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1.	Lesseur, Corina, et al. (author) Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer 2016 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 48:12, s. 1544-1550 Journal article (peer-reviewed)abstract We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 × 10(-8)), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB11301-HLA-DQA10103-HLA-DQB1*0603 (odds ratio (OR) = 0.59, P = 2.7 × 10(-9)). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 × 10(-6)) than in HPV-negative (OR = 0.75, P = 0.16) cancers.

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Type of publication: journal article (1)

Type of content: peer-reviewed (1)

Author/Editor: Kjaerheim, Kristina (1); Agudo, Antonio (1); Bueno-de-Mesquita, H ... (1); Lagiou, Pagona (1); Johansson, Mattias (1); Boffetta, Paolo (1); show more...; Lissowska, Jolanta (1); Ahrens, Wolfgang (1); Brennan, Paul (1); Diergaarde, Brenda (1); Amos, Christopher I. (1); Anantharaman, Devase ... (1); Holcatova, Ivana (1); Polesel, Jerry (1); Canova, Cristina (1); Castellsague, Xavier (1); Znaor, Ariana (1); Robinson, Max (1); Conway, David I. (1); Healy, Claire M. (1); Zaridze, David (1); Szeszenia-Dabrowska, ... (1); Mates, Dana (1); Fabianova, Eleonora (1); Liu, Geoffrey (1); Hung, Rayjean J. (1); McKay, James D. (1); Xiao, Xiangjun (1); Richiardi, Lorenzo (1); Steffen, Annika (1); Franceschi, Silvia (1); Gaborieau, Valerie (1); Chabrier, Amelie (1); Lesseur, Corina (1); Olshan, Andrew F. (1); Macfarlane, Gary J. (1); Curado, Maria Paula (1); Wünsch-Filho, Victor (1); Eluf-Neto, José (1); Boccia, Stefania (1); Ness, Andrew R (1); Herrero, Rolando (1); Thomas, Steve (1); Lacko, Martin (1); Menezes, Ana M (1); Vilensky, Marta (1); Grandis, Jennifer R (1); Weissler, Mark C (1); Tajara, Eloiza H (1); Nunes, Fabio D (1); show less...

University: Umeå University (1)

Language: English (1)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year: 2016 (1)

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