SwePub - search: WFRF:(Sun Jie)

Enumeration	Reference	Cover	Find
1.	Klionsky, Daniel J, et al. (author) Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). 2016 In: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 12:1, s. 1-222 Journal article (peer-reviewed)
2.	Ablikim, M., et al. (author) Search for h(c) -> pi(+)pi(-) J/psi via psi(3686) -> pi(0)pi(+)pi(-) J/psi 2018 In: Physical Review D. - : American Physical Society. - 2470-0010 .- 2470-0029. ; 97:5 Journal article (peer-reviewed)abstract Using a data sample of 448.1 x 10(6) psi(3686) events collected with the BESIII detector operating at the BEPCII, we perform search for the hadronic transition h(c)-> pi(+)pi(-) J/psi via psi (3686) -> pi(0)hc. No signals of the transition are observed, and the upper limit on the product branching fraction B(sigma(3686) -> pi(0)h(c))B(h(c) -> pi(+)pi(-) J/psi) at the 90% confidence level (C. L.) is determined to be 2.0 x 10(-6). This is the most stringent upper limit to date.
3.	Kristanl, Matej, et al. (author) The Seventh Visual Object Tracking VOT2019 Challenge Results 2019 In: 2019 IEEE/CVF INTERNATIONAL CONFERENCE ON COMPUTER VISION WORKSHOPS (ICCVW). - : IEEE COMPUTER SOC. - 9781728150239 ; , s. 2206-2241 Conference paper (peer-reviewed)abstract The Visual Object Tracking challenge VOT2019 is the seventh annual tracker benchmarking activity organized by the VOT initiative. Results of 81 trackers are presented; many are state-of-the-art trackers published at major computer vision conferences or in journals in the recent years. The evaluation included the standard VOT and other popular methodologies for short-term tracking analysis as well as the standard VOT methodology for long-term tracking analysis. The VOT2019 challenge was composed of five challenges focusing on different tracking domains: (i) VOT-ST2019 challenge focused on short-term tracking in RGB, (ii) VOT-RT2019 challenge focused on "real-time" short-term tracking in RGB, (iii) VOT-LT2019 focused on long-term tracking namely coping with target disappearance and reappearance. Two new challenges have been introduced: (iv) VOT-RGBT2019 challenge focused on short-term tracking in RGB and thermal imagery and (v) VOT-RGBD2019 challenge focused on long-term tracking in RGB and depth imagery. The VOT-ST2019, VOT-RT2019 and VOT-LT2019 datasets were refreshed while new datasets were introduced for VOT-RGBT2019 and VOT-RGBD2019. The VOT toolkit has been updated to support both standard short-term, long-term tracking and tracking with multi-channel imagery. Performance of the tested trackers typically by far exceeds standard baselines. The source code for most of the trackers is publicly available from the VOT page. The dataset, the evaluation kit and the results are publicly available at the challenge website(1).
4.	Roselli, Carolina, et al. (author) Multi-ethnic genome-wide association study for atrial fibrillation 2018 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 50:9, s. 1225-1233 Journal article (peer-reviewed)abstract Atrial fibrillation (AF) affects more than 33 million individuals worldwide(1) and has a complex heritability(2). We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.
5.	Zhang, Huai, et al. (author) A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease. 2024 In: Hepatology international. - 1936-0541. Journal article (peer-reviewed)abstract With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020, it is important to establish consensus for the coding of MAFLD in ICD-11. This will inform subsequent revisions of ICD-11.Using the Qualtrics XM and WJX platforms, questionnaires were sent online to MAFLD-ICD-11 coding collaborators, authors of papers, and relevant association members.A total of 890 international experts in various fields from 61 countries responded to the survey. We also achieved full coverage of provincial-level administrative regions in China. 77.1% of respondents agreed that MAFLD should be represented in ICD-11 by updating NAFLD, with no significant regional differences (77.3% in Asia and 76.6% in non-Asia, p=0.819). Over 80% of respondents agreed or somewhat agreed with the need to assign specific codes for progressive stages of MAFLD (i.e. steatohepatitis) (92.2%), MAFLD combined with comorbidities (84.1%), or MAFLD subtypes (i.e., lean, overweight/obese, and diabetic) (86.1%).This global survey by a collaborative panel of clinical, coding, health management and policy experts, indicates agreement that MAFLD should be coded in ICD-11. The data serves as a foundation for corresponding adjustments in the ICD-11 revision.
6.	2019 Journal article (peer-reviewed)
7.	Bhat, Goutam, et al. (author) NTIRE 2022 Burst Super-Resolution Challenge 2022 In: 2022 IEEE/CVF CONFERENCE ON COMPUTER VISION AND PATTERN RECOGNITION WORKSHOPS (CVPRW 2022). - : IEEE. - 9781665487399 - 9781665487405 ; , s. 1040-1060 Conference paper (peer-reviewed)abstract Burst super-resolution has received increased attention in recent years due to its applications in mobile photography. By merging information from multiple shifted images of a scene, burst super-resolution aims to recover details which otherwise cannot be obtained using a simple input image. This paper reviews the NTIRE 2022 challenge on burst super-resolution. In the challenge, the participants were tasked with generating a clean RGB image with 4x higher resolution, given a RAW noisy burst as input. That is, the methods need to perform joint denoising, demosaicking, and super-resolution. The challenge consisted of 2 tracks. Track 1 employed synthetic data, where pixel-accurate high-resolution ground truths are available. Track 2 on the other hand used real-world bursts captured from a handheld camera, along with approximately aligned reference images captured using a DSLR. 14 teams participated in the final testing phase. The top performing methods establish a new state-of-the-art on the burst super-resolution task.
8.	Chen, Jie, et al. (author) Bidirectional Mendelian Randomisation Analysis Provides Evidence for the Causal Involvement of Dysregulation of CXCL9, CCL11 and CASP8 in the Pathogenesis of Ulcerative Colitis 2023 In: Journal of Crohn's & Colitis. - : Oxford University Press. - 1873-9946 .- 1876-4479. ; 17:5, s. 777-785 Journal article (peer-reviewed)abstract Background and Aims Systemic inflammation is well recognised to be associated with ulcerative colitis [UC], but whether these effects are causal or consequential remains unclear. We aimed to define potential causal relationship of cytokine dysregulation with different tiers of evidence. Methods We first synthesised serum proteomic profiling data from two multicentred observational studies, in which a panel of systemic inflammatory proteins was analysed to examine their associations with UC risk. To further dissect observed associations, we then performed a bidirectional two-sample Mendelian randomisation [TSMR] analysis from both forward and reverse directions using five genome-wide association study [GWAS] summary level data for serum proteomic profiles and the largest GWAS of 28 738 European-ancestry individuals for UC risk. Results Pooled analysis of serum proteomic data identified 14 proteins to be associated with the risk of UC. Forward MR analysis using only cis-acting protein quantitative trait loci [cis-pQTLs] or trans-pQTLs further validated causal associations of two chemokines and the increased risk of UC: C-X-C motif chemokine ligand 9 [CXCL9] [OR 1.45, 95% CI 1.08, 1.95, p = 0.012] and C-C motif chemokine ligand 11 [CCL11] [OR 1.14, 95% CI 1.09, 1.18, p = 3.89 x 10(-10)]. Using both cis- and trans-acting pQTLs, an association of caspase-8 [CASP8] [OR 1.04, 95% CI 1.03, 1.05, p = 7.63 x 10(-19)] was additionally identified. Reverse MR did not find any influence of genetic predisposition to UC on any of these three inflammation proteins. Conclusion Pre-existing elevated levels of CXCL9, CCL11 and CASP8 may play a role in the pathogenesis of UC.
9.	Chen, Jie, et al. (author) Therapeutic targets for inflammatory bowel disease : proteome-wide Mendelian randomization and colocalization analyses 2023 In: EBioMedicine. - : Elsevier BV. - 2352-3964. ; 89 Journal article (peer-reviewed)abstract Background: Identifying new drug targets for inflammatory bowel disease (IBD) is urgently needed. The proteome is a major source of therapeutic targets. We conducted a proteome-wide Mendelian randomization (MR) and colocalization analyses to identify possible targets for IBD.Methods: Summary-level data of 4907 circulating protein levels were extracted from a large-scale protein quantitative trait loci study including 35,559 individuals. Genetic associations with IBD and its subtypes were obtained from the Inflammatory Bowel Disease Genetics Consortium (25,024 cases and 34,915 controls), the FinnGen study (7206 cases and 253,199 controls), and the UK Biobank study (7045 cases and 449,282 controls). MR analysis was conducted to estimate the associations between protein and IBD risk. The colocalization analysis was used to examine whether the identified proteins and IBD shared casual variants.Findings: Genetically predicted levels of 3, and 5 circulating proteins were associated with IBD and ulcerative colitis (UC), respectively. With high supporting evidence of colocalization, genetically predicted MST1 (macrophage stim-ulating 1) and HGFAC (hepatocyte growth factor activator) levels were inversely associated with IBD risks. The as-sociations of STAT3 (signal transducer and activator of transcription 3), MST1, CXCL5 (C-X-C motif chemokine ligand 5), and ITPKA (inositol-trisphosphate 3-kinase A) with the risk of UC were supported by colocalization analysis.Interpretation: The proteome-wide MR investigation identified many proteins associated with the risk of IBD. MST1, HGFAC, STAT3, ITPKA, and CXCL5 deserve further investigation as potential therapeutic targets for IBD. 2023;89: Published https://doi.org/10. 1016/j.ebiom.2023. 104494
10.	Chen, Yanping, et al. (author) PKU-20 : A new silicogermanate constructed from sti and asv layers 2016 In: Microporous and Mesoporous Materials. - : Elsevier BV. - 1387-1811 .- 1873-3093. ; 224, s. 384-391 Journal article (peer-reviewed)abstract A new silicogermanate (PKU-20) was hydrothermally synthesized using triethylisopropylammonium cation as the structure directing agent in the presence of fluoride. Its structure was determined from a combination of synchrotron single crystal X-ray diffraction and powder X-ray diffraction data. PKU-20 crystallizes in the monoclinic space group C2/m, with the lattice parameters of a = 18.5901(6) angstrom, b = 13.9118 (4) angstrom, c = 22.2614(7) angstrom and beta = 100.1514 (12)degrees. The framework of PKU-20 is constructed from an alternate stacking of sti and asv layers. The sti layer is exactly the same as that in the STI framework, while the asv layer is a new layer sliced off from the ASV framework parallel to the (112) plane. The takeout scheme of the layer is discussed on the basis of a composite building unit D4R-/au-D4R. PKU-20 possesses a two-dimensional channel system, where the 10-ring channels parallel to the [010] direction are intercrossed by 12-ring pockets along the [101] direction.
11.	Chen, Zhishan, et al. (author) Fine-mapping analysis including over 254 000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes 2024 In: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1 Journal article (peer-reviewed)abstract Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought to fine-map all known CRC risk loci using GWAS data from 100,204 cases and 154,587 controls of East Asian and European ancestry. Our stepwise conditional analyses revealed 238 independent association signals of CRC risk, each with a set of credible causal variants (CCVs), of which 28 signals had a single CCV. Our cis-eQTL/mQTL and colocalization analyses using colorectal tissue-specific transcriptome and methylome data separately from 1299 and 321 individuals, along with functional genomic investigation, uncovered 136 putative CRC susceptibility genes, including 56 genes not previously reported. Analyses of single-cell RNA-seq data from colorectal tissues revealed 17 putative CRC susceptibility genes with distinct expression patterns in specific cell types. Analyses of whole exome sequencing data provided additional support for several target genes identified in this study as CRC susceptibility genes. Enrichment analyses of the 136 genes uncover pathways not previously linked to CRC risk. Our study substantially expanded association signals for CRC and provided additional insight into the biological mechanisms underlying CRC development.
12.	Ding, Haoming, et al. (author) Progress in Structural Tailoring and Properties of Ternary Layered Ceramics 2023 In: Journal of Inorganic Materials. - : SCIENCE PRESS. - 1000-324X. ; 38:8, s. 845-884 Research review (peer-reviewed)abstract MAX/MAB phases are a series of non-van der Waals ternary layered ceramic materials with a hexagonal structure, rich in elemental composition and crystal structure, and embody physical properties of both ceramics and metals. They exhibit great potential for applications in extreme environments such as high temperature, strong corrosion, and irradiation. In recent years, two-dimensional (2D) materials derived from the MAX/MAB phase (MXene and MBene) have attracted enormous interest in the fields of materials physics and materials chemistry and become a new 2D van der Waals material after graphene and transition metal dichalcogenides. Therefore, structural modulation of MAX/MAB phase materials is essential for understanding the intrinsic properties of this broad class of layered ceramics and for investigating the functional properties of their derived structures. In this paper, we summarize new developments in MAX/MAB phases in recent years in terms of structural modulation, theoretical calculation, and fundamental application research and provide an outlook on the key challenges and prospects for the future development of these layered materials.
13.	Huang, Shiliang, et al. (author) SU-79 : a novel germanate with 3D 10-and 11-ring channels templated by a square-planar nickel complex 2014 In: Inorganic Chemistry Frontiers. - : Royal Society of Chemistry (RSC). - 2052-1545 .- 2052-1553. ; 1:3, s. 278-283 Journal article (peer-reviewed)abstract An open-framework germanate denoted as SU-79 with the chemical formula [Ge12.5O26(OH)(2)]-[Ni(C3N2H10)(2)](1.1)(NH4)(0.8)(C3N2H12)(0.5)(C3N2H10)(1.5)(H2O)(2) has been synthesized under hydro/solvothermal conditions using [Ni(1,2-pda)(2)](2+) (1,2-pda = 1,2-diaminopropane) and 1,2-pda as templates. Owing to the complicated pseudo-merohedral twinning in the crystals, the rotation electron diffraction (RED) method was used for the unit cell and space group determination. The structure of SU-79 was solved and refined based on synchrotron single crystal X-ray diffraction data. SU-79 exhibits a 3D open germanate framework built with Ge-13 clusters, consisting of a 3D channel system with interconnected 10- and 11-ring channels. Interestingly, helical GeO4 tetrahedral chains with left-handed/right-handed chirality were found in the structure. The [Ni(1,2-pda)(2)](2+) complexes, adopting in a square-planar geometry, show a structure directing role on the SU-79 framework via hydrogen bonds. Comparing with its related structure, SU-67, the formation of the pseudo-merohedric twinning in SU-79 was also discussed.
14.	Huang, Shiliang, 1984-, et al. (author) Synthesis and characterization of two new nickel germanates : SUT-3 and SUT-4 Other publication (other academic/artistic)
15.	Jiangwei, Liu, et al. (author) Compressive behavior and vibration-damping properties of porous Ti-6Al-4V alloy manufactured by laser powder bed fusion 2021 In: Journal of Manufacturing Processes. - : Elsevier BV. - 1526-6125 .- 2212-4616. ; 66, s. 1-10 Journal article (peer-reviewed)abstract Porous Ti-6Al-4V alloy with various cell geometries and cell sizes was manufactured by laser powder bed fusion (LPBF) technique, and the influence of the structural characteristics on the compressive behavior and vibrationdamping abilities was systematically investigated. In terms of the compressive performance, both elasto-brittle and elasto-plastic features are observed from the compressive stress-strain curves and the corresponding transformation from elasto-brittle to elasto-plastic can be achieved by increasing the cell size. Moreover, the compressive performances are found to be closely related to the relative density determined by both the cell geometries and cell sizes of specimens. The energy absorption capability of each cellular structure increases linearly when increasing the as-manufactured density, while the energy absorption efficiency presents sensitivities to both the cell geometry and the cell size. The results also reveal that the variation of natural frequency is proportional to the specific strength (i.e., strength-weight ratio), and the cellular structure with larger cell size exhibits better damping ability than smaller sized structures.
16.	Kanoni, Stavroula, et al. (author) Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. 2022 In: Genome biology. - : Springer Science and Business Media LLC. - 1474-760X .- 1465-6906 .- 1474-7596. ; 23:1 Journal article (peer-reviewed)abstract Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery.To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N=1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism.Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
17.	Kristan, Matej, et al. (author) The first visual object tracking segmentation VOTS2023 challenge results 2023 In: 2023 IEEE/CVF International conference on computer vision workshops (ICCVW). - : Institute of Electrical and Electronics Engineers Inc.. - 9798350307443 - 9798350307450 ; , s. 1788-1810 Conference paper (peer-reviewed)abstract The Visual Object Tracking Segmentation VOTS2023 challenge is the eleventh annual tracker benchmarking activity of the VOT initiative. This challenge is the first to merge short-term and long-term as well as single-target and multiple-target tracking with segmentation masks as the only target location specification. A new dataset was created; the ground truth has been withheld to prevent overfitting. New performance measures and evaluation protocols have been created along with a new toolkit and an evaluation server. Results of the presented 47 trackers indicate that modern tracking frameworks are well-suited to deal with convergence of short-term and long-term tracking and that multiple and single target tracking can be considered a single problem. A leaderboard, with participating trackers details, the source code, the datasets, and the evaluation kit are publicly available at the challenge website1
18.	Liang, Jie, et al. (author) A 3D 12-Ring Zeolite with Ordered 4-Ring Vacancies Occupied by (H2O)(2) Dimers 2014 In: Chemistry - A European Journal. - : Wiley. - 0947-6539 .- 1521-3765. ; 20:49, s. 16097-16101 Journal article (peer-reviewed)abstract A germanate zeolite, PKU-14, with a three- dimensional large-pore channel system was structurally characterized by a combination of high-resolution powder X-ray diffraction, rotation electron diffraction, NMR, and IR spectroscopy. Ordered Ge4O4 vacancies inside the [4(6).6(12)] cages has been found in PKU-14, in which a unique (H2O)(2) dimer was located at the vacancies and played a structure-directing role. It is the first time that water clusters are found to be templates for ordered framework vacancies.
19.	Liang, Jie, et al. (author) A Crystalline Mesoporous Germanate with 48-Ring Channels for CO2 Separation 2015 In: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 54:25, s. 7290-7294 Journal article (peer-reviewed)abstract One of the challenges in materials science has been to prepare crystalline inorganic compounds with mesopores. Although several design strategies have been developed to address the challenge, expansion of pore sizes in inorganic materials is more difficult compared to that for metal-organic frameworks. Herein, we designed a novel mesoporous germanate PKU-17 with 3D 48 x 16 x 16-ring channels by introducing two large building units (Ge-10 and Ge-7 clusters) into the same framework. The key for this design strategy is the selection of 2-propanolamine (MIPA), which serves as the terminal species to promote the crystallization of Ge-7 clusters. Moreover, it is responsible for the coexistence of Ge-10 and Ge-7 clusters. To our knowledge, the discovery of PKU-17 sets a new record in pore sizes among germanates. It is also the first germanate that exhibits a good selectivity toward CO2 over N-2 and CH4.
20.	Liang, Jie, et al. (author) A multi-dimensional quasi-zeolite with 12 x 10 x 7-ring channels demonstrates high thermal stability and good gas adsorption selectivity 2016 In: Chemical Science. - : Royal Society of Chemistry. - 2041-6520 .- 2041-6539. ; 7:5, s. 3025-3030 Journal article (peer-reviewed)abstract A novel quasi-zeolite PKU-15, with a rare 3-dimensional structure containing interconnected large (12-ring), medium (10-ring) and small (7-ring) multi-pore channels, was hydrothermally synthesised and characterised. A unique tri-bridging O2- anion is found to be encapsulated in the cage-like (Ge,Si)(12)O-31 building unit and energetically stabilises the PKU-15 framework. The removal of this oxygen atom would convert PKU-15 into a hypothetical zeolite PKU-15H. Thus, PKU-15 can be considered as a unique 'quasi-zeolite', which bridges porous germanates and zeolites. Owing to the absence of terminal Ge-OH groups in its structure, PKU-15 shows a remarkably high thermal stability of up to 600 degrees C. PKU-15 is also the first microporous germanate that exhibits permanent porosity, with a BET area of 428 m(2) g(-1) and a good adsorption affinity toward CO2.
21.	Liang, Jie, et al. (author) PKU-21 : A Novel Layered Germanate Built from Ge-7 and Ge-10 Clusters for CO2 Separation 2017 In: Chemistry - A European Journal. - : Wiley. - 0947-6539 .- 1521-3765. ; 23:71, s. 17879-17884 Journal article (peer-reviewed)abstract The attractive properties of layered inorganic materials, which make them suitable for numerous applications in chemical industries and life sciences, originated from their crystalline framework structures. Here, we report a new layered germanate PKU-21, which was prepared by the hydrothermal synthesis method using 2-propanolamine (MIPA) as the structure-directing agent. The structure of PKU-21 was determined from synchrotron single-crystal X-ray diffraction and synchrotron powder X-ray diffraction data. It reveals a complicated framework structure containing 18 unique Ge atoms in the asymmetric unit. PKU-21 is the first layered germanate built from both Ge-7 and Ge-10 clusters, following the 3-dimensional germanate PKU-17. The preparation and structure of PKU-21 are discussed in comparison with PKU-17, which provides new insight into the formation mechanism of germanates. Gas sorption experiments indicate that the layered PKU-21 sample exhibits a better CO2 sorption selectivity over N-2 and CH4 at 298K than at 273K, making it a promising candidate for CO2 separation.
22.	Liu, Jiangwei, et al. (author) Understanding the effect of scanning strategies on the microstructure and crystallographic texture of Ti-6Al-4V alloy manufactured by laser powder bed fusion 2022 In: Journal of Materials Processing Technology. - : Elsevier. - 0924-0136 .- 1873-4774. ; 299 Journal article (peer-reviewed)abstract In this work, experimental and numerical approaches are performed to explore the influence of scanning strategies on the microstructure, crystallographic texture as well as the mechanical behavior of Ti-6Al-4V alloy manufactured by Laser Powder Bed Fusion (LPBF). In-situ monitored data of the energy intensity show that different scanning strategies result in variations of energy intensity distribution. The characterization of the microstructure and crystallographic texture reveals that the sample with hexagon scan pattern displays the structure with columnar primary 13 phase, while the specimens with chessboard scan exhibit equiaxial-like morphology. EBSD and TEM results provide evidence of the appearance of residual 13 nanoparticles. A finite element model is developed to further explain the phase transformation during LPBF and the formation mechanism of residual 13 particles. The numerical results indicate that the appearance of the residual 13 phase is attributed to the preheating/reheating effect by the adjacent tracks and successive layers, and the final phase composition of the LPBF-built Ti-6Al-4V alloy combines the alpha ', alpha, and 13 phases. Findings in the present paper show that various scanning strategies lead to a clear diversification in the microstructure, crystallographic texture, and phase composition of LPBF-built samples, which opens a route towards the tailoring of mechanical properties and isotropic behaviors in additive manufacturing.
23.	Luo, Zhenghui, et al. (author) Fine-Tuning Energy Levels via Asymmetric End Groups Enables Polymer Solar Cells with Efficiencies over 17% 2020 In: Joule. - : CELL PRESS. - 2542-4351. ; 4:6, s. 1236-1247 Journal article (peer-reviewed)abstract Generally, it is important to fine-tune the energy levels of donor and acceptor materials in the field of polymer solar cell (PSCs) to achieve a minimal highest occupied molecular orbital (HOMO) energy offset, which yet is still sufficient for charge separation. Based on the high-performance small-molecule acceptor (SMA) of BTP-4F, we modified the end groups of BTP-4F from IC-2F to CPTCN-Cl. It was found that when both end groups were substituted by CPTCN-Cl, the energy level upshift was too large that caused unfavorable energetic alignment, thus poor device performance. By using the strategy of asymmetric end groups, we were able to achieve near optimal energy level match, resulting in higher open-circuit voltage (V-OC) and power conversion efficiency (PCE) compared with those given by the PM6:BTP-4F system. Our strategy can be useful and potentially applied to othermaterial systems for maximizing efficiency of non-fullerene PSCs.
24.	Ma, Ming-Guo, et al. (author) Fabrication and characterization of Ag/calcium silicate core-shell nanocomposites 2011 In: Materials letters (General ed.). - : Elsevier BV. - 0167-577X .- 1873-4979. ; 65:19-20, s. 3069-3071 Journal article (peer-reviewed)abstract The Ag/calcium silicate nanocomposite with core-shell nanostructure has been successfully synthesized using Ag solution, Ca(NO(3))(2)center dot 4H(2)O and Na(2)SiO(3)center dot 9H(2)O in ethanol/water mixed solvents at room temperature for 48 h. Ag solution was previously prepared by microwave-assisted method in ethylene glycol (EG) at 150 degrees C for 10 min. The nanocomposites consisted of Ag core and an amorphous calcium silicate shell. The XRD and EDS results confirmed that the product was the Ag/calcium silicate nanocomposite. The TEM micrographs indicated that the Ag/calcium silicate nanocomposite was core-shell nanoparticles. The effects of Ca (NO(3))(2)center dot 4H(2)O and Na(2)SiO(3)center dot 9H(2)O concentration on the shells of Ag/calcium silicate nanocomposite were investigated. The products were characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), and energy-dispersive X-ray spectra (EDS). This method is simple, fast and may be extended to the synthesis of the other kinds of core-shell nanocomposites.
25.	Ma, Ming-Guo, et al. (author) Hydrothermal synthesis and characterization of CePO4/C core-shell nanorods 2009 In: Materials letters (General ed.). - : Elsevier B.V.. - 0167-577X .- 1873-4979. ; 63:28, s. 2513-2515 Journal article (peer-reviewed)abstract The CePO4/C nanocomposite with core-shell nanostructure has been successfully synthesized using glucose and CePO4 by a facile and simple hydrothermal method at 160 °C for 24 h. The new material consists of a monoclinic CePO4 core and an amorphous-C shell. The TEM micrograph indicated that the CePO4/C nanocomposite was core-shell nanorods. The effects of glucose concentration on the C shells and luminescent intensity of CePO4/C nanocomposite were investigated. The products were characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HR-TEM), X-ray photoelectron spectroscopy (XPS) and photoluminescence (PL). This method is simple, low-cost and does not need any surfactant.
26.	Ma, Ming-Guo, et al. (author) Microwave-assisted synthesis of hierarchical Bi2O3 spheres assembled from nanosheets with pore structure 2010 In: Materials letters (General ed.). - : Elsevier BV. - 0167-577X .- 1873-4979. ; 64:13, s. 1524-1527 Journal article (peer-reviewed)abstract Hierarchical Bi2O3 spheres assembled from nanosheets with nanopore structure have been successfully synthesized by thermal decomposition of the precursor at 400 degrees C for 3 h in air, which was prepared using Bi (NO3)(3)center dot 5H(2)O and poly(vinylpyrrolidone) (PVP) by a microwave-assisted heating method in ethylene glycol (EG) at 150 degrees C for 10 min The morphology of Bi2O3 is similar to that of the precursor The products were characterized by X-ray powder diffraction (XRD), Fourier transform infrared spectrometry (FT-IR), field-emission scanning electron microscopy (FE-SEM), thermogravimetric analysis (TG) and differential scanning calorimetric analysis (DSC) XRD pattern showed that the product had a high degree of crystallinity. FE-SEM micrograph indicated that hierarchical Bi2O3 spheres had sizes around 10 μm.
27.	Ma, Ming-Guo, et al. (author) Synthesis and characterization of the tellurium/calcium silicate nanocomposite 2011 In: Materials letters (General ed.). - : Elsevier BV. - 0167-577X .- 1873-4979. ; 65:3, s. 424-426 Journal article (peer-reviewed)abstract A novel tellurium/calcium silicate nanocomposite with tellurium nanorods homogeneously dispersed in the calcium silicate matrix has been successfully synthesized using corresponding tellurium nanorods, Ca(NO3)(2)center dot 4H(2)O, and Na2SiO3 center dot 9H(2)O in ethanol/water mixed solvents at room temperature for 48 h. The new material consists of a single crystalline Te core and an amorphous calcium silicate shell. The products were characterized by X-ray powder diffraction (XRD), transmission electron microscopy (TEM), selected area electron diffraction (SAED), and energy-dispersive X-ray spectroscopy (EDS). The method is simple and does not need any surfactant or template or base. Cytotoxicity experiments indicated that the tellurium/calcium silicate nanocomposites with a low concentration had good biocompatibility. This nanocomposite is a very promising candidate for the application as bioactive materials.
28.	Mahajan, Anubha, et al. (author) Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation 2022 In: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 54:5, s. 560-572 Journal article (peer-reviewed)abstract We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi-ancestry GWAS meta-analysis identified 237 loci attaining stringent genome-wide significance (P < 5 x 10(-9)), which were delineated to 338 distinct association signals. Fine-mapping of these signals was enhanced by the increased sample size and expanded population diversity of the multi-ancestry meta-analysis, which localized 54.4% of T2D associations to a single variant with >50% posterior probability. This improved fine-mapping enabled systematic assessment of candidate causal genes and molecular mechanisms through which T2D associations are mediated, laying the foundations for functional investigations. Multi-ancestry genetic risk scores enhanced transferability of T2D prediction across diverse populations. Our study provides a step toward more effective clinical translation of T2D GWAS to improve global health for all, irrespective of genetic background. Genome-wide association and fine-mapping analyses in ancestrally diverse populations implicate candidate causal genes and mechanisms underlying type 2 diabetes. Trans-ancestry genetic risk scores enhance transferability across populations.
29.	Su, Jie, et al. (author) A silicogermanate with 20 ring channels directed by a simple quaternary ammonium cation 2013 In: Dalton Transactions. - : Royal Society of Chemistry (RSC). - 1477-9226 .- 1477-9234. ; 42:5, s. 1360-1363 Journal article (peer-reviewed)abstract A silicogermanate, PKU-12, with the -CLO type of zeolite framework was hydrothermally synthesized under fluoride media using diisopropylethylmethylammonium as a structure directing agent. The formation of the silicogermanate zeolite with 20-ring channels has not only extended the -CLO family from phosphates into silicogermanates, but also demonstrated its structural diversity.
30.	Sun, Yuhao, et al. (author) The Contribution of Genetic Risk and Lifestyle Factors in the Development of Adult-Onset Inflammatory Bowel Disease : A Prospective Cohort Study 2023 In: American Journal of Gastroenterology. - : Lippincott Williams & Wilkins. - 0002-9270 .- 1572-0241. ; 118:3, s. 511-522 Journal article (peer-reviewed)abstract INTRODUCTION: The joint associations across genetic risk, modifiable lifestyle factors, and inflammatory bowel disease (IBD) remains unclear.METHODS: Genetic susceptibility to Crohn's disease (CD) and ulcerative colitis (UC) was estimated by polygenic risk scores and further categorized into high, intermediate, and low genetic risk categories. Weighted healthy lifestyle scores were constructed based on 5 common lifestyle factors and categorized into favorable (4 or 5 healthy lifestyle factors), intermediate (3 healthy lifestyle factors), and unfavorable (0-2 healthy lifestyle factors) groups. Cox proportional hazards regression model was used to estimate the hazard ratios (HR) and 95% confidence interval (CI) for their associations.RESULTS: During the 12-year follow-up, 707 cases with CD and 1576 cases with UC were diagnosed in the UK Biobank cohort. Genetic risk and unhealthy lifestyle categories were monotonically associated with CD and UC risk with no multiplicative interaction between them. The HR of CD and UC were 2.24 (95% CI 1.75-2.86) and 2.15 (95% CI 1.82-2.53) for those with a high genetic risk, respectively. The HR of CD and UC for individuals with an unfavorable lifestyle were 1.94 (95% CI 1.61-2.33) and 1.98 (95% CI 1.73-2.27), respectively. The HR of individuals with a high genetic risk but a favorable lifestyle (2.33, 95% CI 1.58-3.44 for CD, and 2.05, 95% CI 1.58-2.66 for UC) were reduced nearly by half, compared with those with a high genetic risk but an unfavorable lifestyle (4.40, 95% CI 2.91-6.66 for CD and 4.44, 95% CI 3.34-5.91 for UC).DISCUSSION: Genetic and lifestyle factors were independently associated with susceptibility to incident CD and UC. Adherence to a favorable lifestyle was associated with a nearly 50% lower risk of CD and UC among participants at a high genetic risk.
31.	Wheeler, Eleanor, et al. (author) Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations : A transethnic genome-wide meta-analysis 2017 In: PLoS Medicine. - : PUBLIC LIBRARY SCIENCE. - 1549-1277 .- 1549-1676. ; 14:9 Journal article (peer-reviewed)abstract Background: Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in patients with diabetes. Previous genome-wide association studies (GWAS) have identified 18 HbA1c-associated genetic variants. These variants proved to be classifiable by their likely biological action as erythrocytic (also associated with erythrocyte traits) or glycemic (associated with other glucose-related traits). In this study, we tested the hypotheses that, in a very large scale GWAS, we would identify more genetic variants associated with HbA1c and that HbA1c variants implicated in erythrocytic biology would affect the diagnostic accuracy of HbA1c. We therefore expanded the number of HbA1c-associated loci and tested the effect of genetic risk-scores comprised of erythrocytic or glycemic variants on incident diabetes prediction and on prevalent diabetes screening performance. Throughout this multiancestry study, we kept a focus on interancestry differences in HbA1c genetics performance that might influence race-ancestry differences in health outcomes.Methods & findings: Using genome-wide association meta-analyses in up to 159,940 individuals from 82 cohorts of European, African, East Asian, and South Asian ancestry, we identified 60 common genetic variants associated with HbA1c. We classified variants as implicated in glycemic, erythrocytic, or unclassified biology and tested whether additive genetic scores of erythrocytic variants (GS-E) or glycemic variants (GS-G) were associated with higher T2D incidence in multiethnic longitudinal cohorts (N = 33,241). Nineteen glycemic and 22 erythrocytic variants were associated with HbA1c at genome-wide significance. GS-G was associated with higher T2D risk (incidence OR = 1.05, 95% CI 1.04-1.06, per HbA1c-raising allele, p = 3 x 10-29); whereas GS-E was not (OR = 1.00, 95% CI 0.99-1.01, p = 0.60). In Europeans and Asians, erythrocytic variants in aggregate had only modest effects on the diagnostic accuracy of HbA1c. Yet, in African Americans, the X-linked G6PD G202A variant (T-allele frequency 11%) was associated with an absolute decrease in HbA1c of 0.81%-units (95% CI 0.66-0.96) per allele in hemizygous men, and 0.68%-units (95% CI 0.38-0.97) in homozygous women. The G6PD variant may cause approximately 2% (N = 0.65 million, 95% CI0.55-0.74) of African American adults with T2Dto remain undiagnosed when screened with HbA1c. Limitations include the smaller sample sizes for non-European ancestries and the inability to classify approximately one-third of the variants. Further studies in large multiethnic cohorts with HbA1c, glycemic, and erythrocytic traits are required to better determine the biological action of the unclassified variants.Conclusions: As G6PD deficiency can be clinically silent until illness strikes, we recommend investigation of the possible benefits of screening for the G6PD genotype along with using HbA1c to diagnose T2D in populations of African ancestry or groups where G6PD deficiency is common. Screening with direct glucose measurements, or genetically-informed HbA1c diagnostic thresholds in people with G6PD deficiency, may be required to avoid missed or delayed diagnoses.
32.	Yu, Han, et al. (author) Fluorinated End Group Enables High-Performance All-Polymer Solar Cells with Near-Infrared Absorption and Enhanced Device Efficiency over 14% 2021 In: Advanced Energy Materials. - : WILEY-V C H VERLAG GMBH. - 1614-6832 .- 1614-6840. ; 11:4 Journal article (peer-reviewed)abstract Fluorination of end groups has been a great success in developing efficient small molecule acceptors. However, this strategy has not been applied to the development of polymer acceptors. Here, a dihalogenated end group modified by fluorine and bromine atoms simultaneously, namely IC-FBr, is first developed, then employed to construct a new polymer acceptor (named PYF-T) for all-polymer solar cells (all-PSCs). In comparison with its non-fluorinated counterpart (PY-T), PYF-T exhibits stronger and red-shifted absorption spectra, stronger molecular packing and higher electron mobility. Meanwhile, the fluorination on the end groups down-shifts the energy levels of PYF-T, which matches better with the donor polymer PM6, leading to efficient charge transfer and small voltage loss. As a result, an all-PSC based on PM6:PYF-T yields a higher power conversion efficiency (PCE) of 14.1% than that of PM6:PY-T (11.1%), which is among the highest values for all-PSCs reported to date. This work demonstrates the effectiveness of fluorination of end-groups in designing high-performance polymer acceptors, which paves the way toward developing more efficient and stable all-PSCs.
33.	Yuan, Shuai, et al. (author) Sleep duration and daytime napping in relation to incident inflammatory bowel disease : a prospective cohort study 2023 In: Alimentary Pharmacology and Therapeutics. - : John Wiley & Sons. - 0269-2813 .- 1365-2036. ; 57:5, s. 475-485 Journal article (peer-reviewed)abstract BACKGROUND: Sleep dysregulation has been linked to gastrointestinal dysfunction and inflammation.AIMS: To explore the associations between sleep duration, daytime napping and inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC).METHODS: Exposure information was obtained from the baseline questionnaire. Sleep duration was coded as continuous and categorical (≤5, 6, 7, 8, ≥9 h/day) variables. Daytime napping was defined as yes (sometimes/usually) and no (never/rarely). Incident IBD cases were defined from primary care and hospital inpatient records. Polygenic risk scores (PRS) for the outcomes were constructed and categorised into low, intermediate and high risk. Hazard ratio (HR) and confidence interval (CI) were estimated using Cox proportional hazard regression.RESULTS: The analysis included 2604 incident IBD cases (806 CD and 1798 UC) with a median follow-up of 12.0 years. Comparing sleep duration ≤5 with 7 h/day, the HR of IBD, CD and UC was 1.36 (95% CI, 1.17-1.59), 1.53 (95% CI, 1.17-2.00) and 1.29 (95% CI, 1.07-1.56), respectively. Comparing participants with and without daytime napping, the HR of IBD, CD and UC was 1.13 (95% CI, 1.05-1.23), 1.25 (95% CI, 1.08-1.44) and 1.09 (95% CI, 0.90-1.20), respectively. No interaction of sleep duration and daytime napping with PRS was detected. However, the associations appeared stronger in individuals with high rather than low PRS.CONCLUSIONS: This study reveals positive associations between short sleep duration and daytime napping and IBD risk.
34.	Zhang, Guobin, et al. (author) Thermal Analysis of AlGaN/GaN High-Electron-Mobility Transistors with Graphene 2018 In: Journal of Nanoscience and Nanotechnology. - : American Scientific Publishers. - 1533-4880 .- 1533-4899. ; 18:11, s. 7578-7583 Journal article (peer-reviewed)abstract A thermal analysis of AlGaN/GaN high electron mobility transistors (HEMTs) with Graphene is investigated using Silvaco and Finite Element Method. Two thermal management solutions are adopted; first of all, graphene is used as dissipation material between SiC substrate and GaN buffer layer to reduce thermal boundary resistance of the device. At the same time, graphene is also used as a thermal spread material on the top of the source contacts to reduce thermal resistance of the device. The thermal analysis results show that the temperature rise of device adopting graphene decreases by 46.5% in transistors operating at 13.86 W/mm. Meanwhile, the thermal resistance of GaN HEMTs with graphene is 6.8 K/W, which is much lower than the device without graphene, which is 18.5 K/W. The thermal management solutions are useful for integration of large-scale graphene into practical devices for effective heat spreading in AlGaN/GaN HEMT.
35.	Zhou, Shun-Fan, et al. (author) Membrane-associated transcription factor peptidase, site-2 protease, antagonizes ABA signaling in Arabidopsis 2015 In: New Phytologist. - : Wiley. - 0028-646X .- 1469-8137. ; 208:1, s. 188-197 Journal article (peer-reviewed)abstract Abscisic acid plays important roles in maintaining seed dormancy while gibberellins (GA) and other phytohormones antagonize ABA to promote germination. However, how ABA signaling is desensitized during the transition from dormancy to germination is still poorly understood. We functionally characterized the role of membrane-associated transcription factor peptidase, site-2 protease (S2P), in ABA signaling during seed germination in Arabidopsis. Genetic analysis showed that loss-of-function of S2P conferred high ABA sensitivity during seed germination, and expression of the activated form of membrane-associated transcription factor bZIP17, in which the transmembrane domain and endoplasmic reticulum (ER) lumen-facing C-terminus were deleted, in the S2P mutant rescued its ABA-sensitive phenotype. MYC and green fluorescent protein (GFP)-tagged bZIP17 were processed and translocated from the ER to the nucleus in response to ABA treatment. Furthermore, genes encoding negative regulators of ABA signaling, such as the transcription factor ATHB7 and its target genes HAB1, HAB2, HAI1 and AHG3, were up-regulated in seeds of the wild-type upon ABA treatment; this up-regulation was impaired in seeds of S2P mutants. Our results suggest that S2P desensitizes ABA signaling during seed germination through regulating the activation of the membrane-associated transcription factor bZIP17 and therefore controlling the expression level of genes encoding negative regulators of ABA signaling.
36.	Abadikhah, Marie, 1992, et al. (author) Effect of anode material and dispersal limitation on the performance and biofilm community in microbial electrolysis cells 2023 In: Biofilm. - 2590-2075. ; 6 Journal article (peer-reviewed)abstract In a microbial electrolysis cell (MEC), the oxidization of organic compounds is facilitated by an electrogenic biofilm on the anode surface. The biofilm community composition determines the function of the system. Both deterministic and stochastic factors affect the community, but the relative importance of different factors is poorly understood. Anode material is a deterministic factor as materials with different properties may select for different microorganisms. Ecological drift is a stochastic factor, which is amplified by dispersal limitation between communities. Here, we compared the effects of three anode materials (graphene, carbon cloth, and nickel) with the effect of dispersal limitation on the function and biofilm community assembly. Twelve MECs were operated for 56 days in four hydraulically connected loops and shotgun metagenomic sequencing was used to analyse the microbial community composition on the anode surfaces at the end of the experiment. The anode material was the most important factor affecting the performance of the MECs, explaining 54–80 % of the variance observed in peak current density, total electric charge generation, and start-up lag time, while dispersal limitation explained 10–16 % of the variance. Carbon cloth anodes had the highest current generation and shortest lag time. However, dispersal limitation was the most important factor affecting microbial community structure, explaining 61–98 % of the variance in community diversity, evenness, and the relative abundance of the most abundant taxa, while anode material explained 0–20 % of the variance. The biofilms contained nine Desulfobacterota metagenome-assembled genomes (MAGs), which made up 64–89 % of the communities and were likely responsible for electricity generation in the MECs. Different MAGs dominated in different MECs. Particularly two different genotypes related to Geobacter benzoatilyticus competed for dominance on the anodes and reached relative abundances up to 83 %. The winning genotype was the same in all MECs that were hydraulically connected irrespective of anode material used.
37.	Afonina, Irina, et al. (author) The composition and function of Enterococcus faecalis membrane vesicles 2021 In: MicroLife. - : Oxford University Press. - 2633-6693. ; 2 Journal article (peer-reviewed)abstract Membrane vesicles (MVs) contribute to various biological processes in bacteria, including virulence factor delivery, antimicrobial resistance, host immune evasion and cross-species communication. MVs are frequently released from the surface of both Gram-negative and Gram-positive bacteria during growth. In some Gram-positive bacteria, genes affecting MV biogenesis have been identified, but the mechanism of MV formation is unknown. In Enterococcus faecalis, a causative agent of life-threatening bacteraemia and endocarditis, neither mechanisms of MV formation nor their role in virulence has been examined. Since MVs of many bacterial species are implicated in host–pathogen interactions, biofilm formation, horizontal gene transfer, and virulence factor secretion in other species, we sought to identify, describe and functionally characterize MVs from E. faecalis. Here, we show that E. faecalis releases MVs that possess unique lipid and protein profiles, distinct from the intact cell membrane and are enriched in lipoproteins. MVs of E. faecalis are specifically enriched in unsaturated lipids that might provide membrane flexibility to enable MV formation, providing the first insights into the mechanism of MV formation in this Gram-positive organism.
38.	ANDERSSON, MICHAEL, 1988, et al. (author) Microwave characterization of Ti/Au-graphene contacts 2013 In: Applied Physics Letters. - : AIP Publishing. - 0003-6951 .- 1077-3118. ; 103:17, s. 173111- Journal article (peer-reviewed)abstract In this paper, we report on a microwave characterization of the interface between Ti/Au contacts and chemical vapor deposition graphene using structures of Corbino geometry, with primary focus on extracting and modeling the capacitance associated with the contact region. It is found that with the current contact resistivity, ρc∼10^−6 Ωcm2, the contact capacitance, on the order Cc∼1 μF/cm2, has a negligible effect on microwave transmission through the contact below ∼100 GHz. Finally, a parallel plate capacitance model for the contact is presented.
39.	ANDERSSON, MICHAEL, 1988, et al. (author) Towards Graphene Electrodes for High Performance Acoustic Resonators 2013 In: WOCSDICE. ; , s. 99-100 Conference paper (peer-reviewed)abstract The tunable FBAR is a promising building block for versatile microwave systems. Utilizing graphene electrodes promises higher tunability and frequency. Increased parasitic resistance may hamper the Q-factor of the resonator. This paper reports the initiated study of graphene and contacts at DC and microwave frequencies for optimization of these parameters leading to graphene FBARs.
40.	Austin, Thomas R., et al. (author) A plasma protein-based risk score to predict hip fractures 2024 In: NATURE AGING. - 2662-8465. Journal article (peer-reviewed)abstract As there are effective treatments to reduce hip fractures, identification of patients at high risk of hip fracture is important to inform efficient intervention strategies. To obtain a new tool for hip fracture prediction, we developed a protein-based risk score in the Cardiovascular Health Study using an aptamer-based proteomic platform. The proteomic risk score predicted incident hip fractures and improved hip fracture discrimination in two Tr & oslash;ndelag Health Study validation cohorts using the same aptamer-based platform. When transferred to an antibody-based proteomic platform in a UK Biobank validation cohort, the proteomic risk score was strongly associated with hip fractures (hazard ratio per s.d. increase, 1.64; 95% confidence interval 1.53-1.77). The proteomic risk score, but not available polygenic risk scores for fractures or bone mineral density, improved the C-index beyond the fracture risk assessment tool (FRAX), which integrates information from clinical risk factors (C-index, FRAX 0.735 versus FRAX + proteomic risk score 0.776). The developed proteomic risk score constitutes a new tool for stratifying patients according to hip fracture risk; however, its improvement in hip fracture discrimination is modest and its clinical utility beyond FRAX with information on femoral neck bone mineral density remains to be determined. The authors developed a proteomic risk score that improved the prediction of hip fractures in three validation cohorts analyzed by two different proteomic platforms. This risk score constitutes a new tool to stratify patients by hip fracture risk.
41.	Austin, Thomas R, et al. (author) Large-scale circulating proteome association study (CPAS) meta-analysis identifies circulating proteins and pathways predicting incident hip fractures. 2024 In: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. - 1523-4681. ; 39:2, s. 139-149 Journal article (peer-reviewed)abstract Hip fractures are associated with significant disability, high cost, and mortality. However, the exact biological mechanisms underlying susceptibility to hip fractures remain incompletely understood. In an exploratory search of the underlying biology as reflected through the circulating proteome, we performed a comprehensive Circulating Proteome Association Study (CPAS) meta-analysis for incident hip fractures. Analyses included 6430 subjects from two prospective cohort studies (Cardiovascular Health Study and Trøndelag Health Study) with circulating proteomics data (aptamer-based 5K SomaScan version 4.0 assay; 4979 aptamers). Associations between circulating protein levels and incident hip fractures were estimated for each cohort using age and sex-adjusted Cox regression models. Participants experienced 643 incident hip fractures. Compared with the individual studies, inverse-variance weighted meta-analyses yielded more statistically significant associations, identifying 23 aptamers associated with incident hip fractures (conservative Bonferroni correction 0.05/4979, P<1.0×10-5). The aptamers most strongly associated with hip fracture risk corresponded to two proteins of the growth hormone/insulin growth factor system (GHR and IGFBP2), as well as GDF15 and EGFR. High levels of several inflammation-related proteins (CD14, CXCL12, MMP12, ITIH3) were also associated with increased hip fracture risk. Ingenuity pathway analysis identified reduced LXR/RXR activation and increased acute phase response signaling to be overrepresented among those proteins associated with increased hip fracture risk. These analyses identified several circulating proteins and pathways consistently associated with incident hip fractures. These findings underscore the usefulness of the meta-analytic approach for comprehensive CPAS in a similar manner as has previously been observed for large-scale human genetic studies. Future studies should investigate the underlying biology of these potential novel drug targets.
42.	Bai, Qiao, et al. (author) Effect of proinflammatory S100A9 protein on migration and proliferation of microglial cells 2023 In: Journal of Molecular Neuroscience. - : Springer Nature. - 0895-8696 .- 1559-1166. ; 73:11-12, s. 983-995 Journal article (peer-reviewed)abstract Alzheimer’s disease (AD) is a multifactorial disease affecting aging population worldwide. Neuroinflammation became a focus of research as one of the major pathologic processes relating to the disease onset and progression. Proinflammatory S100A9 is the central culprit in the amyloid-neuroinflammatory cascade implicated in AD and other neurodegenerative diseases. We studied the effect of S100A9 on microglial BV-2 cell proliferation and migration. The responses of BV-2 cells to S100A9 stimulation were monitored in real-time using live cell microscopy, transcriptome sequencing, immunofluorescence staining, western blot analysis, and ELISA. We observed that a low dose of S100A9 promotes migration and proliferation of BV-2 cells. However, acute inflammatory condition (i.e., high S100A9 doses) causes diminished cell viability; it is uncovered that S100A9 activates TLR-4 and TLR-7 signaling pathways, leading to TNF-α and IL-6 expression, which affect BV-2 cell migration and proliferation in a concentration-dependent manner. Interestingly, the effects of S100A9 are not only inhibited by TNF-α and IL-6 antibodies. The addition of amyloid-β (Aβ) 1–40 peptide resumes the capacities of BV-2 cells to the level of low S100A9 concentrations. Based on these results, we conclude that in contrast to the beneficial effects of low S100A9 dose, high S100A9 concentration leads to impaired mobility and proliferation of immune cells, reflecting neurotoxicity at acute inflammatory conditions. However, the formation of Aβ plaques may be a natural mechanism that rescues cells from the proinflammatory and cytotoxic effects of S100A9, especially considering that inflammation is one of the primary causes of AD.
43.	Bao, Jie, et al. (author) Application of two-dimensional layered hexagonal boron nitride in chip cooling 2016 In: Yingyong Jichu yu Gongcheng Kexue Xuebao/Journal of Basic Science and Engineering. - 1005-0930. ; 24:1, s. 210-217 Journal article (peer-reviewed)abstract © 2016, The Editorial Board of Journal of Basic Science and Engineering. All right reserved.Research into layered hexagonal boron nitride(h-BN)has recently intensified, due to its superior physicochemical properties compared to that of a typical two-dimensional material. H-BN can be utilized in power chips as both an insulating layer as well as a heat spreader for local hotspots with high heat flux. Single layer h-BN film grown by CVD and h-BN microparticles are respectively transferred onto the surfaces of the thermal evaluation chips, where the influence of h-BN on the heat dissipation performance of the chips can be observed at different power values. The resistance-temperature curve method and infrared thermal imager are both used to measure the temperature of hotspots on the thermal evaluation chips, which can be reduced by between 3~5℃ at 1W after the transfer of h-BN. The cooling efficiency is improved and it can be found that single layer h-BN film shows better heat dissipation ability.
44.	Bentham, James, et al. (author) A century of trends in adult human height 2016 In: eLIFE. - 2050-084X. ; 5 Journal article (peer-reviewed)abstract Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.522.7) and 16.5 cm (13.319.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
45.	Bentham, James, et al. (author) A century of trends in adult human height 2016 In: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 5 Journal article (peer-reviewed)abstract Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5–22.7) and 16.5 cm (13.3– 19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8– 144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
46.	Buron, J.D., et al. (author) Correlation between THz AC and micro-four-point-probe DC conductivity mapping of graphene sheets 2012 In: Laser and Tera-Hertz Science and Technology, LTST 2012. - Washington, D.C. : OSA. Conference paper (peer-reviewed)abstract We present quantitative correlation mapping of the sheet conductance of large areas of graphene. Terahertz time-domain spectroscopy (THz-TDS) maps the nanoscale conductance averaged over the beam spot size whereas micro four-point probe (M4PP) maps the micro-scale conductance.
47.	Buron, J. D., et al. (author) Graphene Conductance Uniformity Mapping 2012 In: Nano Letters. - : American Chemical Society (ACS). - 1530-6992 .- 1530-6984. ; 12:10, s. 5074-5081 Journal article (peer-reviewed)abstract We demonstrate a combination of micro four-point probe (M4PP) and non-contact terahertz time-domain spectroscopy (THz-TDS) measurements for centimeter scale quantitative mapping of the sheet conductance of large area chemical vapor deposited graphene films. Dual configuration M4PP measurements, demonstrated on graphene for the first time, provide valuable statistical insight into the influence of microscale defects on the conductance, while THz-TDS has potential as a fast, non-contact metrology method for mapping of the spatially averaged nanoscopic conductance on wafer-scale graphene with scan times of less than a minute for a 4-in. wafer. The combination of M4PP and THz-TDS conductance measurements, supported by micro Raman spectroscopy and optical imaging, reveals that the film is electrically continuous on the nanoscopic scale with microscopic defects likely originating from the transfer process, dominating the microscale conductance of the investigated graphene film.
48.	Cao, Lingyun, et al. (author) Self-Supporting Metal–Organic Layers as Single-Site Solid Catalysts 2016 In: Angewandte Chemie International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 55:16, s. 4962-4966 Journal article (peer-reviewed)abstract Metal–organic layers (MOLs) represent an emerging class of tunable and functionalizable two-dimensional materials. In this work, the scalable solvothermal synthesis of self-supporting MOLs composed of [Hf6O4(OH)4(HCO2)6] secondary building units (SBUs) and benzene-1,3,5-tribenzoate (BTB) bridging ligands is reported. The MOL structures were directly imaged by TEM and AFM, and doped with 4′-(4-benzoate)-(2,2′,2′′-terpyridine)-5,5′′-dicarboxylate (TPY) before being coordinated with iron centers to afford highly active and reusable single-site solid catalysts for the hydrosilylation of terminal olefins. MOL-based heterogeneous catalysts are free from the diffusional constraints placed on all known porous solid catalysts, including metal–organic frameworks. This work uncovers an entirely new strategy for designing single-site solid catalysts and opens the door to a new class of two-dimensional coordination materials with molecular functionalities.
49.	Chen, Huang, et al. (author) A portable micro glucose sensor based on copper-based nanocomposite structure 2019 In: New Journal of Chemistry. - : Royal Society of Chemistry (RSC). - 1369-9261 .- 1144-0546. ; 43:20, s. 7806-7813 Journal article (peer-reviewed)abstract Precisely detecting the concentration of glucose in the human body is an attractive way to prevent or treat diabetes. Portable glucose sensors with non-enzymatic catalytic materials have received great attention in recent years. Herein, a facile strategy for fabricating a high-performance electrochemical sensor is proposed. A non-enzymatic three-electrode integrated glucose sensor device based on CuO nano-coral arrays/nanoporous Cu (NCA/NPC) is designed and fabricated. The portable NCA/NPC glucose sensor device exhibits high catalytic activity for glucose. The great performance of the NCA/NPC glucose sensor device derives from the excellent conductivity of the NPC substrate and the high electrocatalytic activity of CuO nano-coral arrays. This device exhibits a high sensitivity of 1621 μA mM -1 cm -2 in the linear range of 0.0005-5.0 mM, low detection limit of 200 nM (S/N = 3), fast response time of 3 s, good anti-interference performance, excellent repeatability and considerable stability for glucose detection. This work will certainly provide an efficient structure and proper catalytic material choices for future non-enzymatic glucose sensors.
50.	Chen, Hong, et al. (author) PKU-3 : An HCI-Inclusive Aluminoborate for Strecker Reaction Solved by Combining RED and PXRD 2015 In: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 0002-7863 .- 1520-5126. ; 137:22, s. 7047-7050 Journal article (peer-reviewed)abstract A novel microporous aluminoborate, denoted as PKU-3, was prepared by the boric acid flux method. The structure of PKU-3 was determined by combining the rotation electron diffraction and synchrotron powder X-ray diffraction data with well resolved ordered Cl- ions in the channel. Composition and crystal structure analysis showed that there are both proton and chlorine ions in the channels. Part of these protons and chlorine ions can be washed away by basic solutions to activate the open pores. The washed PKU-3 can be used as an efficient catalyst in the Strecker reaction with yields higher than 90%.

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