theoretical ideas are fulfilled.
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36.
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37.
  • Molina, F., et al. (author)
  • Tz=-1 → 0 β-Decays of 54Ni, 50Fe, 46Cr, and 42Ti and Comparison With Mirror (3He,t) Measurements
  • 2015
  • In: Physical Review C (Nuclear Physics). - 0556-2813. ; 91:1
  • Journal article (peer-reviewed)abstract
    • We have studied the β decay of the Tz=−1, f7/2 shell nuclei Ni54, Fe50, Cr46, and Ti42 produced in fragmentation reactions. The proton separation energies in the daughter Tz=0 nuclei are relatively large (≈4–5 MeV) so studies of the γ rays are essential. The experiments were performed at GSI as part of the Stopped-beam campaign with the RISING setup consisting of 15 Euroball Cluster Ge detectors. From the newly obtained high precision β-decay half-lives, excitation energies, and β branching ratios, we were able to extract Fermi and Gamow-Teller transition strengths in these β decays. With these improved results it was possible to compare in detail the Gamow-Teller (GT) transition strengths observed in beta decay including a sensitivity limit with the strengths of the Tz=+1 to Tz=0 transitions derived from high resolution (3He,t) reactions on the mirror target nuclei at RCNP, Osaka. The accumulated B(GT) strength obtained from both experiments looks very similar although the charge exchange reaction provides information on a broader energy range. Using the “merged analysis” one can obtain a full picture of the B(GT) over the full Qβ range. Looking at the individual transitions some differences are observed, especially for the weak transitions. Their possible origins are discussed.
  •  
38.
  • Regan, P. H., et al. (author)
  • First Results from the Stopped RISING Campaign at GSI: The Mapping of Isomeric Decays in Highly Exotic Nuclei
  • 2007
  • In: AIP Conference Proceedings. - : AIP. - 0094-243X. - 9780735413283 ; 899, s. 19-22
  • Conference paper (peer-reviewed)abstract
    • The first results from the Stopped Beam RISING experimental campaign performed at the GSI laboratory in Darmstadt, Germany, are presented. RISING (Rare ISotope INvestigations at GSI) constitutes a major new experimental program in European nuclear structure physics research aimed at using relativistic‐energy, projectile‐fragmentation reactions to study nuclei with exotic proton‐to‐neutron ratios. This paper introduces the physics aims of the Stopped RISING collaboration and presents some technical details and initial results from experiments using the RISING array to study decays from metastable nuclear states in both proton and neutron‐rich nuclei.
  •  
39.
  • Singh, B. S. Nara, et al. (author)
  • Coulomb shifts and shape changes in the mass 70 region
  • 2007
  • In: Physical Review C. Nuclear Physics. - 0556-2813 .- 1089-490X. ; 75:6
  • Journal article (peer-reviewed)abstract
    • The technique of recoil beta tagging has been developed which allows prompt gamma decays in nuclei from excited states to be correlated with electrons from their subsequent short-lived beta decay. This technique is ideal for studying nuclei very far from stability and improves in sensitivity for very short-lived decays and for high decay Q-values. The method has allowed excited states in Y-78 to be observed for the first time, as well as an extension in the knowledge of T=1 states in Rb-74. From this new information it has been possible to compare Coulomb energy differences (CED) between T=1 states in Br-70/Se-70, Rb-74/Kr-74, and Y-78/Sr-78. The A=70 CED exhibit an anomalous behavior which is inconsistent with all other known CED. This behavior may be accounted for qualitatively in terms of small variations in the Coulomb energy arising from shape changes.
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40.
  •  
41.
  • Alkhomashi, N., et al. (author)
  • Beta(-)-Delayed And Isomer Spectroscopy Of Neutron-Rich Ta And W Isotopes
  • 2009
  • In: Acta Physica Polonica B. - 0587-4254. ; 40:3, s. 875-878
  • Conference paper (peer-reviewed)abstract
    • Decays of neutron-rich A similar to 190 nuclei have been studied following projectile fragmentation of a Pb-208 beam on a Be-9 target at the GSI Fragment Separator. Gamma-ray decays from previously reported isomeric states in Ta-188, W-190 and (192,193) Re were used as internal calibrations for the particle identification analysis, together with the identification of previously unreported isomeric decays in Ta-189 and W-191. The current work also identifies beta-delayed gamma rays following the decay of Ta-188 to W-188 for the first time.
  •  
42.
  • Alkhomashi, N., et al. (author)
  • beta(-)-delayed spectroscopy of neutron-rich tantalum nuclei: Shape evolution in neutron-rich tungsten isotopes
  • 2009
  • In: Physical Review C (Nuclear Physics). - 0556-2813. ; 80:6
  • Journal article (peer-reviewed)abstract
    • The low-lying structure of W-188,W-190,W-192 has been studied following beta decays of the neutron-rich mother nuclei Ta-188,Ta-190,Ta-192 produced following the projectile fragmentation of a 1-GeV-per-nucleon Pb-208 primary beam on a natural beryllium target at the GSI Fragment Separator. The beta-decay half-lives of Ta-188, Ta-190, and Ta-192 have been measured, with gamma-ray decays of low-lying states in their respective W daughter nuclei, using heavy-ion beta-gamma correlations and a position-sensitive silicon detector setup. The data provide information on the low-lying excited states in W-188, W-190, and W-192, which highlight a change in nuclear shape at W-190 compared with that of lighter W isotopes. This evolution of ground-state structure along the W isotopic chain is discussed as evidence for a possible proton subshell effect for the A similar to 190 region and is consistent with maximization of the gamma-softness of the nuclear potential around N similar to 116.
  •  
43.
  • Blazhev, A, et al. (author)
  • High-energy excited states in 98 Cd
  • 2010
  • In: Journal of Physics: Conference Series. ; 205:1
  • Journal article (peer-reviewed)abstract
    • In 98 Cd a new high-energy isomeric γ -ray transition was identified, which confirms previous spin-parity assignments and enables for the first time the measurement of the E 2 and E 4 strength for the two decay branches of the isomer. Preliminary results on the 98 Cd high-excitation level scheme are presented. A comparison to shell-model calculations as well as implications for the nuclear structure around 100 Sn are discussed.
  •  
44.
  •  
45.
  • Caceres, L. S., et al. (author)
  • Identification of Excited States in the N = Z Nucleus 82Nb
  • 2007
  • In: Acta Physica Polonica. Series B: Elementary Particle Physics, Nuclear Physics, Statistical Physics, Theory of Relativity, Field Theory. - 0587-4254. ; 38:4, s. 1271-1275
  • Journal article (peer-reviewed)abstract
    • Information on the first excited states in the N = Z = 41 nucleus Nb-82 sheds light on the competition of isospin T = 0 and T = 1 states in the A similar to 80 region. The measurement was performed at the GSI laboratory using fragmentation of a Ag-107 primary beam at 750 MeV/u on a 4 g/cm(2) Be-9 target. The fragments were separated and identified unambiguously in the FRagment Separator. Three excited states were observed and the half-life estimate for the isomeric state was extracted. A tentative spin assignment based on the isobaric analogue states systematics in the T-z = 1 nucleus Zr-82, and transition probabilities indicate T = 1 character of the first two excited states, and T = 0 for the isomeric state.
  •  
46.
  • Cook, Michael J., et al. (author)
  • Frailty and bone health in European men
  • 2017
  • In: Age and Ageing. - : Oxford University Press (OUP). - 0002-0729 .- 1468-2834. ; 46:4, s. 635-641
  • Journal article (peer-reviewed)abstract
    • Background: frailty is associated with an increased risk of fragility fractures. Less is known, however, about the association between frailty and bone health.Methods: men aged 40-79 years were recruited from population registers in eight European centres for participation in the European Male Aging Study. Subjects completed a comprehensive assessment which included quantitative ultrasound (QUS) scan of the heel (Hologic-SAHARA) and in two centres, dual-energy bone densitometry (dual-energy x-ray absorptiometry, DXA). Frailty was defined based on an adaptation of Fried's phenotype criteria and a frailty index (FI) was constructed. The association between frailty and the QUS and DXA parameters was determined using linear regression, with adjustments for age, body mass index and centre.Results: in total, 3,231 subjects contributed data to the analysis. Using the Fried categorisation of frailty, pre-frail and frail men had significantly lower speed of sound (SOS), broadband ultrasound attenuation (BUA) and quantitative ultrasound index (QUI) compared to robust men (P< 0.05). Similar results were seen using the FI after categorisation into 'high', 'medium' and 'low' levels of frailty. Using the Fried categorisation, frail men had lower femoral neck bone mineral density (BMD) compared to robust men (P < 0.05), but not lower lumbar spine BMD. Using the FI categorisation, a 'high' level of frailty (FI > 0.35) was associated with lower lumbar spine BMD (P < 0.05) when compared to those with low (FI < 0.2), but not lower femoral neck BMD. When analysed as a continuous variable, higher FI was linked with lower SOS, BUA and QUI (P < 0.05).Conclusions: optimisation of bone health as well as prevention of falls should be considered as strategies to reduce fractures in frail older people.
  •  
47.
  • Doornenbal, P., et al. (author)
  • RISING: Gamma‐ray Spectroscopy with Radioactive Beams at GSI
  • 2007
  • In: AIP Conference Proceedings. - : AIP. - 0094-243X. - 9780735413283 ; 891, s. 99-107
  • Conference paper (peer-reviewed)abstract
    • The Rare Isotope Spectroscopic INvestigation at GSI (RISING) project is a major pan‐European collaboration. Its physics aims are the studies of exotic nuclear matter with abnormal proton‐to‐neutron ratios compared with naturally occurring isotopes. RISING combines the FRagment Separator (FRS) which allows relativistic energies and projectile fragmentation reactions with EUROBALL Ge Cluster detectors for γ spectroscopic research. The RISING setup can be used in two different configurations. Either the nuclei of interest are investigated after being stopped or the heavy ions hit a secondary target at relativistic energies and the thereby occurring excitations are studied. For the latter case, MINIBALL Ge detectors and the HECTOR array are used in addition. Example achievements of the Fast Beam setup are presented and compared to various shell model calculations, while for the Stopped Beam setup initial results are shown.
  •  
48.
  • Farrelly, G. F., et al. (author)
  • Revision of the K-Isomer in 190W
  • 2009
  • In: Acta Physica Polonica. Series B: Elementary Particle Physics, Nuclear Physics, Statistical Physics, Theory of Relativity, Field Theory. - 0587-4254. ; 40:3, s. 885-888
  • Journal article (peer-reviewed)abstract
    • Gamma rays from the decay of an isomer in W-190(116) have been observed following projectile fragmentation of a 1 GeV per nucleon Pb-208 beam. An earlier experiment indicated decay from a (10(-)) isomer to the ground state rotational band. Improved statistics have enabled gamma coincidence and time-difference measurements to be made which alter the previous interpretation. Blocked BCS calculations have also been used together with reduced hindrance factors to indicate possible values of spin-parity for the isomer.
  •  
49.
  • Gorska, M., et al. (author)
  • Evolution of the N=82 Shell Gap below 132Sn Inferred from Core Excited States in 131In
  • 2009
  • In: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693 .- 1873-2445. ; 672:4-5, s. 313-316
  • Journal article (peer-reviewed)abstract
    • The gamma-ray decay of ail excited state in In-131, the one proton hole neighbor of the doubly magic (132)sn has been measured. A high-spin, core-excited isomer with T-1/2 = 630(60) us was identified following production by both relativistic fragmentation of a Xe-136 beam and fission Of a U-238 beam. This state deexcites by a single gamma-ray branch of 3782(2) keV from which direct evidence for the size of the N = 82 shell gal) is inferred. The results are discussed in comparison to a shell-model Calculation including configurations across the closed shells at N = 82 and Z = 50. (C) 2009 Elsevier B.V. All rights reserved.
  •  
50.
  • Hoischen, Robert, et al. (author)
  • Isomeric Mirror States as Probes for Effective Charges in the Lower pf Shell
  • 2011
  • In: Journal of Physics G: Nuclear and Particle Physics. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 38:3
  • Journal article (peer-reviewed)abstract
    • Following the fragmentation of a 550 MeV u(-1)primary beam of Ni-58, time-and energy-correlated gamma decays from isomeric states in neutron-deficient nuclei in the 1f(7/2) shell have been identified using the GSI fragment separator in combination with the RISING Ge-detector array. The results on isomers in the mirror pairs Ti-43(22)21-Sc-43(21)22 (I-pi = 3/2(+) and 19/2(-)), Cr-45(24)21-Sc-45(21)24 (I-pi = 3/2(+)) and V-45(23)22-Ti-45(22)23 (I-pi = 3/2(-)) are discussed in the framework of large scale pf and sdpf shell-model calculations, the former in conjunction with isospin symmetry breaking effects with emphasis on effective charges.
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