| 1. |
- Svensson, Tommy, 1970, et al.
(author)
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CELTIC CP5-026 WINNER+, D1.9 Final Innovation Report
- 2010
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Reports (other academic/artistic)abstract
- This deliverable is the final innovation report from the innovation workpackage in WINNER+. The document describes the latest innovations and their assessment as well as summarizes the innovations developed in the work package during the project. We analyze the suitability of these innovations as technology enablers for improving current systems, in particular IMT Advanced and beyond.
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| 2. |
- Bengtsson, Mats, et al.
(author)
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CELTIC CP5-026 WINNER+, D1.4 Initial Report on Advanced Multiple Antenna Systems
- 2008
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Reports (other academic/artistic)abstract
- This deliverable captures the first set of best innovative concepts identified in the field of Advanced Multiple Antenna Systems for potential inclusion into the WINNER+ system concept. The concepts consist of promising principles or ideas as well as detailed innovative techniques. For each concept, the associated benefits as well as the corresponding requirements on the system architecture and protocols, measurements and signalling, are considered. The document involves two main tracks: development of new advanced antenna schemes in the context of conventional cellular networks, and a study of coordinated multipoint transmission and reception, where multiple network nodes cooperate to enhance system performance.
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| 3. |
- Chioncel, Ovidiu, et al.
(author)
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Epidemiology, pathophysiology and contemporary management of cardiogenic shock - a position statement from the Heart Failure Association of the European Society of Cardiology
- 2020
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In: European Journal of Heart Failure. - : WILEY. - 1388-9842 .- 1879-0844. ; 22:8, s. 1315-1341
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Journal article (peer-reviewed)abstract
- Cardiogenic shock (CS) is a complex multifactorial clinical syndrome with extremely high mortality, developing as a continuum, and progressing from the initial insult (underlying cause) to the subsequent occurrence of organ failure and death. There is a large spectrum of CS presentations resulting from the interaction between an acute cardiac insult and a patients underlying cardiac and overall medical condition. Phenotyping patients with CS may have clinical impact on management because classification would support initiation of appropriate therapies. CS management should consider appropriate organization of the health care services, and therapies must be given to the appropriately selected patients, in a timely manner, whilst avoiding iatrogenic harm. Although several consensus-driven algorithms have been proposed, CS management remains challenging and substantial investments in research and development have not yielded proof of efficacy and safety for most of the therapies tested, and outcome in this condition remains poor. Future studies should consider the identification of the new pathophysiological targets, and high-quality translational research should facilitate incorporation of more targeted interventions in clinical research protocols, aimed to improve individual patient outcomes. Designing outcome clinical trials in CS remains particularly challenging in this critical and very costly scenario in cardiology, but information from these trials is imperiously needed to better inform the guidelines and clinical practice. The goal of this review is to summarize the current knowledge concerning the definition, epidemiology, underlying causes, pathophysiology and management of CS based on important lessons from clinical trials and registries, with a focus on improving in-hospital management.
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| 4. |
- Eicher, John D., et al.
(author)
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Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals
- 2016
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In: American Journal of Human Genetics. - : Elsevier BV. - 0002-9297 .- 1537-6605. ; 99:1, s. 40-55
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Journal article (peer-reviewed)abstract
- Platelet production, maintenance, and clearance are tightly controlled processes indicative of platelets' important roles in hemostasis and thrombosis. Platelets are common targets for primary and secondary prevention of several conditions. They are monitored clinically by complete blood counts, specifically with measurements of platelet count (PLT) and mean platelet volume (MPV). Identifying genetic effects on PLT and MPV can provide mechanistic insights into platelet biology and their role in disease. Therefore, we formed the Blood Cell Consortium (BCX) to perform a large-scale meta-analysis of Exomechip association results for PLT and MPV in 157,293 and 57,617 individuals, respectively. Using the low-frequency/rare coding variant-enriched Exomechip genotyping array, we sought to identify genetic variants associated with PLT and MPV. In addition to confirming 47 known PLT and 20 known MPV associations, we identified 32 PLT and 18 MPV associations not previously observed in the literature across the allele frequency spectrum, including rare large effect (FCER1A), low-frequency (IQGAP2, MAP1A, LY75), and common(ZMIZ2, SMG6, PEAR1, ARFGAP3/PACSIN2) variants. Several variants associated with PLT/MPV(PEAR1, MRVI1, PTGES3) were also associated with platelet reactivity. In concurrent BCX analyses, there was overlap of platelet-associated variants with red (MAP1A, TMPRSS6, ZMIZ2) and white (PEAR1, ZMIZ2, LY75) blood cell traits, suggesting common regulatory pathways with shared genetic architecture among these hematopoietic lineages. Our large-scale Exomechip analyses identified previously undocumented associations with platelet traits and further indicate that several complex quantitative hematological, lipid, and cardiovascular traits share genetic factors.
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| 5. |
- Ejerblad, Elisabeth, et al.
(author)
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Diagnosis according to World Health Organization determines the long-term prognosis in patients with myeloproliferative neoplasms treated with anagrelide : Results of a prospective long-term follow-up
- 2013
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In: Hematology. - 1024-5332 .- 1607-8454. ; 18:1, s. 8-13
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Journal article (peer-reviewed)abstract
- OBJECTIVES:During long term follow-up of a cohort of patients with essential thrombocythemia (ET) and polycythemia vera (PV) a higher than expected incidence of myelofibrosis (MF) was noted. In order to test if the explanation could be found in the diagnostic criteria a re-evaluation of diagnosis using the 2008 WHO diagnostic criteria for ET and MF was performed.METHODS: This prospective study of 60 patients with ET and PV was set up in 1998 to evaluate the long-term efficacy and tolerability of anagrelide treatment. Bone marrow trephine biopsies were requested from study start, after 2 and 7 years of follow-up. A blinded re-evaluation of the bone marrow trephines was performed. The 2008 WHO bone marrow criteria were used for diagnosis and fibrosis grading.RESULTS: Of 40 patients with an initial diagnosis of ET, 21 were confirmed as 'true ET' whereas 17 were reclassified as primary myelofibrosis (PMF) (12 PMF-0, 3 PMF-1, 2 PMF-2) and 2 as myeloproliferative neoplasms of uncertain origin. After 7 years of follow-up, 19 of 21 patients with 'true ET' were alive, none had transformed to MF, leukemia, or myelodysplastic syndrome. In contrast, 4/17 patients reclassified as PMF had died, two patients transformed to myelodysplastic syndrome and 7 patients progressed to overt MF.DISCUSSION:We conclude that a blinded re-evaluation of bone marrow trephines from study start and after 7 years of follow-up using 2008 World Health Organization criteria was able to differentiate between true ET and PMF with a marked difference in follow-up outcome.
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| 6. |
- Elkoumy, Ahmed, et al.
(author)
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ACURATE neo2 Transcatheter aortic valve implantation without balloon aortic valvuloplasty : direct ACURATE neo2
- 2024
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In: International Journal of Cardiology. - 0167-5273 .- 1874-1754. ; 400
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Journal article (peer-reviewed)abstract
- Background: ACURATE neo2 (Neo2) implantation is performed after systematic Balloon Aortic Valvuloplasty (BAV) in most patients. No reports exist about the feasibility and safety of direct Neo2 transcatheter aortic valve implantation (TAVI) in comparison to the standard practice. Aim: We aimed to identify the patients' baseline anatomical characteristics, procedural, and early post-procedural outcomes in patients treated using Neo2 with and without BAV. Methodology: This is a retrospective multicentre analysis of 499 patients with severe aortic stenosis who underwent TAVI using Neo2. The comparison was done according to the performance or omission of BAV. Echocardiography and computed tomography were analysed by an independent Core Lab. Propensity score matching (PSM) was performed based on the annular diameter and AV calcium volume, which identified 84 matched pairs. Results: Among the cohort included, 391 (78%) patients received BAV (BAV-yes) and 108 (22%) were not attempted (BAV-no or Direct TAVI). Patients in BAV-no cohort had smaller annular diameter (22.6 vs 23.4 mm; p < 0.001) and lower calcium volume (163 vs 581 mm3; p < 0.001) compared to BAV-yes cohort. In the matched cohort, VARC-3 device technical success was similar (95%) and all other outcome measures were statistically comparable between cohorts. Conclusion: Direct TAVI using ACURATEneo2 without pre-TAVI balloon aortic valvuloplasty in patients with mild or less valve calcifications might be feasible and associated with comparable early outcomes compared to patients with similar anatomical features undergoing systematic balloon valvuloplasty.
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| 7. |
- Fritzson, Peter, 1952-, et al.
(author)
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The OpenModelica Integrated Environment for Modeling, Simulation, and Model-Based Development
- 2020
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In: Modeling, Identification and Control. - Kristiansand, Norway : Norsk Forening for Automatisering. - 0332-7353 .- 1890-1328. ; 41:4, s. 241-295
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Journal article (peer-reviewed)abstract
- OpenModelica is a unique large-scale integrated open-source Modelica- and FMI-based modeling, simulation, optimization, model-based analysis and development environment. Moreover, the OpenModelica environment provides a number of facilities such as debugging; optimization; visualization and 3D animation; web-based model editing and simulation; scripting from Modelica, Python, Julia, and Matlab; efficient simulation and co-simulation of FMI-based models; compilation for embedded systems; Modelica-UML integration; requirement verification; and generation of parallel code for multi-core architectures. The environment is based on the equation-based object-oriented Modelica language and currently uses the MetaModelica extended version of Modelica for its model compiler implementation. This overview paper gives an up-to-date description of the capabilities of the system, short overviews of used open source symbolic and numeric algorithms with pointers to published literature, tool integration aspects, some lessons learned, and the main vision behind its development.
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| 8. |
- Mosson, R., et al.
(author)
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Exploring the role of line managers in implementing evidence-based practice in social services and older people care
- 2017
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In: British Journal of Social Work. - : Oxford University Press. - 0045-3102 .- 1468-263X. ; 47:2, s. 542-560
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Journal article (peer-reviewed)abstract
- This qualitative study explored the vital role of line managers, namely the managerial level directly above employees, in effectively implementing evidence-based practice (EBP) from their own perspectives. Interviews were carried out with twenty-eight line managers within social services and older people care in seven Swedish municipalities. Thematic analysis was performed. Findings revealed that managers in social care perceived their role as important in implementing EBP. However, notable differences were observed between the two settings, where social services managers had more knowledge and held more positive attitudes towards working according to EBP, and described a more active role in the implementation process than managers in older people care. Overall, the implementation of EBP was performed ad hoc rather than systematically, and with little consideration to analysis of needs according to the local context and limited focus on follow-up and sustainability. This study highlighted that line managers in social services and older people care have different prerequisites for implementing EBP, and are greatly dependent on organisational strategies and context. Gaining knowledge of line managers' perceptions is essential for making informed decisions regarding the support required to achieve EBP in social care, and thus for providing the best possible care for clients.
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| 9. |
- Osseiran, Afif, et al.
(author)
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CELTIC CP5-026 WINNER+, D2.2 Enabling Techniques for LTE-A and beyond
- 2010
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Reports (other academic/artistic)abstract
- This deliverable summarizes the most promising enabling techniques for LTE-A and beyond in seven major areas. These areas are: Carrier Aggregation, Coordinated Multipoint Systems, Femtocells, Network Coding, MIMO, Quality of Service, Resource allocation, and Relaying. A description of the most relevant scenarios where the techniques can be used is given. Further the end-2-end performance approach is presented. Finally future research directions of enabling techniques beyond LTE-A are given.
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| 10. |
- Rieke, Johanna Magdalena, et al.
(author)
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SLC20A1Is Involved in Urinary Tract and Urorectal Development
- 2020
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In: Frontiers in Cell and Developmental Biology. - : FRONTIERS MEDIA SA. - 2296-634X. ; 8
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Journal article (peer-reviewed)abstract
- Previous studies in developingXenopusand zebrafish reported that the phosphate transporterslc20a1ais expressed in pronephric kidneys. The recent identification ofSLC20A1as a monoallelic candidate gene for cloacal exstrophy further suggests its involvement in the urinary tract and urorectal development. However, little is known of the functional role ofSLC20A1in urinary tract development. Here, we investigated this using morpholino oligonucleotide knockdown of the zebrafish orthologslc20a1a. This caused kidney cysts and malformations of the cloaca. Moreover, in morphants we demonstrated dysfunctional voiding and hindgut opening defects mimicking imperforate anus in human cloacal exstrophy. Furthermore, we performed immunohistochemistry of an unaffected 6-week-old human embryo and detectedSLC20A1in the urinary tract and the abdominal midline, structures implicated in the pathogenesis of cloacal exstrophy. Additionally, we resequencedSLC20A1in 690 individuals with bladder exstrophy-epispadias complex (BEEC) including 84 individuals with cloacal exstrophy. We identified two additional monoallelicde novovariants. One was identified in a case-parent trio with classic bladder exstrophy, and one additional novelde novovariant was detected in an affected mother who transmitted this variant to her affected son. To study the potential cellular impact ofSLC20A1variants, we expressed them in HEK293 cells. Here, phosphate transport was not compromised, suggesting that it is not a disease mechanism. However, there was a tendency for lower levels of cleaved caspase-3, perhaps implicating apoptosis pathways in the disease. Our results suggestSLC20A1is involved in urinary tract and urorectal development and implicateSLC20A1as a disease-gene for BEEC.
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| 11. |
- Rück, Andreas, et al.
(author)
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The Early neo2 Registry : Transcatheter Aortic Valve Implantation With ACURATE neo2 in a European Population
- 2023
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In: Journal of the American Heart Association. - 2047-9980. ; 12:15
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Journal article (peer-reviewed)abstract
- BACKGROUND: ACURATE neo2 is a transcatheter aortic valve implantation system consisting of a self-expanding bioprosthetic valve with supra-annular leaflet position and featuring innovations to facilitate placement accuracy and reduce paravalvular regurgitation. METHODS AND RESULTS: The goal of the Early neo2 (Early neo2 Registry of the ACURATE neo2 TAVI Prosthesis) was to gather real-life data on safety and efficacy in a European transcatheter aortic valve implantation population treated with ACURATE neo2. Data were collected from 554 consecutive patients treated with ACURATE neo2 at 12 European sites (mean age, 82 years; 66% women; mean European System for Cardiac Operative Risk Evaluation II, 4.5%±3.8%) between September 2020 and March 2021. The composite primary end point was the occurrence of any of the following: postoperative (in-hospital) paravalvular regurgitation grade ≥2, in-hospital acute kidney injury stage 3, postoperative pacemaker implantation, 30-day death, and 30-day stroke. The primary end point occurred in 12.6% of patients. The 30-day rates for all-cause death and all stroke were 1.3% and 2.7%, respectively, and 1.5% of patients exhibited stage 3 acute kidney injury. A total of 34 patients (6.2%) received a postoperative permanent pacemaker. Per core laboratory–adjudicated echocardiographic analysis, mean postoperative aortic valve gradient was 7.6±3.3 mm Hg, and 2.8% of patients exhibited paravalvular regurgitation grade ≥2. CONCLUSIONS: In this report of postmarket use of the ACURATE neo2 valve in a real-world transcatheter aortic valve implantation population, patients exhibited favorable postoperative hemodynamics and clinical outcomes and a low rate of postoperative pacemaker implantation.
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| 12. |
- Tafvelin, Susanne, et al.
(author)
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Organizational behaviour managemant (OBM) as an intervention in occupational health psychology
- 2012
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In: Book of proceedings. - : European Academy of Occupational Health Psychology. - 9780955436598 ; , s. 350-350
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Conference paper (peer-reviewed)abstract
- Organizational behaviour management (OBM) is the application of behavioural principles to individuals and groups in organizations. OBM has its roots in the field of applied behaviour analysis and focus on behaviour and the contingencies that influence behaviour. OBM has traditionally been used to increase organizational performance, but as the field develops other employee behaviours such as safety and satisfaction are increasingly studied as well. This makes OBM a potential candidate as an effective intervention in occupational health psychology. The purpose of this study is to examine the effects of an intervention based on OBM, which aims at increasing not only production but also safety climate and organizational learning climate.The intervention: This OBM intervention has just been launched in a company in the forest industry in Sweden. The intervention is designed as a leadership training program with focus on production, safety and learning. All leaders and engineers in the company are attending the program, which includes 24 days of training divided in three different blocks over a period of 18 months. The training is gradually shifting focus from theory of behaviour analysis to applying and using the principles of behavioural change in their leadership role. Before training all leaders are given multi source feedback (MSF) on their leadership behaviours, which is later used asa starting point in their individual action plan.This study employs a quasi-experimental design with a pre-test and two follow ups and control group from the same industry and region. At all three waves of datacollection, both self-rated measures of leadership behaviours, learning climate, safety climate, health and productivity are collected, together with objective measures of productivity, accidents and sick leave. The first wave of data collection has been completed in November 2011. The second wave is planned in December 2012 and the last time point in June 2013. We anticipate reporting our results at future conferences and hope at this point to get valuable feedback from colleagues at the conference.
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| 13. |
- Thiele, Lars, et al.
(author)
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Scheduling-Assisted Joint Processing for CoMP in the Framework of the WINNER+ Project
- 2010
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In: Proc. Future Network & MobileSummit 2010, June 2010, Florence, Italy..
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Conference paper (peer-reviewed)abstract
- The goal of this paper is to present the main achievements reached within the WINNER+ project concerning, in particular, clustering as a way to improve thefeasibility of joint processing schemes as enablers of coordinated multipoint solutions. Three different approaches are presented. First, a single and static cluster of base stations is considered. In this case, a user-centric partial joint processing scheme isproposed to reduce with respect to a fully centralized approach both the inter-base information exchange and feedback from the users. Second, a dynamic and network centric clustering approach is presented. It is shown that substantial gains can be obtained with respect to a static clustering scenario when a central unit jointly createsthe clusters of collaborating base stations, schedules the users in these clusters and calculates the beamforming coefficients and the power allocation. Finally, a dynamicclustering technique is combined with multi-antenna receivers. In addition, a concept for a scalable channel state information feedback is also presented.
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| 14. |
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