SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "WFRF:(Wang Zhuo) "

Search: WFRF:(Wang Zhuo)

  • Result 1-50 of 61
Sort/group result
   
EnumerationReferenceCoverFind
1.
  •  
2.
  • Ma, Tao, et al. (author)
  • Genomic insights into salt adaptation in a desert poplar
  • 2013
  • In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 4, s. 2797-
  • Journal article (peer-reviewed)abstract
    • Despite the high economic and ecological importance of forests, our knowledge of the genomic evolution of trees under salt stress remains very limited. Here we report the genome sequence of the desert poplar, Populus euphratica, which exhibits high tolerance to salt stress. Its genome is very similar and collinear to that of the closely related mesophytic congener, P. trichocarpa. However, we find that several gene families likely to be involved in tolerance to salt stress contain significantly more gene copies within the P. euphratica lineage. Furthermore, genes showing evidence of positive selection are significantly enriched in functional categories related to salt stress. Some of these genes, and others within the same categories, are significantly upregulated under salt stress relative to their expression in another salt-sensitive poplar. Our results provide an important background for understanding tree adaptation to salt stress and facilitating the genetic improvement of cultivated poplars for saline soils.
  •  
3.
  • Wang, Peng, et al. (author)
  • The Existence of Autonomous Chaos in EDM Process
  • 2022
  • In: Machines. - : MDPI AG. - 2075-1702. ; 10:4
  • Journal article (peer-reviewed)abstract
    • The dynamical evolution of electrical discharge machining (EDM) has drawn immense research interest. Previous research on mechanism analysis has discussed the deterministic nonlinearity of gap states at pulse-on discharging duration, while describing the pulse-off deionization process separately as a stochastic evolutionary process. In this case, the precise model describing a complete machining process, as well as the optimum performance parameters of EDM, can hardly be determined. The main purpose of this paper is to clarify whether the EDM system can maintain consistency in dynamic characteristics within a discharge interval. A nonlinear self-maintained equivalent model is first established, and two threshold conditions are obtained by the Shilnikov theory. The theoretical results prove that the EDM system could lead to chaos without external excitation. The time series of the deionization process recorded in the EDM experiments are then analyzed to further validate this theoretical conclusion. Qualitative chaotic analyses verify that the autonomous EDM process has chaotic characteristics. Quantitative methods are used to estimate the chaotic feature of the autonomous EDM process. By comparing the quantitative results of the autonomous EDM process with the non-autonomous EDM process, a deduction is further made that the EDM system will evolve towards steady chaos under an autonomous state.
  •  
4.
  •  
5.
  • Wang, Longwei, et al. (author)
  • A Molybdenum Disulfide Nanozyme with Charge-Enhanced Activity for Ultrasound-Mediated Cascade-Catalytic Tumor Ferroptosis
  • 2023
  • In: Angewandte Chemie - International Edition. - : Wiley. - 1433-7851 .- 1521-3773. ; 62:11
  • Journal article (peer-reviewed)abstract
    • The deficient catalytic activity of nanozymes and insufficient endogenous H2O2 in the tumor microenvironment (TME) are major obstacles for nanozyme-mediated catalytic tumor therapy. Since electron transfer is the basic essence of catalysis-mediated redox reactions, we explored the contributing factors of enzymatic activity based on positive and negative charges, which are experimentally and theoretically demonstrated to enhance the peroxidase (POD)-like activity of a MoS2 nanozyme. Hence, an acidic tumor microenvironment-responsive and ultrasound-mediated cascade nanocatalyst (BTO/MoS2@CA) is presented that is made from few-layer MoS2 nanosheets grown on the surface of piezoelectric tetragonal barium titanate (T-BTO) and modified with pH-responsive cinnamaldehyde (CA). The integration of pH-responsive CA-mediated H2O2 self-supply, ultrasound-mediated charge-enhanced enzymatic activity, and glutathione (GSH) depletion enables out-of-balance redox homeostasis, leading to effective tumor ferroptosis with minimal side effects.
  •  
6.
  •  
7.
  • Abelev, B., et al. (author)
  • Azimuthal anisotropy of D-meson production in Pb-Pb collisions at root s(NN)=2.76 TeV
  • 2014
  • In: Physical Review C (Nuclear Physics). - 0556-2813. ; 90:3
  • Journal article (peer-reviewed)abstract
    • The production of the prompt charmed mesonsD(0), D+, andD(*+) relative to the reaction plane was measured in Pb-Pb collisions at a center-of-mass energy per nucleon-nucleon collision of root s(NN) = 2.76 TeV with the ALICE detector at the CERN Large Hadron Collider. D mesons were reconstructed via their hadronic decays at central rapidity in the transverse-momentum (pT) interval 2-16 GeV/c. The azimuthal anisotropy is quantified in terms of the second coefficient v(2) in a Fourier expansion of the D-meson azimuthal distribution and in terms of the nuclear modification factor R-AA, measured in the direction of the reaction plane and orthogonal to it. The v(2) coefficient was measured with three different methods and in three centrality classes in the interval 0%-50%. A positive v(2) is observed in midcentral collisions (30%-50% centrality class), with a mean value of 0.204(-0.036)(+0.099) (tot.unc.) in the interval 2 < pT < 6 GeV/c, which decreases towards more central collisions (10%-30% and 0%-10% classes). The positive v(2) is also reflected in the nuclear modification factor, which shows a stronger suppression in the direction orthogonal to the reaction plane formidcentral collisions. The measurements are compared to theoretical calculations of charm-quark transport and energy loss in high-density strongly interacting matter at high temperature. The models that include substantial elastic interactions with an expanding medium provide a good description of the observed anisotropy. However, they are challenged to simultaneously describe the strong suppression of high-pT yield of D mesons in central collisions and their azimuthal anisotropy in noncentral collisions.
  •  
8.
  • Abelev, B., et al. (author)
  • Beauty production in pp collisions at root s=2.76 TeV measured via semi-electronic decays
  • 2014
  • In: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 738, s. 97-108
  • Journal article (peer-reviewed)abstract
    • The ALICE Collaboration at the LHC reports measurement of the inclusive production cross section of electrons from semi-leptonic decays of beauty hadrons with rapidity |y| < 0.8 and transverse momentum 1 < p(T)< 10 GeV/c, in pp collisions at root s = 2.76 TeV. Electrons not originating from semi-electronic decay of beauty hadrons are suppressed using the impact parameter of the corresponding tracks. The production cross section of beauty decay electrons is compared to the result obtained with an alternative method which uses the distribution of the azimuthal angle between heavy-flavour decay electrons and charged hadrons. Perturbative QCD predictions agree with the measured cross section within the experimental and theoretical uncertainties. The integrated visible cross section, sigma(b -> e) = 3.47 +/- 0.40(stat)(+1.12)(-1.33)(sys) +/- 0.07(norm) mu b, was extrapolated to full phase space using Fixed Order plus Next-to-Leading Log (FONLL) calculations to obtain the total b (b) over bar production cross section, sigma(b (b) over bar) = 130 +/- 15.1(stat)(+42.1)(-49.8)(sys)(+3.4)(-3.1)(extr) +/- 2.5(norm) +/- 4.4(BR) mu b. (C) 2014 The Authors. Published by Elsevier B.V.
  •  
9.
  • Abelev, B., et al. (author)
  • Charged jet cross sections and properties in proton-proton collisions at root s=7 TeV
  • 2015
  • In: Physical Review D (Particles, Fields, Gravitation and Cosmology). - 1550-2368. ; 91:11
  • Journal article (peer-reviewed)abstract
    • The differential charged jet cross sections, jet fragmentation distributions, and jet shapes are measured in minimum bias proton-proton collisions at center-of-mass energy root s = 7 TeV using the ALICE detector at the LHC. Jets are reconstructed from charged particle momenta in the midrapidity region using the sequential recombination k(T) and anti-k(T) as well as the SISCone jet finding algorithms with several resolution parameters in the range R = 0.2-0.6. Differential jet production cross sections measured with the three jet finders are in agreement in the transverse momentum (p(T)) interval 20 < p(T)(jet,ch) < 100 GeV/c. They are also consistent with prior measurements carried out at the LHC by the ATLAS Collaboration. The jet charged particle multiplicity rises monotonically with increasing jet p(T), in qualitative agreement with prior observations at lower energies. The transverse profiles of leading jets are investigated using radial momentum density distributions as well as distributions of the average radius containing 80% (< R-80 >) of the reconstructed jet p(T). The fragmentation of leading jets with R = 0.4 using scaled p(T) spectra of the jet constituents is studied. The measurements are compared to model calculations from event generators (PYTHIA, PHOJET, HERWIG). The measured radial density distributions and < R-80 > distributions are well described by the PYTHIA model (tune Perugia-2011). The fragmentation distributions are better described by HERWIG.
  •  
10.
  • Abelev, B., et al. (author)
  • Elliptic flow of identified hadrons in Pb-Pb collisions at root(NN)-N-s=2.76 Tev
  • 2015
  • In: Journal of High Energy Physics. - 1029-8479. ; :6
  • Journal article (peer-reviewed)abstract
    • The elliptic flow coefficient (v(2)) of identified particles in Pb-Pb collisions at root s(NN) = 2.76 TeV was measured with the ALICE detector at the Large Hadron Collider (LHC). The results were obtained with the Scalar Product method, a two-particle correlation technique, using a pseudo-rapidity gap of |Delta eta| > 0.9 between the identified hadron under study and the reference particles. The v (2) is reported for pi(+/-), K-+/-, K-S(0), p+(p) over bar, phi, Lambda+(Lambda) over bar, Xi+(Xi) over bar (+) and Omega(-)+(Omega) over bar (+) in several collision centralities. In the low transverse momentum (p(T)) region, p(T) < 3 GeV/c, v(2)(p(T)) exhibits a particle mass dependence consistent with elliptic flow accompanied by the transverse radial expansion of the system with a common velocity field. The experimental data for pi (+/-) and the combined K-+/- and K-S(0) results, are described fairly well by hydrodynamic calculations coupled to a hadronic cascade model (VISHNU) for central collisions. However, the same calculations fail to reproduce the v(2)(p(T)) for p+(p) over bar, phi, Lambda+(Lambda) over bar, Xi+(Xi) over bar (+). For transverse momentum values larger than about 3 GeV/c, particles tend to group according to their type, i.e. mesons and baryons. The present measurements exhibit deviations from the number of constituent quark (NCQ) scaling at the level of +/- 20% for p(T) > 3 GeV/c.
  •  
11.
  • Abelev, B., et al. (author)
  • Event-by-event mean p(T) fluctuations in pp and Pb-Pb collisions at the LHC
  • 2014
  • In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 74:10
  • Journal article (peer-reviewed)abstract
    • Event-by-event fluctuations of the mean transverse momentum of charged particles produced in pp collisions at root s = 0.9, 2.76 and 7 TeV, and Pb-Pb collisions at root S-NN = 2.76 TeV are studied as a function of the charged-particle multiplicity using the ALICE detector at the LHC. Dynamical fluctuations indicative of correlated particle emission are observed in all systems. The results in pp collisions show little dependence on collision energy. The Monte Carlo event generators PYTHIA and PHOJET are in qualitative agreement with the data. Peripheral Pb-Pb data exhibit a similar-multiplicity dependence as that observed in pp. In central Pb-Pb, the results deviate from this trend, featuring a significant reduction of the fluctuation strength. The results in Pb-Pb are in qualitative agreement with previous measurements in Au-Au at lower collision energies and with expectations from models that incorporate collective phenomena.
  •  
12.
  •  
13.
  • Abelev, B., et al. (author)
  • Freeze-out radii extracted from three-pion cumulants in pp, p-Pb and Pb-Pb collisions at the LHC
  • 2014
  • In: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 739, s. 139-151
  • Journal article (peer-reviewed)abstract
    • In high-energy collisions, the spatio-temporal size of the particle production region can be measured using the Bose-Einstein correlations of identical bosons at low relative momentum. The source radii are typically extracted using two-pion correlations, and characterize the system at the last stage of interaction, called kinetic freeze-out. In low-multiplicity collisions, unlike in high-multiplicity collisions, two-pion correlations are substantially altered by background correlations, e. g. mini-jets. Such correlations can be suppressed using three-pion cumulant correlations. We present the first measurements of the size of the system at freeze-out extracted from three-pion cumulant correlations in pp, p-Pb and Pb-Pb collisions at the LHC with ALICE. At similar multiplicity, the invariant radii extracted in p-Pb collisions are found to be 5-15% larger than those in pp, while those in Pb-Pb are 35-55% larger than those in p-Pb. Our measurements disfavor models which incorporate substantially stronger collective expansion in p-Pb as compared to pp collisions at similar multiplicity. (C) 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license
  •  
14.
  • Abelev, B., et al. (author)
  • Inclusive photon production at forward rapidities in proton-proton collisions at root s=0.9, 2.76 and 7 TeV
  • 2015
  • In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 75:4
  • Journal article (peer-reviewed)abstract
    • The multiplicity and pseudorapidity distributions of inclusive photons have been measured at forward rapidities (2.3 < eta < 3.9) in proton-proton collisions at three center-of-mass energies, root s = 0.9, 2.76 and 7 TeV using the ALICE detector. It is observed that the increase in the average photon multiplicity as a function of beam energy is compatible with both a logarithmic and a power-law dependence. The relative increase in average photon multiplicity produced in inelastic pp collisions at 2.76 and 7 TeV center-of-mass energies with respect to 0.9 TeV are 37.2 +/- 0.3% (stat) +/- 8.8% (sys) and 61.2 +/- 0.3% (stat) +/- 7.6% (sys), respectively. The photon multiplicity distributions for all center-of-mass energies are well described by negative binomial distributions. The multiplicity distributions are also presented in terms of KNO variables. The results are compared to model predictions, which are found in general to underestimate the data at large photon multiplicities, in particular at the highest center-of-mass energy. Limiting fragmentation behavior of photons has been explored with the data, but is not observed in the measured pseudorapidity range.
  •  
15.
  • Abelev, B., et al. (author)
  • Measurement of electrons from semileptonic heavy-flavor hadron decays in pp collisions at root s=2.76 TeV
  • 2015
  • In: Physical Review D (Particles, Fields, Gravitation and Cosmology). - 1550-2368. ; 91:1
  • Journal article (peer-reviewed)abstract
    • The p(T)-differential production cross section of electrons from semileptonic decays of heavy-flavor hadrons has been measured at midrapidity in proton-proton collisions at root s = 2.76 TeV in the transverse momentum range 0.5 < p(T) < 12 GeV/c with the ALICE detector at the LHC. The analysis was performed using minimum bias events and events triggered by the electromagnetic calorimeter. Predictions from perturbative QCD calculations agree with the data within the theoretical and experimental uncertainties.
  •  
16.
  • Abelev, B., et al. (author)
  • Measurement of visible cross sections in proton-lead collisions at root s(NN)=5.02 TeV in van der Meer scans with the ALICE detector
  • 2014
  • In: Journal of Instrumentation. - 1748-0221. ; 9
  • Journal article (peer-reviewed)abstract
    • In 2013, the Large Hadron Collider provided proton-lead and lead-proton collisions at the center-of-mass energy per nucleon pair root s(NN) = 5.02 TeV. Van der Meer scans were performed for both configurations of colliding beams, and the cross section was measured for two reference processes, based on particle detection by the T0 and V0 detectors, with pseudo-rapidity coverage 4.6 < eta < 4.9, -3.3 < eta < -3.0 and 2.8 < eta < 5.1, -3.7 < eta < -1.7, respectively. Given the asymmetric detector acceptance, the cross section was measured separately for the two configurations. The measured visible cross sections are used to calculate the integrated luminosity of the proton-lead and lead-proton data samples, and to indirectly measure the cross section for a third, configuration-independent, reference process, based on neutron detection by the Zero Degree Calorimeters.
  •  
17.
  • Abelev, B., et al. (author)
  • Multiparticle azimuthal correlations in p-Pb and Pb-Pb collisions at the CERN Large Hadron Collider
  • 2014
  • In: Physical Review C (Nuclear Physics). - 0556-2813. ; 90:5
  • Journal article (peer-reviewed)abstract
    • Measurements of multiparticle azimuthal correlations (cumulants) for charged particles in p-Pb at root s(NN) = 5.02 TeV and Pb-Pb at root s(NN) = 2.76 TeV collisions are presented. They help address the question of whether there is evidence for global, flowlike, azimuthal correlations in the p-Pb system. Comparisons are made to measurements from the larger Pb-Pb system, where such evidence is established. In particular, the second harmonic two-particle cumulants are found to decrease with multiplicity, characteristic of a dominance of few-particle correlations in p-Pb collisions. However, when a vertical bar Delta eta vertical bar gap is placed to suppress such correlations, the two-particle cumulants begin to rise at high multiplicity, indicating the presence of global azimuthal correlations. The Pb-Pb values are higher than the p-Pb values at similar multiplicities. In both systems, the second harmonic four-particle cumulants exhibit a transition from positive to negative values when the multiplicity increases. The negative values allow for a measurement of v(2){4} to be made, which is found to be higher in Pb-Pb collisions at similar multiplicities. The second harmonic six-particle cumulants are also found to be higher in Pb-Pb collisions. In Pb-Pb collisions, we generally find v(2){4} similar or equal to v(2){6} not equal 0 which is indicative of a Bessel-Gaussian function for the v(2) distribution. For very high-multiplicity Pb-Pb collisions, we observe that the four-and six-particle cumulants become consistent with 0. Finally, third harmonic two-particle cumulants in p-Pb and Pb-Pb are measured. These are found to be similar for overlapping multiplicities, when a vertical bar Delta eta vertical bar > 1.4 gap is placed.
  •  
18.
  • Abelev, B., et al. (author)
  • Multiplicity dependence of jet-like two-particle correlation structures in p-Pb collisions at root s(NN)=5.02 TeV
  • 2015
  • In: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 741, s. 38-50
  • Journal article (peer-reviewed)abstract
    • Two-particle angular correlations between unidentified charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV. The transverse-momentum range 0.7 < p(T),(assoc) < p(T),(trig) < 5.0 GeV/c is examined, to include correlations induced by jets originating from low momentum-transfer scatterings (minijets). The correlations expressed as associated yield per trigger particle are obtained in the pseudorapidity range vertical bar eta vertical bar < 0.9. The near-side long-range pseudorapidity correlations observed in high-multiplicity p-Pb collisions are subtracted from both near-side short-range and away-side correlations in order to remove the non-jet-like components. The yields in the jet-like peaks are found to be invariant with event multiplicity with the exception of events with low multiplicity. This invariance is consistent with the particles being produced via the incoherent fragmentation of multiple parton-parton scatterings, while the yield related to the previously observed ridge structures is not jet-related. The number of uncorrelated sources of particle production is found to increase linearly with multiplicity, suggesting no saturation of the number of multi-parton interactions even in the highest multiplicity p-Pb collisions. Further, the number scales only in the intermediate multiplicity region with the number of binary nucleon-nucleon collisions estimated with a Glauber Monte-Carlo simulation. (C) 2014 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
  •  
19.
  • Abelev, B., et al. (author)
  • Neutral pion production at midrapidity in pp and Pb-Pb collisions at root(NN)-N-S=2.76 TeV
  • 2014
  • In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 74:10
  • Journal article (peer-reviewed)abstract
    • Invariant yields of neutral pions at midrapidity in the transverse momentum range 0.6 < pT < 12 GeV/c measured in Pb-Pb collisions at root(NN)-N-s = 2.76 TeV are presented for six centrality classes. The pp reference spectrum was measured in the range 0.4 < pT < 10 GeV/c at the same center-of-mass energy. The nuclear modification factor, R-AA, shows a suppression of neutral pions in central Pb-Pb collisions by a factor of up to about 8-10 for 5 less than or similar to p(T) less than or similar to 7 GeV/c. The presented measurements are compared with results at lower center-of-mass energies and with theoretical calculations.
  •  
20.
  • Abelev, B., et al. (author)
  • Production of Sigma (1385)(+/-) and Xi (1530)(0) in proton-proton collisions at root s=7 TeV
  • 2015
  • In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 75:1
  • Journal article (peer-reviewed)abstract
    • The production of the strange and double-strange baryon resonances (Sigma (1385)(+/-), Xi (1530)(0)) has been measured at mid-rapidity (vertical bar y vertical bar < 0.5) in proton-proton collisions at root s = 7 TeV with the ALICE detector at the LHC. Transverse momentum spectra for inelastic collisions are compared to QCD-inspired models, which in general underpredict the data. A search for the phi (1860) pentaquark, decaying in the Xi pi channel, has been carried out but no evidence is seen.
  •  
21.
  • Abelev, B., et al. (author)
  • Suppression of Upsilon(1S) at forward rapidity in Pb-Pb collisions at root s(NN)=2.76 TeV
  • 2014
  • In: Physics Letters. Section B: Nuclear, Elementary Particle and High-Energy Physics. - : Elsevier BV. - 0370-2693. ; 738, s. 361-372
  • Journal article (peer-reviewed)abstract
    • We report on the measurement of the inclusive Upsilon(1S) production in Pb-Pb collisions at root s(NN) = 2.76 TeV carried out at forward rapidity (2.5 < y < 4) and down to zero transverse momentum using its mu(+)mu(-) decay channel with the ALICE detector at the Large Hadron Collider. Astrong suppression of the inclusive Upsilon(1S) yield is observed with respect to pp collisions scaled by the number of independent nucleo-nnucleon collisions. The nuclear modification factor, for events in the 0-90% centrality range, amounts to 0.30 +/- 0.05(stat) +/- 0.04(syst). The observed Upsilon(1S) suppression tends to increase with the centrality of the collision and seems more pronounced than in corresponding mid-rapidity measurements. Our results are compared with model calculations, which are found to underestimate the measured suppression and fail to reproduce its rapidity dependence. (C) 2014 The Authors. Published by Elsevier B. V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/). Funded by SCOAP(3).
  •  
22.
  • Abelev, B., et al. (author)
  • Transverse momentum dependence of inclusive primary charged-particle production in p-Pb collisions at root S-NN=5.02 TeV
  • 2014
  • In: European Physical Journal C. Particles and Fields. - : Springer Science and Business Media LLC. - 1434-6044. ; 74:9
  • Journal article (peer-reviewed)abstract
    • The transverse momentum (pT) distribution of primary charged particles is measured at midrapidity in minimum-bias p-Pb collisions at root S-NN = 5.02 TeV with the ALICE detector at the LHC in the range 0.15 < pT < 50 GeV/c. The spectra are compared to the expectation based on binary collision scaling of particle production in pp collisions, leading to a nuclear modification factor consistent with unity for pT larger than 2 GeV/c, with a weak indication of a Cronin-like enhancement for pT around 4 GeV/c. The measurement is compared to theoretical calculations and to data in Pb-Pb collisions at root S-NN = 2.76 TeV.
  •  
23.
  • Liu, Lizheng, et al. (author)
  • A FPGA-based Hardware Accelerator for Bayesian Confidence Propagation Neural Network
  • 2020
  • In: 2020 IEEE Nordic Circuits and Systems Conference, NORCAS 2020 - Proceedings. - : Institute of Electrical and Electronics Engineers (IEEE).
  • Conference paper (peer-reviewed)abstract
    • The Bayesian Confidence Propagation Neural Network (BCPNN) has been applied in higher level of cognitive intelligence (e.g. working memory, associative memory). However, in the spike-based version of this learning rule the pre-, postsynaptic and coincident activity is traced in three low-passfiltering stages, the calculation processes of weight update are very computationally intensive. In this paper, a hardware architecture of the updating process for lazy update mode is proposed for updating 8 local synaptic state variables. The parallelism by decomposing the calculation steps of formulas based on the inherent data dependencies is optimized. The FPGA-based hardware accelerator of BCPNN is designed and implemented. The experimental results show the updating process on FPGA can be accomplished within 110 ns with a clock frequency of 200 MHz, the updating speed is greatly enhanced compared with the CPU test. The trade-off between performance, accuracy and resources on dedicated hardware is evaluated, and the impact of the module reuse on resource consumption and computing performance is evaluated.
  •  
24.
  • Liu, Shiping, et al. (author)
  • Population Genomics Reveal Recent Speciation and Rapid Evolutionary Adaptation in Polar Bears
  • 2014
  • In: Cell. - : Elsevier BV. - 0092-8674 .- 1097-4172. ; 157:4, s. 785-794
  • Journal article (peer-reviewed)abstract
    • Polar bears are uniquely adapted to life in the High Arctic and have undergone drastic physiological changes in response to Arctic climates and a hyper-lipid diet of primarily marine mammal prey. We analyzed 89 complete genomes of polar bear and brown bear using population genomic modeling and show that the species diverged only 479-343 thousand years BP. We find that genes on the polar bear lineage have been under stronger positive selection than in brown bears; nine of the top 16 genes under strong positive selection are associated with cardiomyopathy and vascular disease, implying important reorganization of the cardiovascular system. One of the genes showing the strongest evidence of selection, APOB, encodes the primary lipoprotein component of low-density lipoprotein (LDL); functional mutations in APOB may explain how polar bears are able to cope with life-long elevated LDL levels that are associated with high risk of heart disease in humans.
  •  
25.
  • Maddali, Manoj V., et al. (author)
  • Validation and utility of ARDS subphenotypes identified by machine-learning models using clinical data : an observational, multicohort, retrospective analysis
  • 2022
  • In: The Lancet Respiratory Medicine. - 2213-2600. ; 10:4, s. 367-377
  • Journal article (peer-reviewed)abstract
    • Background: Two acute respiratory distress syndrome (ARDS) subphenotypes (hyperinflammatory and hypoinflammatory) with distinct clinical and biological features and differential treatment responses have been identified using latent class analysis (LCA) in seven individual cohorts. To facilitate bedside identification of subphenotypes, clinical classifier models using readily available clinical variables have been described in four randomised controlled trials. We aimed to assess the performance of these models in observational cohorts of ARDS. Methods: In this observational, multicohort, retrospective study, we validated two machine-learning clinical classifier models for assigning ARDS subphenotypes in two observational cohorts of patients with ARDS: Early Assessment of Renal and Lung Injury (EARLI; n=335) and Validating Acute Lung Injury Markers for Diagnosis (VALID; n=452), with LCA-derived subphenotypes as the gold standard. The primary model comprised only vital signs and laboratory variables, and the secondary model comprised all predictors in the primary model, with the addition of ventilatory variables and demographics. Model performance was assessed by calculating the area under the receiver operating characteristic curve (AUC) and calibration plots, and assigning subphenotypes using a probability cutoff value of 0·5 to determine sensitivity, specificity, and accuracy of the assignments. We also assessed the performance of the primary model in EARLI using data automatically extracted from an electronic health record (EHR; EHR-derived EARLI cohort). In Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG SAFE; n=2813), a multinational, observational ARDS cohort, we applied a custom classifier model (with fewer variables than the primary model) to determine the prognostic value of the subphenotypes and tested their interaction with the positive end-expiratory pressure (PEEP) strategy, with 90-day mortality as the dependent variable. Findings: The primary clinical classifier model had an area under receiver operating characteristic curve (AUC) of 0·92 (95% CI 0·90–0·95) in EARLI and 0·88 (0·84–0·91) in VALID. Performance of the primary model was similar when using exclusively EHR-derived predictors compared with manually curated predictors (AUC=0·88 [95% CI 0·81–0·94] vs 0·92 [0·88–0·97]). In LUNG SAFE, 90-day mortality was higher in patients assigned the hyperinflammatory subphenotype than in those with the hypoinflammatory phenotype (414 [57%] of 725 vs 694 [33%] of 2088; p<0·0001). There was a significant treatment interaction with PEEP strategy and ARDS subphenotype (p=0·041), with lower 90-day mortality in the high PEEP group of patients with the hyperinflammatory subphenotype (hyperinflammatory subphenotype: 169 [54%] of 313 patients in the high PEEP group vs 127 [62%] of 205 patients in the low PEEP group; hypoinflammatory subphenotype: 231 [34%] of 675 patients in the high PEEP group vs 233 [32%] of 734 patients in the low PEEP group). Interpretation: Classifier models using clinical variables alone can accurately assign ARDS subphenotypes in observational cohorts. Application of these models can provide valuable prognostic information and could inform management strategies for personalised treatment, including application of PEEP, once prospectively validated. Funding: US National Institutes of Health and European Society of Intensive Care Medicine.
  •  
26.
  • Qiu, WB, et al. (author)
  • Resistin increases platelet P-selectin levels via p38 MAPK signal pathway
  • 2014
  • In: Diabetes & vascular disease research. - : SAGE Publications. - 1752-8984 .- 1479-1641. ; 11:2, s. 121-124
  • Journal article (peer-reviewed)abstract
    • Resistin, an adipokine associated with the metabolic syndrome, is believed to have a role in thrombotic conditions. This work analyses the effects of resistin on P-selectin expression using a combination of ex vivo human studies, in vivo animal models and in vitro cell cultures. Human platelets and vascular endothelial cells were incubated with resistin, with or without anti-Toll-like receptor 4 (TLR-4) or mitogen-activated protein kinases (MAPK) pathway inhibitors, whereas mice were treated with resistin infusion followed by analysis of P-selectin expression. Resistin increased both human and murine platelet P-selectin expression compared with controls (human: 48.02% ± 7.6% vs 35.12% ± 2.62%, p < 0.05; mouse: 8.17% ± 0.37% vs 4.44% ± 0.37%, p < 0.05), through the p38 MAPK pathway. In contrast, resistin had no effect on endothelial P-selectin production. We conclude that resistin induces platelet activation by increasing P-selectin expression through the p38 MAPK-dependent pathway. These data provide one mechanism for the prothrombotic state in individuals with the metabolic syndrome.
  •  
27.
  • Rasmussen, Morten, et al. (author)
  • Ancient human genome sequence of an extinct Palaeo-Eskimo
  • 2010
  • In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 463:7282, s. 757-762
  • Journal article (peer-reviewed)abstract
    • We report here the genome sequence of an ancient human. Obtained from ∼4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20×, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit.
  •  
28.
  • Wang, Deyu, et al. (author)
  • FPGA-Based HPC for Associative Memory System
  • 2024
  • In: 29TH ASIA AND SOUTH PACIFIC DESIGN AUTOMATION CONFERENCE, ASP-DAC 2024. - : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 52-57
  • Conference paper (peer-reviewed)abstract
    • Associative memory plays a crucial role in the cognitive capabilities of the human brain. The Bayesian Confidence Propagation Neural Network (BCPNN) is a cortex model capable of emulating brain-like cognitive capabilities, particularly associative memory. However, the existing GPU-based approach for BCPNN simulations faces challenges in terms of time overhead and power efficiency. In this paper, we propose a novel FPGA-based high performance computing (HPC) design for the BCPNN-based associative memory system. Our design endeavors to maximize the spatial and timing utilization of FPGA while adhering to the constraints of the available hardware resources. By incorporating optimization techniques including shared parallel computing units, hybrid-precision computing for a hybrid update mechanism, and the globally asynchronous and locally synchronous (GALS) strategy, we achieve a maximum network size of 150x10 and a peak working frequency of 100 MHz for the BCPNN-based associative memory system on the Xilinx Alveo U200 Card. The tradeoff between performance and hardware overhead of the design is explored and evaluated. Compared with the GPU counterpart, the FPGA-based implementation demonstrates significant improvements in both performance and energy efficiency, achieving a maximum latency reduction of 33.25x, and a power reduction of over 6.9x, all while maintaining the same network configuration.
  •  
29.
  • Wang, Deyu, et al. (author)
  • Memristor-Based In-Circuit Computation for Trace-Based STDP
  • 2022
  • In: 2022 Ieee International Conference On Artificial Intelligence Circuits And Systems (Aicas 2022). - : Institute of Electrical and Electronics Engineers (IEEE). ; , s. 1-4
  • Conference paper (peer-reviewed)abstract
    • Recently, memristors have been widely used to implement Spiking Neural Networks (SNNs), which is promising in edge computing scenarios. However, most memristor-based SNN implementations adopt simplified spike-timing-dependent plasticity (STDP) for the online learning process. It is challenging for memristor-based implementations to support the trace-based STDP learning rules that have been widely used in neuromorphic applications. This paper proposed a versatile memristor-based architecture to implement the synaptic-level trace-based STDP learning rules. Especially, the similarity between synaptic trace dynamics and the memristor nonlinearity is explored and exploited to emulate the trace variables of trace-based STDP. As two typical trace-based STDP learning rules, the pairwise STDP and the triplet STDP, are simulated on two typical nonlinear bipolar memristor devices. The simulation results show that the behavior of physical memristor devices can be well estimated (below 6% in terms of the relative root-mean-square error), and the memristor-based in-circuit computation for trace-based STDP learning rules can achieve a high correlation coefficient over 98%.
  •  
30.
  • Bao, D., et al. (author)
  • A wirelessly-powered UWB sensor tag with time-domain sensor interface
  • 2014
  • In: Proceedings - IEEE International Symposium on Circuits and Systems. - 9781479934324 ; , s. 2503-2506
  • Conference paper (peer-reviewed)abstract
    • This paper presents a wirelessly-powered sensor tag with a time-domain sensor interface for wireless sensing applications. The tag is remotely powered by RF wave. Instead of traditional approaches employing conventional ADCs for quantization and transmitter for data communication, in this work, a Pulse Position Modulator incorporating simple impulse radio UWB (IR-UWB) transmitter is proposed to convert and transmit the analog sensing information in time domain. The analog signal is compared with an adjustable triangular wave for analog to time conversion in signal-varying environments. Then a UWB transmitter converts the PPM signal to very short pulses and sends it back to the reader. The time interval of UWB pulses represents the original input signal in time domain which can be measured on the reader side by a time-to-digital conversion. This approach not only simplifies the ADC design but also relaxes the number of bits transmitted on the tag side. The sensor tag is designed in 180nm CMOS process. Simulation results demonstrate that the proposed approach reduce transmission power consumption by nearly 3 orders of magnitude over traditional approaches, while consuming only 85 μW for 1.5 MS/s sampling rate.
  •  
31.
  • Block, Keith I., et al. (author)
  • Designing a broad-spectrum integrative approach for cancer prevention and treatment
  • 2015
  • In: Seminars in Cancer Biology. - : Academic Press. - 1044-579X .- 1096-3650. ; 35, s. S276-S304
  • Research review (peer-reviewed)abstract
    • Targeted therapies and the consequent adoption of "personalized" oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few disease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistant immortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are not reliant upon the same mechanisms as those which have been targeted). To address these limitations, an international task force of 180 scientists was assembled to explore the concept of a low-toxicity "broadspectrum" therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspects of relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a wide range of high-priority targets (74 in total) that could be modified to improve patient outcomes. For these targets, corresponding low-toxicity therapeutic approaches were then suggested, many of which were phytochemicals. Proposed actions on each target and all of the approaches were further reviewed for known effects on other hallmark areas and the tumor microenvironment Potential contrary or procarcinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixed evidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of the relationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. This novel approach has potential to be relatively inexpensive, it should help us address stages and types of cancer that lack conventional treatment, and it may reduce relapse risks. A proposed agenda for future research is offered. (C) 2015 The Authors. Published by Elsevier Ltd.
  •  
32.
  • Chen, Zhuo, et al. (author)
  • Reliability-Oriented Multi-Objective Optimization of Electrical Machines Considering Insulation Thermal Lifetime Prediction
  • 2024
  • In: IEEE Transactions on Transportation Electrification. - : Institute of Electrical and Electronics Engineers (IEEE). - 2332-7782. ; 10:1, s. 2264-2276
  • Journal article (peer-reviewed)abstract
    • With the trend toward transportation electrification, the power density of electrical machines faces ever-increasing requirement owing to the stringent limit of weight, especially for aerospace applications. Conventionally, the reliability of electrical machines in such safety-critical application is guaranteed by considerable safety margins, i.e., the over-engineering approach, which prevents electrical machines from reaching higher power densities and leads to a design conflict. This paper proposes a reliability-oriented design approach for low-voltage electrical machines by integrating model-based lifetime prediction into a multi-objective optimization process. Accelerated thermal degradation tests are carried out on mainwall insulation and turn insulation, then the thermal degradation model is built to predict the lifetimes, accordingly. Thermal lifetime models are developed at several lifetime percentiles for both continuous duty and variable duty applications. Finally, a feasible reliability-oriented multi-objective optimization platform is established, based on which a study-case electrical machine for aerospace application is designed and optimized. The prototype is manufactured to verify the optimized performances.
  •  
33.
  •  
34.
  • Cui, K., et al. (author)
  • An all-digital phase-locked-loop with a robustness enhanced dual-mode DCO
  • 2017
  • In: Microwave and optical technology letters (Print). - : John Wiley & Sons. - 0895-2477 .- 1098-2760. ; 59:2, s. 312-315
  • Journal article (peer-reviewed)abstract
    • An all-digital-phase-locked-loop (ADPLL) with a dual-mode Class-A/Class-C Digital-controlled-oscillator (DCO) is presented in this letter. During the start-up phase, the DCO operates in the Class-A mode with increasing tail current. A low-power amplitude-to-pulse-converter (APC) is proposed to detect the oscillating amplitude of the DCO. After the start-up, the DCO switches to the Class-C mode with reduced tail current, resulting in better phase noise and lower power consumption. The ADPLL with the proposed DCO is implemented in a 65-nm CMOS technology. The Class-C mode DCO exhibits a phase noise of −123.3 dBc/Hz at 1-MHz offset with a 2.7-GHz carrier frequency. Measured results show about a 2.9-dB phase noise improvement at 1-MHz offset among the tuning range of 2.5–2.9 GHz, compared to the Class-A DCO under the same power consumption. The figure-of-merit (FOM) and FOM including the tuning range (FOMT) of the DCO is 188.7 and 192.1, respectively.
  •  
35.
  • Feng, Meng-Yao, et al. (author)
  • Work-Related Stress and Occurrence of Cardiovascular Disease A 13-Year Prospective Study
  • 2022
  • In: Journal of Occupational and Environmental Medicine. - 1076-2752 .- 1536-5948. ; 64:11, s. 927-933
  • Journal article (peer-reviewed)abstract
    • Objective: The aim of the study is to investigate the influence of work-related psychological and physical stresses on risk of cardiovascular disease (CVD). Methods : A total of 5651 CVD-free participants older than 50 years from the Survey of Health, Ageing and Retirement in Europe were followed up for 13 years to detect incident CVD. Work-related stress was assessed using job strain and job reward questionnaire. Cox regression model was used to estimate the association. Results: High physical demands (hazard ratio [HR], 1.30) and low reward (HR, 1.19) compared with their counterparts, as well as active physical jobs (HR, 1.41) and high physical strain (HR, 1.45) in comparison with low physical strain were associated with higher risk of incident CVD after adjusting for confounders. However, combining physically stressful jobs with low reward did not further increase the CVD risk. Conclusions: Avoiding physically stressful jobs or providing appropriate reward may reduce the occurrence of CVD.
  •  
36.
  • Ge, Rongbin, et al. (author)
  • Metformin represses cancer cells via alternate pathways in N-cadherin expressing vs. N-cadherin deficient cells.
  • 2015
  • In: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 6:30
  • Journal article (peer-reviewed)abstract
    • Metformin has emerged as a potential anticancer agent. Here, we demonstrate that metformin plays an anti-tumor role via repressing N-cadherin, independent of AMPK, in wild-type N-cadherin cancer cells. Ectopic-expression of N-cadherin develops metformin-resistant cancer cells, while suppression of N-cadherin sensitizes cancer to metformin. Manipulation of AMPK expression does not alter sensitivity of cancer to metformin. We show that NF-kappaB is a downstream molecule of N-cadherin and metformin regulates NF-kappaB signaling via suppressing N-cadherin. Moreover, we also suggest that TWIST1 is an upstream molecule of N-cadherin/NF-kappaB signaling and manipulation of TWIST1 expression changes the sensitivity of cancer cells to metformin. In contrast to the cells that express N-cadherin, in N-cadherin deficient cells, metformin plays an anti-tumor role via activation of AMPK. Ectopic expression of N-cadherin makes cancer more resistant to metformin. Therefore, we suggest that metformin's anti-cancer therapeutic effect is mediated through different molecular mechanism in wild-type vs. deficient N-cadherin cancer cells. At last, we selected 49 out of 984 patients' samples with prostatic cancer after radical prostatectomy (selection criteria: Gleason score ≥ 7 and all patients taking metformin) and showed levels of N-cadherin, p65 and AMPK could predict post-surgical recurrence in prostate cancer after treatment of metformin.
  •  
37.
  • Hu, Shuanglin, et al. (author)
  • Simulation of IRRAS Spectra for Molecules on Oxide Surfaces : CO on TiO2(110)
  • 2015
  • In: The Journal of Physical Chemistry C. - : American Chemical Society (ACS). - 1932-7447 .- 1932-7455. ; 119:10, s. 5403-5411
  • Journal article (peer-reviewed)abstract
    • We explore a method that cart sirriulate infrared refiection absotption spectroscopy (IRRAS) spectra for molecules adsjorlied on semiconductor surfaces. The method rakes it possible to directly correlate experimental spectra with possible adsorbate structures. Our example in thiS paper is CO adsoihed on rutile TiO2(110). We present simulated IRRAS spectra for coverages in the range from 0.125 to 1.5 Monolayer (ML) An explanation is provided. for the apparent inconsistency in the literature concerning the tilting geometry of 1 ML CO on this surface. We find that a tilted structure (which is also the lowest-energy configuration) generates IRRAS spectra in excellent agreement with the experimental spectra. Furthermore, we predict the adsorption structure for 1.5 ML CO coverage over TiO2 (110), which consists of very weakly bound CO molecules on top of the monolayer. In all cases, our simulation method) which is based On density functioual theory (PFT) vibrational calculations, produces s- and p-polarized IRRAS spectra in excellent agreement with the experimental spectra.
  •  
38.
  • Li, Furong, et al. (author)
  • Towards quantification of Holocene anthropogenic land-cover change in temperate China : A review in the light of pollen-based REVEALS reconstructions of regional plant cover
  • 2020
  • In: Earth-Science Reviews. - : Elsevier. - 0012-8252 .- 1872-6828. ; 203, s. 1-25
  • Research review (peer-reviewed)abstract
    • In an attempt to quantify Holocene anthropogenic land-cover change in temperate China, we 1) applied the REVEALS model to estimate plant-cover change using 94 pollen records and relative pollen productivity for 27 plant taxa, 2) reviewed earlier interpretation of pollen studies in terms of climate- and human-induced vegetation change, and 3) reviewed information on past land use from archaeological studies. REVEALS achieved a more realistic reconstruction of plant-cover change than pollen percentages in terms of openland versus woodland. The study suggests successive human-induced changes in vegetation cover. The first signs of human-induced land-cover change (crop cultivation, otherwise specified) are found c. 7 ka BP in the temperate deciduous forest, and S and NE Tibetan Plateau (mainly grazing, possibly crop cultivation), 6.5-6 ka BP in the temperate steppe and temperate desert (grazing, uncertain), and 5.5-5 ka BP in the coniferous-deciduous mixed forest, NE subtropical region, and NW Tibetan Plateau (grazing). Further intensification of anthropogenic land-cover change is indicated 5-4.5 ka BP in the E temperate steppe, and S and NE Tibetan Plateau (grazing, cultivation uncertain), 3.5-3 ka BP in S and NE Tibetan Plateau, W temperate steppe, temperate desert (grazing), and NW Tibetan Plateau (probably grazing), and 2.5-2 ka BP in the temperate deciduous forest, N subtropical region, and temperate desert (grazing). These changes generally agree with increased human activity as documented by archaeological studies. REVEALS reconstructions have a stronger potential than biomization to evaluate scenarios of anthropogenic land-cover change such as HYDE, given they are combined with information from archaeological studies.
  •  
39.
  • Mao, Jia, et al. (author)
  • A 90nm CMOS UHF/UWB asymmetric transceiver for RFID readers
  • 2011
  • In: European Solid-State Circuits Conference. ; , s. 179-182
  • Conference paper (other academic/artistic)abstract
    • This paper presents an integrated asymmetric transceiver in 90nm CMOS technology for RFID reader. The proposed reader uses UHF transmitter to power up and inventory the tags. In the reverse link, a non-coherent Ultra-wide Band (UWB) receiver is deployed for data reception with high throughput and ranging capability. The transmitter delivers 160 kb/s ASK modulated data by an integrated modulator and a Digital Controlled Oscillator (DCO) in UHF band with 11% tuning range. The DCO consume 6 mW with 0.12 mm2 area. On the other side, adopting two integration channels, the 3-5 GHz energy detection receiver supports maximum 33 Mb/s data rate both in OOK and PPM modulations. The receiver front-end provides 59 dB voltage gain and 8.5 dB noise figure (NF). Measurement results shows that the receiver achieves an input sensitivity of -79 dBm at 10 Mb/s, with power consumption of 15.5 mW.
  •  
40.
  • Mao, Jia, et al. (author)
  • A hybrid reader tranceiver design for industrial internet of things
  • 2016
  • In: Journal of Industrial Information Integration. - : Elsevier. - 2467-964X .- 2452-414X. ; 2, s. 19-29
  • Journal article (peer-reviewed)abstract
    • This paper presents an integrated asymmetric UHF/UWB reader transceiver in 90 nm CMOS technology for industrial enterprise IoT applications. The reader uses UHF transmitter to power up and inventory the tags. Instead of backscattering, tag replies the reader using Ultra-wideband (UWB) pulses, allowing high throughput transmission and precise positioning. Therefore, a UWB receiver is deployed in the proposed reader for data reception and Time-of-Arrival (ToA) estimation using energy detection schemes. The transmitter delivers 160 kb/s ASK modulated data by an integrated modulator and a Digital Controlled Oscillator (DCO). The DCO has 11% tuning range ability to cover different UHF signal channels. On the UWB receiver side, the 3–5 GHz energy detection receiver supports maximum 33 Mb/s data rate in both OOK and PPM modulations. The receiver front-end provides 59 dB voltage gain and 8.5 dB noise figure (NF). Measurement results shows that the receiver achieves an input sensitivity of -79 dBm at 10 Mb/s, and the power consumption of transceiver is 21.5 mW.
  •  
41.
  • Sarmiento M., David, et al. (author)
  • Analog front-end RX design for UWB impulse radio in 90nm CMOS
  • 2011
  • In: 2011 IEEE International Symposium of Circuits and Systems, ISCAS 2011. ; , s. 1552-1555
  • Conference paper (peer-reviewed)abstract
    • In this paper a reconfigurable differential Ultra Wideband-Impulse Radio (UWB-IR) energy receiver architecture has been simulated and implemented in UMC 90nm. The signal is amplified, rectified and integrated. By using an integration windowed scheme the SNR requirements are relaxed increasing the sensitivity. The design has been optimized for large bandwidths, low implementation area and configurability. The RX can be adapted to work at different data rates, processing gains, and channel environments. It works between the 3.1-4.8 GHz bands with OOK or PPM modulation with a tunable data rate up to 33Mb/s. In order to relax the ADC sampling time an interleave mode of operation has been implemented. It has a maximum power consumption of 22m W with a power supply of 1V. The complete RX occupies an area of 1.11mm2.
  •  
42.
  •  
43.
  • Wang, Deyu, et al. (author)
  • A Memristor-Based Learning Engine for Synaptic Trace-Based Online Learning
  • 2023
  • In: IEEE Transactions on Biomedical Circuits and Systems. - : Institute of Electrical and Electronics Engineers (IEEE). - 1932-4545 .- 1940-9990. ; 17:5, s. 1153-1165
  • Journal article (peer-reviewed)abstract
    • The memristor has been extensively used to facilitate the synaptic online learning of brain-inspired spiking neural networks (SNNs). However, the current memristor-based work can not support the widely used yet sophisticated trace-based learning rules, including the trace-based Spike-Timing-Dependent Plasticity (STDP) and the Bayesian Confidence Propagation Neural Network (BCPNN) learning rules. This paper proposes a learning engine to implement trace-based online learning, consisting of memristor-based blocks and analog computing blocks. The memristor is used to mimic the synaptic trace dynamics by exploiting the nonlinear physical property of the device. The analog computing blocks are used for the addition, multiplication, logarithmic and integral operations. By organizing these building blocks, a reconfigurable learning engine is architected and realized to simulate the STDP and BCPNN online learning rules, using memristors and 180 nm analog CMOS technology. The results show that the proposed learning engine can achieve energy consumption of 10.61 pJ and 51.49 pJ per synaptic update for the STDP and BCPNN learning rules, respectively, with a 147.03× and 93.61× reduction compared to the 180 nm ASIC counterparts, and also a 9.39× and 5.63× reduction compared to the 40 nm ASIC counterparts. Compared with the state-of-the-art work of Loihi and eBrainII, the learning engine can reduce the energy per synaptic update by 11.31× and 13.13× for trace-based STDP and BCPNN learning rules, respectively.
  •  
44.
  • Wang, Deyu, et al. (author)
  • Mapping the BCPNN Learning Rule to a Memristor Model
  • 2021
  • In: Frontiers in Neuroscience. - : Frontiers Media SA. - 1662-4548 .- 1662-453X. ; 15
  • Journal article (peer-reviewed)abstract
    • The Bayesian Confidence Propagation Neural Network (BCPNN) has been implemented in a way that allows mapping to neural and synaptic processes in the human cortexandhas been used extensively in detailed spiking models of cortical associative memory function and recently also for machine learning applications. In conventional digital implementations of BCPNN, the von Neumann bottleneck is a major challenge with synaptic storage and access to it as the dominant cost. The memristor is a non-volatile device ideal for artificial synapses that fuses computation and storage and thus fundamentally overcomes the von Neumann bottleneck. While the implementation of other neural networks like Spiking Neural Network (SNN) and even Convolutional Neural Network (CNN) on memristor has been studied, the implementation of BCPNN has not. In this paper, the BCPNN learning rule is mapped to a memristor model and implemented with a memristor-based architecture. The implementation of the BCPNN learning rule is a mixed-signal design with the main computation and storage happening in the analog domain. In particular, the nonlinear dopant drift phenomenon of the memristor is exploited to simulate the exponential decay of the synaptic state variables in the BCPNN learning rule. The consistency between the memristor-based solution and the BCPNN learning rule is simulated and verified in Matlab, with a correlation coefficient as high as 0.99. The analog circuit is designed and implemented in the SPICE simulation environment, demonstrating a good emulation effect for the BCPNN learning rule with a correlation coefficient as high as 0.98. This work focuses on demonstrating the feasibility of mapping the BCPNN learning rule to in-circuit computation in memristor. The feasibility of the memristor-based implementation is evaluated and validated in the paper, to pave the way for a more efficient BCPNN implementation, toward a real-time brain emulation engine.
  •  
45.
  • Wang, Ke, et al. (author)
  • 100 Gb/s RZ-OOK transmission through 212 km deployed SSMF using monolithically integrated ETDM receiver module
  • 2011
  • In: Optics Communications. - : Elsevier BV. - 0030-4018 .- 1873-0310. ; 284:3, s. 782-786
  • Journal article (peer-reviewed)abstract
    • 100 Gb/s on-off keying (OOK) transmission over 212 km installed standard single-mode fibers using an Indium Phosphide (InP)-based electrical clock-data-recovery (CDR) and demultiplexer module was demonstrated 5 5 x 10(-11) bit error rate (BER) performance was achieved and 11 dB optical signal-to-noise ratio (OSNR) penalty was required at 10(-9) BER after transmission
  •  
46.
  • Wang, L., et al. (author)
  • Design of wideband mixer and VGA for Software Defined Radio in RFID application
  • 2015
  • In: NORCHIP 2014 - 32nd NORCHIP Conference. - 9781479954421
  • Conference paper (peer-reviewed)abstract
    • This paper presents Software Defined Radio (SDR) in RFID sensing applications focusing on wideband mixer and VGA design. The wideband receiver can support UHF, UWB band for commonly used long-range RFID standards ranging from 400MHz to 6GHz. The wideband mixer is of folded topology with switching biased technique, achieving a maximum 11.5dB conversion gain with only an 8dB DSB noise figure and 16dB flicker noise at 10kHz. The VGA utilizes a four-stage modified Cherry-Hopper amplifier, along with DC-offset cancelling and common-mode feedback. A maximum gain of 67dB can be achieved with more than 600MHz of bandwidth. The design is implemented in a 65nm CMOS process. The total power consumption of the mixer and the VGA is 7mW by simulation. The die area of these two blocks is 0.045mm2.
  •  
47.
  • Wang, T., et al. (author)
  • Architectural design of radiation-hardened SOC solution for nanosatellite power management
  • 2015
  • In: Proceedings of the International Astronautical Congress, IAC. - : International Astronautical Federation. - 9781510818934 ; , s. 7171-7174
  • Conference paper (peer-reviewed)abstract
    • With the rapid development of nanosatellite industry, adaptive and ultra-small-scale power management system is demanded for maintenance and sustainable use of space power supply. Radiation-tolerant System-on-Chip (SoC) technology has been recognized as a promising solution but challenges still exist. In this paper, we present a comprehensive architectural design of SoC power solution for nanosatellite applications including space-level 16-bit processor, 8-channel ADC, precision amplifiers, interface units etc. Based on antiradiation requirements, we customize three application scenarios for nanosatellite. It comprises reconfigurable architecture, fault tolerance strategy and in-orbit calibration strategy. The space-level processor named FC-4065 uses these anti-irradiation solutions after Total Ionizing Dose (TID) and Single Event Upset (SEU) tests. Then, by exsiting radiation-tolerant SoC platform, optimized nanosatellite power conditioning procedures are proposed. The modularized power management system is composed of Main Error Amplifier (MEA) IP, Pulse Width Modulation (PWM) IP, Battery Balancing (BB) IP, S3R IP and other soft IP cores. This microsystem can monitor and control the entire nanosatellite power modules without manual operations. Finally, TID trial is carried out in the Shanghai Institute of Applied Physics in China. Practical stability and accuracy of SoC architectures are proven, and suggestions for future nanosatellite power development are discussed based on the spaceflight missions.
  •  
48.
  • Wu, Shi-Xun, et al. (author)
  • Expression profiles of genes involved in apoptosis and selenium metabolism in articular cartilage of patients with Kashin-Beck osteoarthritis.
  • 2014
  • In: Gene. - : Elsevier. - 0378-1119 .- 1879-0038. ; 535:2, s. 124-130
  • Journal article (peer-reviewed)abstract
    • Kashin-Beck disease (KBD) is a special type of endemic osteoarthritis. It has been suggested that alterations in selenium metabolism and apoptosis play a role in KBD. However, the underlying molecular mechanism remains largely unclear. We performed a microarray analysis using RNA isolated from cartilages of KBD patients and healthy controls, through Significance Analysis of Microarray (SAM) software. Functional gene networks and crucial molecules associated with differentially expressed genes were investigated via Ingenuity Pathway Analysis (IPA) and hub gene analysis. Quantitative real-time PCR was used to check the validation of chip test. We identified 52 up-regulated apoptosis-related genes and 26 down-regulated selenium-related genes between KBD and controls, and these genes associated with the "MYC-mediated apoptosis signaling pathway". We confirmed the results from array studies with quantitative real-time PCR analysis. Our results suggest that abnormal regulation of selenium metabolism and apoptosis through the MYC mediated signaling pathway contributes to the pathogenesis of KBD, but the relationship between apoptosis gene and selenium gene was not found.
  •  
49.
  • Xing, Ji, et al. (author)
  • Scaling analysis and evaluation for the design of integral test facility of HPR1000 containment (PANGU)
  • 2021
  • In: Nuclear Engineering and Design. - : Elsevier BV. - 0029-5493 .- 1872-759X. ; 373
  • Journal article (peer-reviewed)abstract
    • This paper summarized the key aspects of the scaling analysis method adopted in the design of the integral test facility for the containment of HPR1000-an advanced pressurized water reactor featuring both active and passive safety systems in reactor coolant (RCS) and containment. Based on the existing scaling analysis methods for complicated thermal-hydraulic systems, i.e. Hierarchical Two-Tiered Scaling (H2TS) method and Three-Level Scaling method, the present study developed a specific scaling analysis method which did not only provide theoretical derivation of scaling parameters and ratios, but also implemented the scaling criteria in the engineering design of the HPR1000 containment integral test facility (PANGU), with an evaluation of distortions in the final design. This approach allowed the theoretical scaling parameters can be reasonably adjusted to meet the boundary limits/conditions of the facility design. The scaling analysis and evaluation of so-designed test facility ensured the experimental results are applicable to verify the safety functions of the HPR1000 containment coping with representative accident scenarios.
  •  
50.
  • Xu, Jiawei, et al. (author)
  • A Memristor Model with Concise Window Function for Spiking Brain-Inspired Computation
  • 2021
  • In: 3rd IEEE International Conference on Artificial Intelligence Circuits and Systems, AICAS. - : Institute of Electrical and Electronics Engineers (IEEE).
  • Conference paper (peer-reviewed)abstract
    • This paper proposes a concise window function to build a memristor model, simulating the widely-observed non-linear dopant drift phenomenon of the memristor. Exploiting the non-linearity, the memristor model is applied to the in-situ neuromorphic solution for a cortex-inspired spiking neural network (SNN), spike-based Bayesian Confidence Propagation Neural Network (BCPNN). The improved memristor model utilizing the proposed window function is able to retain the boundary effect and resolve the boundary lock and inflexibility problem, while it is simple in form that can facilitate large-scale neuromorphic model simulation. Compared with the state-of-the-art general memristor model, the proposed memristor model can achieve a 5.8x reduction of simulation time at a competitive fitting level in cortex-comparable large-scale software simulation. The evaluation results show an explicit similarity between the non-linear dopant drift phenomenon of the memristor and the BCPNN learning rule, and the memristor model is able to emulate the key traces of BCPNN with a correlation coefficient over 0.99.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-50 of 61
Type of publication
journal article (47)
conference paper (11)
research review (2)
other publication (1)
Type of content
peer-reviewed (58)
other academic/artistic (3)
Author/Editor
Li, S. (17)
Zhu, J. (17)
Zhou, Y. (17)
Silvermyr, D. (16)
Stenlund, Evert (16)
Kretz, M. (16)
show more...
Yamaguchi, Y. (16)
Yang, H. (16)
Zaman, A. (16)
Zhang, H. (16)
Zhang, X. (16)
Zhu, H. (16)
Ferencei, J. (16)
Weber, M. (16)
Gupta, A. (16)
Zhang, Y. (16)
Sharma, S. (16)
Podesta-Lerma, P. L. ... (16)
Yang, S. (16)
Roy, P. (16)
Adamova, D. (16)
Ahammed, Z. (16)
Ahmad, N. (16)
Ahn, S. U. (16)
Akindinov, A. (16)
Aleksandrov, D. (16)
Alessandro, B. (16)
Alici, A. (16)
Alme, J. (16)
Altinpinar, S. (16)
Andrei, C. (16)
Andronic, A. (16)
Anticic, T. (16)
Antinori, F. (16)
Antonioli, P. (16)
Aphecetche, L. (16)
Arcelli, S. (16)
Armesto, N. (16)
Arnaldi, R. (16)
Aronsson, T. (16)
Arsene, I. C. (16)
Augustinus, A. (16)
Averbeck, R. (16)
Awes, T. C. (16)
Azmi, M. D. (16)
Bach, M. (16)
Badala, A. (16)
Baek, Y. W. (16)
Bagnasco, S. (16)
Bailhache, R. (16)
show less...
University
Royal Institute of Technology (23)
Lund University (20)
Karolinska Institutet (8)
Uppsala University (5)
Stockholm University (5)
Umeå University (3)
show more...
Linköping University (2)
University of Gothenburg (1)
Örebro University (1)
Chalmers University of Technology (1)
Linnaeus University (1)
Swedish Museum of Natural History (1)
Swedish University of Agricultural Sciences (1)
show less...
Language
English (61)
Research subject (UKÄ/SCB)
Natural sciences (26)
Engineering and Technology (19)
Medical and Health Sciences (9)
Social Sciences (3)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view