| 1. |
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| 2. |
- Björkqvist, Maria, et al.
(author)
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Phenotypic and genotypic characterisation of blood isolates of coagulase-negative staphylococci in the newborn
- 2002
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In: Acta Pathologica, Microbiologica et Immunologica Scandinavica (APMIS). - : Wiley. - 0903-4641 .- 1600-0463. ; 110:4, s. 332-339
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Journal article (peer-reviewed)abstract
- Coagulase-negative staphylococci (CNS) are the leading cause of late-onset sepsis in newborns (>72 h of age). Our aim was to determine whether phenotypic and/or genotypic differences existed between blood isolates of CNS regarded as inducers of sepsis or as contaminants. Ninety-seven bloodisolates of CNS recovered from newborns at the neonatal intensive care unit, Örebro, Sweden in 1983–1997 were analysed. Twenty-nine of them (30%) were classified as sepsis isolates and 68 (70%) as contaminants. The most prevalent species was Staphylococcus epidermidis (n=59). Staphylococcus haemolyticus (n=16) was most often isolated from newborns with the lowest gestational age and birth weight. Biochemical typing using the Phene Plate system (PhP) and genotyping using pulsed-field gel electrophoresis (PFGE) showed that the S. epidermidis isolates regarded as inducers of sepsis (n=16) were more homogeneous than isolates considered contaminants (n=37). One main genotypic group, representing seven (44%) isolates, was identified among the sepsis isolates. Phenotypically the S. epidermidis sepsis isolates comprised three major clusters. In contrast, among the S. epidermidis contaminants, eight genotypic groups and two phenotypic clusters were identified. The dominating genotypic group among the sepsis isolates of S. epidermidis may represent strains with higher invasive capacity.
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| 3. |
- Collins, Matthew D., et al.
(author)
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Characterization of some Strains from Human Clinical Sources which resemble “Leptotrichia sanguinegens”: Description of Sneathia sanguinegens sp. nov., gen. nov.
- 2001
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In: Systematic and Applied Microbiology. - : Elsevier BV. - 0723-2020. ; 24:3, s. 358-361
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Journal article (peer-reviewed)abstract
- Three strains of a Gram-negative, blood or serum requiring, rod-shaped bacterium recovered from human clinical specimens were characterised by phenotypic and molecular taxonomic methods. Comparative 16S rRNA gene sequencing showed the unknown rod-shaped strains are members of the same species as some fastidious isolates recovered from human blood specimens and previously designated “Leptotrichia sanguinegens”. Based on phylogenetic and phenotypic evidence, it is proposed that the isolates from human sources be classified in a new genus Sneathia, as Sneathia sanguinegens gen. nov., sp. nov. The type strain of Sneathia sanguinegens is CCUG 41628T.
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| 4. |
- Dalmo, Johanna, et al.
(author)
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Evaluation of retinol binding protein 4 and carbamoylated haemoglobin as potential renal toxicity biomarkers in adult mice treated with Lu-177-octreotate
- 2014
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In: EJNMMI Research. - : Springer Science and Business Media LLC. - 2191-219X. ; 4:59
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Journal article (peer-reviewed)abstract
- Background: The kidneys are regarded as one of the main dose-limiting organs in the treatment of neuroendocrine tumours with Lu-177-[DOTA(0), Tyr(3)]-octreotate (Lu-177-octreotate), despite the successful use of kidney uptake blocking agents such as lysine and arginine. To avoid renal toxicity but still give each patient as high amount of Lu-177-octreotate as possible, there is a need for methods/biomarkers that indicate renal injury in an early stage of the treatment. The aim of this study was to investigate the potential of using urinary retinol binding protein 4 (RBP4) and carbamoylated haemoglobin (Hb) in blood as biomarkers of nephrotoxic effects on adult mice after Lu-177-octreotate treatment. Methods: Adult BALB/c nude mice were injected with 60 MBq or 120 MBq of Lu-177-octreotate or with saline (control). Urine was collected before injection and concentrations of urinary RBP4 and creatinine were determined 14 to 90 days after injection Blood samples were collected after 90 days, and carbamoylated N-terminal valine in Hb, formed from urea, was measured as valine hydantoin (VH) after detachment from Hb. Results: The RBP4 values increased with administered activity and time. For the 60 and 120 MBq groups, statistically significantly higher RBP4 levels (p <0.05) were found at day 60 and 90 compared to baseline, also at day 30 for 120 MBq group. For VH, the mean values were similar for the 60 MBq and control groups, while a small increase was observed for the 120 MBq group; but there were no statistically significant differences between any of the groups (p >0.05). No morphological changes in the kidney tissue were found. Conclusions: Urinary RBP4 is a promising new biomarker for radiation-induced renal toxicity. For the conditions used in this experiment, carbamoylated Hb (from urea) measured as VH may not be a sufficiently sensitive biomarker to be used for renal toxicity.
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| 5. |
- Dalmo, Johanna, et al.
(author)
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Potential renal toxicity biomarkers indicating radiation injury after 177Lu-octreotate treatment
- 2013
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In: Annual congress of the European association of nuclear medicine, october 19-23, 2013, Lyon, France. Posterwalk.
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Conference paper (other academic/artistic)abstract
- The kidneys are one of the most exposed non-tumor tissues and regarded as one of the main dose-limiting organs in peptide receptor radionuclide therapy (PRRT). [177Lu-DOTA0, Tyr3]-octreotate (177Lu-octreotate) has shown promising results in the treatment of somatostatin receptor overexpressing neuroendocrine tumors, but optimization is still needed. The ability to give each patient as much 177Lu-octreotate as possible without inducing nephrotoxicity is necessary for an efficient treatment. However, due to large inter-individual differences in uptake and retention in the kidneys, there is a need for efficient Methods that early can indicate renal injury. A possible way is to identify biomarkers for high risk of radiation nephrotoxicity. The aim of this study was to investigate the potential of using urinary retinol binding protein (RBP), and blood valinhydantoin (VH) as biomarkers of nephrotoxicity on adult mice after 177Lu-octreotate treatment. BALB/c nude mice (n=6/group) were i.v. injected with 60 MBq or 120 MBq of 177Lu-octreotate. The control group was mock treated with saline. Spot urine samples were collected before injection, and 14, 30, 60 and 90 days after injection. Analysis of RBP4 and creatinine was performed using Mouse RBP4 ELISA kit and Creatinine kit from R&D Systems, respectively. Erythrocytes were separated from whole blood samples collected 90 days after injection, and analysed for VH by LC-MS/MS. The ratio between VH and a volumetric standard was calculated. The RBP/creatinine level increased with time in both groups given 177Lu-octreotate, with earlier and higher response for the 120 MBq group. No clear change in VH level between the different groups was observed. The result show that RBP may be a promising new biomarker for radiation induced kidney toxicity. The presently used method based on VH was not sensitive enough to be used as kidney toxicity marker. Further studies on mice are ongoing to validate if RBP4 may be efficient in predicting late nephrotoxicity. In patients, RBP/creatinine levels are followed in urine samples after treatment with 177Lu-octreotate.
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| 6. |
- Eriksson, Hans, et al.
(author)
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Evidence for the key role of the adipocyte cGMP-inhibited cAMP phosphodiesterase in the antilipolytic action of insulin
- 1995
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In: Biochimica et Biophysica Acta. - : Elsevier BV. - 0006-3002. ; 1266:1, s. 101-107
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Journal article (peer-reviewed)abstract
- Enhancement of cAMP degradation by increased cGMP-inhibited cAMP phosphodiesterase (cGI-PDE) activity is thought to be an important component of the mechanism whereby insulin counteracts catecholamine-induced lipolysis in adipocytes. In this study the selective cGI-PDE inhibitor OPC3911 was used to evaluate this role of cGI-PDE activation in intact rat adipocytes with special reference to changes in cAMP levels measured as cAMP-dependent protein kinase (cAMP-PK) activity ratios. OPC3911 completely blocked (IC50 = 0.3 microM) the maximal inhibitory effect of insulin on noradrenaline-induced lipolysis and the net dephosphorylation of hormone-sensitive lipase and other intracellular target proteins for insulin action, whereas insulin-induced lipogenesis was not changed. The effect of OPC3911 on cAMP-PK activity ratios at different levels of lipolysis achieved by noradrenaline stimulation revealed that the reduction of cAMP-PK caused by 1 nM insulin was completely blocked by 3 microM OPC3911. The effect of OPC3911 was not due to an excessive increase in cellular cAMP resulting in 'supramaximal' lipolysis unresponsive to insulin. These data demonstrate that reduction in cAMP levels by the activation of cGI-PDE may be sufficient to account for the antilipolytic action of insulin.
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| 7. |
- Erlandsson, Ann, 1968-, et al.
(author)
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PCR assay or culture for diagnosis of Bordetella pertussis in the routine diagnostic laboratory?
- 1997
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In: Journal of Infection. - : Elsevier. - 0163-4453 .- 1532-2742. ; 35:3, s. 221-224
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Journal article (peer-reviewed)abstract
- A nested PCR method was compared with culture for the detection of Bordetella pertussis in a routine clinical diagnostic laboratory. A total of 241 clinical nasopharyngeal aspirates were examined in parallel in the laboratory. Both methods were positive for 75 samples (31%), eight samples were positive by nested PCR only (3.3%), and one sample was positive by culture only (0.4%). The mean time actually required in the clinical laboratory (not operating with pertussis diagnosis during weekends) from the day of arrival to the diagnosis of a positive or negative sample by the nested PCR assay was 1.8 _+ 1.3 days (mean _+ SD), for positive culture 4.5 _+ 1.4 days and for negative culture 10.5 +_ 1.0 days. The hands-on time in the laboratory to perform the nested PCR was 2 h, for a positive culture 25 min, and for a negative culture 15 min. The cost analysis of the methods, when running one sample at a time, showed that the laboratory cost for PCR was six times higher than culture. When running four samples together the cost for PCR was three times higher than culture. In conclusion, the nested PCR is the more rapid and sensitive method compared to culture. With the present design, the PCR-protocol involves higher material expenditure and claims more bands-on time.
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| 8. |
- Fraenkel, Carl-Johan, et al.
(author)
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In vitro activities of three carbapenems against recent bacterial isolates from severely ill patients at Swedish hospitals
- 2006
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In: Scandinavian Journal of Infectious Diseases. - : Informa UK Limited. - 0036-5548 .- 1651-1980. ; 38:10, s. 853-859
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Journal article (peer-reviewed)abstract
- To study the in vitro activity of imipenem, meropenem and ertapenem against common pathogens isolated from patients in intensive care, haematology and dialysis/nephrology units at 7 Swedish university hospitals, a total of 788 isolates were collected during 2002-2003. The distribution of the isolates was as follows: Escherichia coli (n = 140), Klebsiella spp. (n = 132), Proteus spp. (n = 97), Enterobacter spp. (n = 113), Pseudomonas aeruginosa (n = 126), Acinetobacter spp. (n = 53) and Enterococcus faecalis (n = 127). The susceptibility to the 3 carbapenems was determined by E-test, and the MICs were interpreted according to SRGA criteria. All 3 carbapenems were highly active against Enterobacteriaceae. The overall susceptibility to imipenem, meropenem and ertapenem was 90%, 98% and 93%, respectively. Against Enterobacteriaceae, Enterobacter spp. excluded, ertapenem had an equal or lower MIC(90) than meropenem. Apart from being the most active carbapenem against Enterobacteriaceae, meropenem was also the most active carbapenem against P. aeruginosa, whereas imipenem was the most active drug against Acinetobacter spp. The carbapenems are still potent antibiotics. With the introduction of ertapenem, and an expected increase in the carbapenem consumption due to an increased prevalence of strains with extended-spectrum beta-lactamases, continuous surveillance of carbapenem resistance appears to be warranted, with special attention to P. aeruginosa, Enterobacter and Proteus spp.
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| 9. |
- Gunnarsson, Fredrik, et al.
(author)
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Uplink Transmission Timing in WCDMA
- 2003
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In: Proceedings of the 58th IEEE Vehicular Technology Conference. - Linköping : Linköping University Electronic Press. - 0780379543 ; , s. 1688-1692 vol.3
-
Conference paper (peer-reviewed)abstract
- In wireless network uplink communications, there is a trade off between transmission coordination to avoid overload situations, and distributed transmission decisions to adapt to fast channel variations. Here, uplink transmission timing (UTT) is proposed as a scheme to allow some load control support, while transmitting mainly when the channel is favorable. It utilizes channel state feedback in the form of power control commands, which already are available in the system. Simulations illustrate the transmission timing behavior, and also indicate that UTT is a power and intercell interference efficient scheme to transport data compared to traditional dedicated channels with continuous transmissions and to schemes where transmission decisions are random.
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| 10. |
- Gustafsson, Lars L., et al.
(author)
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The 'wise list'- a comprehensive concept to select, communicate and achieve adherence to recommendations of essential drugs in ambulatory care in Stockholm
- 2011
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In: Basic & Clinical Pharmacology & Toxicology. - Copenhagen : Blackwell Publishing. - 1742-7835 .- 1742-7843. ; 108:4, s. 224-233
-
Journal article (peer-reviewed)abstract
- The aim was to present and evaluate the impact of a comprehensive strategy over 10 years to select, communicate and achieve adherence to essential drug recommendations (EDR) in ambulatory care in a metropolitan healthcare region. EDRs were issued and launched as a 'Wise List' by the regional Drug and Therapeutics Committee in Stockholm. This study presents the concept by: (i) documenting the process for selecting, communicating and monitoring the impact of the 'Wise List'; (ii) analysing the variation in the number of drug substances recommended between 2000 and 2010; (iii) assessing the attitudes to the 'Wise List' among prescribers and the public; (iv) evaluating the adherence to recommendations between 2003 and 2009. The 'Wise List' consistently contained 200 drug substances for treating common diseases. The drugs were selected based on their efficacy, safety, suitability and cost-effectiveness. The 'Wise List' was known among one-third of a surveyed sample of the public in 2002 after initial marketing campaigns. All surveyed prescribers knew about the concept and 81% found the recommendations trustworthy in 2005. Adherence to recommendations increased from 69% in 1999 to 77% in 2009. In primary care, adherence increased from 83% to 87% from 2003 to 2009. The coefficient of variation (CV%) decreased from 6.1% to 3.8% for 156 healthcare centres between these years. The acceptance of the 'Wise List' in terms of trust among physicians and among the public and increased adherence may be explained by clear criteria for drug recommendations, a comprehensive communication strategy, electronic access to recommendations, continuous medical education and involvement of professional networks and patients.
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| 11. |
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| 12. |
- Holmström, Gerd, et al.
(author)
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Ten years of ROP-screening and treatment in Sweden - consideration of modified screening guidelines based on a national quality register
- 2019
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In: Investigative Ophthalmology and Visual Science. - : The Association for Research in Vision and Ophtalmology. - 0146-0404 .- 1552-5783. ; 60:9
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Journal article (other academic/artistic)abstract
- Purpose : Description of ten years of national ROP-screening and treatment in Sweden and evaluation of the national screening program for ROP.Methods : The study is based on a national register for ROP, SWEDROP, with around 96% coverage. According to Swedish guidelines, all infants born at 30 weeks gestational age (GA) or less, as well as children born later but being extremely sick, should be screened for ROP during the neonatal period. Birth data are validated in the Swedish neonatal quality register, SNQ.Results : During the ten-year period between 2008 and 2017, 7257 infants with a GA of 30 weeks or less were registered in SWEDROP and 46.294 examinations were performed, of which 5.328 (11.5%) in infants born in gestational week 30. Mean GA was 27.6 w (range 21-30 w) and mean BW was 1116 g (range 390-2405 g). Overall, during the ten years, ROP was found in 31.8% (range 26.8-36.8%) and treatment for ROP was performed in 6% (range 4.1-7.7%) of the screened infants. Only nine infants with GA 28 w and four with GA 29 w were treated for ROP. No infant with GA 30 w was treated. Eighty-two per cent (361/441) of the treated infants had laser only and 17.7% (78/441) were treated with Anti-VEGF, alone (17 infants) or in combination with laser and/or other treatment.Conclusions : SWEDROP is a national register for ROP with a high national coverage. The incidence of ROP and frequency of treatment remained similar over the ten-year period. Only 13 infants born at 28 – 29 weeks GA and no child born at 30 w GA were treated for ROP. Modification of guidelines is considered, with lowering the upper limit of screening with one week, i.e. to less than 30 weeks GA. During the ten-year study period, this would have resulted in a reduction of 1680 infants (23.2%) screened for ROP and of 5.328 (11.5%) examinations.
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| 13. |
- K. Törnqvist, Eva, 1952-
(author)
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In Search of Elks and Birds : Two Case Studies on the Creative Use of ICT in Sweden
- 2011
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In: New Media Technologies and User Empowerment. - Frankfurt am Main, Berlin, Bern, Bruxelles, New York, Oxford, Wien : Peter Lang International Academic Publishers. - 9783631600313
-
Book chapter (peer-reviewed)abstract
- 'This collection provides numerous and refreshing insights into the claims about the ever more proactive role of users of information and communication technologies. Through a variety of case studies, illustrating the array of theoretical frameworks available, the authors throw light upon the diverse ways in which users engage with innovations. From outlining the challenges of involving users in design, through appreciating the diverse origins and nature of user engagement with ICTs to critically commenting upon the constraints of the user experience, this book provides a welcome and useful contribution to the field.
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| 14. |
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| 15. |
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| 16. |
- Lundberg, Jonas, et al.
(author)
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Establishing conversation spaces in hastily formed networks : the worst fire in modern Swedish history
- 2014
-
In: Disasters. The Journal of Disaster Studies, Policy and Management. - : Wiley-Blackwell. - 0361-3666 .- 1467-7717. ; 38:4, s. 790-807
-
Journal article (peer-reviewed)abstract
- In presenting examples from the most extensive and demanding fire in modern Swedish history, this paper describes challenges facing hastily formed networks in exceptional situations. Two concepts that have been used in the analysis of the socio-technical systems that make up a response are conversation space and sensemaking. This paper argues that a framework designed to promote understanding of the sensemaking process must take into consideration the time at which as well as the location in which an individual is engaged in an event. In hastily formed networks, location is partly mediated through physical systems that form conversation spaces of players and their interaction practices. This paper identifies and discusses four challenges to the formation of shared conversation spaces. It is based on the case study of the 2006 Bodträskfors forest fire in Sweden and draws on the experiences of organised volunteers and firefighters who participated in a hastily formed network created to combat the fire.
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| 17. |
- Lundberg, Jonas, et al.
(author)
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Resilience in Sensemaking and Control of Emergency Response
- 2012
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In: International Journal of Emergency Management. - : InderScience Publishers. - 1471-4825 .- 1741-5071. ; 8:2, s. 99-122
-
Journal article (peer-reviewed)abstract
- This paper proposes a model for describing resilience in emergency management of irregular events. The purpose of our model is to describe three parallel developments in an emergency response scenario. Namely, changes in the ongoing events processes, the actors' sensemaking and control functions, and the technologies used for sensemaking and control. Focusing on the three separate developments enables identifying resilience in the choice of control functions and technologies in response to foreseen and actual process changes, their consequences and new disturbances. Our model was created following an emergency exercise that proved to be difficult to analyse with respect to resilience using existing models. We use the exercise to illustrate and apply our model through a qualitative analysis.
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| 18. |
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| 19. |
- Palm, Jenny, et al.
(author)
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Governing the sea rescue service in Sweden: communicating in networks
- 2008
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In: Journal of Risk Research. - : Informa UK Limited. - 1366-9877 .- 1466-4461. ; 11:1, s. 269-280
-
Journal article (peer-reviewed)abstract
- This paper discusses how various actors communicate about and coordinate sea rescue activities in networks. We combine a network approach with theories of inter-organization communication to understand how communication can facilitate or limit coordination in networks. Search and rescue officers retain the overall authority to direct rescue missions, and coordination with several other professions is central to this. When coordinating different professional actors in a network it is important to develop trust, legitimacy, and a shared and uniform understanding of the situation and of how to act. Communication deficiencies often result from the fact that involved actors belong to different organizations with different cultures or representing different professions. The greatest gap we found was between those working and not working at sea, and between those habitually or seldom involved in rescue activities. Communication comprises more than simply exchanging information; it also entails the forging of relationships, to facilitate future coordination and cooperation and to develop mutual trust and understanding. In any rescue operation it is important that the actors interpret communication in the same way and act according to a shared pattern. Joint training and follow-up are important conditions for continuous learning and development in this regard.
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| 20. |
- Rahn, Tova, et al.
(author)
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Essential role of phosphatidylinositol 3-kinase in insulin-induced activation and phosphorylation of the cGMP-inhibited cAMP phosphodiesterase in rat adipocytes. Studies using the selective inhibitor wortmannin
- 1994
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In: FEBS Letters. - : Wiley. - 1873-3468 .- 0014-5793. ; 350:2-3, s. 314-318
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Journal article (peer-reviewed)abstract
- Incubation of rat adipocytes with wortmannin, a potent and selective phosphatidylinositol 3-kinase (PI 3-kinase) inhibitor, completely blocked the antilipolytic action of insulin (IC50 = 100 nM), the insulin-induced activation and phosphorylation of cGMP-inhibited cAMP phosphodiesterase (cGI-PDE) as well as the activation of the insulin-stimulated cGI-PDE kinase (IC50 = 10-30 nM). No direct effects of the inhibitor on the insulin-stimulated cGI-PDE kinase, the cGI-PDE and the hormone-sensitive lipase were observed. These data suggest that activation of PI 3-kinase upstream of the insulin-stimulated cGI-PDE kinase in the antilipolytic insulin signalchain has an essential role for insulin-induced cGI-PDE activation/phosphorylation and anti-lipolysis.
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| 21. |
- Rascon, Ana, et al.
(author)
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Identification of the phosphorylation site in vitro for cAMP-dependent protein kinase on the rat adipocyte cGMP-inhibited cAMP phosphodiesterase
- 1994
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In: Journal of Biological Chemistry. - 1083-351X. ; 269:16, s. 11962-11966
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Journal article (peer-reviewed)abstract
- Rat adipocyte cGMP-inhibited cAMP phosphodiesterase (cGI-PDE) appears to be dually regulated in intact cells by serine phosphorylations induced by isoprenaline and insulin, respectively (Degerman, E., Smith, C. J., Tornqvist, H., Vasta, V., Belfrage, P., and Manganiello, V. C. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 533-537; Smith, C. J., Vasta, V., Degerman, E., Belfrage, P., and Manganiello, V. C. (1991) J. Biol. Chem. 266, 13385-13390). Since cAMP-dependent protein kinase (cAMP-PK) catalyzes the beta-adrenergic effects, the site in the isolated cGI-PDE phosphorylated by this kinase was explored. A peptide, LRRSSGASGLLTSEHHSR (P18), corresponding to the amino acid sequence Leu423-Arg440 in the putative regulatory domain of the rat adipocyte cGI-PDE was synthesized. It contains a consensus substrate sequence -RRXS- for cAMP-PK within two tryptic cleavage sites and was readily phosphorylated by cAMP-PK. Two phosphopeptides, identified as RS-[32P]SGASGLLTSEHHSR and S-[32P]SGASGLLTSEHHSR, were obtained after stoichiometric phosphorylation and trypsinization of the peptide. These two peptides and the two main tryptic phosphopeptides obtained from immunoisolated [32P]cGI-PDE phosphorylated with cAMP-PK in a solubilized crude adipocyte membrane fraction were immuno-precipitated by an affinity-purified polyclonal antibody raised against P18 and exhibited the same chromatographic and electrophoretic profiles in three different separation systems. Similar radiosequencing profiles indicated that the second most N-terminal serine, corresponding to Ser-427 in the intact cGI-PDE, was phosphorylated by cAMP-PK in both P18 and authentic cGI-PDE. It is concluded that serine 427 is the target for cAMP-PK phosphorylation of the rat adipocyte cGI-PDE in vitro.
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| 22. |
- Ridderstrale, Martin, et al.
(author)
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Growth hormone stimulates the tyrosine phosphorylation of the insulin receptor substrate-1 and its association with phosphatidylinositol 3-kinase in primary adipocytes
- 1995
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In: Journal of Biological Chemistry. - 1083-351X. ; 270:8, s. 3471-3474
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Journal article (peer-reviewed)abstract
- Insulin receptor substrate-1 (IRS-1) is tyrosine-phosphorylated in response to insulin resulting in association with and activation of phosphatidylinositol 3-kinase (PI 3-kinase), thereby initiating some of the effects of insulin. We have recently shown that the insulin-like effects of growth hormone (GH) in adipocytes can be inhibited by the selective PI 3-kinase inhibitor wortmannin (Ridderstrale, M., and Tornqvist, H. (1994) Biochem. Biophys. Res. Commun. 203, 306-310), suggesting a similar role for PI 3-kinase in GH action. Here we show that IRS-1 is tyrosine-phosphorylated in a time- and dose-dependent manner in response to GH in primary rat adipocytes. This phosphorylation coincided with the extent of interaction between IRS-1 and the 85-kDa subunit of PI 3-kinase as evidenced by coimmunoprecipitation. Stimulation with 23 nM GH increased the PI 3-kinase activity associated with IRS1 4-fold. Our data suggest that GH-induced tyrosine phosphorylation of IRS-1 and the subsequent docking of PI 3-kinase are important postreceptor events in GH action. The mechanism for the phosphorylation of IRS-1 induced by GH is unknown, but involvement of JAK2, the only known GH receptor-associated tyrosine kinase, seems possible.
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| 23. |
- Strålin, Kristoffer, 1969-, et al.
(author)
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Etiologic diagnosis of adult bacterial pneumonia by culture and PCR applied to respiratory tract samples
- 2006
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In: Journal of Clinical Microbiology. - 0095-1137 .- 1098-660X. ; 44:2, s. 643-645
-
Journal article (peer-reviewed)abstract
- Respiratory culture and multiplex PCR for Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, and Chlamydophila pneumoniae were applied to sputum, nasopharyngeal swabs, and nasopharyngeal aspirates from 235 adult patients with community-acquired pneumonia and 113 controls. Both culture and multiplex PCR performed well with the different samples and appear to be useful as diagnostic tools.
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| 24. |
- Thorin, Eva, et al.
(author)
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Examination med hjälp av dagbok- erfarenheter från en kurs tillhörande civilingenjörsutbildningen i samhällsteknik vid Mälardalens högskola
- 2007
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Other publication (pop. science, debate, etc.)abstract
- Ett intressant sätt att kombinera examination och inlärning är att examinera genom att studenterna under kursens gång får skriva dagbok och göra reflektioner över sin egen inlärning. Fördelen är också att det befrämjar kontinuerlig inlärning. Vi har provat denna examinationsform i en kurs tillhörande årskurs 4 inom vår civilingenjörsutbildning (civilingenjör i samhällsteknik). En stor del av kursen består av ett projektarbete och anledningen till att vi från början valde dagbok som examinationsform var att vi bedömde att vi därmed skulle få större möjligheter att göra en rättvis bedömning av studenternas individuella kunskaper. Kursen gick första gången under vårterminen 2006 och för andra gången vårtterminen 2007. Våra erfarenheter är övervägande positiva men det finns också nackdelar och svårigheter som t ex lärarinsats, studenters ovana vid formen och kriterier för betygssättning.
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| 25. |
- Törnqvist, Eva, 1952-
(author)
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Bland grynnor och blindskär : Kommunikation, lärande och teknik i samarbetsprojektet Sjöräddning
- 2004
-
Doctoral thesis (other academic/artistic)abstract
- The complexity and diversification that characterise society of today arereflected both in socio-technological systems and labour organisations but also in the renewal of the language a profession uses. The transfer of knowledge, meaning and understanding through communication between people is not neutral and unproblematic.In the Maritime Search and Rescue Service different professionals withdifferent norms, knowledge bases and use of technology have to communicate effectively in order to be able to carry out their duties in the best way possible. The Maritime Search and Rescue (sAR) undergo big changes and the activities make great demands on co-ordination, organisational as well as geographical. The development of ICT has lead to new technology and new organisational structures being established within the former organisation.Information and communication technologies (ICT) are a condition for the inter- and intraprofessional communication in the modem Maritime Search and Rescue Service. Its participants are found in geographical separated pockets of local order, which together creates the virtual pocket of local order of Maritime Search and Rescue organisation. ICT makes it possible to coordinate all the activities that are needed to create an order (temporary pockets of local order) at SAR operations. Further, ICT create new and big potentials for learning. They are however not yet fully used, partly because the different actors during their everyday work at the same time handles both old and new ICT. Rules and laws restrict the cooperation between the different organisations in the same virtual and local pocket of local order but the cooperation is also restricted by how ICT is used in its socio-cultural context.
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| 26. |
- Törnqvist, Eva, 1952-
(author)
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Cross Discipinary Projects : A Cooperation Between Linköping University, Demola and the Surrounding Society
- 2015
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In: Proceedings of the 11th International CDIO Conference.
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Conference paper (peer-reviewed)abstract
- Demola is both a concept and an international organization that facilitates co-creation projects between university students and companies, either locally or internationally. The network consists of various partners including universities: faculties, researcher as well as students but also of both local and international companies, and different types of agencies. The co-creative concept aims to solve real challenges where the outcome can be a new concept, a demo, or a prototype. If the partner company finds the students’ outcome useful, the company can license or purchase it, and take it for further development. The framework makes is easy for partners outside the university to cooperate with student groups. Each partner has a clear role, and the work is guided by simple procedures. Contracts, intellectual property rights, licensing models, and other legal requirements are in place and meet international business standards and practices. At Linköping University the Demola concept is implemented through the course Cross Disciplinary Projects that also is designed to meet the demands expressed in the CDIO Syllabus. What makes this course unique and different from other project courses is that students from the Faculty of Arts and Science, The Institute of Technology and the Faculty of Health Sciences are working together in one course towards the same goal. The students are participating in the work order to creatively and independently contribute with expertise from their different areas and therefore the course is open only to those who are at the end of their studies. The course is conducted in the form of independent cross disciplinary projects. The briefs are externally specified from companies or other interested parties who wish to have an idea eloborated or a problem solved. In addition to the project some lectures are given, for instance in applied ethics and inter professional communication. Upon completion of the course the student is expected to have acquired knowledge and understanding concerning how to independently work on issues related to the knowledge and skills previously acquired in education. The course also aims to enforce their capabilities and competences regarding communication with representatives of other professions since they are expected to demonstrate ability to work in a team and in close collaboration with other professions. Demola is now listed by OECD and World Bank Group as a best practice for innovation policy-makers globally.
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| 27. |
- Törnqvist, Eva, 1952-
(author)
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DTV IN SWEDEN
- 2008
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In: Digital Television in Europe. - Brussels : VUBpress. - 9789054875413 ; , s. 213-220
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Book chapter (other academic/artistic)
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| 28. |
- Törnqvist, Eva, 1952-, et al.
(author)
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Hastily Formed Networks for Disaster Response : Technical Heterogeneity and Virtual Pockets of Local Order
- 2009
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In: Proceedings of the 6th International Conference on Information Systems for Crisis Response and Management. - : ISCRAM. - 9789163347153
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Conference paper (peer-reviewed)abstract
- As natural and man-made disasters become increasingly common, ensuring effective disaster response, mitigation and recovery is growing into a high-priority task for governments and administrations globally. This paper describes the challenges of collaboration within multi-organisational hastily formed networks for post-disaster response, which are increasingly relying on emerging ICT infrastructures for communication and cooperation. We present an interdisciplinary analysis of the conditions for establishing an effective mutual conversation space for involved stakeholders, and how the development of socio-technological systems affects cognitive and behavioural aspects such as established communities of practice and virtual pockets of local order.Our observations thus far suggest that some of the key issues are overcoming organisational and cultural heterogeneity, and finding solutions for technical interoperability, to ensure effective, pervasive and sustainable information exchange within and between organisations participating in hastily formed networks.
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| 29. |
- Törnqvist, Eva, et al.
(author)
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How to integrate ethical aspects in a technical course : - The Example Project semester including the bachelor thesis project: Secure Mobile Systems
- 2015
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In: Proceedings of the 11th International CDIO Conference, Chengdu.
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Conference paper (peer-reviewed)abstract
- The aim of the course is to create understanding for how to be an engineer; this is achieved by imitating the situation many engineers face when they are introduced into the workplace. As a new employee at a company, it is often many things the students need to learn in a short amount of time. In the course the students are expected to take on the role of a new employee in a company. They are expected to learn about the technical-, group-and project aspects that are needed for working within the company. The student is expected to live up to the company's requirements for technical solutions, professional communication with customers and internal requirements. They learn to cooperate actively with the project members/customers/experts with different backgrounds and knowledge and see how organizations influence the structure of the team and the individual's freedom of action. In addition, they must learn to see the big picture and thus reflect on societal and ethical aspects. They also gain knowledge of the organization's significance from an economic perspective and how organization affects the team structure and process which in turn can affect an individual's freedom of action and behavior. The course is connected the CDIO Syllabus v2.0 in that sense that the student shall
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| 30. |
- Törnqvist, Eva, 1952-
(author)
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In Search of Birds and Elks : two case studies of creative use of ICT in Sweden
- 2009
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In: THE, GOOD, THE BAD AND THE CHALLENGING. - Koper : ABS-Center. - 978 9 616277 17 4 ; , s. 62-68
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Conference paper (peer-reviewed)abstract
- This paper will describe and try to understand how user together functions as innovators when they use already established information and communication technology (ict) in creative ways. The paper describes two case studies that both are about mobile recreational activities in nature, namely elk hunting and bird watching. Both these cases show that the social context plays a significant role in the introduction and use of ict and that the development takes place in interaction between individuals. In the first case, producing users, in this case (the hunting association and its web editor) that starts and in some way monitors the development while in the later case it is both producing users and everyday users (different bird watchers with different technological knowledge and competence) that during different development stages are active. Both cases show that it is a process innovation and that it could be enabling and constraining in the same time depending on which virtual pocket of local order the user belongs to.
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| 31. |
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| 32. |
- Törnqvist, Jeanette, et al.
(author)
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Double documentation in electronic health records
- 2016
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In: Nordic Journal of Nursing Research. - : SAGE Publications. - 2057-1585 .- 2057-1593. ; 36:2, s. 88-94
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Journal article (peer-reviewed)abstract
- Documentation in the patient record must be systematic and rigorous. However, each health care profession documents parts of the electronic health record (EHR) separately. This system can lead to double documentation. The aim of the study was to describe the amount of double documentation in health records for in-patients. A retrospective descriptive review of 30 records for in-patients diagnosed with hip fracture was conducted. Double documentation occurred on all records reviewed during the stay in hospital and in or between all professions reviewed. In total, 822 instances of double documentation were found. The EHRs available today are not designed to monitor processes. Instead, they follow each health profession, which can lead to double documentation. It would be desirable to develop an EHR from a process perspective and not a record per profession.
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| 33. |
- Törnqvist, Oscar, 1969-
(author)
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Röster från ingenmansland : En identitetsarkeologi i ett maritimt mellanrum
- 2019
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Doctoral thesis (other academic/artistic)abstract
- Archaeological investigations into late iron age and medieval coastal societies in Sweden have been focusing on a maritime culture, a traditional coastal and island-dwelling fisher-farmer and activities centered on fishing in a long maritime tradition as well as a specific maritime identity and habitus. By deconstructing commonly used concepts and by using primarily written sources, it is here shown that there is a need for putting this culture and its agents into perspective by opening up the history of the maritime interspace and let in previously overlooked or disregarded historical actors in the narrative field dominated by men and landed farmers, such as landless, powerless, strangers, foreigners and women.The coast is shown to have been an arena for opportunism, societal expansion under landed gentry, nodes for procurement and social oppression and focal points for inter-cultural contacts, trade, networking and self-realization and that the role of the islands and the “fisheries” was constantly remolded to fit different power strategies.Through a series of case studies, seldom discussed social relations, social groups and social predicaments are unmasked and discussed; the relation between norse and proto-Saami cultures, the role of women in fishing, employment of the poor or serfs, of incentives by strangers and foreigners. Many localities speak of conflict, struggle and self-sought or forced marginalization; the emergence of taxation and the control of fishing, piracy and insurgency but also of exile, reclusion and asceticism. Running through history there has been a dichotomy and tension between the workforce and the benefactor, between small-scale and large-scale maritime procurement, between cooperation and conflict and between the meeting place and the hidden refuge.To conclude, the study sketches the ethno genesis of the hitherto “fisher-farmer” and exposes a wider set of actors and their strategies in the maritime space and ends with advocating a series of potentially fruitful research frameworks of study; cultural niches in the maritime environment, actor geographies in the outback, the use of maritime produce in societal transformations, and to further investigate the harsh, hidden or exposed, islands as places for sociocultural and economical strategies with profound social, psychological and spiritual impact.
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| 34. |
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| 35. |
- Wiggins, Sally, Dr, 1975-, et al.
(author)
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Breaking the ice : how students present themselves to the group in an interprofessional problem-based learning context
- 2020
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In: Interactional Research in Problem-Based Learning.. - West Lafayette : Purdue University Press. - 9781557538048 ; , s. 197-222
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Book chapter (peer-reviewed)abstract
- The first time that students meet for a problem-based learning (PBL) tutorial is important for setting the framework for the rest of the PBL process (Hempel & Jern, 2000). This occasion typically involves introducing themselves, meeting the tutor, writing a group contract, and starting work on the first scenario or case. When students are working in interprofessional groups—with peers from other educational programmes—there is the additional complexity of establishing common ground while maintaining one’s own professional focus. It is within this context of interprofessional health education that the current chapter is based. We provide a discursive analysis of the early moments of the first tutorial in which students introduce themselves to their fellow group members. The research question is: How do students present themselves in the first tutorial of a new PBL group in which they come from different professional programmes? In the remainder of the introduction, we situate this work within a broader theoretical and empirical context of work on interprofessional learning and communication, group formation, and academic identities.
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| 36. |
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| 37. |
- Zidar, Josefina, et al.
(author)
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Group and Single Housing of Male Mice : Collected Experiences from Research Facilities in Sweden
- 2019
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In: Animals. - : MDPI AG. - 2076-2615. ; 9:12
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Journal article (peer-reviewed)abstract
- Animals used for scientific purposes are protected by EU legislation. Social animals should be kept in stable groups that enable species-typical social behavior and provide individuals with social comfort. However, when group-housing male mice, aggression within the homecage is a common husbandry and welfare problem. Excessive fighting and injuries due to aggression can cause pain and stress, resulting in individuals being euthanized or housed individually. In addition, stress can alter physiological parameters, risking scientific validity and generating larger sample sizes. Mouse aggression, and the consequences thereof, thus opposes the 3R goals of Refining the methods to minimize potential pain and suffering and Reducing the number of animals used. Animal technicians, veterinarians, and scientists using animals have valuable information on how these problems are experienced and handled in practice. We assembled these experiences from laboratory animal facilities in Sweden, mapping problems observed and identifying strategies used to prevent mouse aggression. In line with current literature, less aggression was perceived if mice were grouped before sexual maturity, re-grouping avoided and nesting material transferred at cage cleaning. Preventing aggression will minimize pain and suffering and enable housing of stable groups, leading to more reliable scientific outcomes and is thus of high 3Rs relevance.
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