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1.
  • Klionsky, Daniel J., et al. (author)
  • Guidelines for the use and interpretation of assays for monitoring autophagy
  • 2012
  • In: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 8:4, s. 445-544
  • Research review (peer-reviewed)abstract
    • In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. A key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process vs. those that measure flux through the autophagy pathway (i.e., the complete process); thus, a block in macroautophagy that results in autophagosome accumulation needs to be differentiated from stimuli that result in increased autophagic activity, defined as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (in most higher eukaryotes and some protists such as Dictyostelium) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the field understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field.
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2.
  • de Nooijer, Wesley, et al. (author)
  • Evaluation of Arctic warming in mid-Pliocene climate simulations
  • 2020
  • In: Climate of the Past. - : Copernicus GmbH. - 1814-9324 .- 1814-9332. ; 16:6, s. 2325-2341
  • Journal article (peer-reviewed)abstract
    • Palaeoclimate simulations improve our understanding of the climate, inform us about the performance of climate models in a different climate scenario, and help to identify robust features of the climate system. Here, we analyse Arctic warming in an ensemble of 16 simulations of the mid-Pliocene Warm Period (mPWP), derived from the Pliocene Model Intercomparison Project Phase 2 (PlioMIP2). The PlioMIP2 ensemble simulates Arctic (60-90 degrees N) annual mean surface air temperature (SAT) increases of 3.7 to 11.6 degrees C compared to the pre-industrial period, with a multimodel mean (MMM) increase of 7.2 degrees C. The Arctic warming amplification ratio relative to global SAT anomalies in the ensemble ranges from 1.8 to 3.1 (MMM is 2.3). Sea ice extent anomalies range from -3.0 to -10.4 x 10(6) km(2), with a MMM anomaly of -5.6 x 10 6 km(2), which constitutes a decrease of 53 % compared to the pre-industrial period. The majority (11 out of 16) of models simulate summer seaice-free conditions (<= 1 x 10(6) km(2)) in their mPWP simulation. The ensemble tends to underestimate SAT in the Arctic when compared to available reconstructions, although the degree of underestimation varies strongly between the simulations. The simulations with the highest Arctic SAT anomalies tend to match the proxy dataset in its current form better. The ensemble shows some agreement with reconstructions of sea ice, particularly with regard to seasonal sea ice. Large uncertainties limit the confidence that can be placed in the findings and the compatibility of the different proxy datasets. We show that while reducing uncertainties in the reconstructions could decrease the SAT data-model discord substantially, further improvements are likely to be found in enhanced boundary conditions or model physics. Lastly, we compare the Arctic warming in the mPWP to projections of future Arctic warming and find that the PlioMIP2 ensemble simulates greater Arctic amplification than CMIP5 future climate simulations and an increase instead of a decrease in Atlantic Meridional Overturning Circulation (AMOC) strength compared to pre-industrial period. The results highlight the importance of slow feedbacks in equilibrium climate simulations, and that caution must be taken when using simulations of the mPWP as an analogue for future climate change.
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3.
  • Fu, Yunfei, et al. (author)
  • Fundamental Characteristics of Tropical Rain Cell Structures as Measured by TRMM PR
  • 2020
  • In: Journal of Meteorological Research. - : Springer Science and Business Media LLC. - 2095-6037 .- 2198-0934. ; 34:6, s. 1129-1150
  • Journal article (peer-reviewed)abstract
    • Rain cells are the most elementary unit of precipitation system in nature. In this study, fundamental geometric and physical characteristics of rain cells over tropical land and ocean areas are investigated by using 15-yr measurements of the Tropical Rainfall Measuring Mission (TRMM) Precipitation Radar (PR). The rain cells are identified with a minimum bounding rectangle (MBR) method. The results indicate that about 50% of rain cells occur at length of about 20 km and width of 15 km. The proportion of rain cells with length > 200 km and width > 100 km is less than 1%. There is a a log-linear relationship between the mean length and width of rain cells. Usually, for the same horizontal geometric parameters, rain cells tend to be square horizontally and lanky vertically over land, while vertically squatty over ocean. The rainfall intensity of rain cells varies from 0.4 to 10 mm h(-1) over land to 0.4-8 mm h(-1) over ocean. Statistical results indicate that the occurrence frequency of rain cells decreases as the areal fraction of convective precipitation in rain cells increases, while such frequency remains almost invariant when the areal fraction of stratiform precipitation varies from 10% to 80%. The relationship between physical and geometric parameters of rain cells shows that the mean rain rate of rain cells is more frequently associated with the increase of their area, with the increasing rate over land greater than that over ocean. The results also illustrate that heavy convective rain rate prefers to occur in larger rain cells over land while heavy stratiform rain rate tends to appear in larger rain cells over ocean. For the same size of rain cells, the areal fraction and the contribution of convective precipitation are about 10%-15% higher over land than over ocean.
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4.
  • Han, Ning, et al. (author)
  • Achieving Efficient Electrocatalytic Oxygen Evolution in Acidic Media on Yttrium Ruthenate Pyrochlore through Cobalt Incorporation
  • 2023
  • In: Advanced Functional Materials. - : Wiley. - 1616-301X .- 1616-3028. ; 33:20
  • Journal article (peer-reviewed)abstract
    • The development of electrocatalysts for the oxygen evolution reaction (OER) especially in acidic media remains the major challenge that still requires significant advances, both in material design and mechanistic exploration. In this study, the incorporation of cobalt in Y2-xCoxRu2O7−δ results in an ultrahigh OER activity because of the charge redistribution at eg orbitals between Ru and Co atoms. The Y1.75Co0.25Ru2O7−δ electrocatalyst exhibits an extremely small overpotential of 275 mV in 0.5 m H2SO4 at the current density of 10 mA cm−2, which is smaller than that of parent Y2Ru2O7−δ (360 mV) and commercial RuO2 (286 mV) catalysts. The systematic investigation of the composition related to OER activity shows that the Co substitution will also bring other effective changes, such as reducing the bandgap, and creating oxygen vacancies, which result in fast OER charge transfer. Meanwhile, the strengthening of the bond hybridization between the d orbitals of metal (Y and Ru) and the 2p orbitals of O will intrinsically enhance the chemical stability. Finally, theoretical calculations indicate that cobalt substitution reduces the theoretical overpotential both through an adsorbate evolution mechanism and a lattice oxygen-mediated mechanism.
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5.
  • Hu, Zhang-Jun, et al. (author)
  • A TPA-caged precursor of (imino)coumarin for "turn-on" fluorogenic detection of Cu
  • 2016
  • In: Analytica Chimica Acta. - : ELSEVIER SCIENCE BV. - 0003-2670 .- 1873-4324. ; 933, s. 189-195
  • Journal article (peer-reviewed)abstract
    • We strategize to utilize the precursors of (imino) coumarin fluorophores to deliver novel reactive Cu+ probes, where tris[(2-pyridyl)-methyl] amine (TPA) works as a reactive receptor towards Cu+. To verify this strategy, CP1, a representative probe and relevant sensing behaviors towards Cu+ are presented here. CP1 features good solubility and fast response for monitoring labile copper in aqueous solution and live cells. The sensing mechanism of CP1 is determined by HPLC titration and mass spectrometric analysis. The probe CP1 exhibits a 60-fold fluorescence enhancement and a detection limitation of 10.8 nM upon the detection of Cu+. CP1 is further applied for imaging labile copper in live cells. This work provides a starting point for future development of Cu+ probes, based on in situ formation of (imino) coumarin scaffolds, as well as their further investigations of copper signaling and biological events. (C) 2016 Elsevier B.V. All rights reserved.
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6.
  • Kageyama, Masa, et al. (author)
  • The PMIP4 contribution to CMIP6-Part 4 : Scientific objectives and experimental design of the PMIP4-CMIP6 Last Glacial Maximum experiments and PMIP4 sensitivity experiments
  • 2017
  • In: Geoscientific Model Development. - : Copernicus GmbH. - 1991-959X .- 1991-9603. ; 10:11, s. 4035-4055
  • Journal article (peer-reviewed)abstract
    • The Last Glacial Maximum (LGM, 21 000 years ago) is one of the suite of paleoclimate simulations included in the current phase of the Coupled Model Intercomparison Project (CMIP6). It is an interval when insolation was similar to the present, but global ice volume was at a maximum, eustatic sea level was at or close to a minimum, greenhouse gas concentrations were lower, atmospheric aerosol loadings were higher than today, and vegetation and land-surface characteristics were different from today. The LGM has been a focus for the Paleoclimate Modelling Intercomparison Project (PMIP) since its inception, and thus many of the problems that might be associated with simulating such a radically different climate are well documented. The LGM state provides an ideal case study for evaluating climate model performance because the changes in forcing and temperature between the LGM and pre-industrial are of the same order of magnitude as those projected for the end of the 21st century. Thus, the CMIP6 LGM experiment could provide additional information that can be used to constrain estimates of climate sensitivity. The design of the Tier 1 LGM experiment (lgm) includes an assessment of uncertainties in boundary conditions, in particular through the use of different reconstructions of the ice sheets and of the change in dust forcing. Additional (Tier 2) sensitivity experiments have been designed to quantify feedbacks associated with land-surface changes and aerosol loadings, and to isolate the role of individual forcings. Model analysis and evaluation will capitalize on the relative abundance of paleoenvironmental observations and quantitative climate reconstructions already available for the LGM.
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7.
  • Li, Cai, et al. (author)
  • Two Antarctic penguin genomes reveal insights into their evolutionary history and molecular changes related to the Antarctic environment
  • 2014
  • In: GigaScience. - 2047-217X. ; 3
  • Journal article (peer-reviewed)abstract
    • Background: Penguins are flightless aquatic birds widely distributed in the Southern Hemisphere. The distinctive morphological and physiological features of penguins allow them to live an aquatic life, and some of them have successfully adapted to the hostile environments in Antarctica. To study the phylogenetic and population history of penguins and the molecular basis of their adaptations to Antarctica, we sequenced the genomes of the two Antarctic dwelling penguin species, the Adelie penguin [Pygoscelis adeliae] and emperor penguin [Aptenodytes forsteri]. Results: Phylogenetic dating suggests that early penguins arose similar to 60 million years ago, coinciding with a period of global warming. Analysis of effective population sizes reveals that the two penguin species experienced population expansions from similar to 1 million years ago to similar to 100 thousand years ago, but responded differently to the climatic cooling of the last glacial period. Comparative genomic analyses with other available avian genomes identified molecular changes in genes related to epidermal structure, phototransduction, lipid metabolism, and forelimb morphology. Conclusions: Our sequencing and initial analyses of the first two penguin genomes provide insights into the timing of penguin origin, fluctuations in effective population sizes of the two penguin species over the past 10 million years, and the potential associations between these biological patterns and global climate change. The molecular changes compared with other avian genomes reflect both shared and diverse adaptations of the two penguin species to the Antarctic environment.
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8.
  • Lin, Qing, et al. (author)
  • Exosome-like nanoplatform modified with targeting ligand improves anti-cancer and anti-inflammation effects of imperialine
  • 2019
  • In: Journal of Controlled Release. - : ELSEVIER. - 0168-3659 .- 1873-4995. ; 311, s. 104-116
  • Journal article (peer-reviewed)abstract
    • Currently, most anti-cancer therapies are still haunted by serious and deleterious adverse effects. Here, we report a highly biocompatible tumor cell-targeting delivery systems utilizing exosome-like vesicles (ELVs) that delivers a low-toxicity anti-cancer agent imperialine against non-small cell lung cancer (NSCLC). First, we introduced a novel micelle-aided method to efficiently load imperialine into intact ELVs. Then, integrin alpha 3 beta 1-binding octapeptide cNGQGEQc was modified onto ELV platform for tumor targeting as integrin alpha 3 beta 1 is overexpressed on NSCLC cells. This system not only significantly improved imperialine tumor accumulation and retention, but also had extremely low systemic toxicity both in vitro and in vivo. Our discoveries offer new ways to utilize ELV more efficiently for both drug loading and targeting. The solid pharmacokinetics improvement and extraordinary safety of this system also highlight possibilities of alternative long course cancer therapies using similar strategies.
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9.
  • Wang, Zhenqian, et al. (author)
  • Northward migration of the East Asian summer monsoon northern boundary during the twenty-first century
  • 2022
  • In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 12
  • Journal article (peer-reviewed)abstract
    • The northern fringe area of the East Asian summer monsoon (EASM) between arid and semiarid regions is a fragile eco-environment zone and ecological transition zone, and it is highly sensitive to climate change. Predicting the future migration of the northern boundary of the EASM is important for understanding future East Asian climate change and formulating of decisions on ecological protection and economic development in arid and semiarid regions. The reanalysis dataset and simulations of 23 models from the Coupled Models Intercomparison Project Phase 6 (CMIP6) were used to investigate the response of the boundary of the ESAM to the global warming. The multi-model ensemble showed a northwestward migration of the EASM northern boundary during the near-term (2020–2060) and late-term (2061–2099) of the twenty-first century under various Shared Socioeconomic Pathways (SSPs). The northern boundary migrated northwestward by 23–28 and 74–76 km in the near-term and late-term respectively, under SSP1-2.6, 2-4.5 and 3-7.0 and by ~ 44 km and ~ 107 km respectively during the near-term and late-term under SSP5-8.5. During the twenty-first century, under various SSPs, the surface of the East Asian subcontinent warmed more than the ocean, thereby increasing the contrast of near-surface temperature and sea level pressure in summer between the East Asian subcontinent and the surrounding oceans. In turn, the intensified land–sea thermal contrast reinforced the EASM meridional circulation and thus transported more moisture from the Indian Ocean into northern China. Additionally, a poleward migration and weakening of the East Asian subtropical westerly jet would also favor an increase in precipitation, eventually caused a northwestward migration of the EASM northern boundary. The results suggest that the arid and semiarid ecotone will become wetter, which could dramatically improve the eco-environment in the future.
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10.
  • Xu, Guobao, et al. (author)
  • Tree ring O-18's indication of a shift to a wetter climate since the 1880s in the western Tianshan Mountains of northwestern China
  • 2015
  • In: Journal of Geophysical Research - Atmospheres. - 2169-897X .- 2169-8996. ; 120:13, s. 6409-6425
  • Journal article (peer-reviewed)abstract
    • Central Asian droughts have drastically and significantly affected agriculture and water resource management in these arid and semiarid areas. Based on tree ring O-18 from native, dominant Schrenk spruce (Picea schrenkiana Fisch. et Mey.), we developed a 300year (1710-2010) standard precipitation-evaporation index (SPEI) reconstruction from January to August for China's western Tianshan Mountains. The regression model explained 37.6% of the variation in the SPEI reconstruction during the calibration period from 1950 to 2010. Comparison with previous drought reconstructions confirmed the robustness of our reconstruction. The 20th century has been a relatively wet period during the past 300years. The SPEI showed quasi 2, 5, and 10year cycles. Several pluvials and droughts with covariability over large areas were revealed clearly in the reconstruction. The two longest pluvials (lasting for 12years), separated by 50years, appeared in the 1900s and the 1960s. The most severe drought occurred from 1739 to 1761 and from 1886 to 1911 was the wettest period since 1710. Compared to previous investigations of hydroclimatic changes in the western Tianshan Mountains, our reconstruction revealed more low-frequency variability and indicated that climate in the western Tianshan Mountains shifted from dry to wet in 1886. This regime shift was generally consistent with other moisture reconstructions for the northeastern Tibetan Plateau and northern Pakistan and may have resulted from a strengthened westerly circulation. The opposite hydrological trends in the western Tianshan Mountains and southeastern Tibetan Plateau reveal a substantial influence of strengthened westerlies and weakening of the Indian summer monsoon.
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11.
  • Zhang, Aoqi, et al. (author)
  • Structure of Cyclonic Precipitation in the Northern Pacific Storm Track Measured by GPM DPR
  • 2020
  • In: Journal of Hydrometeorology. - 1525-755X .- 1525-7541. ; 21:2, s. 227-240
  • Journal article (peer-reviewed)abstract
    • Despite the long existence of theoretical studies, few statistical studies of precipitation characteristics on the northern Pacific storm track have been reported due to lack of observation. Using data from GPM DPR and ERA-Interim, we examined the precipitation features of extratropical cyclones in the northern Pacific storm-track region. Extratropical cyclones were classified into four categories including developing, mature, dissipating, and short-term based on their life stages. Our results show that extratropical cyclones of all categories had a comma rainband and precipitation mostly occurred to the east of the cyclonic center. The extratropical cyclones promote precipitation to the east of their centers, but suppress precipitation to the west. Precipitation to the east of the extratropical cyclones had larger and more condensed droplets, a stronger intensity, and a higher rain top than the local seasonal average, while the opposite characteristics were seen to the west. Our results suggest that the different types of vertical air motion and moisture content in these two regions induced by the frontal structure of extratropical cyclones play important roles in the different impact of extratropical cyclones. Furthermore, the different life stages of extratropical cyclones had different degrees of impact on precipitation: the highest impact in the developing stage, followed by the mature stage, and the weakest impact in the dissipating stage.
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12.
  • Zhang, Qiong, et al. (author)
  • NIR-region two-photon fluorescent probes for Fe3+/Cu2+ ions based on pyrimidine derivatives with different flexible chain
  • 2016
  • In: Sensors and actuators. B, Chemical. - : ELSEVIER SCIENCE SA. - 0925-4005 .- 1873-3077. ; 222, s. 574-578
  • Journal article (peer-reviewed)abstract
    • Two novel NIR-region two-photon fluorescent probes CCP and COP, show strong fluorescence quenching and good ratiometric responses toward Fe3+ and Cu2+, respectively; and their two-photon fluorescence are reversible by the subsequent addition of EDTA. CCP and COP are valuable candidates for two-photon imaging in the biological transparency window. (C) 2015 Elsevier B.V. All rights reserved.
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13.
  • An, Wenling, et al. (author)
  • Enhanced Recent Local Moisture Recycling on the Northwestern Tibetan Plateau Deduced From Ice Core Deuterium Excess Records
  • 2017
  • In: Journal of Geophysical Research - Atmospheres. - 2169-897X .- 2169-8996. ; 122:23, s. 12541-12556
  • Journal article (peer-reviewed)abstract
    • Local moisture recycling plays an essential role in maintaining an active hydrological cycle of the Tibetan Plateau (TP). Previous studies were largely limited to the seasonal time scale due to short and sparse observations, especially for the northwestern TP. In this study, we used a two-component mixing model to estimate local moisture recycling over the past decades from the deuterium excess records of two ice cores (i.e., Chongce and Zangser Kangri) from the northwestern TP. The results show that on average almost half of the precipitation on the northwestern TP is provided by local moisture recycling. In addition, the local moisture recycling ratio has increased evidently on the northwestern TP, suggesting an enhanced hydrological cycle. This recent increase could be due to the climatic and environmental changes on the TP in the past decades. Rapid increases in temperature and precipitation have enhanced evaporation. Changes of land surface of plateau have significantly increased evapotranspiration. All of these have intensified local moisture recycling. However, the mixing model used in this study only includes a limited number of climate factors. Some of the extreme values of moisture recycling ratio could be caused by large-scale atmospheric circulation and other climatic and weather events. Moreover, the potential mechanisms for the increase in local recycling need to be further examined, since the numeric simulations from climate models did not reproduce the increased contribution of local moisture recycling in precipitation.
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14.
  • Berntell, Ellen, et al. (author)
  • Mid-Pliocene West African Monsoon rainfall as simulated in the PlioMIP2 ensemble
  • 2021
  • In: Climate of the Past. - : Copernicus GmbH. - 1814-9324 .- 1814-9332. ; 17:4, s. 1777-1794
  • Journal article (peer-reviewed)abstract
    • The mid-Pliocene warm period (mPWP; ∼3.2 million years ago) is seen as the most recent time period characterized by a warm climate state, with similar to modern geography and ∼400 ppmv atmospheric CO2 concentration, and is therefore often considered an interesting analogue for near-future climate projections. Paleoenvironmental reconstructions indicate higher surface temperatures, decreasing tropical deserts, and a more humid climate in West Africa characterized by a strengthened West African Monsoon (WAM). Using model results from the second phase of the Pliocene Modelling Intercomparison Project (PlioMIP2) ensemble, we analyse changes of the WAM rainfall during the mPWP by comparing them with the control simulations for the pre-industrial period. The ensemble shows a robust increase in the summer rainfall over West Africa and the Sahara region, with an average increase of 2.5 mm/d, contrasted by a rainfall decrease over the equatorial Atlantic. An anomalous warming of the Sahara and deepening of the Saharan Heat Low, seen in >90 % of the models, leads to a strengthening of the WAM and an increased monsoonal flow into the continent. A similar warming of the Sahara is seen in future projections using both phase 3 and 5 of the Coupled Model Intercomparison Project (CMIP3 and CMIP5). Though previous studies of future projections indicate a west–east drying–wetting contrast over the Sahel, PlioMIP2 simulations indicate a uniform rainfall increase in that region in warm climates characterized by increasing greenhouse gas forcing. We note that this effect will further depend on the long-term response of the vegetation to the CO2 forcing.
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15.
  • Brierley, Chris M., et al. (author)
  • Large-scale features and evaluation of the PMIP4-CMIP6 midHolocene simulations
  • 2020
  • In: Climate of the Past. - : Copernicus GmbH. - 1814-9324 .- 1814-9332. ; 16:5, s. 1847-1872
  • Journal article (peer-reviewed)abstract
    • The mid-Holocene (6000 years ago) is a standard time period for the evaluation of the simulated response of global climate models using palaeoclimate reconstructions. The latest mid-Holocene simulations are a palaeoclimate entry card for the Palaeoclimate Model Intercomparison Project (PMIP4) component of the current phase of the Coupled Model Intercomparison Project (CMIP6) - hereafter referred to as PMIP4-CMIP6. Here we provide an initial analysis and evaluation of the results of the experiment for the mid-Holocene. We show that state-of-the-art models produce climate changes that are broadly consistent with theory and observations, including increased summer warming of the Northern Hemisphere and associated shifts in tropical rainfall. Many features of the PMIP4-CMIP6 simulations were present in the previous generation (PMIP3-CMIP5) of simulations. The PMIP4-CMIP6 ensemble for the mid-Holocene has a global mean temperature change of -0.3 K, which is -0.2K cooler than the PMIP3-CMIP5 simulations predominantly as a result of the prescription of realistic greenhouse gas concentrations in PMIP4-CMIP6. Biases in the magnitude and the sign of regional responses identified in PMIP3-CMIP5, such as the amplification of the northern African monsoon, precipitation changes over Europe, and simulated aridity in mid-Eurasia, are still present in the PMIP4-CMIP6 simulations. Despite these issues, PMIP4-CMIP6 and the mid-Holocene provide an opportunity both for quantitative evaluation and derivation of emergent constraints on the hydrological cycle, feedback strength, and potentially climate sensitivity.
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16.
  • Brown, Josephine R., et al. (author)
  • Comparison of past and future simulations of ENSO in CMIP5/PMIP3 and CMIP6/PMIP4 models
  • 2020
  • In: Climate of the Past. - : Copernicus GmbH. - 1814-9324 .- 1814-9332. ; 16:5, s. 1777-1805
  • Journal article (peer-reviewed)abstract
    • El Niño–Southern Oscillation (ENSO) is the strongest mode of interannual climate variability in the current climate, influencing ecosystems, agriculture, and weather systems across the globe, but future projections of ENSO frequency and amplitude remain highly uncertain. A comparison of changes in ENSO in a range of past and future climate simulations can provide insights into the sensitivity of ENSO to changes in the mean state, including changes in the seasonality of incoming solar radiation, global average temperatures, and spatial patterns of sea surface temperatures. As a comprehensive set of coupled model simulations is now available for both palaeoclimate time slices (the Last Glacial Maximum, mid-Holocene, and last interglacial) and idealised future warming scenarios (1 % per year CO2 increase, abrupt four-time CO2 increase), this allows a detailed evaluation of ENSO changes in this wide range of climates. Such a comparison can assist in constraining uncertainty in future projections, providing insights into model agreement and the sensitivity of ENSO to a range of factors. The majority of models simulate a consistent weakening of ENSO activity in the last interglacial and mid-Holocene experiments, and there is an ensemble mean reduction of variability in the western equatorial Pacific in the Last Glacial Maximum experiments. Changes in global temperature produce a weaker precipitation response to ENSO in the cold Last Glacial Maximum experiments and an enhanced precipitation response to ENSO in the warm increased CO2 experiments. No consistent relationship between changes in ENSO amplitude and annual cycle was identified across experiments.
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17.
  • Charpentier Ljungqvist, Fredrik, et al. (author)
  • Centennial-Scale Temperature Change in Last Millennium Simulations and Proxy-Based Reconstructions
  • 2019
  • In: Journal of Climate. - 0894-8755 .- 1520-0442. ; 32:9, s. 2441-2482
  • Journal article (peer-reviewed)abstract
    • Systematic comparisons of proxy-based reconstructions and climate model simulations of past millennium temperature variability offer insights into climate sensitivity and feedback mechanisms, besides allowing model evaluation independently from the period covered by instrumental data. Such simulation-reconstruction comparisons can help to distinguish more skillful models from less skillful ones, which may subsequently help to develop more reliable future projections. This study evaluates the low-frequency simulation-reconstruction agreement within the past millennium through assessing the amplitude of temperature change between the Medieval Climate Anomaly (here, 950-1250 CE) and the Little Ice Age (here, 1450-1850 CE) in PMIP3 model simulations compared to proxy-based local and continental-scale reconstructions. The simulations consistently show a smaller temperature change than the reconstructions for most regions in the Northern Hemisphere, but not in the Southern Hemisphere, as well as a partly different spatial pattern. A cost function analysis assesses how well the various simulations agree with reconstructions. Disregarding spatial correlation, significant differences are seen in the agreement with the local temperature reconstructions between groups of models, but insignificant differences are noted when compared to continental-scale reconstructions. This result points toward a limited possibility to rank models by means of their low-frequency temperature variability alone. The systematically lower amplitude of simulated versus reconstructed temperature change indicates either too-small simulated internal variability or that the analyzed models lack some critical forcing or have missing or too-weak feedback mechanisms. We hypothesize that too-cold initial ocean conditions in the models-in combination with too-weak internal variability and slow feedbacks over longer time scales-could account for much of the simulation-reconstruction disagreement.
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18.
  • Chen, Deliang, 1961, et al. (author)
  • Summary of a workshop on extreme weather events in a warming world organized by the Royal Swedish Academy of Sciences
  • 2020
  • In: Tellus Series B-Chemical and Physical Meteorology. - : Stockholm University Press. - 1600-0889 .- 0280-6509. ; 72:1
  • Journal article (peer-reviewed)abstract
    • Climate change is not only about changes in means of climatic variables such as temperature, precipitation and wind, but also their extreme values which are of critical importance to human society and ecosystems. To inspire the Swedish climate research community and to promote assessments of international research on past and future changes in extreme weather events against the global climate change background, the Earth Science Class of the Royal Swedish Academy of Sciences organized a workshop entitled 'Extreme weather events in a warming world' in 2019. This article summarizes and synthesizes the key points from the presentations and discussions of the workshop on changes in floods, droughts, heat waves, as well as on tropical cyclones and extratropical storms. In addition to reviewing past achievements in these research fields and identifying research gaps with a focus on Sweden, future challenges and opportunities for the Swedish climate research community are highlighted.
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19.
  • Chen, Jie, et al. (author)
  • Northwestward shift of the northern boundary of the East Asian summer monsoon during the mid-Holocene caused by orbital forcing and vegetation feedbacks
  • 2021
  • In: Quaternary Science Reviews. - : Elsevier BV. - 0277-3791 .- 1873-457X. ; 268
  • Journal article (peer-reviewed)abstract
    • The East Asian summer monsoon (EASM) northern boundary is a critical indicator of EASM variations. Movement of the boundary is modulated by both the EASM and the mid-latitude westerlies. Here, we use the Earth system model EC-Earth to quantify the contribution of orbital forcing and vegetation feedbacks in modulating the movement of EASM northern boundary. The results show that the simulated EASM northern boundary during the mid-Holocene shifts by a maximum of ∼213 km northwestward due to orbital forcing. When the model was coupled with a dynamic vegetation module LPJ-GUESS, the northern boundary shifts further northwestward by a maximum of ∼90 km, indicating the importance of vegetation feedbacks. During the mid-Holocene, temperature increased in the mid-latitude during the boreal summer due to insolation, leading to increased meridional air temperature differences (MTDs) over the region north of 45°N and to decreased MTDs to the south. The changes in the temperature gradient weakened the East Asian Westly Jet (EAWJ) and displaced it northward, resulting in an earlier transition of the Meiyu stage and a more prolonged Midsummer stage. The northward movement of EAWJ, combined with the enhanced southerly moisture flow from South China, caused more precipitation in North China and eventually to a northwestward shift of the northern boundary of the EASM. The coupled dynamic vegetation module LPJ-GUESS simulated more grassland and less forest over Northeast Asia during the mid-Holocene. The increased surface albedo tended to lower the temperature in the region, and further enhanced the MTDs in mid-latitude East Asia, leading to the further northward movement of the EAWJ and a northwestward shift of the EASM northern boundary. Although the simulated vegetation distribution in several regions may be not accurate, it reflects the substantial contribution of climate-vegetation interaction on modulating the EASM.
  •  
20.
  • Chen, Qiman, et al. (author)
  • Flexible Service Chain Mapping in Server-Centric Optical Datacenter Networks
  • 2018
  • In: 2018 ASIA COMMUNICATIONS AND PHOTONICS CONFERENCE (ACP). - : IEEE. - 9781538661581
  • Conference paper (peer-reviewed)abstract
    • We investigate flexible service chain mapping in server-centric optical terconnects, handling virtual network function (VNF) dependency operly. Blocking probability decreases by a factor of 10 when signing multiple VNFs in the same server is allowed.
  •  
21.
  • Feng, Ran, et al. (author)
  • Past terrestrial hydroclimate sensitivity controlled by Earth system feedbacks
  • 2022
  • In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 13:1
  • Journal article (peer-reviewed)abstract
    • Despite tectonic conditions and atmospheric CO2 levels (pCO2) similar to those of present-day, geological reconstructions from the mid-Pliocene (3.3-3.0 Ma) document high lake levels in the Sahel and mesic conditions in subtropical Eurasia, suggesting drastic reorganizations of subtropical terrestrial hydroclimate during this interval. Here, using a compilation of proxy data and multi-model paleoclimate simulations, we show that the mid-Pliocene hydroclimate state is not driven by direct CO2 radiative forcing but by a loss of northern high-latitude ice sheets and continental greening. These ice sheet and vegetation changes are long-term Earth system feedbacks to elevated pCO2. Further, the moist conditions in the Sahel and subtropical Eurasia during the mid-Pliocene are a product of enhanced tropospheric humidity and a stationary wave response to the surface warming pattern, which varies strongly with land cover changes. These findings highlight the potential for amplified terrestrial hydroclimate responses over long timescales to a sustained CO2 forcing.
  •  
22.
  • Feng, Yanli, et al. (author)
  • A supramolecular photoswitch constructed by intermolecular hydrogen bond between BTEPy and TTF-COOH
  • 2008
  • In: Chemical Physics Letters. - : Elsevier BV. - 0009-2614 .- 1873-4448. ; 455:4-6, s. 256-260
  • Journal article (peer-reviewed)abstract
    • A novel supramolecular photoswitch containing bisthienylethene- pyridine (BTEPy) and carboxyl attached tetrathiafluvalene (TTF-COOH) was constructed via intermolecular hydrogen bond. FT-IR spectra, XPS characterizations, H-1 NMR and theoretical calculation were carried out to verify the formation of the intermolecular hydrogen bond. The supramolecular self-assemblies BTEPy 2TTF show good photo-chromic properties. A molecular switch with UV/vis light as inputs and electrochemical signals as outputs was obtained.
  •  
23.
  • Guo, Donglin, et al. (author)
  • Highly restricted near-surface permafrost extent during the mid-Pliocene warm period
  • 2023
  • In: Proceedings of the National Academy of Sciences of the United States of America. - 0027-8424 .- 1091-6490. ; 120:36
  • Journal article (peer-reviewed)abstract
    • Accurate understanding of permafrost dynamics is critical for evaluating and mitigating impacts that may arise as permafrost degrades in the future; however, existing projections have large uncertainties. Studies of how permafrost responded historically during Earth's past warm periods are helpful in exploring potential future permafrost behavior and to evaluate the uncertainty of future permafrost change projections. Here, we combine a surface frost index model with outputs from the second phase of the Pliocene Model Intercomparison Project to simulate the near-surface (similar to 3 to 4 m depth) permafrost state in the Northern Hemisphere during the mid-Pliocene warm period (mPWP, similar to 3.264 to 3.025 Ma). This period shares similarities with the projected future climate. Constrained by proxy-based surface air temperature records, our simulations demonstrate that near-surface permafrost was highly spatially restricted during the mPWP and was 93 +/- 3% smaller than the preindustrial extent. Near-surface permafrost was present only in the eastern Siberian uplands, Canadian high Arctic Archipelago, and northernmost Greenland. The simulations are similar to near-surface permafrost changes projected for the end of this century under the SSP5-8.5 scenario and provide a perspective on the potential permafrost behavior that may be expected in a warmer world.
  •  
24.
  • Han, Ning, et al. (author)
  • Rational design of Ruddlesden–Popper perovskite electrocatalyst for oxygen reduction to hydrogen peroxide
  • 2022
  • In: SusMat. - : Wiley. - 2766-8479 .- 2692-4552. ; 2:4, s. 456-465
  • Journal article (peer-reviewed)abstract
    • Although the oxygen reduction process to hydrogen peroxide (H2O2) is a green option for H2O2 generation, the low activity and selectivity hindered the industry's process. In recent years, the electrochemical synthesis of H2O2 through a 2e– transfer method of oxygen reduction reaction (ORR) has piqued the interest of both academics and industry. Metal oxide catalysts have emerged as a novel family of electrochemical catalysts due to their unusual physical, chemical, and electrical characteristics. In this work, we first developed a Ruddlesden–Popper perovskite oxide (Pr2NiO4+δ) as a highly selective and active catalyst for 2e– ORR to produce H2O2. Molybdenum was introduced here to adjust the oxidation states of these transition metals with successful substitution into Ni-site to prepare Pr2Ni1-xMoxO4+δ, and the molybdenum substitution improves the H2O2 selectivity during the ORR process, in 0.1 M KOH, from 60% of Pr2NiO4+δ to 79% of Pr2Ni0.8Mo0.2O4+δ at 0.55 V versus RHE. A limiting H2O2 concentration of 0.24 mM for Pr2NiO4+δ and 0.42 mM for Pr2Ni0.8Mo0.2O4+δ was obtained at a constant current of 10 mA/cm2 using a flow-cell reactor using a gas-diffusion electrode. 
  •  
25.
  • Han, Zixuan, et al. (author)
  • Evaluating the large-scale hydrological cycle response within the Pliocene Model Intercomparison Project Phase 2 (PlioMIP2) ensemble
  • 2021
  • In: Climate of the Past. - : Copernicus GmbH. - 1814-9324 .- 1814-9332. ; 17:6, s. 2537-2558
  • Journal article (peer-reviewed)abstract
    • The mid-Pliocene (∼3 Ma) is one of the most recent warm periods with high CO2 concentrations in the atmosphere and resulting high temperatures, and it is often cited as an analog for near-term future climate change. Here, we apply a moisture budget analysis to investigate the response of the large-scale hydrological cycle at low latitudes within a 13-model ensemble from the Pliocene Model Intercomparison Project Phase 2 (PlioMIP2). The results show that increased atmospheric moisture content within the mid-Pliocene ensemble (due to the thermodynamic effect) results in wetter conditions over the deep tropics, i.e., the Pacific intertropical convergence zone (ITCZ) and the Maritime Continent, and drier conditions over the subtropics. Note that the dynamic effect plays a more important role than the thermodynamic effect in regional precipitation minus evaporation (PmE) changes (i.e., northward ITCZ shift and wetter northern Indian Ocean). The thermodynamic effect is offset to some extent by a dynamic effect involving a northward shift of the Hadley circulation that dries the deep tropics and moistens the subtropics in the Northern Hemisphere (i.e., the subtropical Pacific). From the perspective of Earth's energy budget, the enhanced southward cross-equatorial atmospheric transport (0.22 PW), induced by the hemispheric asymmetries of the atmospheric energy, favors an approximately 1∘ northward shift of the ITCZ. The shift of the ITCZ reorganizes atmospheric circulation, favoring a northward shift of the Hadley circulation. In addition, the Walker circulation consistently shifts westward within PlioMIP2 models, leading to wetter conditions over the northern Indian Ocean. The PlioMIP2 ensemble highlights that an imbalance of interhemispheric atmospheric energy during the mid-Pliocene could have led to changes in the dynamic effect, offsetting the thermodynamic effect and, hence, altering mid-Pliocene hydroclimate.
  •  
26.
  • Han, Zixuan, et al. (author)
  • The changes in ENSO-induced tropical Pacific precipitation variability in the past warm and cold climates from the EC-Earth simulations
  • 2020
  • In: Climate Dynamics. - : Springer Science and Business Media LLC. - 0930-7575 .- 1432-0894. ; 55, s. 503-519
  • Journal article (peer-reviewed)abstract
    • The El Nino-Southern Oscillation (ENSO) is one of the most significant climate variability signals. Studying the changes in ENSO-induced precipitation variability (ENSO precipitation) in the past climate offers a possibility to a better understanding of how they may change under future climate conditions. This study uses simulations performed with the European community Earth-System Model (EC-Earth) to investigate the relative contributions of dynamic effect (the circulation anomalies together with the climatological specific humidity) and thermodynamic effect (the specific humidity anomalies together with the climatological circulation) on the changes in ENSO precipitation in the past warm and cold climates, represented by the Pliocene and the Last Glacial Maximum (LGM), respectively. The results show that the changes in ENSO precipitation are intensified (weakened) over the tropical western Pacific but weakened (intensified) over the tropical central Pacific in Pliocene (LGM) compared with the pre-industrial (PI) simulation. Based on the decomposed moisture budget equation, these changes in ENSO precipitation patterns are highly related to the dynamic effect. The mechanism can be understood as follows: the zonal gradient of the mean sea surface temperature (SST) over the tropical Indo-Pacific is increased (reduced) during the Pliocene (LGM), leading to the strengthening (weakening) of Pacific Walker Circulation as well as a westward (eastward) shift. In the Pliocene, the westward shift of Walker Circulation results in an increased (decreased) ENSO-induced low-level vertical velocity variability in the tropical western Pacific (central Pacific), and, in turn, favoring convergent (divergent) moisture transport through a dynamic process, and then causing intensified (weakened) ENSO precipitation there. The opposite mechanism exists in LGM. These results suggest that changes in the zonal SST gradient over tropical Indo-Pacific under different climate conditions determine the changes in ENSO precipitation through a dynamic process.
  •  
27.
  • Haywood, Alan M., et al. (author)
  • The Pliocene Model Intercomparison Project Phase 2 : large-scale climate features and climate sensitivity
  • 2020
  • In: Climate of the Past. - : Copernicus GmbH. - 1814-9324 .- 1814-9332. ; 16:6, s. 2095-2123
  • Journal article (peer-reviewed)abstract
    • The Pliocene epoch has great potential to improve our understanding of the long-term climatic and environmental consequences of an atmospheric CO2 concentration near similar to 400 parts per million by volume. Here we present the large-scale features of Pliocene climate as simulated by a new ensemble of climate models of varying complexity and spatial resolution based on new reconstructions of boundary conditions (the Pliocene Model Intercomparison Project Phase 2; PlioMIP2). As a global annual average, modelled surface air temperatures increase by between 1.7 and 5.2 degrees C relative to the pre-industrial era with a multi-model mean value of 3.2 degrees C. Annual mean total precipitation rates increase by 7 % (range: 2 %-13 %). On average, surface air temperature (SAT) increases by 4.3 degrees C over land and 2.8 degrees C over the oceans. There is a clear pattern of polar amplification with warming polewards of 60 degrees N and 60 degrees S exceeding the global mean warming by a factor of 2.3. In the Atlantic and Pacific oceans, meridional temperature gradients are reduced, while tropical zonal gradients remain largely unchanged. There is a statistically significant relationship between a model's climate response associated with a doubling in CO2 (equilibrium climate sensitivity; ECS) and its simulated Pliocene surface temperature response. The mean ensemble Earth system response to a doubling of CO2 (including ice sheet feedbacks) is 67 % greater than ECS; this is larger than the increase of 47 % obtained from the PlioMIP1 ensemble. Proxy-derived estimates of Pliocene sea surface temperatures are used to assess model estimates of ECS and give an ECS range of 2.6-4.8 degrees C. This result is in general accord with the ECS range presented by previous Intergovernmental Panel on Climate Change (IPCC) Assessment Reports.
  •  
28.
  • Hou, Yandong, et al. (author)
  • Sahara's surface transformation forced an abrupt hydroclimate decline and Neolithic culture transition in northern China
  • 2024
  • In: The Innovation. - 2666-6758. ; 5:1
  • Journal article (peer-reviewed)abstract
    • The remote forcing from land surface changes in the Sahara is hypothesized to play a pivotal role in modulating the intensity of the East Asian summer monsoon (EASM) through ocean-atmospheric teleconnections. This modu-lation has far-reaching consequences, particularly in facilitating societal shifts documented in northern China. Here, we present a well-dated lake-level record from the Daihai Lake Basin in northern China, providing quantitative assessments of Holocene monsoonal precipitation and the consequent mi-grations of the northern boundary of the EASM. Our reconstruction, informed by a water-and-energy balance model, indicates that annual precipitation reached -700 mm during 8-5 ka, followed by a rapid decline to -550 mm be-tween 5 and 4 ka. This shift coherently aligns with a significant -300 km northwestward movement of the EASM northern boundary during the Middle Holocene (MH), in contrast to its current position. Our findings underscore that these changes cannot be entirely attributed to orbital forcing, as corrob-orated by simulation tests. Climate model simulations deployed in our study suggest that the presence of the Green Sahara during the MH significantly strengthened the EASM and led to a northward shift of the monsoon rainfall belt. Conversely, the Sahara's reversion to a desert landscape in the late Ho-locene was accompanied by a corresponding southward retraction of monsoon influence. These dramatic hydroclimate changes during -5-4 ka likely triggered or at least contributed to a shift in Neolithic cultures and societal transformation in northern China. With decreasing agricultural pro-ductivity, communities transitioned from millet farming to a mixed rainfed agriculture and animal husbandry system. Thus, our findings elucidate not only the variability of the EASM but also the profound implications of a remote forcing, such as surface transformations of the Sahara, on climatic changes and cultural evolution in northern China.
  •  
29.
  • Hu, Jiwen, et al. (author)
  • A new ratiometric fluorescent chemodosimeter based on an ICT modulation for the detection of Hg2
  • 2016
  • In: Sensors and actuators. B, Chemical. - : ELSEVIER SCIENCE SA. - 0925-4005 .- 1873-3077. ; 230, s. 639-644
  • Journal article (peer-reviewed)abstract
    • We design and synthesize a new ratiometric fluorescent chemodosimeter (S1) for the selective and sensitive detection of Hg2+. Upon addition of Hg2+, the emission of the S1 exhibits a large bathochromic shift from 393 to 515 nm (up to 122 nm) which is ascribed to an intramolecular charge transfer process in the resultant. The Hg2+-induced dethioacetalization for sensing mechanism has been demonstrated by using high-performance liquid chromatography analysis of the sensing process. The interference experiments further demonstrate that S1 exhibits very high selectivity towards Hg2+ over other coexisting cations/anions. Subsequently, a good linearity of the concentrations of Hg2+ (0-15 mu M) vs the ratiometric signals (I-515/I-393) allows a fluorogenic method for the quantitative detection of Hg2+, with the limitation of detection determined to be 5.22 x 10(-7) M. (C) 2016 Elsevier B.V. All rights reserved.
  •  
30.
  • Kageyama, Masa, et al. (author)
  • A multi-model CMIP6-PMIP4 study of Arctic sea ice at 127 ka : sea ice data compilation and model differences
  • 2021
  • In: Climate of the Past. - : Copernicus GmbH. - 1814-9324 .- 1814-9332. ; 17:1, s. 37-62
  • Journal article (peer-reviewed)abstract
    • The Last Interglacial period (LIG) is a period with increased summer insolation at high northern latitudes, which results in strong changes in the terrestrial and marine cryosphere. Understanding the mechanisms for this response via climate modelling and comparing the models' representation of climate reconstructions is one of the objectives set up by the Paleoclimate Modelling Intercomparison Project for its contribution to the sixth phase of the Coupled Model Intercomparison Project. Here we analyse the results from 16 climate models in terms of Arctic sea ice. The multi-model mean reduction in minimum sea ice area from the pre industrial period (PI) to the LIG reaches 50 % (multi-model mean LIG area is 3.20×106 km2, compared to 6.46×106 km2 for the PI). On the other hand, there is little change for the maximum sea ice area (which is 15–16×106 km2 for both the PI and the LIG. To evaluate the model results we synthesise LIG sea ice data from marine cores collected in the Arctic Ocean, Nordic Seas and northern North Atlantic. The reconstructions for the northern North Atlantic show year-round ice-free conditions, and most models yield results in agreement with these reconstructions. Model–data disagreement appear for the sites in the Nordic Seas close to Greenland and at the edge of the Arctic Ocean. The northernmost site with good chronology, for which a sea ice concentration larger than 75 % is reconstructed even in summer, discriminates those models which simulate too little sea ice. However, the remaining models appear to simulate too much sea ice over the two sites south of the northernmost one, for which the reconstructed sea ice cover is seasonal. Hence models either underestimate or overestimate sea ice cover for the LIG, and their bias does not appear to be related to their bias for the pre-industrial period. Drivers for the inter-model differences are different phasing of the up and down short-wave anomalies over the Arctic Ocean, which are associated with differences in model albedo; possible cloud property differences, in terms of optical depth; and LIG ocean circulation changes which occur for some, but not all, LIG simulations. Finally, we note that inter-comparisons between the LIG simulations and simulations for future climate with moderate (1 % yr−1) CO2 increase show a relationship between LIG sea ice and sea ice simulated under CO2 increase around the years of doubling CO2. The LIG may therefore yield insight into likely 21st century Arctic sea ice changes using these LIG simulations.
  •  
31.
  • Koettgen, Anna, et al. (author)
  • Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
  • 2013
  • In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:2, s. 145-154
  • Journal article (peer-reviewed)abstract
    • Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SEMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.
  •  
32.
  • Lu, Zhengyao, et al. (author)
  • Impacts of Large-Scale Sahara Solar Farms on Global Climate and Vegetation Cover
  • 2021
  • In: Geophysical Research Letters. - 0094-8276 .- 1944-8007. ; 48:2
  • Journal article (peer-reviewed)abstract
    • Large-scale photovoltaic solar farms envisioned over the Sahara desert can meet the world's energy demand while increasing regional rainfall and vegetation cover. However, adverse remote effects resulting from atmospheric teleconnections could offset such regional benefits. We use state-of-the-art Earth-system model simulations to evaluate the global impacts of Sahara solar farms. Our results indicate a redistribution of precipitation causing Amazon droughts and forest degradation, and global surface temperature rise and sea-ice loss, particularly over the Arctic due to increased polarward heat transport, and northward expansion of deciduous forests in the Northern Hemisphere. We also identify reduced El Niño-Southern Oscillation and Atlantic Niño variability and enhanced tropical cyclone activity. Comparison to proxy inferences for a wetter and greener Sahara ∼6,000 years ago appears to substantiate these results. Understanding these responses within the Earth system provides insights into the site selection concerning any massive deployment of solar energy in the world's deserts.
  •  
33.
  • Messori, Gabriele, et al. (author)
  • The water cycle of the mid-Holocene West African monsoon : The role of vegetation and dust emission changes
  • 2019
  • In: International Journal of Climatology. - : Wiley. - 0899-8418 .- 1097-0088. ; 39:4, s. 1927-1939
  • Journal article (peer-reviewed)abstract
    • During the mid-Holocene (6 kyr BP), West Africa experienced a much stronger and geographically extensive monsoon than in the present day. Changes in orbital forcing, vegetation and dust emissions from the Sahara have been identified as key factors driving this intensification. Here, we analyse how the timing, origin and convergence of moisture fluxes contributing to the monsoonal precipitation change under a range of scenarios: orbital forcing only; orbital and vegetation forcings (Green Sahara); orbital, vegetation and dust forcings (Green Sahara-reduced dust). We further compare our results to a range of reconstructions of mid-Holocene precipitation from palaeoclimate archives. In our simulations, the greening of the Sahara leads to a cyclonic water vapour flux anomaly over North Africa with an anomalous westerly flow bringing large amounts of moisture into the Sahel from the Atlantic Ocean. Changes in atmospheric dust under a vegetated Sahara shift the anomalous moisture advection pattern northwards, increasing both moisture convergence and precipitation recycling over the northern Sahel and Sahara and the associated precipitation during the boreal summer. During this season, under both the Green Sahara and Green Sahara-reduced dust scenarios, local recycling in the Saharan domain exceeds that of the Sahel. This points to local recycling as an important factor modulating vegetation-precipitation feedbacks and the impact of Saharan dust emissions. Our results also show that temperature and evapotranspiration over the Sahara in the mid-Holocene are close to Sahelian pre-industrial values. This suggests that pollen-based paleoclimate reconstructions of precipitation during the Green Sahara period are likely not biased by possible large evapotranspiration changes in the region.
  •  
34.
  • Oldeman, Arthur M., et al. (author)
  • Reduced El Niño variability in the mid-Pliocene according to the PlioMIP2 ensemble
  • 2021
  • In: Climate of the Past. - : Copernicus GmbH. - 1814-9324 .- 1814-9332. ; 17:6, s. 2427-2450
  • Journal article (peer-reviewed)abstract
    • The mid-Pliocene warm period (3.264–3.025 Ma) is the most recent geological period during which atmospheric CO2 levels were similar to recent historical values (∼400 ppm). Several proxy reconstructions for the mid-Pliocene show highly reduced zonal sea surface temperature (SST) gradients in the tropical Pacific Ocean, indicating an El Niño-like mean state. However, past modelling studies do not show these highly reduced gradients. Efforts to understand mid-Pliocene climate dynamics have led to the Pliocene Model Intercomparison Project (PlioMIP). Results from the first phase (PlioMIP1) showed clear El Niño variability (albeit significantly reduced) and did not show the greatly reduced time-mean zonal SST gradient suggested by some of the proxies.In this work, we study El Niño–Southern Oscillation (ENSO) variability in the PlioMIP2 ensemble, which consists of additional global coupled climate models and updated boundary conditions compared to PlioMIP1. We quantify ENSO amplitude, period, spatial structure and “flavour”, as well as the tropical Pacific annual mean state in mid-Pliocene and pre-industrial simulations. Results show a reduced ENSO amplitude in the model-ensemble mean (−24 %) with respect to the pre-industrial, with 15 out of 17 individual models showing such a reduction. Furthermore, the spectral power of this variability considerably decreases in the 3–4-year band. The spatial structure of the dominant empirical orthogonal function shows no particular change in the patterns of tropical Pacific variability in the model-ensemble mean, compared to the pre-industrial. Although the time-mean zonal SST gradient in the equatorial Pacific decreases for 14 out of 17 models (0.2 ∘C reduction in the ensemble mean), there does not seem to be a correlation with the decrease in ENSO amplitude. The models showing the most “El Niño-like” mean state changes show a similar ENSO amplitude to that in the pre-industrial reference, while models showing more “La Niña-like” mean state changes generally show a large reduction in ENSO variability. The PlioMIP2 results show a reasonable agreement with both time-mean proxies indicating a reduced zonal SST gradient and reconstructions indicating a reduced, or similar, ENSO variability.
  •  
35.
  • Otto-Bliesner, Bette L., et al. (author)
  • Large-scale features of Last Interglacial climate : results from evaluating the lig127k simulations for the Coupled Model Intercomparison Project (CMIP6)–Paleoclimate Modeling Intercomparison Project (PMIP4)
  • 2021
  • In: Climate of the Past. - : Copernicus GmbH. - 1814-9324 .- 1814-9332. ; 17:1, s. 63-94
  • Journal article (peer-reviewed)abstract
    • The modeling of paleoclimate, using physically based tools, is increasingly seen as a strong out-of-sample test of the models that are used for the projection of future climate changes. New to the Coupled Model Intercomparison Project (CMIP6) is the Tier 1 Last Interglacial experiment for 127 000 years ago (lig127k), designed to address the climate responses to stronger orbital forcing than the midHolocene experiment, using the same state-of-the-art models as for the future and following a common experimental protocol. Here we present a first analysis of a multi-model ensemble of 17 climate models, all of which have completed the CMIP6 DECK (Diagnostic, Evaluation and Characterization of Klima) experiments. The equilibrium climate sensitivity (ECS) of these models varies from 1.8 to 5.6 ∘C. The seasonal character of the insolation anomalies results in strong summer warming over the Northern Hemisphere continents in the lig127k ensemble as compared to the CMIP6 piControl and much-reduced minimum sea ice in the Arctic. The multi-model results indicate enhanced summer monsoonal precipitation in the Northern Hemisphere and reductions in the Southern Hemisphere. These responses are greater in the lig127k than the CMIP6 midHolocene simulations as expected from the larger insolation anomalies at 127 than 6 ka.New synthesis for surface temperature and precipitation, targeted for 127 ka, have been developed for comparison to the multi-model ensemble. The lig127k model ensemble and data reconstructions are in good agreement for summer temperature anomalies over Canada, Scandinavia, and the North Atlantic and for precipitation over the Northern Hemisphere continents. The model–data comparisons and mismatches point to further study of the sensitivity of the simulations to uncertainties in the boundary conditions and of the uncertainties and sparse coverage in current proxy reconstructions.The CMIP6–Paleoclimate Modeling Intercomparison Project (PMIP4) lig127k simulations, in combination with the proxy record, improve our confidence in future projections of monsoons, surface temperature, and Arctic sea ice, thus providing a key target for model evaluation and optimization.
  •  
36.
  • Pontes, Gabriel M., et al. (author)
  • Drier tropical and subtropical Southern Hemisphere in the mid-Pliocene Warm Period
  • 2020
  • In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 10:1
  • Journal article (peer-reviewed)abstract
    • Thermodynamic arguments imply that global mean rainfall increases in a warmer atmosphere; however, dynamical effects may result in more significant diversity of regional precipitation change. Here we investigate rainfall changes in the mid-Pliocene Warm Period (similar to 3 Ma), a time when temperatures were 2-3 degrees C warmer than the pre-industrial era, using output from the Pliocene Model Intercomparison Projects phases 1 and 2 and sensitivity climate model experiments. In the Mid-Pliocene simulations, the higher rates of warming in the northern hemisphere create an interhemispheric temperature gradient that enhances the southward cross-equatorial energy flux by up to 48%. This intensified energy flux reorganizes the atmospheric circulation leading to a northward shift of the Inter-Tropical Convergence Zone and a weakened and poleward displaced Southern Hemisphere Subtropical Convergences Zones. These changes result in drier-than-normal Southern Hemisphere tropics and subtropics. The evaluation of the mid-Pliocene adds a constraint to possible future warmer scenarios associated with differing rates of warming between hemispheres.
  •  
37.
  • Pontes, Gabriel M., et al. (author)
  • Mid-Pliocene El Niño/Southern Oscillation suppressed by Pacific intertropical convergence zone shift
  • 2022
  • In: Nature Geoscience. - : Springer Science and Business Media LLC. - 1752-0894 .- 1752-0908. ; 15:9, s. 726-734
  • Journal article (peer-reviewed)abstract
    • The El Niño/Southern Oscillation (ENSO), the dominant driver of year-to-year climate variability in the equatorial Pacific Ocean, impacts climate pattern across the globe. However, the response of the ENSO system to past and potential future temperature increases is not fully understood. Here we investigate ENSO variability in the warmer climate of the mid-Pliocene (~3.0–3.3 Ma), when surface temperatures were ~2–3 °C above modern values, in a large ensemble of climate models—the Pliocene Model Intercomparison Project. We show that the ensemble consistently suggests a weakening of ENSO variability, with a mean reduction of 25% (±16%). We further show that shifts in the equatorial Pacific mean state cannot fully explain these changes. Instead, ENSO was suppressed by a series of off-equatorial processes triggered by a northward displacement of the Pacific intertropical convergence zone: weakened convective feedback and intensified Southern Hemisphere circulation, which inhibit various processes that initiate ENSO. The connection between the climatological intertropical convergence zone position and ENSO we find in the past is expected to operate in our warming world with important ramifications for ENSO variability. 
  •  
38.
  • Ren, Xin, et al. (author)
  • The hydrological cycle and ocean circulation of the Maritime Continent in the Pliocene : results from PlioMIP2
  • 2023
  • In: Climate of the Past. - 1814-9324 .- 1814-9332. ; 19:10, s. 2053-2077
  • Journal article (peer-reviewed)abstract
    • The Maritime Continent (MC) forms the western boundary of the tropical Pacific Ocean, and relatively small changes in this region can impact the climate locally and remotely. In the mid-Piacenzian warm period of the Pliocene (mPWP; 3.264 to 3.025 Ma) atmospheric CO2 concentrations were ∼ 400 ppm, and the subaerial Sunda and Sahul shelves made the land–sea distribution of the MC different to today. Topographic changes and elevated levels of CO2, combined with other forcings, are therefore expected to have driven a substantial climate signal in the MC region at this time. By using the results from the Pliocene Model Intercomparison Project Phase 2 (PlioMIP2), we study the mean climatic features of the MC in the mPWP and changes in Indonesian Throughflow (ITF) with respect to the preindustrial. Results show a warmer and wetter mPWP climate of the MC and lower sea surface salinity in the surrounding ocean compared with the preindustrial. Furthermore, we quantify the volume transfer through the ITF; although the ITF may be expected to be hindered by the subaerial shelves, 10 out of 15 models show an increased volume transport compared with the preindustrial.In order to avoid undue influence from closely related models that are present in the PlioMIP2 ensemble, we introduce a new metric, the multi-cluster mean (MCM), which is based on cluster analysis of the individual models. We study the effect that the choice of MCM versus the more traditional analysis of multi-model mean (MMM) and individual models has on the discrepancy between model results and data. We find that models, which reproduce modern MC climate well, are not always good at simulating the mPWP climate anomaly of the MC. By comparing with individual models, the MMM and MCM reproduce the preindustrial sea surface temperature (SST) of the reanalysis better than most individual models and produce less discrepancy with reconstructed sea surface temperature anomalies (SSTA) than most individual models in the MC. In addition, the clusters reveal spatial signals that are not captured by the MMM, so that the MCM provides us with a new way to explore the results from model ensembles that include similar models.
  •  
39.
  • Tian, Ye, et al. (author)
  • Holocene climate change in southern Oman deciphered by speleothem records and climate model simulations
  • 2023
  • In: Nature Communications. - 2041-1723. ; 14:1
  • Journal article (peer-reviewed)abstract
    • Qunf Cave oxygen isotope (& delta;O-18(c)) record from southern Oman is one of the most significant of few Holocene Indian summer monsoon cave records. However, the interpretation of the Qunf & delta;O-18(c) remains in dispute. Here we provide a multi-proxy record from Qunf Cave and climate model simulations to reconstruct the Holocene local and regional hydroclimate changes. The results indicate that besides the Indian summer monsoon, the North African summer monsoon also contributes water vapor to southern Oman during the early to middle Holocene. In principle, Qunf & delta;O-18(c) values reflect integrated oxygen-isotope fractionations over a broad moisture transport swath from moisture sources to the cave site, rather than local precipitation amount alone, and thus the Qunf & delta;O-18(c) record characterizes primary changes in the Afro-Asian monsoon regime across the Holocene. In contrast, local climate proxies appear to suggest an overall slightly increased or unchanged wetness over the Holocene at the cave site. Southern Oman speleothem oxygen isotope and multi-proxy data reveal diverse changes in the Afro-Indian summer monsoon circulations and local hydroclimate conditions during the Holocene, confirming climate model simulations.
  •  
40.
  • Wang, Hui, et al. (author)
  • Two-Photon Active Organotin(IV) Carboxylate Complexes for Visualization of Anticancer Action
  • 2017
  • In: ACS Biomaterials Science & Engineering. - : AMER CHEMICAL SOC. - 2373-9878. ; 3:5, s. 836-842
  • Journal article (peer-reviewed)abstract
    • It is still a challenge that organotin(IV) carboxylate complexes with high-performance two-photon activity for cancer therapy. At present work, two novel organotin carboxylate complexes LSn1 and LSn2, containing coumarin moiety, were rationally designed for two-photon fluorescent imaging and anticancer purpose. The complexes possessed large two-photon action cross-sections and high quantum yields. Living cells evaluation revealed that complexes LSn1 and LSn2 exhibited good biocompatibility and deep tissue penetration over femtosecond laser with wavelength of 840 nm. Furthermore, the antitumor active and as well as possible mechanism of complexes LSn1 and LSn2 have been investigated systematically. The results indicated that complexes LSn1 and LSn2 could induce apoptotic cell death through a mitochondria] dysfunction and ROS elevation pathway. The present work provides a strategy for rationally designing organotin(IV) carboxylate complexes with two-photon activity and antitumor activity.
  •  
41.
  • Weiffenbach, Julia E., et al. (author)
  • Unraveling the mechanisms and implications of a stronger mid-Pliocene Atlantic Meridional Overturning Circulation (AMOC) in PlioMIP2
  • 2023
  • In: Climate of the Past. - : COPERNICUS GESELLSCHAFT MBH. - 1814-9324 .- 1814-9332. ; 19:1, s. 61-85
  • Journal article (peer-reviewed)abstract
    • The mid-Pliocene warm period (3.264-3.025 Ma) is the most recent geological period in which the atmospheric CO2 concentration was approximately equal to the concentration we measure today (ca. 400 ppm). Sea surface temperature (SST) proxies indicate above-average warming over the North Atlantic in the mid-Pliocene with respect to the pre-industrial period, which may be linked to an intensified Atlantic Meridional Overturning Circulation (AMOC). Earlier results from the Pliocene Model Intercomparison Project Phase 2 (PlioMIP2) show that the ensemble simulates a stronger AMOC in the mid-Pliocene than in the pre-industrial. However, no consistent relationship between the stronger mid-Pliocene AMOC and either the Atlantic northward ocean heat transport (OHT) or average North Atlantic SSTs has been found. In this study, we look further into the drivers and consequences of a stronger AMOC in mid-Pliocene compared to pre-industrial simulations in PlioMIP2. We find that all model simulations with a closed Bering Strait and Canadian Archipelago show reduced freshwater transport from the Arctic Ocean into the North Atlantic. This contributes to an increase in salinity in the subpolar North Atlantic and Labrador Sea that can be linked to the stronger AMOC in the mid-Pliocene. To investigate the dynamics behind the ensembles variable response of the total Atlantic OHT to the stronger AMOC, we separate the Atlantic OHT into two components associated with either the overturning circulation or the wind-driven gyre circulation. While the ensemble mean of the overturning component is increased significantly in magnitude in the mid-Pliocene, it is partly compensated by a reduction in the gyre component in the northern subtropical gyre region. This indicates that the lack of relationship between the total OHT and AMOC is due to changes in OHT by the subtropical gyre. The overturning and gyre components should therefore be considered separately to gain a more complete understanding of the OHT response to a stronger mid-Pliocene AMOC. In addition, we show that the AMOC exerts a stronger influence on North Atlantic SSTs in the mid-Pliocene than in the pre-industrial, providing a possible explanation for the improved agreement of the PlioMIP2 ensemble mean SSTs with reconstructions in the North Atlantic.
  •  
42.
  • Xu, Chao-Qun, et al. (author)
  • Genome sequence of Malania oleifera, a tree with great value for nervonic acid production
  • 2019
  • In: GigaScience. - : Oxford University Press. - 2047-217X. ; 8:2
  • Journal article (peer-reviewed)abstract
    • Background Malania oleifera, a member of the Olacaceae family, is an IUCN red listed tree, endemic and restricted to the Karst region of southwest China. This tree's seed is valued for its high content of precious fatty acids (especially nervonic acid). However, studies on its genetic makeup and fatty acid biogenesis are severely hampered by a lack of molecular and genetic tools. Findings We generated 51 Gb and 135Gb of raw DNA sequences, using Pacific Biosciences (PacBio) single-molecule real-time and 10x Genomics sequencing, respectively. A final genome assembly, with a scaffold N50 size of 4.65 Mb and a total length of 1.51Gb, was obtained by primary assembly based on PacBio long reads plus scaffolding with 10x Genomics reads. Identified repeats constituted approximate to 82% of the genome, and 24,064 protein-coding genes were predicted with high support. The genome has low heterozygosity and shows no evidence for recent whole genome duplication. Metabolic pathway genes relating to the accumulation of long-chain fatty acid were identified and studied in detail. Conclusions Here, we provide the first genome assembly and gene annotation for M. oleifera. The availability of these resources will be of great importance for conservation biology and for the functional genomics of nervonic acid biosynthesis.
  •  
43.
  • Xu, Guobao, et al. (author)
  • Century-scale temperature variability and onset of industrial-era warming in the Eastern Tibetan Plateau
  • 2019
  • In: Climate Dynamics. - : Springer Science and Business Media LLC. - 0930-7575 .- 1432-0894. ; 53:7-8, s. 4569-4590
  • Journal article (peer-reviewed)abstract
    • To improve our understanding of climate variability in the Tibetan Plateau (TP) and its sensitivity to external forcings, recent temperature changes need to be placed in a long-term historical context. Here, we present two tree-ring based temperature reconstructions: a 1003-year (1000-2002 CE) annual temperature reconstruction for the northeastern TP (NETP) based on seven series and a 522-year (1489-2010 CE) summer (June-July-August) temperature reconstruction for the southeastern TP (SETP) based on 11 series. Our reconstructions show six centuries of generally warm NETP temperatures (1000-1586 CE), followed by a transition to cooler temperatures (1587-1887 CE for NETP and 1588-1930 CE for SETP). The transition from the Medieval Climate Anomaly to the Little Ice Age thus happened in the 1580s in NETP and SETP, which is about 150 years later than in larger-scale (e.g. Asia and the Northern Hemisphere) temperature reconstructions. We found that TP temperature variability, especially in SETP, was influenced by the Atlantic multi-decadal oscillation and that the twentieth century was the warmest on record in NETP and SETP. Our reconstructions and climate model simulations both show industrial-era warming trends, the onset of which happened earlier in NETP (1812 CE) compared to SETP (1887 CE) and other temperature reconstructions for Western China, East Asia, Asia, and the Northern Hemisphere. The early NETP onset of industrial-era warming can likely be explained by NETP's faster warming rate and by local feedback factors (i.e., ice-snow cover-albedo). Comparisons between climate model simulations and our reconstructions reveal that cooler TP temperatures from 1600 to 1800 CE might be related to land-use and land-cover change.
  •  
44.
  • Zhang, Dong, et al. (author)
  • A dual-ion-switched molecular brake based on ferrocene
  • 2009
  • In: Chemical Communications. - : Royal Society of Chemistry (RSC). - 1359-7345 .- 1364-548X. ; :13, s. 1700-1702
  • Journal article (peer-reviewed)abstract
    • A new dual-ion-switched molecular brake was synthesized and operated by chemical reagents (H+/OH- and Zn2+/EDTA), and its rotation could be read out by chromogenic, fluorogenic and electrochemical signals.
  •  
45.
  • Zhang, Haoran, et al. (author)
  • 1.6 Million transactions replicate distributed PV market slowdown by COVID-19 lockdown
  • 2021
  • In: Applied Energy. - : ELSEVIER SCI LTD. - 0306-2619 .- 1872-9118. ; 283
  • Journal article (peer-reviewed)abstract
    • Solar PV has seen a spectacular market development in recent years and has become a cost competitive source of electricity in many parts of the world. Yet, prospective observations show that the coronavirus pandemic could impact renewable energy projects, especially in the distributed market. Tracking and attributing the economic footprint of COVID-19 lockdowns in the photovoltaic sector poses a significant research challenge. Based on millions of financial transaction records and 44 thousand photovoltaic installation records, we tracked the spatiotemporal sale network of the distributed photovoltaic market and explored the extent of market slowdown. We found that a two-month lockdown duration can be assessed as a high-risk threshold value. When the lockdown duration exceeds the threshold value, the monthly value-added loss reaches 67.7%, and emission reduction capacity is cut by 64.2% over the whole year. We show that risks of a slowdown in PV deployment due to COVID19 lockdowns can be mitigated by comprehensive incentive strategies for the distributed PV market amid market uncertainties.
  •  
46.
  • Zhang, Peng, et al. (author)
  • How similar are annual and summer temperature variability in central Sweden?
  • 2015
  • In: Advances in Climate Change Research. - : Elsevier BV. - 1674-9278 .- 2524-1761. ; 6, s. 159-170
  • Journal article (peer-reviewed)abstract
    • Tree-ring based temperature reconstructions have successfully inferred the past inter-annual to millennium scales summer temperaturevariability. A clear relationship between annual and summer temperatures can provide insights into the variability of past annual mean temperaturefrom the reconstructed summer temperature. However, how similar are summer and annual temperatures is to a large extent stillunknown. This study aims at investigating the relationship between annual and summer temperatures at different timescales in central Swedenduring the last millennium. The temperature variability in central Sweden can represent large parts of Scandinavia which has been a key regionfor dendroclimatological research. The observed annual and summer temperatures during 1901e2005 were firstly decomposed into differentfrequency bands using ensemble empirical mode decomposition (EEMD) method, and then the scale-dependent relationship was quantifiedusing Pearson correlation coefficients. The relationship between the observed annual and summer temperatures determined by the instrumentaldata was subsequently used to evaluate 7 climate models. The model with the best performance was used to infer the relationship for the lastmillennium. The results show that the relationship between the observed annual and summer temperatures becomes stronger as the timescaleincreases, except for the 4e16 years timescales at which it does not show any relationship. The summer temperature variability at shorttimescales (2e4 years) shows much higher variance than the annual variability, while the annual temperature variability at long timescales (>32years) has a much higher variance than the summer one. During the last millennium, the simulated summer temperature also shows highervariance at the short timescales (2e4 years) and lower variance at the long timescales (>1024 years) than those of the annual temperature. Therelationship between the two temperatures is generally close at the long timescales, and weak at the short timescales. Overall the summertemperature variability cannot well reflect the annual mean temperature variability for the study region during both the 20th century and the lastmillennium. Furthermore, all the climate models examined overestimate the annual mean temperature variance at the 2e4 years timescales,which indicates that the overestimate could be one of reasons why the volcanic eruption induced cooling is larger in climate models than inproxy data.
  •  
47.
  • Zhang, Qiong, et al. (author)
  • A series of Zn(II) terpyridine complexes with enhanced two-photon-excited fluorescence for in vitro and in vivo bioimaging
  • 2015
  • In: Journal of materials chemistry. B. - : ROYAL SOC CHEMISTRY. - 2050-750X .- 2050-7518. ; 3:36, s. 7213-7221
  • Journal article (peer-reviewed)abstract
    • It is still a challenge to obtain two-photon excited fluorescent bioimaging probes with intense emission, high photo-stability and low cytotoxicity. In the present work, four Zn(II)-coordinated complexes (1-4) constructed from two novel D-A and D-p-A ligands (L-1 and L-2) are investigated both experimentally and theoretically, aiming to explore efficient two-photon probes for bioimaging. Molecular geometry optimization used for theoretical calculations is achieved using the crystallographic data. Notably, the results indicate that complexes 1 and 2 display enhanced two-photon absorption (2PA) cross sections compared to their corresponding D-A ligand (L1). Furthermore, it was found that complex 1 has the advantages of moderate 2PA cross section in the near-infrared region, longer fluorescence lifetime, higher quantum yield, good biocompatibility and enhanced two-photon excited fluorescence. Therefore, complex 1 is evaluated as a bioimaging probe for in vitro imaging of HepG2 cells, in which it is observed under a two-photon scanning microscope that complex 1 exhibits effective co-staining with endoplasmic reticulum (ER) and nuclear membrane; as well as for in vivo imaging of zebrafish larva, in which it is observed that complex 1 exhibits specificity in the intestinal system.
  •  
48.
  • Zhang, Qiong, et al. (author)
  • Design, synthesis, linear and nonlinear photophysical properties of novel pyrimidine-based imidazole derivatives
  • 2016
  • In: New Journal of Chemistry. - : ROYAL SOC CHEMISTRY. - 1144-0546 .- 1369-9261. ; 40:4, s. 3456-3463
  • Journal article (peer-reviewed)abstract
    • Novel donor-pi-acceptor (D-pi-A) and donor-pi-acceptor-pi-donor (D-pi-A-pi-D) type pyrimidine imidazole derivatives with flexible ether chains (L1 and L2) have been efficiently synthesized through improved Knoevenagel condensation and Ullmann reactions with high yields. Based on systematic photophysical investigations and theoretical calculations, the structure-property relationships can be described as follows: (1) the linear and nonlinear optical properties of the target chromophores change regularly with increasing the number of branches and the polarity of the solvents. (2) The single-substituted chromophore L2 exhibited a remarkable negative solvato-kinetic effect, while the double-substituted chromophore L1 showed a positive solvato-kinetic effect. Significant bathochromic shifting of the emission spectra and larger Stokes shifts were observed in polar solvents. (3) The two-photon absorption (TPA) cross-section results further demonstrated that their TPA cross section values (delta) increase notably with increasing branch number, and the presence of high pi-delocalization could induce large size-scalable TPA enhancements. (4) By comprehensively considering the optical performance, cytotoxicity and solubility, L1 was identified as the better candidate for living cell (HepG2) imaging.
  •  
49.
  • Zhang, Qiong, et al. (author)
  • Nonlinear optical response and two-photon biological applications of a new family of imidazole-pyrimidine derivatives
  • 2016
  • In: Dyes and pigments. - : ELSEVIER SCI LTD. - 0143-7208 .- 1873-3743. ; 126, s. 286-295
  • Journal article (peer-reviewed)abstract
    • A series of novel D-pi-A type two-photon absorption (2PA) imidazole-pyrimidine derivatives (EX-1 similar to EX-4) have been synthesized and characterized, with EX-1 was crystallography confirmed. Based on systematic photophysical investigations, the structure property relationships can be drawn as follows: (1) Both theoretical and experimental studies indicated that the different donor groups have large influences on the optical properties. (2) The 2PA cross-section values (sigma) were obtained both by Z-Scan and two photon excited fluorescence (2PEF) measurements. 2PA cross sections show an increasing trend with increasing electron-donating strength and the number of branches. (3) Comprehensively considered the optical performance, molecular volume, cytotoxicity and solubility, EX-1 and EX-2 were identified to be the best candidates for living cells (HepG2) imaging. Moreover, the 2PA excitable features of EX-1 and EX-2 are capable of imaging in fresh mouses liver tissues with a depth of ca. 70 mu m. (C) 2015 Elsevier Ltd. All rights reserved.
  •  
50.
  • Zhang, Qiong, et al. (author)
  • Simulating the mid-Holocene, last interglacial and mid-Pliocene climate with EC-Earth3-LR
  • 2021
  • In: Geoscientific Model Development. - : Copernicus GmbH. - 1991-959X .- 1991-9603. ; 14:2, s. 1147-1169
  • Journal article (peer-reviewed)abstract
    • As global warming is proceeding due to rising greenhouse gas concentrations, the Earth system moves towards climate states that challenge adaptation. Past Earth system states are offering possible modelling systems for the global warming of the coming decades. These include the climate of the mid-Pliocene (similar to 3 Ma), the last interglacial (similar to 129-116 ka) and the mid-Holocene (similar to 6 ka). The simulations for these past warm periods are the key experiments in the Paleoclimate Model Intercomparison Project (PMIP) phase 4, contributing to phase 6 of the Coupled Model Intercomparison Project (CMIP6). Paleoclimate modelling has long been regarded as a robust out-of-sample test bed of the climate models used to project future climate changes. Here, we document the model setup for PMIP4 experiments with EC-Earth3-LR and present the large-scale features from the simulations for the mid-Holocene, the last interglacial and the mid-Pliocene. Using the pre-industrial climate as a reference state, we show global temperature changes, large-scale Hadley circulation and Walker circulation, polar warming, global monsoons and the climate variability modes - El Nino-Southern Oscillation (ENSO), the Pacific Decadal Oscillation (PDO) and the Atlantic Multidecadal Oscillation (AMO). EC-Earth3-LR simulates reasonable climate responses during past warm periods, as shown in the other PMIP4-CMIP6 model ensemble. The systematic comparison of these climate changes in past three warm periods in an individual model demonstrates the model's ability to capture the climate response under different climate forcings, providing potential implications for confidence in future projections with the EC-Earth model.
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