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- Callaway, EM, et al.
(author)
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A multimodal cell census and atlas of the mammalian primary motor cortex
- 2021
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In: Nature. - : Springer Science and Business Media LLC. - 1476-4687 .- 0028-0836. ; 598:7879, s. 86-102
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Journal article (peer-reviewed)abstract
- Here we report the generation of a multimodal cell census and atlas of the mammalian primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network (BICCN). This was achieved by coordinated large-scale analyses of single-cell transcriptomes, chromatin accessibility, DNA methylomes, spatially resolved single-cell transcriptomes, morphological and electrophysiological properties and cellular resolution input–output mapping, integrated through cross-modal computational analysis. Our results advance the collective knowledge and understanding of brain cell-type organization1–5. First, our study reveals a unified molecular genetic landscape of cortical cell types that integrates their transcriptome, open chromatin and DNA methylation maps. Second, cross-species analysis achieves a consensus taxonomy of transcriptomic types and their hierarchical organization that is conserved from mouse to marmoset and human. Third, in situ single-cell transcriptomics provides a spatially resolved cell-type atlas of the motor cortex. Fourth, cross-modal analysis provides compelling evidence for the transcriptomic, epigenomic and gene regulatory basis of neuronal phenotypes such as their physiological and anatomical properties, demonstrating the biological validity and genomic underpinning of neuron types. We further present an extensive genetic toolset for targeting glutamatergic neuron types towards linking their molecular and developmental identity to their circuit function. Together, our results establish a unifying and mechanistic framework of neuronal cell-type organization that integrates multi-layered molecular genetic and spatial information with multi-faceted phenotypic properties.
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- Krajcarz, M., et al.
(author)
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The history of the domestic cat in Central Europe
- 2022
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In: Antiquity. - : Antiquity Publications. - 0003-598X .- 1745-1744. ; 96:390, s. 1628-1633
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Journal article (peer-reviewed)abstract
- A recent study from Central Europe has changed our perception of the cat's domestication history. The authors discuss how this has led to the development of an interdisciplinary project combining palaeogenetics, zooarchaeologv and radiocarbon dating, with the aim of providing insight into the domestic cat's expansion beyond the Mediterranean.
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- Polukeev, Alexey V., et al.
(author)
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Oxidation-induced C-H bond activation in iridium pincer complexes
- 2023
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In: Dalton Transactions. - 1477-9226. ; 52:22, s. 7701-7708
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Journal article (peer-reviewed)abstract
- Dehydrogenation reactions that produce molecular hydrogen are thermodynamically unfavourable. Desired is to couple them with a green driving force, such as oxidation with oxygen or an electric current. This, in turn, requires understanding of the catalyst's redox properties. Here we report oxidation of the iridium pincer complexes (POCOP)IrHCl (POCOP = 2,6-(tBu2PO)2C6H3; 1a) and (PCP)IrHCl (PCP = 2,6-(tBu2PCH2)2C6H3; 1c) that induced intramolecular C-H activation, followed by the formation of complexes with a cyclometallated tert-butyl group. Based on an electrochemical study and DFT calculations, we propose a mechanism that involves H+ loss from hydrochlorides 1a and 1c to give a highly reactive (pincer)IrCl+ compound.
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