| 1. |
|
|
| 2. |
- Santangelo, James S., et al.
(författare)
-
Global urban environmental change drives adaptation in white clover
- 2022
-
Ingår i: Science. - : American Association for the Advancement of Science (AAAS). - 0036-8075 .- 1095-9203. ; 375
-
Tidskriftsartikel (refereegranskat)abstract
- Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense that also affects tolerance to abiotic stressors. Urban-rural gradients were associated with the evolution of clines in defense in 47% of cities throughout the world. Variation in the strength of clines was explained by environmental changes in drought stress and vegetation cover that varied among cities. Sequencing 2074 genomes from 26 cities revealed that the evolution of urban-rural dines was best explained by adaptive evolution, but the degree of parallel adaptation varied among cities. Our results demonstrate that urbanization leads to adaptation at a global scale.
|
|
| 3. |
|
|
| 4. |
|
|
| 5. |
- Borsato, M., et al.
(författare)
-
Unleashing the full power of LHCb to probe stealth new physics
- 2022
-
Ingår i: Reports on Progress in Physics. - : IOP Publishing. - 0034-4885 .- 1361-6633. ; 85:2
-
Tidskriftsartikel (refereegranskat)abstract
- In this paper, we describe the potential of the LHCb experiment to detect stealth physics. This refers to dynamics beyond the standard model that would elude searches that focus on energetic objects or precision measurements of known processes. Stealth signatures include long-lived particles and light resonances that are produced very rarely or together with overwhelming backgrounds. We will discuss why LHCb is equipped to discover this kind of physics at the Large Hadron Collider and provide examples of well-motivated theoretical models that can be probed with great detail at the experiment.
|
|
| 6. |
- Arabaci, M. Özbey, et al.
(författare)
-
Detection of a large Be circumstellar disk during X-ray quiescence of XTE J1946+274
- 2015
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 582
-
Tidskriftsartikel (refereegranskat)abstract
- Aims: We present a multiwavelength study of the Be/X-ray binary system XTE J1946+274 with the main goal of better characterizing its behavior during X-ray quiescence. We also aim to shed light on the possible mechanisms which trigger the X-ray activity for this source.Methods: XTE J1946+274 was observed by Chandra-ACIS during quiescence in 2013 March 12. In addition, this source has been monitored from the ground-based astronomical observatories of El Teide (Tenerife, Spain), Roque de los Muchachos (La Palma, Spain) and Sierra Nevada (Granada, Spain) since 2011 September, and from the TUBITAK National Observatory (Antalya, Turkey) since 2005 April. We have performed spectral and photometric temporal analyses in order to investigate the quiescent state and transient behavior of this binary system.Results: Our optical study revealed that a long mass ejection event from the Be star took place in 2006, lasting for about seven years, and another one is currently ongoing. We also found that a large Be circumstellar disk is present during quiescence, although major X-ray activity is not observed. We made an attempt to explain this by assuming the permanently presence of a tilted (sometimes warped) Be decretion disk. The 0.3-10 keV X-ray spectrum of the neutron star during quiescence was well fitted with either an absorbed black-body or an absorbed power-law models. The main parameters obtained for these models were kT = 1.43 +/- 0.17 and Gamma = 0.9 +/- 0.4 (with N-H similar to 2-7 x 10(22) cm(-2)). The 0.3-10 keV flux of the source was similar to 0.8-1 x 10(-12) erg(-1) cm(-2) s(-1). Pulsations were found with P-pulse = 15.757(1) s (epoch MJD 56 363.115) and an rms pulse fraction of 32.1(3)%. The observed X-ray luminosity during quiescent periods was close to that of expected in supersonic propeller regimen.
|
|
| 7. |
- Alimena, Juliette, et al.
(författare)
-
Searching for long-lived particles beyond the Standard Model at the Large Hadron Collider
- 2020
-
Ingår i: Journal of Physics G. - : IOP Publishing. - 0954-3899 .- 1361-6471. ; 47:9
-
Tidskriftsartikel (refereegranskat)abstract
- Particles beyond the Standard Model (SM) can generically have lifetimes that are long compared to SM particles at the weak scale. When produced at experiments such as the Large Hadron Collider (LHC) at CERN, these long-lived particles (LLPs) can decay far from the interaction vertex of the primary proton-proton collision. Such LLP signatures are distinct from those of promptly decaying particles that are targeted by the majority of searches for new physics at the LHC, often requiring customized techniques to identify, for example, significantly displaced decay vertices, tracks with atypical properties, and short track segments. Given their non-standard nature, a comprehensive overview of LLP signatures at the LHC is beneficial to ensure that possible avenues of the discovery of new physics are not overlooked. Here we report on the joint work of a community of theorists and experimentalists with the ATLAS, CMS, and LHCb experiments-as well as those working on dedicated experiments such as MoEDAL, milliQan, MATHUSLA, CODEX-b, and FASER-to survey the current state of LLP searches at the LHC, and to chart a path for the development of LLP searches into the future, both in the upcoming Run 3 and at the high-luminosity LHC. The work is organized around the current and future potential capabilities of LHC experiments to generally discover new LLPs, and takes a signature-based approach to surveying classes of models that give rise to LLPs rather than emphasizing any particular theory motivation. We develop a set of simplified models; assess the coverage of current searches; document known, often unexpected backgrounds; explore the capabilities of proposed detector upgrades; provide recommendations for the presentation of search results; and look towards the newest frontiers, namely high-multiplicity 'dark showers', highlighting opportunities for expanding the LHC reach for these signals.
|
|
| 8. |
- Caballero-Garcia, M. D., et al.
(författare)
-
Activity from the Be/X-ray binary system V0332+53 during its intermediate-luminosity outburst in 2008
- 2016
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 589
-
Tidskriftsartikel (refereegranskat)abstract
- Aims. We present a study of the Be/X-ray binary system V 0332+53 with the main goal of characterizing its behaviour mainly during the intermediate-luminosity X-ray event in 2008. In addition, we aim to contribute to the understanding of the behaviour of the donor companion by including optical data from our dedicated campaign starting in 2006. Methods. V 0332+53 was observed by RXTE and Swift during the decay of the intermediate-luminosity X-ray outburst of 2008, and with Suzaku before the rising of the third normal outburst of the 2010 series. In addition, we present recent data from the Spanish ground-based astronomical observatories of El Teide (Tenerife), Roque de los Muchachos (La Palma), and Sierra Nevada (Granada), and since 2006 from the Turkish TUBITAK National Observatory (Antalya). We have performed temporal analyses to investigate the transient behaviour of this system during several outbursts. Results. Our optical study revealed that continuous mass ejection episodes from the Be star have been taking place since 2006 and another is currently ongoing. The broad-band 1-60 keV X-ray spectrum of the neutron star during the decay of the 2008 outburst was well fitted with standard phenomenological models that were enhanced by an absorption feature of unknown origin at about 10 keV and a narrow iron K-alpha fluorescence line at 6.4 keV. For the first time in V 0332+ 53 we tentatively see an increase in the cyclotron line energy with increasing flux (although further and more sensitive observations are needed to confirm this). The fast aperiodic variability shows a quasi-periodic oscillation (QPO) at 227 +/- 9 mHz only during the lowest luminosities, which might indicate that the inner regions surrounding the magnetosphere are more visible during the lowest flux states.
|
|
| 9. |
- Camero, A., et al.
(författare)
-
Recent activity of the Be/X-ray binary system SAX J2103.5+4545
- 2014
-
Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 568, s. A115-
-
Tidskriftsartikel (refereegranskat)abstract
- Aims. We present a multi wavelength study of the Be/X-ray binary system SAX J2103.5+4545 with the goal of better characterizing the transient behaviour of this source. Methods. SAXJ2103.5+4545 was observed by Swift/XRT four times in 2007 from April 25 to May 5, and during quiescence in 2012 August 31. In addition, this source has been monitored from the ground-based astronomical observatories of El Teide (Tenerife. Spain), Roque de los Muchachos (La Palma, Spain), and Sierra Nevada (Granada, Spain) since 2011 August, and from the TOM-TAR National Observatory (Antalya, Turkey) since 2009 June. We performed spectral and photometric temporal analyses to investigate the different states exhibited by SAXJ2103.5+4545. Results. In X-rays, an absorbed power-law model provided the best fit for all the XRT spectra. An iron-line feature at similar to 6.42 key was present in all the observations except for that taken during quiescence in 2012. The photon indexes are consistent with previous studies of SAX J2103.5+4545 in high/low-luminosity states, Pulsations were found in all the XRT data from 2007 (2.839(2) mHz; MJD 54 222.02), but not during quiescence. The two optical outbursts in 2010 and 2012 lasted for about eight or nine months (as the one in 2007 probably did and the current one in 2014 might do) and were most probably caused by mass-ejection events from the Be star that eventually fed the circumstellar disc. All of these outbursts started about three months before the triggering of the X-ray activity and at about the same period before the maximum of the Ho line equivalent width (in emission) was reached at only similar to 8-5 angstrom. The global correlation between the BV variability and the X-ray intensity was also observed at longer wavelengths in the IR domain.
|
|
| 10. |
|
|
| 11. |
- Jiménez-Ortega, E., et al.
(författare)
-
Dose painting by means of Monte Carlo treatment planning at the voxel level
- 2017
-
Ingår i: Physica medica (Testo stampato). - : Elsevier BV. - 1120-1797 .- 1724-191X. ; 42, s. 339-344
-
Tidskriftsartikel (refereegranskat)abstract
- Purpose: To develop a new optimization algorithm to carry out true dose painting by numbers (DPBN) planning based on full Monte Carlo (MC) calculation.Methods: Four configurations with different clustering of the voxel values from PET data were proposed. An optimization method at the voxel level under Lineal Programming (LP) formulation was used for an inverse planning and implemented in CARMEN, an in-house Monte Carlo treatment planning system.Results: Beamlet solutions fulfilled the objectives and did not show significant differences between the different configurations. More differences were observed between the segment solutions. The plan for the dose prescription map without clustering was the better solution.Conclusions: LP optimization at voxel level without dose-volume restrictions can carry out true DPBN planning with the MC accuracy.
|
|
| 12. |
|
|
| 13. |
|
|
| 14. |
- Rabe, Benjamin, et al.
(författare)
-
The MOSAiC Distributed Network: Observing the coupled Arctic system with multidisciplinary, coordinated platforms
- 2024
-
Ingår i: Elementa. - 2325-1026. ; 12:1
-
Tidskriftsartikel (refereegranskat)abstract
- Central Arctic properties and processes are important to the regional and global coupled climate system. The Multidisciplinary drifting Observatory for the Study of Arctic Climate (MOSAiC) Distributed Network (DN) of autonomous ice-tethered systems aimed to bridge gaps in our understanding of temporal and spatial scales, in particular with respect to the resolution of Earth system models. By characterizing variability around local measurements made at a Central Observatory, the DN covers both the coupled system interactions involving the ocean-ice-atmosphere interfaces as well as three-dimensional processes in the ocean, sea ice, and atmosphere. The more than 200 autonomous instruments (“buoys”) were of varying complexity and set up at different sites mostly within 50 km of the Central Observatory. During an exemplary midwinter month, the DN observations captured the spatial variability of atmospheric processes on sub-monthly time scales, but less so for monthly means. They show significant variability in snow depth and ice thickness, and provide a temporally and spatially resolved characterization of ice motion and deformation, showing coherency at the DN scale but less at smaller spatial scales. Ocean data show the background gradient across the DN as well as spatially dependent time variability due to local mixed layer sub-mesoscale and mesoscale processes, influenced by a variable ice cover. The second case (May–June 2020) illustrates the utility of the DN during the absence of manually obtained data by providing continuity of physical and biological observations during this key transitional period. We show examples of synergies between the extensive MOSAiC remote sensing observations and numerical modeling, such as estimating the skill of ice drift forecasts and evaluating coupled system modeling. The MOSAiC DN has been proven to enable analysis of local to mesoscale processes in the coupled atmosphere-ice-ocean system and has the potential to improve model parameterizations of important, unresolved processes in the future.
|
|
| 15. |
|
|
| 16. |
|
|
| 17. |
- Abada, A., et al.
(författare)
-
FCC-ee: The Lepton Collider: Future Circular Collider Conceptual Design Report Volume 2
- 2019
-
Ingår i: European Physical Journal: Special Topics. - : Springer Science and Business Media LLC. - 1951-6355 .- 1951-6401. ; 228:2, s. 261-623
-
Tidskriftsartikel (refereegranskat)abstract
- In response to the 2013 Update of the European Strategy for Particle Physics, the Future Circular Collider (FCC) study was launched, as an international collaboration hosted by CERN. This study covers a highest-luminosity high-energy lepton collider (FCC-ee) and an energy-frontier hadron collider (FCC-hh), which could, successively, be installed in the same 100 km tunnel. The scientific capabilities of the integrated FCC programme would serve the worldwide community throughout the 21st century. The FCC study also investigates an LHC energy upgrade, using FCC-hh technology. This document constitutes the second volume of the FCC Conceptual Design Report, devoted to the electron-positron collider FCC-ee. After summarizing the physics discovery opportunities, it presents the accelerator design, performance reach, a staged operation scenario, the underlying technologies, civil engineering, technical infrastructure, and an implementation plan. FCC-ee can be built with today’s technology. Most of the FCC-ee infrastructure could be reused for FCC-hh. Combining concepts from past and present lepton colliders and adding a few novel elements, the FCC-ee design promises outstandingly high luminosity. This will make the FCC-ee a unique precision instrument to study the heaviest known particles (Z, W and H bosons and the top quark), offering great direct and indirect sensitivity to new physics. © 2019, The Author(s).
|
|
| 18. |
- Abada, A., et al.
(författare)
-
FCC-hh : The Hadron Collider: Future Circular Collider Conceptual Design Report Volume 3
- 2019
-
Ingår i: The European Physical Journal Special Topics. - : SPRINGER HEIDELBERG. - 1951-6355 .- 1951-6401. ; 228:4, s. 755-1107
-
Tidskriftsartikel (refereegranskat)abstract
- In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100TeV. Its unprecedented centre of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries.
|
|
| 19. |
- Abada, A., et al.
(författare)
-
FCC Physics Opportunities: Future Circular Collider Conceptual Design Report Volume 1
- 2019
-
Ingår i: European Physical Journal C. - : Springer Science and Business Media LLC. - 1434-6044 .- 1434-6052. ; 79:6
-
Tidskriftsartikel (refereegranskat)abstract
- We review the physics opportunities of the Future Circular Collider, covering its e+e-, pp, ep and heavy ion programmes. We describe the measurement capabilities of each FCC component, addressing the study of electroweak, Higgs and strong interactions, the top quark and flavour, as well as phenomena beyond the Standard Model. We highlight the synergy and complementarity of the different colliders, which will contribute to a uniquely coherent and ambitious research programme, providing an unmatchable combination of precision and sensitivity to new physics. © 2019, The Author(s).
|
|
| 20. |
- Abada, A., et al.
(författare)
-
HE-LHC: The High-Energy Large Hadron Collider: Future Circular Collider Conceptual Design Report Volume 4
- 2019
-
Ingår i: European Physical Journal: Special Topics. - : Springer Science and Business Media LLC. - 1951-6355 .- 1951-6401. ; 228:5, s. 1109-1382
-
Tidskriftsartikel (refereegranskat)abstract
- In response to the 2013 Update of the European Strategy for Particle Physics (EPPSU), the Future Circular Collider (FCC) study was launched as a world-wide international collaboration hosted by CERN. The FCC study covered an energy-frontier hadron collider (FCC-hh), a highest-luminosity high-energy lepton collider (FCC-ee), the corresponding 100 km tunnel infrastructure, as well as the physics opportunities of these two colliders, and a high-energy LHC, based on FCC-hh technology. This document constitutes the third volume of the FCC Conceptual Design Report, devoted to the hadron collider FCC-hh. It summarizes the FCC-hh physics discovery opportunities, presents the FCC-hh accelerator design, performance reach, and staged operation plan, discusses the underlying technologies, the civil engineering and technical infrastructure, and also sketches a possible implementation. Combining ingredients from the Large Hadron Collider (LHC), the high-luminosity LHC upgrade and adding novel technologies and approaches, the FCC-hh design aims at significantly extending the energy frontier to 100 TeV. Its unprecedented centre-of-mass collision energy will make the FCC-hh a unique instrument to explore physics beyond the Standard Model, offering great direct sensitivity to new physics and discoveries. © 2019, The Author(s).
|
|
| 21. |
|
|
| 22. |
- Hanna, Catherine R., et al.
(författare)
-
Three Versus Six Months of Adjuvant Doublet Chemotherapy for Patients With Colorectal Cancer : A Multi-Country Cost-Effectiveness and Budget Impact Analysis
- 2021
-
Ingår i: Clinical colorectal cancer. - : Elsevier. - 1533-0028. ; 20:3, s. 236-244
-
Tidskriftsartikel (refereegranskat)abstract
- This study widens the transferability of cost-utility results from the SCOT trial showing that administering 3 months of adjuvant, oxaliplatin-based chemotherapy is cost-effective and cost saving compared to 6 months from the perspective of all countries recruited to SCOT. The impact on healthcare budgets if the findings are implemented as predicted will amount to savings of at least US$150 million over 5 years. Background: The Short Course Oncology Treatment (SCOT) trial demonstrated non-inferiority, less toxicity, and cost-effectiveness from a UK perspective of 3 versus 6 months of oxaliplatin-based chemotherapy for patients with colorectal cancer. This study assessed the cost-effectiveness of shorter treatment and the budget impact of implementing trial findings from the perspectives of all countries recruited to SCOT: Australia, Denmark, New Zealand, Spain, Sweden, and the United Kingdom. Patients and Methods: Individual cost-utility analyses were performed from the perspective of each country. Resource, quality of life, and survival estimates from the SCOT trial (N = 6065) were used. Probabilistic sensitivity analysis and subgroup analyses were undertaken. Using undiscounted costs from these cost-utility analyses, the impact on country-specific healthcare budgets of implementing the SCOT trial findings was calculated over a 5-year period. The currency used was US dollars (US$), and 2019 was the base year. One-way and scenario sensitivity analysis addressed uncertainty within the budget impact analysis. Results: Three months of treatment were cost saving and cost-effective compared to 6 months from the perspective of all countries. The incremental net monetary benefit per patient ranged from US$8972 (Spain) to US$13,884 (Denmark). The healthcare budget impact over 5 years for the base-case scenario ranged from US$3.6 million (New Zealand) to US$61.4 million (UK) and totaled over US$150 million across all countries. Conclusion: This study has widened the transferability of results from the SCOT trial, showing that shorter treatment is cost-effective from a multi-country perspective. The vast savings from implementation could fully justify the investment in conducting the SCOT trial.
|
|
| 23. |
- Mashayekhy Rad, Farshid, et al.
(författare)
-
Measurements of Atmospheric Proteinaceous Aerosol in the Arctic Using a Selective UHPLC/ESI-MS/MS Strategy
- 2019
-
Ingår i: Journal of the American Society for Mass Spectrometry. - : American Chemical Society (ACS). - 1044-0305 .- 1879-1123. ; 30:1, s. 161-173
-
Tidskriftsartikel (refereegranskat)abstract
- In this article, an analytical methodology to investigate the proteinaceous content in atmospheric size-resolved aerosols collected at the Zeppelin observatory (79 °N, 12 °E) at Ny Ålesund, Svalbard, from September to December 2015, is proposed. Quantitative determination was performed after acidic hydrolysis using ultrahigh-performance liquid chromatography in reversed-phase mode coupled to electrospray ionization tandem mass spectrometry. Chromatographic separation, as well as specificity in the identification, was achieved by derivatization of the amino acids with N-butyl nicotinic acid N-hydroxysuccinimide ester prior to the analysis. The chromatographic run was performed within 11 min and instrumental levels of detection (LODs) were between 0.2 and 8.1 pg injected on the column, except for arginine which exhibited an LOD of 37 pg. Corresponding method LODs were between 0.01 and 1.9 fmol/m3, based on the average air sampling volume of 57 m3. The sum of free amino acids and hydrolyzed polyamino acids was shown to vary within 6–2914 and 0.02–1417 pmol/m3 for particles in sizes < 2 and 2–10 μm in equivalent aerodynamic diameter, respectively. Leucine, alanine, and valine were the most abundant among the amino acids in both aerosol size fractions. In an attempt to elucidate source areas of the collected aerosols, 5- to 10-day 3D backward trajectories reaching the sampling station were calculated. Overall, the method described here provides a first time estimate of the proteinaceous content, that is, the sum of free and polyamino acids, in size-resolved aerosols collected in the Arctic.
|
|
| 24. |
- Melo Zurita, Maria de Lourdes, et al.
(författare)
-
Global Water Governance and Climate Change : Identifying Innovative Arrangements for Adaptive Transformation
- 2018
-
Ingår i: Water. - : MDPI AG. - 2073-4441. ; 10:1
-
Forskningsöversikt (refereegranskat)abstract
- A convoluted network of different water governance systems exists around the world. Collectively, these systems provide insight into how to build sustainable regimes of water use and management. We argue that the challenge is not to make the system less convoluted, but rather to support positive and promising trends in governance, creating a vision for future environmental outcomes. In this paper, we analyse nine water case studies from around the world to help identify potential innovative arrangements' for addressing existing dilemmas. We argue that such arrangements can be used as a catalyst for crafting new global water governance futures. The nine case studies were selected for their diversity in terms of location, scale and water dilemma, and through an examination of their contexts, structures and processes we identify key themes to consider in the milieu of adaptive transformation. These themes include the importance of acknowledging socio-ecological entanglements, understanding the political dimensions of environmental dilemmas, the recognition of different constructions of the dillema, and the importance of democratized processes.
|
|
| 25. |
|
|
