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- Sioutas, Apostolos, et al.
(author)
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Oxidant-induced autophagy and ferritin degradation contribute to epithelial-mesenchymal transition through lysosomal iron
- 2017
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In: Journal of Inflammation Research. - : Dove Medical Press. - 1178-7031. ; 10, s. 29-39
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Journal article (peer-reviewed)abstract
- Transforming growth factor (TGF)-ß1 triggers epithelial-mesenchymal transition (EMT) through autophagy, which is partly driven by reactive oxygen species (ROS). The aim of this study was to determine whether leaking lysosomes and enhanced degradation of H-ferritin could be involved in EMT and whether it could be possible to prevent EMT by iron chelation targeting of the lysosome.
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