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- Churchard, A. J., et al.
(author)
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A multifaceted approach to hydrogen storage
- 2011
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In: Physical Chemistry Chemical Physics. - : Royal Society of Chemistry (RSC). - 1463-9084 .- 1463-9076. ; 13:38, s. 16955-16972
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Journal article (peer-reviewed)abstract
- The widespread adoption of hydrogen as an energy carrier could bring significant benefits, but only if a number of currently intractable problems can be overcome. Not the least of these is the problem of storage, particularly when aimed at use onboard light-vehicles. The aim of this overview is to look in depth at a number of areas linked by the recently concluded HYDROGEN research network, representing an intentionally multi-faceted selection with the goal of advancing the field on a number of fronts simultaneously. For the general reader we provide a concise outline of the main approaches to storing hydrogen before moving on to detailed reviews of recent research in the solid chemical storage of hydrogen, and so provide an entry point for the interested reader on these diverse topics. The subjects covered include: the mechanisms of Ti catalysis in alanates; the kinetics of the borohydrides and the resulting limitations; novel transition metal catalysts for use with complex hydrides; less common borohydrides; protic-hydridic stores; metal ammines and novel approaches to nano-confined metal hydrides.
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- Johannesson, Liza, 1976, et al.
(author)
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Preclinical report on allogeneic uterus transplantation in non-human primates.
- 2013
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In: Human reproduction (Oxford, England). - : Oxford University Press (OUP). - 1460-2350 .- 0268-1161. ; 28:1, s. 189-98
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Journal article (peer-reviewed)abstract
- STUDY QUESTION: Is it possible to perform allogeneic uterus transplantation (UTx) with a donation from a live donor in a non-human primate species and what immunosuppression is needed to prevent rejection? SUMMARY ANSWER: Allogeneic UTx in the baboon is a donor- and recipient-safe surgical procedure; immunosuppression with induction therapy and a triple protocol should be used. WHAT IS KNOWN ALREADY: UTx may become a treatment for absolute uterine factor infertility. Autologous UTx models have been developed in non-human primates with reports on long-term survival of the uterine grafts. STUDY DESIGN, SIZEAND DURATION: This experimental study included 18 female baboons as uterus donors and 18 female baboons as uterus recipients. The follow-up time was 5-8 weeks. PARTICIPANTS/MATERIALS, SETTINGAND METHODS: Uterus retrieval was performed with extended hysterectomy including bilateral uterine and internal iliac arteries and ovarian veins. After UTx, with vascular anastomoses unilateral to the internal iliac artery and the external iliac vein, the uterus recipients received one of the following: no immunosuppression (n = 4); monotherapy (oral slow release tacrolimus) (n = 4) or induction therapy (antithymocyte globulin) followed by triple therapy (tacrolimus, mycophenolate, corticosteroids; n = 10). Surgical parameters, survival, immunosuppression and rejection patterns were evaluated. MAIN RESULTS AND THE ROLE OF CHANCE: The durations of uterus retrieval and recipient surgery were around 3 and 3.5 h, respectively. The total ischemic time was around 3 h. All the recipients and the donors survived the surgery. All the recipients presented rejection to some extent within the first weeks following UTx. In one recipient, the uterus was of normal appearance at the end of the study period. In spite of occasional high (>60 ng/ml) blood levels of tacrolimus, there was no evidence of nephrotoxicity. LIMITATIONS AND REASONS FOR CAUTION: This initial non-human primate allogeneic UTx study indicates that further research is needed to optimize immunosuppression protocols in order to avoid uterine rejection. WIDER IMPLICATIONS OF THE FINDINGS: The findings suggest that allogeneic UTx in primate species is feasible but continued work on this issue is needed. STUDY FUNDING/COMPETING INTEREST(S): The study was funded by the Swedish Research Council, ALF University of Gothenburg, Hjalmar Svensson Foundation and by Jane and Dan Olsson Research Foundation. The authors do not have any competing interest.
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- Goz, I., et al.
(author)
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Does Semantic Association Play a Role in Post-Event Misinformation Effect?
- 2015
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In: Turk Psikoloji Dergisi. - 1300-4433. ; 30:75, s. 36-46
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Journal article (peer-reviewed)abstract
- According to one of the most prominent false memory theories (Fuzzy Trace Theory), false memories stem from the semantic association between the original information and post-event misinformation. Furthermore, the strength of this association predicts the probability of accepting the post-event misinformation as original information. In order to test this prediction within the eyewitness testimony framework, the current study used a video of a mock-theft and a narrative of the event in which some original information was changed as post-event misinformation. To that end, the strong and the weak members of the category to which original information belongs to, and semantically unrelated options were given as distractors in addition to the original information in a recognition test. Analysis revealed that semantically strong and weak distractors were significantly more likely to be accepted as original information than the semantically unrelated item. Semantically strong distractors were accepted as original information more than weak distractors, although the difference did not reach significance. Findings were discussed in terms of Fuzzy Trace Theory and the "developmental reversals" approach by Brainerd and Reyna (2012).
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- Kalem, S., et al.
(author)
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Si measurements : SiOx on Si
- 2017
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In: Joint International EUROSOl Workshop and International Conference on Ultimate Integration on Silicon-ULIS, EUROSOI-ULIS 2017 - Proceedings. - 2472-9132. - 9781509053131 ; , s. 235-238
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Conference paper (peer-reviewed)abstract
- We review the results of silicon measurements, which we have performed on suboxide SiOx formed on n and p type Si wafers with different surface textures. Localized vibrational modes through Raman and FTIR, light emission properties by photoluminescence (PL), energy critical points for optical transitions, excited state dynamics and non-linear electrical properties can be used as effective methods in investigating thin oxide layers on Si. Infrared vibrational spectrum of Si-O-Si bondings in terms of transverse-optic (TO) and longitudinal-optic (LO) phonons indicating that disorder induced LO-TO optical mode coupling can be an effective tool in assessing the structural quality of the SiOx. Excited carrier dynamics and switching mechanisms can provide critical information about electronic quality of sub oxides for applications in CMOS circuits.
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- Roeske-Nielsen, A., et al.
(author)
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Sulfatide inhibits fibroblast growth, activation and oxidative stress induced by ectopic insulin
- 2023
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In: Diabetes Obesity & Metabolism. - 1462-8902.
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Journal article (peer-reviewed)abstract
- Aim: To study the effect of sulfatide on gene expression and proliferation of human primary fibroblasts induced by insulin, insulin-like growth factor-1 and human growth hormone. Materials and Methods: Human primary fibroblasts were exposed to 1, 3 and 30 mu M of sulfatide or its precursor galactosylceramide (GalCer). Proliferation was determined by 3H-thymidine incorporation and gene expression via microarray analysis. Results: Sulfatide and GalCer reduced the growth rate of fibroblasts by 32%-82% when exposed to 0.5 nM insulin. After challenge with 120 mu M of H2O2, sulfatide reduced membrane leakage. Fibroblast gene expression was altered by sulfatide in gene pathways associated with cell cycle/growth, transforming growth factor-beta function, and encoding of proteins involved in intracellular signalling. NFKBIA, a key control element in NF-kappa B regulation, was decreased 2-fold by sulfatide. Conclusions: Sulfatide strongly inhibits fibroblast growth. We therefore suggest the addition of sulfatide to injectable commercial insulin formulations, which would reduce adverse fibroblast growth and improve well-being in patients with diabetes.
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