| 1. |
- Abbafati, Cristiana, et al.
(author)
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- 2020
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Journal article (peer-reviewed)
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| 2. |
- Bahrami, Behdokht, et al.
(author)
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Folate-conjugated nanoparticles as a potent therapeutic approach in targeted cancer therapy
- 2015
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In: Tumor Biology. - Stockholm : Karolinska Institutet, Dept of Oncology-Pathology. - 1423-0380 .- 1010-4283.
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Journal article (peer-reviewed)abstract
- The selective and efficient drug delivery to tumor cells can remarkably improve different cancer therapeutic approaches. There are several nanoparticles (NPs) which can act as a potent drug carrier for cancer therapy. However, the specific drug delivery to cancer cells is an important issue which should be considered before designing new NPs for in vivo application. It has been shown that cancer cells over-express folate receptor (FR) in order to improve their growth. As normal cells express a significantly lower levels of FR compared to tumor cells, it seems that folate molecules can be used as potent targeting moieties in different nanocarrier-based therapeutic approaches. Moreover, there is evidence which implies folate-conjugated NPs can selectively deliver anti-tumor drugs into cancer cells both in vitro and in vivo. In this review, we will discuss about the efficiency of different folate-conjugated NPs in cancer therapy.
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| 3. |
- Mohammadi Amirabad, Leila, et al.
(author)
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Improved antifungal activity and stability of chitosan nanofibers using cellulose nanocrystal on banknote papers
- 2018
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In: Carbohydrate Polymers. - : Elsevier. - 0144-8617 .- 1879-1344. ; 189, s. 229-237
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Journal article (peer-reviewed)abstract
- Microorganisms can spread on the surface of banknotes and cause many infectious diseases. Chitosan nanofibers (CNFs) and cellulose nanocrystals (CNCs) are nanomaterials, which can affect the antimicrobial properties. In this study, the fungal species that grew on the surfaces of collected banknotes from different places were identified. To examine the antifungal effect of the both nanomaterials on the banknotes, the stable coatings using CNFs and CNCs emulsions were prepared by roller coating. The results revealed that the most colonies in the banknotes obtained from the bakeries and butcheries were Aspergillus sp., whereas the colonies in bus terminals and the hospitals were Aspergillus niger and Penicillium, respectively. The results showed that the CNCs had no antifungal effect alone on the aforementioned species, but it could improve the antifungal effect, adhesion, and stability of CNFs on the banknote surfaces. This study suggested a new approach to decrease the infection spreads through banknotes.
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| 4. |
- Yousefi, Ali, et al.
(author)
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Modulation of turbulence by finite-size particles in statistically steady-state homogeneous shear turbulence
- 2020
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In: Journal of Fluid Mechanics. - : Cambridge University Press (CUP). - 0022-1120 .- 1469-7645. ; 899
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Journal article (peer-reviewed)abstract
- We perform interface-resolved simulations to study the modulation of statistically steady-state homogeneous shear turbulence by neutrally buoyant finite-size particles. We consider two shapes, spheres and oblates, and various solid volume fractions, up to 20%. The results show that a statistically steady state is not exclusive to single-phase homogeneous shear turbulence as the production and dissipation rates of the turbulent kinetic energy are also statistically in balance in particle-laden cases. The turbulent kinetic energy shows a non-monotonic behaviour with increasing solid volume fraction: increasing turbulence attenuation up to a certain concentration of solid particles and then enhancement of the turbulent kinetic energy at higher concentrations. This behaviour is observed at lower volume fractions for oblate particles than for spheres. The attenuation of the turbulence activity at lower volume fractions is explained through the enhancement of the dissipation rate close to the surface of particles. At higher volume fractions, however, particle pair interactions induce regions of high Reynolds shear stress, resulting in the enhancement of the turbulence activity. We show that the oblate particles of the considered size have larger rotational rates than spheres with no preferential orientation. This is in contrast to previous studies in wall-bounded flows where preferential orientation close to the wall and reduced rotation rates result in turbulence attenuation and thus drag reduction. Our results shed some light on the effect of rigid particles, smaller than the near-wall turbulent structures but still comparable to the viscous length scale, on the dynamics of the equilibrium logarithmic layer in wall-bounded flows.
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| 5. |
- Yousefi, Ali, et al.
(author)
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Regimes of heat transfer in finite-size particle suspensions
- 2021
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In: International Journal of Heat and Mass Transfer. - : Elsevier BV. - 0017-9310 .- 1879-2189. ; 177, s. 121514-121514
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Journal article (peer-reviewed)abstract
- We present results of interface-resolved simulations of heat transfer in suspensions of finite-size neutrally-buoyant spherical particles for solid volume fractions up to 35% and bulk Reynolds numbers from 500 to 5600. An Immersed Boundary-Volume of Fluid method is used to solve the energy equation in the fluid and solid phase.We relate the heat transfer to the regimes of particle motion previously identified, i.e. a viscous regime at low volume fractions and low Reynolds number, particle-laden turbulence at high Reynolds and moderate volume fraction and particulate regime at high volume fractions. We show that in the viscous dominated regime, the heat transfer is mainly due to thermal diffusion with enhancement due to the particle-induced fluctuations. In the turbulent-like regime, we observe the largest enhancement of the global heat transfer, dominated by the turbulent heat flux. In the particulate shear-thickening regime, however, the heat transfer enhancement decreases as mixing is quenched by the particle migration towards the channel core. As a result, a compact loosely-packed core region forms and the contribution of thermal diffusion to the total heat transfer becomes significant once again. The global heat transfer becomes, in these flows at volume fractions larger than 25%, lower than in single phase turbulence.
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| 6. |
- Yousefi, Fazilat, et al.
(author)
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Mineral chemistry and P-T conditions of the adakitic rocks from Torud–Ahmad Abad magmatic belt, S-SE Shahrood, NE Iran
- 2017
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In: Journal of Geochemical Exploration. - : Elsevier. - 0375-6742 .- 1879-1689. ; 182:A, s. 110-120
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Journal article (peer-reviewed)abstract
- Torud-Ahmad Abad magmatic belt is located 175 km east and southeast of Shahrood in the northern part of the Central Iran Structural Zone and includes a thick sequence of Paleocene to middle Eocene volcanic and volcanosedimentary rocks. This magmatic belt was formed by numerous hypabyssal igneous adakitic domes constituting basaltic andesite, andesite, trachyandesite, dacite, trachydacite, and dacite. The investigated rocks are mainly composed of pyroxene, amphibole, and plagioclase, with minor biotite and opaque minerals. Mineral chemical analysis reveals that plagioclase composition varies from albite to labradorite, clinopyroxene varies from diopside to augite, and amphibole varies from Mg-hastingsite to Mg-hornblende.Amphibole geothermobarometry suggests crystallization temperatures of 850–1050 °C, at 2–6 kbar and the temperature of 920–970 °C, at a pressure of 3–4.5 kbar, which are conditions in agreement with andesite and dacite formation. Clinopyroxene crystallized at temperatures of 1020–1170 °C, at 2–10 kbar, indicating crystallization at crustal depths of maximum 30 km for the studied intrusive rocks in the Torud-Ahmad Abad magmatic belt.
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| 7. |
- Yousefi, Mehdi, et al.
(author)
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The skewed balance between regulatory T cells and Th17 in chronic lymphocytic leukemia
- 2015
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In: Future Oncology. - Stockholm : Karolinska Institutet, Dept of Oncology-Pathology. - 1479-6694 .- 1744-8301.
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Journal article (peer-reviewed)abstract
- While Tregs maintain self-tolerance and inhibit antitumor responses, T helper (Th)17 cells may enhance inflammatory and antitumor responses. The balance between these two important T-cell subsets has been skewed in many immunopathologic conditions such as autoimmune and cancer diseases. B-cell chronic lymphocytic leukemia (CLL) is the most common form of leukemia in the western world and is characterized with monoclonal expansion of B lymphocytes. There is evidence which implies that the progression of CLL is associated with expansion of Treg and downregulation of Th17 cells. In this review, we will discuss about immunobiology of Treg and Th17 cells and their role in immunopathogenesis of CLL as well as their reciprocal changes during disease progression.
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