| 1. |
- Ekstrom, S., et al.
(author)
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Body mass index status and peripheral airway obstruction in school-age children: a population-based cohort study
- 2018
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In: Thorax. - : BMJ. - 0040-6376 .- 1468-3296. ; 73:6, s. 538-545
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Journal article (peer-reviewed)abstract
- Background Few large prospective studies have investigated the impact of body mass index (BMI) on lung function during childhood. Methods Using data collected between 2002 and 2013, we analysed associations between BMI status and lung function (assessed by spirometry) from 8 to 16 years, as well as cross-sectional associations with small airway function (impulse oscillometry) at 16 years in the BAMSE cohort (n=2889). At 16 years, cross-sectional associations with local and systemic inflammation were investigated by analysing FE NO, blood eosinophils and neutrophils. Results Overweight and obesity at 8 years were associated with higher FVC, but lower FEV 1 /FVC ratio at 8 and 16 years. In boys, but not girls, obesity at 8 years was associated with a further reduction in FEV 1 /FVC between 8 and 16 years. In cross-sectional analyses, overweight and obesity were associated with higher frequency dependence of resistance (R 5-20) and larger area under the reactance curve (AX0.5) at 16 years. Increased blood neutrophil counts were seen in overweight and obese girls, but not in boys. No association was found between BMI status and FE NO. Persistent, but not transient, overweight/obesity between 8 and 16 years was associated with higher R 5-20 and AX0.5 and lower FEV 1 /FVC (-2.8% (95% CI -4.1 to -1.2) in girls and -2.7% (95% CI -4.4 to -1.1) in boys) at 16 years, compared with persistent normal weight. Conclusion I n childhood and adolescence, overweight and obesity, particularly persistent overweight, were associated with evidence of airway obstruction, including the small airways.
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| 4. |
- Hallberg, J, et al.
(author)
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Asthma phenotypes and lung function up to 16years of age-the BAMSE cohort.
- 2015
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In: Allergy. - : Wiley. - 1398-9995 .- 0105-4538. ; 70:6, s. 667-673
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Journal article (peer-reviewed)abstract
- Asthma is a disease affecting many locations throughout the airway. Most studies have used spirometry as the primary assessment of airway obstruction, a method that may be less sensitive in regard to peripheral airway obstruction. The aim of this study was to elucidate the associations between asthma phenotypes based on age of onset and duration of symptoms, and (i) spirometry and (ii) small airway involvement measured by impulse oscillometry (IOS) in adolescence.
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| 5. |
- Hallberg, J, et al.
(author)
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Corrigendum
- 2016
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In: Allergy. - : Wiley. - 1398-9995 .- 0105-4538. ; 71:8, s. 1228-1229
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Journal article (peer-reviewed)
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| 6. |
- Landqvist, Håkan, et al.
(author)
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If you ask, you'll get an answer. Two opening routines and their consequences for the beginning for emergency calls
- 2012
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In: Språk och stil. - 1101-1165 .- 2002-4010. ; 22:2, s. 127-152
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Journal article (peer-reviewed)abstract
- This is a conversation analytic study examining how two ways of answering emergency calls have different implications and consequences for the ensuing interaction. In an older corpus of 22 calls to a Swedish emergency center, the calls were routinely answered with an identification phrase "ninety thousand" (i.e. the telephone number 90 000) or "SOS ninety thousand", whereas the 52 calls in a recently collected corpus are routinely answered with an identification phrase followed by a question, taking the format "SOS 1-1-2, what has occurred?" The analysis shows how the different answering formats affect what is being brought up at different sequential positions during call beginnings, and also how the standardized relational pair of "help provider" and "help seeker", each with its respective rights and obligations, is constructed. The article concludes with a discussion of the benefits of the latter way of answering emergency calls, arguing that it helps making the distribution of responsibilities among the interactants clear, and that it allows for a truncation of an unnecessary sequence. In this way, the latter format enhances topical progression and promotes institutional relevance.
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| 10. |
- Schultz, E. S., et al.
(author)
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Early life determinants of lung function change from childhood to adolescence
- 2018
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In: Respiratory Medicine. - : Elsevier BV. - 0954-6111 .- 1532-3064. ; 139, s. 48-54
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Journal article (peer-reviewed)abstract
- Rationale: Little is known about how perinatal and childhood factors influence lung function change between childhood and adolescence. Objectives: To investigate possible early life predictors of change in FEV1 between age 8 and 16 years. In addition, to investigate possible predictors of having persistently low lung function (FEV1 < 25th percentiles both at age 8 and 16) up to adolescence. Methods: The BAMSE birth cohort study collected data throughout childhood on environmental factors, individual characteristics, and spirometric measures at 8 and 16 years (n = 1425). Associations between early life predictors (n = 31) and FEV1 increase between 8 and 16 years were assessed with linear regression. Predictors of having persistently low lung function were examined. Results: Few factors were consistently associated with altered lung function growth, although low birth weight, asthma heredity (paternal), secondhand smoke in infancy, and season of birth had a significant impact (p-value <= 0.01). The majority of subjects stayed however within the same category of lung function between ages 8 and 16 years (in total 821/1425 = 58%). Predictors associated with having persistently low lung function were gestational age, secondhand smoke (at 2 and 8 years of age), and factors related to lower respiratory tract infections in infancy. Conclusions: In summary, rather few exposures in childhood were identified to have a significant impact on lung function growth between childhood and adolescence. Our data support previous study findings indicating that lung function development is influenced by factors before birth and in infancy, including second hand tobacco smoke.
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| 11. |
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| 12. |
- Thacher, J. D., et al.
(author)
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Tobacco smoke exposure in early life and adolescence in relation to lung function
- 2018
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In: European Respiratory Journal. - : European Respiratory Society (ERS). - 0903-1936 .- 1399-3003. ; 51:6
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Journal article (peer-reviewed)abstract
- Maternal smoking during pregnancy is associated with impaired lung function among young children, but less is known about long-term effects and the impact of adolescents' own smoking. We investigated the influence of maternal smoking during pregnancy, secondhand smoke exposure and adolescent smoking on lung function at age 16 years. The BAMSE (Barn/Child, Allergy, Milieu, Stockholm, Epidemiology) birth cohort collected information on participants' tobacco smoke exposure through repeated questionnaires, and measured saliva cotinine concentrations at age 16 years. Participants performed spirometry and impulse oscillometry (IOS) at age 16 years (n=2295). Exposure to maternal smoking during pregnancy was associated with reduced forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) ratio of -1.1% (95% CI -2.0 to -0.2%). IOS demonstrated greater resistance at 5-20 Hz (R5-20) in participants exposed to maternal smoking during pregnancy. Adolescents who smoked had reduced FEV1/FVC ratios of -0.9% (95% CI -1.8 to -0.1%) and increased resistance of 6.5 Pa.L-1.s (95% CI 0.7 to 12.2 Pa.L-1.s) in R5-20. Comparable associations for FEV1/FVC ratio were observed for cotinine concentrations, using. 12 ng.mL(-1) as a cut-off for adolescent smoking. Maternal smoking during pregnancy was associated with lower FEV1/FVC ratios and increased airway resistance. In addition, adolescent smoking appears to be associated with reduced FEV1/FVC ratios and increased peripheral airway resistance.
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| 15. |
- Thunqvist, P., et al.
(author)
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Lung Function at 8 and 16 Years After Moderate-to-Late Preterm Birth: A Prospective Cohort Study
- 2016
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In: Pediatrics. - : American Academy of Pediatrics (AAP). - 0031-4005 .- 1098-4275. ; 137:4
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Journal article (peer-reviewed)abstract
- BACKGROUND AND OBJECTIVE: Knowledge regarding lung function after moderately preterm birth is limited. We therefore investigated lung function at early school age and adolescence among children born moderately preterm. METHODS: Data were used from the Swedish prospective birth cohort BAMSE (Swedish abbreviation for Children, Allergy, Milieu, Stockholm, Epidemiology study; N = 4089), with a 4.8% prevalence of moderate to late preterm birth defined as a gestational age of 32 to 36 weeks. Participants underwent spirometry at ages 8 and 16 years, and impulse oscillometry additionally at age 16 years. In total, 2621 children (149 preterm and 2472 term) provided lung function data. RESULTS: At age 8 years, adjusted forced expiratory volume in 1 second was lower in preterm female subjects (-64 mL [95% confidence interval (CI): -118 to -10]) compared with term female subjects but not in preterm male subjects. At age 16 years, both genders in the preterm group demonstrated lower forced expiratory volume in 1 second (female subjects: -116 mL [95% CI: -212 to -20]; male subjects: -177 mL [95% CI: -329 to -25]) compared with the term group. For the preterm group, impulse oscillometry demonstrated higher adjusted resistance at 5 Hz (female subjects: 31.3 Pa.L-1.s(-1) [95% CI: 6.3 to 56.3]; male subjects: 34.9 Pa.L-1.s(-1) [95% CI: 12.0 to 57.7]) and frequency dependence of resistance (resistance at 5 and 20 Hz) for male subjects (20.9 Pa.L-1.s(-1) [95% CI: 9.8 to 31.9]) compared with the term group. CONCLUSIONS: Measures of airway function assessed in adolescence were reduced in children born moderate to late preterm, and no catch-up in lung function between ages 8 and 16 years was observed.
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