| 1. |
- Algaba, Juan-Carlos, et al.
(author)
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Broadband Multi-wavelength Properties of M87 during the 2017 Event Horizon Telescope Campaign
- 2021
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In: Astrophysical Journal Letters. - : American Astronomical Society. - 2041-8213 .- 2041-8205. ; 911:1
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Research review (peer-reviewed)abstract
- In 2017, the Event Horizon Telescope (EHT) Collaboration succeeded in capturing the first direct image of the center of the M87 galaxy. The asymmetric ring morphology and size are consistent with theoretical expectations for a weakly accreting supermassive black hole of mass ∼6.5 × 109 M o˙. The EHTC also partnered with several international facilities in space and on the ground, to arrange an extensive, quasi-simultaneous multi-wavelength campaign. This Letter presents the results and analysis of this campaign, as well as the multi-wavelength data as a legacy data repository. We captured M87 in a historically low state, and the core flux dominates over HST-1 at high energies, making it possible to combine core flux constraints with the more spatially precise very long baseline interferometry data. We present the most complete simultaneous multi-wavelength spectrum of the active nucleus to date, and discuss the complexity and caveats of combining data from different spatial scales into one broadband spectrum. We apply two heuristic, isotropic leptonic single-zone models to provide insight into the basic source properties, but conclude that a structured jet is necessary to explain M87's spectrum. We can exclude that the simultaneous γ-ray emission is produced via inverse Compton emission in the same region producing the EHT mm-band emission, and further conclude that the γ-rays can only be produced in the inner jets (inward of HST-1) if there are strongly particle-dominated regions. Direct synchrotron emission from accelerated protons and secondaries cannot yet be excluded.
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| 2. |
- Aebersold, Ruedi, et al.
(author)
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How many human proteoforms are there?
- 2018
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In: Nature Chemical Biology. - : NATURE PUBLISHING GROUP. - 1552-4450 .- 1552-4469. ; 14:3, s. 206-214
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Journal article (peer-reviewed)abstract
- Despite decades of accumulated knowledge about proteins and their post-translational modifications (PTMs), numerous questions remain regarding their molecular composition and biological function. One of the most fundamental queries is the extent to which the combinations of DNA-, RNA-and PTM-level variations explode the complexity of the human proteome. Here, we outline what we know from current databases and measurement strategies including mass spectrometry-based proteomics. In doing so, we examine prevailing notions about the number of modifications displayed on human proteins and how they combine to generate the protein diversity underlying health and disease. We frame central issues regarding determination of protein-level variation and PTMs, including some paradoxes present in the field today. We use this framework to assess existing data and to ask the question, "How many distinct primary structures of proteins (proteoforms) are created from the 20,300 human genes?" We also explore prospects for improving measurements to better regularize protein-level biology and efficiently associate PTMs to function and phenotype.
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| 3. |
- Karambelkar, Viraj R., et al.
(author)
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Volumetric Rates of Luminous Red Novae and Intermediate-luminosity Red Transients with the Zwicky Transient Facility
- 2023
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In: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 948:2
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Journal article (peer-reviewed)abstract
- Luminous red novae (LRNe) are transients characterized by low luminosities and expansion velocities, and they are associated with mergers or common-envelope ejections in stellar binaries. Intermediate-luminosity red transients (ILRTs) are an observationally similar class with unknown origins, but they are generally believed to be either electron-capture supernovae in super-asymptotic giant branch stars or outbursts in dusty luminous blue variables (LBVs). In this paper, we present a systematic sample of eight LRNe and eight ILRTs detected as part of the Census of the Local Universe (CLU) experiment on the Zwicky Transient Facility (ZTF). The CLU experiment spectroscopically classifies ZTF transients associated with nearby (<150 Mpc) galaxies, achieving 80% completeness for m ( r ) < 20 mag. Using the ZTF-CLU sample, we derive the first systematic LRNe volumetric rate of 7.8-3.7+6.5x10-5 M ( r ) <= -11 mag. We find that, in this luminosity range, the LRN rate scales as dN/dL proportional to L-2.5 +/- 0.3 L (-1.4 +/- 0.3) for lower-luminosity LRNe (M ( V ) >= -10 mag). The steeper power law for LRNe at high luminosities is consistent with the massive merger rates predicted by binary population synthesis models. We find that the rates of the brightest LRNe (M ( r ) <= -13 mag) are consistent with a significant fraction of them being progenitors of double compact objects that merge within a Hubble time. For ILRTs, we derive a volumetric rate of 2.6-1.4+1.8x10-6 M ( r ) <= -13.5 mag, which scales as dN/dL proportional to L-2.5 +/- 0.5
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| 4. |
- Burnum-Johnson, Kristin E., et al.
(author)
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New Views of Old Proteins : Clarifying the Enigmatic Proteome
- 2022
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In: Molecular & Cellular Proteomics. - : Elsevier BV. - 1535-9476 .- 1535-9484. ; 21:7
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Journal article (peer-reviewed)abstract
- All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. To better elucidate proteins across space, time, and molecular composition, we provide a >10 years of projection for technologies to meet the challenges that protein biology presents. With a broad perspective, we discuss grand opportunities to transition the science of proteomics into a more propulsive enterprise. Extrapolating recent trends, we describe a next generation of approaches to define, quantify, and visualize the multiple dimensions of the proteome, thereby transforming our understanding and interactions with human disease in the coming decade.
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