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  • Seldén, Anders I., et al. (author)
  • Porphyrin Status in Aluminum Foundry Workers Exposed to Hexachlorobenzene and Octachlorostyrene
  • 1999
  • In: Archives of Environmental Health. - : Informa UK Limited. - 0003-9896. ; 54:4, s. 248-253
  • Journal article (peer-reviewed)abstract
    • The possible interference of hexachlorobenzene and octachlorostyrene (i.e., thermal byproducts from hexachloroethane in aluminum degassing) with porphyrin metabolism was investigated in exposed workers. Urine specimens from 9 male aluminum foundry workers (i.e., smelters) at 6 different companies and from 18 controls—matched for sex, age, residence, and socioeconomic status—were analyzed for total porphyrins and porphyrin isomers. Workers exposed to hexachlorobenzene and octachlorostyrene had a statistically significant increase in urinary total porphyrins, compared with controls (mean ± standard deviation: 13.63 ± 11.13 μmol/mol creatinine and 6.24 ± 3.84 μmol/mol creatinine, respectively; p = .02). The authors attributed the results mainly to differences in excretion of coproporphyrins—notably coproporphyrin III. Erythrocyte uroporphyrinogen decarboxylase activity was similar in both groups. There was a high correlation between levels of hexachlorobenzene and octachlorostyrene, respectively, in plasma and urinary excretion of porphyrins; these findings, however, relied heavily on 1 subject for whom extreme values were obtained. The results indicated that occupational exposure to hexachlorobenzene and octachlorostyrene in aluminum degassing with hexachloroethane may affect porphyrin metabolism in a manner consistent with early secondary coproporphyrinuria—the first recognized step in the development of chronic hepatic porphyria. It was also noted that changes remained detectable some years after exposure ceased.
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  • THUNELL, S, et al. (author)
  • Markers for vulnerability in acute porphyria. A hypothesis paper
  • 1995
  • In: European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies. - : Walter de Gruyter GmbH. - 0939-4974. ; 33:4, s. 179-194
  • Journal article (peer-reviewed)
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  • Thunell, S, et al. (author)
  • Porphyria in Sweden
  • 2006
  • In: Physiological research. - 0862-8408. ; 5555 Suppl 2, s. S109-S118
  • Journal article (peer-reviewed)
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  • Result 1-28 of 28

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