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  • Al-Shanqeeti, A, et al. (author)
  • Protein Z and protein Z-dependent protease inhibitor - Determinants of levels and risk of venous thrombosis
  • 2005
  • In: Thrombosis and Haemostasis. - 0340-6245. ; 93:3, s. 411-413
  • Journal article (peer-reviewed)abstract
    • To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI and venous thrombosis was not detected in the overall case-control study. PZ and ZPI circulate as a complex and their plasma levels are interdependent. Both PZ and ZPI are increased with oral contraceptive use and reduced with oral anticoagulant therapy.
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