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- Högberg, Lotta, et al.
(author)
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Intranasal versus intravenous administration of midazolam to children undergoing small bowel biopsy
- 1995
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In: Acta Paediatrica. - : Wiley. - 0803-5253 .- 1651-2227. ; 84:12, s. 1429-1431
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Journal article (peer-reviewed)abstract
- Sixty-three children under the age of 9 years were randomized to receive intravenous (group A, n= 33) or intranasal (group B, n= 30) midazolam as sedation for small bowel biopsy. Mean doses of midazolam given to produce adequate sedation were 0.31 mg (kg body weight)−1 in group A and 0.34 mg (kg body weight)−1 in group B (NS). Four children in group A and 10 children in group B required additional doses to maintain adequate sedation throughout the biopsy procedure (p <0.05). There was no significant difference between the groups regarding the median procedure time (7 min in group A, 8.5 min in group B) or median fluoroscopy time (5 s in group A, 4 s in group B). All children in group B showed signs of discomfort from the nose when given midazolam intranasally. In conclusion, this study indicates that intravenous administration of midazolam is preferable to the intranasal route.
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